Oluwole Akinola

Oluwole B. Akinola is a Professor of Anatomy and the Dean of Basic Medical Sciences. He was the Head of Anatomy and presently PI of the Laboratory of Neuro-endocrinology. Akinola’s Laboratory seeks to understand the link between androgen deprivation, insulin resistance and synaptic plasticity; including understanding how impaired insulin receptor signalling contributes to the pathogenesis and progression of neurodegenerative diseases. His lab also studies the association between heavy metals, obesogenic diets and corticogenesis. Specifically, he studies how gestational co-exposure to these environmental factors impact the migration of GABAergic and glutamatergic neurons during corticogenesis in rodent models, in a bid to understand the developmental mechanisms of certain neurological conditions such as autism spectrum disorders, epilepsy and schizophrenia. Prof. Akinola is the recipient of the IBRO Research Fellowship, UniLecce Pre-doctoral Fellowship and IBRO Return Home Fellowship.

EDUCATION

Postdoctoral Research Fellowship, 2012-2013; Uniformed Services University of the Health Sciences, Bethesda, USA.
Doctor of Philosophy (PhD Anatomy), 2007-2011; University of Ilorin, Nigeria.
Pre-doctoral Research Fellowship, 2007-2008; University of Lecce, Italy.
Master of Science (MSc Anatomy), 1999-2001; University of Lagos, Nigeria.
Bachelor of Science (BSc Anatomy), 1992-1997; University of Ilorin, Nigeria.

RESEARCH, TEACHING, or OTHER INTERESTS

Anatomy, Endocrinology, Structural Biology, Developmental Neuroscience

Scopus Publications

Histological and immunohistochemical study of the neuroprotective potentials of trans-cinnamaldehyde in Wistar rat model of insulin resistance
S. Olorunnado and O. Akinola
African Journals Online (AJOL)
INTRODUCTION: The incidence of insulin resistance is on the increase globally. Earlier reports linked impaired insulin signaling and glucose intolerance to cognitive decline, suggesting that improving insulin signaling could enhance neuronal survival. Trans-cinnamaldehyde (TCA) is an active component of cinnamon and has many pharmacological importance. However, the effects of TCA on insulin resistance-induced neurodegenerative changes are unclear. This study, therefore, aimed at evaluating the effects of trans-cinnamaldehyde on hippocampal histoarchitecture in insulin-resistant rats. METHODS: Twenty adult Wistar rats were fed with a high-fat diet for 8 weeks and then injected with a low dose of STZ (30 mg/kg body weight intraperitoneally). 60mg/kg of TCA was orally administered once daily for 4 weeks. Histological and immunohistochemical techniques were used to investigate the ameliorative potentials of TCA on the hippocampus of Wistar Rats. RESULTS: TCA administration to insulin-resistant rats histologically and immunohistochemically reduced pyknosis, astrogliosis, and neurodegenerative changes in the hippocampus when compared with untreated insulin-resistant rats. CONCLUSION: TCA prospect as a novel therapy in insulin-resistant subjects with neurogenerative diseases could be further explored.


Curcumin intervention in hippocampal atrophy of diet-induceAlzheimer-like deficits in insulin-resistant rats
A. A. Mohammed and O. B. Akinola
African Journals Online (AJOL)
INTRODUCTION: The primary mechanism connecting Type 2 diabetes mellitus (T2DM) to the neurodegenerative deficits in brain regions such as the hippocampus is insulin resistance. Neurodegenerative deficits in the form of amyloid aggregation and Tau hyperphosphorylation, which are hallmarks of Alzheimer's disease, are documented for both conditions in scientific literature. A mouse model of insulin resistance was used to study this relationship, and curcumin, a flavonoid contained in the spice turmeric, was evaluated as a potential treatment because of its reported benefits in lowering hyperglycemia and hyperlipidemia in diabetes mellitus. Curcumin is a prime contender against these pervasive diseases due to its efficacy, accessibility, affordability, and safety. METHODS: The study methodology included measuring fasting blood glucose levels, staining hippocampal sections for histomorphological examination, and ELISA to quantify hippocampal PI3K expression, AKT expression, and GSK3-β. Data were processed using one-way ANOVA and Turkey's post hoc test. RESULTS: The findings demonstrated that oral curcumin effectively corrected hyperglycemia and reduced insulin resistance. The study further revealed that insulin resistance was related to hippocampal atrophy and related deficits in the assessed rat model. Curcumin ameliorated these changes, reduced the aggregation of Aβ in the hippocampus, and reversed impaired signaling of proteins PI3K, AKT, and GSK-3β. CONCLUSION: The study's findings imply that oral curcumin has potential therapeutic advantages against prevalent neuronal death linked to abnormalities mimicking Alzheimer's disease and insulin resistance. Hence, curcumin may benefit dementia patients who also have insulin resistance.


Evaluation of the neuroprotective potential of Trans-cinnamaldehyde in female Wistar rat model of insulin resistance




The synergistic ameliorative activity of peroxisome proliferator-activated receptor-alpha and gamma agonists, fenofibrate and pioglitazone, on hippocampal neurodegeneration in a rat model of insulin resistance
Olumayowa K. Idowu, Olushola O. Oluyomi, Oluwatomisin O. Faniyan, Olufunke O. Dosumu, and Oluwole B. Akinola
Wiley
AbstractInsulin resistance (IR) is a risk factor for metabolic disorders and neurodegeneration. Peroxisome proliferator‐activated receptor (PPAR) agonists have been proven to mitigate the neuronal pathology associated with IR. However, the synergetic efficacy of these agonists is yet to be fully described. Hence, we aimed to investigate the efficacy of PPARα/γ agonists (fenofibrate and pioglitazone) on a high‐fat diet (HFD) and streptozotocin (STZ)‐induced hippocampal neurodegeneration. Male Wistar rats (200 ± 25 mg/body weight [BW]) were divided into five groups. The experimental groups were fed on an HFD for 12 weeks coupled with 5 days of an STZ injection (30 mg/kg/BW, i.p) to induce IR. Fenofibrate (FEN; 100 mg/kg/BW, orally), pioglitazone (PIO; 20 mg/kg/BW, orally), and their combination were administered for 2 weeks postinduction. Behavioral tests were conducted, and blood was collected to determine insulin sensitivity after treatment. Animals were killed for assessment of oxidative stress, cellular morphology characterization, and astrocytic evaluation. HFD/STZ‐induced IR increased malondialdehyde (MDA) levels and decreased glutathione (GSH) levels. Evidence of cellular alterations and overexpression of astrocytic protein was observed in the hippocampus. By contrast, monotherapy of FEN and PIO increased the GSH level (p < 0.05), decreased the MDA level (p < 0.05), and improved cellular morphology and astrocytic expression. Furthermore, the combined treatment led to improved therapeutic activities compared to monotherapies. In conclusion, FEN and PIO exerted a therapeutic synergistic effect on HFD/STZ‐induced IR in the hippocampus.


Structural Changes in the Medial Prefrontal Cortex and Anterior Cingulate Cortex of Dehydroepiandrosterone- Induced Wistar Rat Model of Polycystic Ovarian Syndrome
Enya Joseph Igbo and
Negah Scientific Publisher
Introduction: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder in women that is associated with an increased risk of infertility. This study aims to evaluate the neurobehavioral and neurochemical changes along with the associated changes in the medial prefrontal cortex (mPFC) and anterior cingulate cortex (ACC) of the dehydroepiandrosterone (DHEA)-induced PCOS model rats. Methods: A total of 12 female juvenile Wistar rats (30 to 50 g) about 22 to 44 days old were divided into 2 groups. The control group received sesame oil while the PCOS group received sesame oil plus DHEA. All treatment was done via daily subcutaneous injection for 21 days. Results: Subcutaneous DHEA-induced PCOS significantly depleted the line crossing and rearing frequency in the open field, along with the percentage of the time in the white box, line crossing, rearing, and peeping frequency in the black and white box, and the percentage of alternation in the Y-maze. PCOS significantly increased the immobility time, freezing period, and the percentage of time in the dark area in the forced swim test, open field test, and black and white box, respectively. The level of luteinizing hormone, follicle-stimulating hormone, malondialdehyde (MDA), reactive oxygen species (ROS), and interleukin-6 (IL-6) increased significantly, while norepinephrine depleted significantly with an obvious decrease in the brain-derived neurotrophic factor level in the PCOS model rats. PCOS rats exhibited cystic follicles in the ovaries and necrotic or degenerative like features in the hippocampal pyramidal cells. Conclusion: DHEA-induced PCOS results in anxiety and depressive behavior with structural alteration in rats, possibly through the elevation of MDA, ROS, and IL-6 levels, which also attributes to impaired emotional and executive functions in the mPFC and ACC.


Lasting metabolic effect of a high-fructose diet on global cerebral ischemia
Oluwatomilayo Patience Ojo, Paula Andrea Perez-Corredor, Johanna Andrea Gutierrez-Vargas, Oluwole Busayo Akinola, and Gloria Patricia Cardona-Gómez
Informa UK Limited
ABSTRACT Introduction: Obesity is a public health problem that is associated with cerebrovascular diseases, such as ischemic stroke. The coexistence of obesity with cerebral ischemia has been suggested to be considerably detrimental to the neurological system. Objective: Hence, in this study, we evaluated the long-term effects of a 20% high fructose diet (HFD) and global cerebral ischemia on neurological, cognitive and emotional performance in three-month-old male Wistar rats. Results: Our results demonstrated that fructose intake led to increases in body weight and blood glucose, as well as reduced insulin sensitivity. The co-morbidity of fructose intake and cerebral ischemia resulted to hyperlipidemia, as well as increases in liver and adipocyte damage, which worsened neurological performance and resulted in alterations in learning and emotional skills at two weeks post-ischemia. No significant biochemical changes in autophagy and plasticity markers at the late stage of ischemia were observed. Conclusion: These results suggested that obesity causes a lasting effect on metabolic disorders that can contribute to increased neurological impairment after cerebral ischemia.


Effect of naproxen on testicular morphometry and serum gonadotropin level of cadmium intoxication in rats




Hippocampal cellular changes in androgen deprived insulin resistant rats
Emmanuel O. Yawson and Oluwole B. Akinola
Springer Science and Business Media LLC



Low testicular zinc level, p53 expression and impairment of Sertoli cell phagocytosis of residual bodies in rat subjected to psychological stress
Leke Jacob Medubi, Oluwole Busayo Akinola, and Adeoye Oyetunji Oyewopo
Hindawi Limited
Psychological stress is a known aetiology of infertility. However, the mechanisms translating it to reproductive dysfunction are not fully elucidated. Three experiments were performed on Wistar rats were designed to evaluate Sertoli cell function under stress. In Experiment I, rats were randomised into three groups: saline baseline group given saline, ASEMA baseline group given aqueous extract of Massularia acuminata, zinc baseline group administered zinc orally. In Experiment II, exposure to psychological stress (for 1 hour per day) was layered on Experiment I while Experiment III substituted stress with administration of dexamethasone (DX). Six rats were sacrificed per group per experiment on days 7 and 14 and the right testis was excised and processed for PAS‐haematoxylin staining and the left used for Zn determination. Results show significantly lower testicular Zn level as well more intensely immunoexpression of p53 in saline stress and saline DX groups compared with other groups. Also seen are the presence of residual bodies in the seminiferous tubular lumen of saline groups in Experiments II and III suggesting failure of residual bodies to be transported back towards the basement membrane. This study demonstrates that psychological stress impairs the ability of Sertoli cells to recycle residual bodies.


Plasmodium berghei-induced malaria decreases pain sensitivity in mice
Aboyeji L. Oyewole, Oluwole Akinola, and Bamidele V. Owoyele
AOSIS
Various types of pain were reported by people with Plasmodium falciparum and were mostly attributed to a symptom of malarial infection. Neural processes of pain sensation during malarial infection and their contributions to malaria-related death are poorly understood. Thus, these form the focus of this study. Swiss mice used for this study were randomly divided into two groups. Animals in the first group (Pb-infected group) were inoculated with Plasmodium berghei to induce malaria whilst the other group (intact group) was not infected. Formalin test was used to assess pain sensitivity in both groups and using various antagonists, the possible mechanism for deviation in pain sensitivity was probed. Also, plasma and brain samples collected from animals in both groups were subjected to biochemical and/or histological studies. The results showed that Pb-infected mice exhibited diminished pain-related behaviours to noxious chemical. The observed parasite-induced analgesia appeared to be synergistically mediated via µ-opioid, α2 and 5HT2A receptors. When varied drugs capable of decreasing pain threshold (pro-nociceptive drugs) were used, the survival rate was not significantly different in the Pb-infected mice. This showed little or no contribution of the pain processing system to malaria-related death. Also, using an anti-CD68 antibody, there was no immunopositive cell in the brain to attribute the observed effects to cerebral malaria. Although in the haematoxylin and eosin-stained tissues, there were mild morphological changes in the motor and anterior cingulate cortices. In conclusion, the pain symptom was remarkably decreased in the animal model for malaria, and thus, the model may not be appropriate for investigating malaria-linked pain as reported in humans. This is the first report showing that at a critical point, the malaria parasite caused pain-relieving effects in Swiss mice.


Western diet-induced fear memory impairment is attenuated by 6-shogaol in C57BL/6N mice
Michael O. Gabriel, Maria Nikou, Oluwole B. Akinola, Daniela D. Pollak, and Spyridon Sideromenos
Elsevier BV



Cuprizone toxicity and Garcinia kola biflavonoid complex activity on hippocampal morphology and neurobehaviour
G.O. Omotoso, O.J. Olajide, I.T. Gbadamosi, J.O. Adebayo, B.U. Enaibe, O.B. Akinola, and B.V. Owoyele
Elsevier BV



Comparison of indices of insulin resistance and islet beta-cell dysfunction across rat models of diabetes mellitus induced by modified diets or streptozotocin




Neuroanatomical and molecular correlates of cognitive and behavioural outcomes in hypogonadal males
O. B. Akinola and M. O. Gabriel
Springer Science and Business Media LLC



Distribution and Cellular Localization of KCC2 in the Ferret Neocortex
Francis T. Djankpa, Oluwole B. Akinola, and Sharon L. Juliano
S. Karger AG
KCC2 (a brain-specific potassium-chloride cotransporter) affects development of the cerebral cortex, including aspects of neuronal migration and cellular maturation and differentiation. KCC2 also modulates chloride homeostasis by influencing the switch of GABA from depolarizing in young neurons to hyperpolarizing in mature neurons. We describe the expression pattern, regional distribution, and cellular colocalization of KCC2 in the ferret cortex in normal kits and those treated with methylazoxymethanol acetate (MAM). We earlier developed a model of impaired cortical development by injecting MAM during mid-cortical gestation, which briefly interferes with neuronal production and additionally results in increased levels of KCC2 at P0. Using immunohistochemistry, we show a shift in KCC2 expression during development, being high in the subplate at P0, repositioning into a subtle laminar pattern in the neocortex at P7-P14, and becoming homogeneous at P35. KCC2 colocalizes with neuronal markers in the developing and mature cerebral cortex of normal ferrets and those treated with MAM, but shows a differential pattern of expression at different ages and locates in distinct cellular compartments during development. Subcellular localization shows that KCC2 predominantly situates in the membrane fraction of neocortical samples. These findings reveal that KCC2 colocalizes differentially with neurons and its expression pattern alters during development.


Lactational lead exposure perturbates androgenesis in Juvenile and pubertal wistar rats




Peripheral insulin resistance induced by streptozotocin and modified ddiets: Implications for hippocampal structural and functional iintegrity




Effects of Unripe Musa Paradisiaca on the Histochemistry of the Testis and Testosterone Levels in Adult Albino Rats




Sweet old memories: a review of the experimental models of the association between diabetes, senility and dementia
O. B. Akinola
Springer Science and Business Media LLC



Combined effects of chronic hyperglycaemia and oral aluminium intoxication on testicular tissue and some male reproductive parameters in Wistar rats
O. B. Akinola, S. A. Biliaminu, O. G. Adedeji, B. S. Oluwaseun, O. M. Olawoyin, and T. A. Adelabu
Hindawi Limited
Exposure to either environmental toxicants or chronic hyperglycaemia could impair male reproductive function. However, the extent to which exposure to such toxicants, in the presence of pre‐existing metabolic dysfunction, could affect male reproduction is unclear. Streptozotocin‐induced diabetic Wistar rats (12 weeks old) were exposed to oral aluminium chloride at 250 ppm for 30 days; followed by evaluation of caudal epididymal sperm count and motility, assay for serum follicle stimulating hormone (FSH), testosterone (T) and oestradiol; and assessment of testicular histology. Moreover, blood glucose was evaluated by the glucose oxidase method. In rats treated with streptozotocin (STZ) or aluminium (Al) alone, erosion of testicular parenchyma and stroma was observed. This effect was most severe in diabetic rats simultaneously exposed to Al; coupled with reduced caudal epididymal sperm count that was least in this (STZ+Al) group (18.75 × 106 ml−1) compared with controls (61.25 × 106 ml−1; P < 0.05), STZ group or Al group. Moreover, these reproductive perturbations (in the STZ+Al group) were associated with reduced sperm motility and significantly reduced serum FSH (P < 0.05); but elevated serum T and oestradiol (P < 0.05), compared with control. These suggest that diabetes‐induced testicular lesion is exacerbated by simultaneous oral Al toxicity in Wistar rats.


Short Wavelength Cone Opsin Is Not Expressed in the Retina of Arboreal African Pangolin (Manis tricuspis)
Adejoke J. Adekanmbi, Adefisayo A. Adekanmbi, and Oluwole B. Akinola
Hindawi Limited
This paper reports a study of cone photoreceptors present in the retina ofManis tricuspis. Specifically, the LWS (L-) opsin expressed in longwave-sensitive cones and SWS1 (S-) opsin shortwave-sensitive cones were targeted. Vertical sections revealed reactivity to a cone marker, peanut agglutinin (PNA), and to an LWS antibody, but not to an SWS1 antibody. This suggests that theManis tricuspisvisual system is not able to discriminate shorter wavelengths from longer wavelengths because the short wavelength cones are not expressed in their retina.


Repeated acute oral exposure to Cannabis sativa impaired neurocognitive behaviours and cortico-hippocampal architectonics in Wistar rats




Sodium azide-induced degenerative changes in the dorsolateral prefrontal cortex of rats: Attenuating mechanisms of kolaviron




Characterization of prefrontal cortex microstructure and antioxidant status in a rat model of neurodegeneration induced by aluminium chloride and multiple low-dose streptozotocin
Oluwole B. Akinola, Sikiru A. Biliaminu, Rianat A. Adediran, Kehinde A. Adeniye, and Fatimah C. Abdulquadir
Springer Science and Business Media LLC



PPAR-γ agonist pioglitazone improves semen quality and testicular histomorphometrics with partial reversal of hyperglycaemia in alloxan-induced diabetic rats
O.B. Akinola, O.O. Dosumu, S.A. Sanusi, T.F. Ajayi, and T.H. Olajide
Springer Science and Business Media LLC

RECENT SCHOLAR PUBLICATIONS

EVALUATION OF THE NEUROPROTECTIVE POTENTIAL OF TRANS-CINNAMALDEHYDE IN A RAT MODEL OF INSULIN RESISTANCE
S Olorunnado, O Akinola
IBRO Neuroscience Reports 15, S467-S468 2023



Neuromorphological and Biochemical Effects of Co-exposure to Bisphenol A and Cadmium in Insulin-resistant Rats
AT Lawal, AO Sharafadeen, OB Akinola
The Journal of Neurobehavioral Sciences 10 (3), 74-81 2023



Evaluation of the neuroprotective potential of Trans-cinnamaldehyde in female Wistar rat model of insulin resistance.
SE Olorunnado, OP Odum, OB Akinola
Journal of Krishna Institute of Medical Sciences (JKIMSU) 12 (2) 2023



Structural Changes in the Medial Prefrontal Cortex and Anterior Cingulate Cortex of Dehydroepiandrosterone-Induced Wistar Rat Model of Polycystic Ovarian Syndrome
EJ Igbo, U Okoliko, I Aminu, A Kopada, S Olorunnado, OB Akinola
Basic and Clinical Neuroscience 13 (5), 695 2022



The synergistic ameliorative activity of peroxisome proliferator‐activated receptor‐alpha and gamma agonists, fenofibrate and pioglitazone, on hippocampal neurodegeneration in
OK Idowu, OO Oluyomi, OO Faniyan, OO Dosumu, OB Akinola
ibrain 8 (3), 251-263 2022



Curcumin ameliorate cortical histomorphological deficits in Streptozocin and western diet induced neurodegeneration in Wistar Rats
AA Mohammed, OB Akinola
2022



The effects of flavonoids in curcumin on neurobehavioral deficits in insulin-resistant rats
AA Mohammed, OB Akinola
The Journal of Neurobehavioral Sciences 9 (2), 51-57 2022



Hippocampal cellular changes in androgen deprived insulin resistant rats
EO Yawson, OB Akinola
Metabolic Brain Disease 36 (5), 1037-1048 2021



Low testicular zinc level, p53 expression and impairment of Sertoli cell phagocytosis of residual bodies in rat subjected to psychological stress
LJ Medubi, OB Akinola, AO Oyewopo
Andrologia 53 (3), e13958 2021



Plasmodium berghei-induced malaria decreases pain sensitivity in mice
AL Oyewole, O Akinola, BV Owoyele
Onderstepoort Journal of Veterinary Research 88 (1), 1871 2021



Effect of naproxen on testicular morphometry and serum gonadotropin level of cadmium intoxication in rats
OP Odum, OA Adeyanju, TS Olawuyi, AO Soladoye, OB Akinola
Eur. J. Anat 25, 5 2021



Western diet-induced fear memory impairment is attenuated by 6-shogaol in C57BL/6N mice
MO Gabriel, M Nikou, OB Akinola, DD Pollak, S Sideromenos
Behavioural Brain Research 380, 112419 2020



Kolaviron improves behavioral outcomes and cortico-hippocampal morphology in mice following cuprizone neurotoxicity
G Omotoso, O Olajide, I Gbadamosi, B Enaibe, O Akinola, B Owoyele, ...
IBRO Reports 6, S493-S494 2019



Hippocampal structural correlates of neurocognitive perturbations in androgen-deprived rats
O Akinola, A Aiyedogbon, A Rahmon, F Fadele, A Oyewopo
IBRO Reports 6, S65 2019



Pain behavioural response in plasmodium berghei-induced malaria
A Oyewole, O Akinola, B Owoyele
JOURNAL OF NEUROCHEMISTRY 150, 119-119 2019



Cuprizone toxicity and Garcinia kola biflavonoid complex activity on hippocampal morphology and neurobehaviour
GO Omotoso, OJ Olajide, IT Gbadamosi, JO Adebayo, BU Enaibe, ...
Heliyon 5 (7) 2019



Comparison of indices of insulin resistance and islet beta-cell dysfunction across rat models of diabetes mellitus induced by modified diets or streptozotocin
O Gabriel
2018



Neuroanatomical and molecular correlates of cognitive and behavioural outcomes in hypogonadal males
OB Akinola, MO Gabriel
Metabolic brain disease 33, 491-505 2018



Distribution and cellular localization of KCC2 in the ferret neocortex
FT Djankpa, OB Akinola, SL Juliano
Developmental Neuroscience 40 (1), 39-53 2018



Effects of virgin coconut oil on aluminium chloride-induced alzheimer-like dementia in the prefrontal cortex
JA Olanrewaju, OB Akinola, SY Olatunji, JO Owolabi, OS Fabiyi, ...
Journal of Advances in Medical and Pharmaceutical Sciences 18 (1), 1-12 2018

MOST CITED SCHOLAR PUBLICATIONS

Evaluation of the histo-gastroprotective and antimicrobial activities of Heliotropium indicum Linn (Boraginaceae)
AA Adelaja, MD Ayoola, JO Otulana, OB Akinola, A Olayiwola, ...
The Malaysian Journal of Medical Sciences: MJMS 15 (3), 22 2008
Citations: 62



Alcohol-induced testicular oxidative stress and cholesterol homeostasis in rats–The therapeutic potential of virgin coconut oil
OO Dosumu, OB Akinola, EN Akang
Middle East Fertility Society Journal 17 (2), 122-128 2012
Citations: 60



Treatment of alloxan-induced diabetic rats with metformin or glitazones is associated with amelioration of hyperglycaemia and neuroprotection
O Akinola, M Gabriel, AA Suleiman, F Olorunsogbon
The Open Diabetes Journal 5 (1), 8-12 2012
Citations: 60



Chronic Treatment with Ethanolic Extract of the Leaves of Azadirachta indica Ameliorates Lesions of Pancreatic Islets in Streptozotocin Diabetes.
OB Akinola, EA Caxton-Martins, L Dini
International Journal of Morphology 28 (1) 2010
Citations: 53



Formal body bequest program in Nigerian medical schools: When do we start?
OB Akinola
Anatomical sciences education 4 (4), 239-242 2011
Citations: 42



Kolaviron was protective against sodium azide (NaN₃) induced oxidative stress in the prefrontal cortex
OJ Olajide, BU Enaibe, OO Bankole, OB Akinola, BJ Laoye, OM Ogundele
Metabolic brain disease 31, 25-35 2016
Citations: 40



Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies
JO Adebayo, EA Balogun, SO Malomo, AO Soladoye, LA Olatunji, ...
Evidence‐Based Complementary and Alternative Medicine 2013 (1), 742476 2013
Citations: 35



Cuprizone toxicity and Garcinia kola biflavonoid complex activity on hippocampal morphology and neurobehaviour
GO Omotoso, OJ Olajide, IT Gbadamosi, JO Adebayo, BU Enaibe, ...
Heliyon 5 (7) 2019
Citations: 33



Beneficial effects of low dose Musa paradisiaca on the semen quality of male Wistar rats
AS Alabi, GO Omotoso, BU Enaibe, OB Akinola, CNB Tagoe
Nigerian Medical Journal 54 (2), 92-95 2013
Citations: 30



Black seed oil ameliorated scopolamine-induced memory dysfunction and cortico-hippocampal neural alterations in male Wistar rats
A Imam, MS Ajao, MI Ajibola, A Amin, WI Abdulmajeed, AZ Lawal, ...
Bulletin of faculty of pharmacy, cairo university 54 (1), 49-57 2016
Citations: 27



Ethanol extract of the leaves of Psidium guajava Linn enhances sperm output in healthy Wistar rats
O Akinola, OS OB, OO Dosumu
2007
Citations: 27



Ameliorative Effects of Ethanolic Leaf Extract of Azadirachta indica on Renal Histologic Alterations in Streptozotocin-Induced Diabetic Rats
A Oluwole Busayo, Z Laura, D Olufunke Olubusola, ...
The American Journal of Chinese Medicine 39 (05), 903-916 2011
Citations: 25



Spermatoprotective activity of the leaf extract of Psidium guajava Linn
OB Akinola, OS Oladosu, OO Dosumu
Niger Postgrad Med J 14 (4), 273-276 2007
Citations: 24



Western diet-induced fear memory impairment is attenuated by 6-shogaol in C57BL/6N mice
MO Gabriel, M Nikou, OB Akinola, DD Pollak, S Sideromenos
Behavioural Brain Research 380, 112419 2020
Citations: 21



Diabetes-induced prefrontal Nissl substance deficit and the effects of neem-bitter leaf extract treatment
EH de Neem Amargo
Int. J. Morphol 29 (3), 850-856 2011
Citations: 21



Sweet old memories: a review of the experimental models of the association between diabetes, senility and dementia
OB Akinola
Metabolic Brain Disease 31, 1003-1010 2016
Citations: 20



Supracondylar and infratubercular processes observed in the humeri of Nigerians
KA Oluyemi, UC Okwuonu, OA Adesanya, OB Akinola, DA Ofusori, ...
African Journal of Biotechnology 6 (21) 2007
Citations: 19



Neuroanatomical and molecular correlates of cognitive and behavioural outcomes in hypogonadal males
OB Akinola, MO Gabriel
Metabolic brain disease 33, 491-505 2018
Citations: 18



PPAR-γ agonist pioglitazone improves semen quality and testicular histomorphometrics with partial reversal of hyperglycaemia in alloxan-induced diabetic rats
OB Akinola, OO Dosumu, SA Sanusi, TF Ajayi, TH Olajide
Middle East fertility society journal 20 (4), 271-279 2015
Citations: 18



Characterization of prefrontal cortex microstructure and antioxidant status in a rat model of neurodegeneration induced by aluminium chloride and multiple low-dose streptozotocin
OB Akinola, SA Biliaminu, RA Adediran, KA Adeniye, FC Abdulquadir
Metabolic brain disease 30, 1531-1536 2015
Citations: 17