Felipe Augusto Beñaldo Fuentes

@uchile.cl

Vascular Function & Reactivity Lab, Pathophysiology Program, ICBM, Faculty of Medicine, Universidad de Chile, Santiago, Chile
Universidad de Chile

Felipe Augusto Beñaldo Fuentes


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https://researchid.co/fbenaldo
I have a PhD in Biomedical Sciences from the ICBM (National Institute of Biomedical Research), Faculty of Medicine, University of Chile, thanks to a Chilean ANID scholarship (21191647). My research studies the contribution of hypoxia during fetal development and the possible generation of pathological states for the rest of life (DoHAD). We determine the effects of chronic intrauterine hypoxia that affected proteins related to vasodilatory gasotransmitters (NO, CO, H₂S) or enzymes involved in cardiac homeostasis (PKCe), decreasing their expression and/or activity, which affects cardiovascular functionality (myographies, Langendorff, fetal echocardiograms) in the short, medium, and long term. I am also interested in applying artificial intelligence to medical educational models.

EDUCATION

DVM (2012), Faculty of Veterinary and Livestock Sciences, University of Chile.
Master's in Pathophysiology (2019), Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile.
PhD in Biomedical Sciences (2024), Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile.

RESEARCH, TEACHING, or OTHER INTERESTS

Pathophysiology, Cardiology and Cardiovascular Medicine, Veterinary, Artificial Intelligence
11

Scopus Publications

144

Scholar Citations

8

Scholar h-index

5

Scholar i10-index

Scopus Publications

  • Gestational hypoxia increases brain-blood barrier permeability in the neonatal cerebral cortex of Guinea pigs
    Esteban G. Figueroa, Adolfo A. Paz, Tamara A. Jiménez, Osvaldo Meza-Vilches, Daniel Palma C, et al.
    Pediatric Research, 2026
  • Prenatal Melatonin Modulates Cardiovascular Function and Oxidative Stress in Guinea Pig Neonates Under Normoxic and Hypoxic Gestation
    Adolfo A. Paz, Tamara A. Jiménez, Pedro Herrera, Josefa Carreño, Damaris Cornejo, et al.
    Antioxidants, 2026
    Introduction: Gestational hypoxia (GH) increases the risk of cardiovascular diseases by inducing oxidative stress and vascular dysfunction. This study investigates whether prenatal melatonin can mitigate these effects in guinea pigs. Methods: Pregnant guinea pigs were exposed to normoxia or hypoxia and treated with melatonin (1 mg/kg/day). Echocardiography, vascular reactivity, and molecular assays were used to assess cardiovascular structure, function, and redox balance in neonates. Results: GH reduced neonatal birth weight and altered left ventricular (LV) development, resulting in increased LV systolic function and aortic blood flow velocity. Melatonin treatment reversed these effects, restoring endothelial-dependent vasodilation and decreasing oxidative stress in the LV and thoracic aorta. Catalase antioxidant enzyme activity was elevated in melatonin-treated hypoxic neonates. Unexpectedly, melatonin treatment altered cardiac structure in normoxic pregnancies, increasing LV length and decreasing LV myocardial nuclei density. Conclusions: Prenatal melatonin partially modulates GH-induced endothelial dysfunction and oxidative stress, offering potential therapeutic value. However, its effects under normoxic conditions deserve caution, emphasizing the need for targeted use only in pregnancies with evident hypoxic and oxidative stress conditions.
  • Long-lasting cardiovascular responses to gestation at high altitude: Lessons from a sheep model
    Emilio A. Herrera, Adolfo Paz, Alejandro Gonzalez-Candia, Tamara Jimenez, Felipe Beñaldo, et al.
    Philosophical Transactions of the Royal Society B Biological Sciences, 2025
    Adaptations of maternal and fetal cardiovascular physiology may be most important when there are unfavourable environmental conditions during pregnancy, such as hypoxia when living at high altitudes. Chronic hypobaric hypoxia during intrauterine development may permanently modify fetal organ function, conditioning an increased risk for cardiovascular adult diseases. This review summarizes our 20 years of work on a sheep model assessing the impact of high-altitude hypoxia on the offspring’s cardiovascular development and function at fetal, neonatal and adult stages. We further discuss diverse experimental approaches to describe the involved mechanisms in the systemic and pulmonary circulation, such as the pulmonary hypoxic vasoconstriction, the roles of nitric oxide, carbon monoxide and oxidative stress in short- and long-lasting consequences. Research on high-altitude sheep models lays the groundwork for further studies into how hypoxic conditions during development impact long-term cardiovascular health and the potential therapeutic approaches, with promising findings pertinent for human health at highlands. This article is part of the discussion meeting issue ‘Pregnancy at high altitude: the challenge of hypoxia’.
  • Gestational hypoxia elicits long-term cardiovascular dysfunction in female guinea pigs
    Adolfo A. Paz, Tamara A. Jiménez, Julieta Ibarra-Gonzalez, Cristian Astudillo-Maya, Felipe A. Beñaldo, et al.
    Life Sciences, 2025
  • Developmental Ultrasound Characteristics in Guinea Pigs: Similarities with Human Pregnancy
    Alejandro A. Candia, Tamara Jiménez, Álvaro Navarrete, Felipe Beñaldo, Pablo Silva, et al.
    Veterinary Sciences, 2023
    Background: Biometrical and blood flow examinations are fundamental for assessing fetoplacental development during pregnancy. Guinea pigs have been proposed as a good model to study fetal development and related gestational complications; however, longitudinal growth and blood flow changes in utero have not been properly described. This study aimed to describe fetal and placental growth and blood flow of the main intrauterine vascular beds across normal guinea pig pregnancy and to discuss the relevance of this data for human pregnancy. Methods: Pregnant guinea pigs were studied from day 25 of pregnancy until term (day ~70) by ultrasound and Doppler assessment. The results were compared to human data from the literature. Results: Measurements of biparietal diameter (BPD), cranial circumference (CC), abdominal circumference, and placental biometry, as well as pulsatility index determination of umbilical artery, middle cerebral artery (MCA), and cerebroplacental ratio (CPR), were feasible to determine across pregnancy, and they could be adjusted to linear or nonlinear functions. In addition, several of these parameters showed a high correlation coefficient and could be used to assess gestational age in guinea pigs. We further compared these data to ultrasound variables from human pregnancy with high similarities. Conclusions: BPD and CC are the most reliable measurements to assess fetal growth in guinea pigs. Furthermore, this is the first report in which the MCA pulsatility index and CPR are described across guinea pig gestation. The guinea pig is a valuable model to assess fetal growth and blood flow distribution, variables that are comparable with human pregnancy.
  • Cinaciguat (BAY-582667) Modifies Cardiopulmonary and Systemic Circulation in Chronically Hypoxic and Pulmonary Hypertensive Neonatal Lambs in the Alto Andino
    Felipe A. Beñaldo, Claudio Araya-Quijada, Germán Ebensperger, Emilio A. Herrera, Roberto V. Reyes, et al.
    Frontiers in Physiology, 2022
    Neonatal pulmonary hypertension (NPHT) is produced by sustained pulmonary vasoconstriction and increased vascular remodeling. Soluble guanylyl cyclase (sGC) participates in signaling pathways that induce vascular vasodilation and reduce vascular remodeling. However, when sGC is oxidized and/or loses its heme group, it does not respond to nitric oxide (NO), losing its vasodilating effects. sGC protein expression and function is reduced in hypertensive neonatal lambs. Currently, NPHT is treated with NO inhalation therapy; however, new treatments are needed for improved outcomes. We used Cinaciguat (BAY-582667), which activates oxidized and/or without heme group sGC in pulmonary hypertensive lambs studied at 3,600 m. Our study included 6 Cinaciguat-treated (35 ug kg−1 day−1x 7 days) and 6 Control neonates. We measured acute and chronic basal cardiovascular variables in pulmonary and systemic circulation, cardiovascular variables during a superimposed episode of acute hypoxia, remodeling of pulmonary arteries and changes in the right ventricle weight, vasoactive functions in small pulmonary arteries, and expression of NO-sGC-cGMP signaling pathway proteins involved in vasodilation. We observed a decrease in pulmonary arterial pressure and vascular resistance during the acute treatment. In contrast, the pulmonary pressure did not change in the chronic study due to increased cardiac output, resulting in lower pulmonary vascular resistance in the last 2 days of chronic study. The latter may have had a role in decreasing right ventricular hypertrophy, although the direct effect of Cinaciguat on the heart should also be considered. During acute hypoxia, the pulmonary vascular resistance remained low compared to the Control lambs. We observed a higher lung artery density, accompanied by reduced smooth muscle and adventitia layers in the pulmonary arteries. Additionally, vasodilator function was increased, and vasoconstrictor function was decreased, with modifications in the expression of proteins linked to pulmonary vasodilation, consistent with low pulmonary vascular resistance. In summary, Cinaciguat, an activator of sGC, induces cardiopulmonary modifications in chronically hypoxic and pulmonary hypertensive newborn lambs. Therefore, Cinaciguat is a potential therapeutic tool for reducing pulmonary vascular remodeling and/or right ventricular hypertrophy in pulmonary arterial hypertension syndrome.
  • Study of the Effect of Treatment With Atrial Natriuretic Peptide (ANP) and Cinaciguat in Chronic Hypoxic Neonatal Lambs on Residual Strain and Microstructure of the Arteries
    Alvaro Navarrete, Zhuoming Chen, Pedro Aranda, Daniel Poblete, Andrés Utrera, et al.
    Frontiers in Bioengineering and Biotechnology, 2020
    In this study, we assessed the effects of Atrial Natriuretic Peptide (ANP) and Cinaciguat, as experimental medicines to treat neonatal lambs exposed to chronic hypoxic conditions. To compare the different treatments, the mechanical responses of aorta, carotid, and femoral arterial walls were analyzed by means of axial pre-stretch and ring-opening tests, through a study with n = 6 animals for each group analyzed. The axial pre-stretch test measures the level of shortening in different zones of the arteries when extracted from lambs, while the ring-opening test is used to quantify the degree of residual circumferential deformation in a given zone of an artery. In addition, histological studies were carried out to measure elastin, collagen, and smooth muscle cell (SMC) nuclei densities, both in control and treated groups. The results show that mechanical response is related with histological results, specifically in the proximal abdominal aorta (PAA) and distal carotid zones (DCA), where the cell nuclei content is related to a decrease of residual deformations. The opening angle and the elastic fibers of the aorta artery were statistically correlated (p < 0.05). Specifically, in PAA zone, there are significant differences of opening angle and cell nuclei density values between control and treated groups (p-values to opening angle: Control-ANP = 2 ⋅ 10–2, Control-Cinaciguat = 1 ⋅ 10–2; p-values to cell nuclei density: Control-ANP = 5 ⋅ 10–4, Control-Cinaciguat = 2 ⋅ 10–2). Respect to distal carotid zone (DCA), significant differences between Control and Cinaciguat groups were observed to opening angle (p-value = 4 ⋅ 10–2), and cell nuclei density (p-value = 1 ⋅ 10–2). Our findings add evidence that medical treatments may have effects on the mechanical responses of arterial walls and should be taken into account when evaluating the complete medical outcome.
  • Effects of melatonin on the defense to acute hypoxia in newborn lambs
    Felipe A. Beñaldo, Aníbal J. Llanos, Claudio Araya-Quijada, Auristela Rojas, Alejandro Gonzalez-Candia, et al.
    Frontiers in Endocrinology, 2019
    Neonatal lambs, as other neonates, have physiologically a very low plasma melatonin concentration throughout 24 h. Previously, we found that melatonin given to neonates daily for 5 days decreased heart weight and changed plasma cortisol and gene expression in the adrenal and heart. Whether these changes could compromise the responses to life challenges is unknown. Therefore, firstly, we studied acute effects of melatonin on the defense mechanisms to acute hypoxia in the neonate. Eleven lambs, 2 weeks old, were instrumented and subjected to an episode of acute isocapnic hypoxia, consisting of four 30 min periods: normoxia (room air), normoxia after an i.v. bolus of melatonin (0.27 mg kg−1, n = 6) or vehicle (ethanol 1:10 NaCl 0.9%, n = 5), hypoxia (PaO2: 30 ± 2 mmHg), and recovery (room air). Mean pulmonary and systemic blood pressures, heart rate, and cardiac output were measured, and systemic and pulmonary vascular resistance and stroke volume were calculated. Blood samples were taken every 30 min to measure plasma norepinephrine, cortisol, glucose, triglycerides, and redox markers (8-isoprostane and FRAP). Melatonin blunted the increase of pulmonary vascular resistance triggered by hypoxia, markedly exacerbated the heart rate response, decreased heart stroke volume, and lessened the magnitude of the increase of plasmatic norepinephrine and cortisol levels induced by hypoxia. No changes were observed in pulmonary blood pressure, systemic blood pressures and resistance, cardiac output, glucose, triglyceride plasma concentrations, or redox markers. Melatonin had no effect on cardiovascular, endocrine, or metabolic variables, under normoxia. Secondly, we examined whether acute melatonin administration under normoxia could have an effect in gene expression on the adrenal, lung, and heart. Lambs received a bolus of vehicle or melatonin and were euthanized 30 min later to collect tissues. We found that melatonin affected expression of the immediate early genes egr1 in adrenal, ctgf in lung, and nr3c1, the glucocorticoid receptor, in adrenal and heart. We speculate that these early gene responses may contribute to the observed alterations of the newborn defense mechanisms to hypoxia. This could be particularly important since the use of melatonin is proposed for several diseases in the neonatal period in humans.
  • Circulation in neonatal llamas and sheep: A tale of two species
    Iatreia, 2018
  • Role of the RhoA/ROCK pathway in high-altitude associated neonatal pulmonary hypertension in lambs
    Nandy C. Lopez, German Ebensperger, Emilio A. Herrera, Roberto V. Reyes, Gloria Calaf, et al.
    American Journal of Physiology Regulatory Integrative and Comparative Physiology, 2016
    Exposure to high-altitude chronic hypoxia during pregnancy may cause pulmonary hypertension in neonates, as a result of vasoconstriction and vascular remodeling. We hypothesized that susceptibility to pulmonary hypertension, due to an augmented expression and activity of the RhoA/Rho-kinase (ROCK) pathway in these neonates, can be reduced by daily administration of fasudil, a ROCK inhibitor. We studied 10 highland newborn lambs with conception, gestation, and birth at 3,600 m in Putre, Chile. Five highland controls (HLC) were compared with 5 highland lambs treated with fasudil (HL-FAS; 3 mg·kg−1·day−1 iv for 10 days). Ten lowland controls were studied in Lluta (50 m; LLC). During the 10 days of fasudil daily administration, the drug decreased pulmonary arterial pressure (PAP) and resistance (PVR), basally and during a superimposed episode of acute hypoxia. HL-FAS small pulmonary arteries showed diminished muscular area and a reduced contractile response to the thromboxane analog U46619 compared with HLC. Hypoxia, but not fasudil, changed the protein expression pattern of the RhoA/ROCKII pathway. Moreover, HL-FAS lungs expressed less pMYPT1T850 and pMYPT1T696 than HLC, with a potential increase of the myosin light chain phosphatase activity. Finally, hypoxia induced RhoA, ROCKII, and PKG mRNA expression in PASMCs of HLC, but fasudil reduced them (HL-FAS) similarly to LLC. We conclude that fasudil decreases the function of the RhoA/ROCK pathway, reducing the PAP and PVR in chronically hypoxic highland neonatal lambs. The inhibition of ROCKs by fasudil may offer a possible therapeutic tool for the pulmonary hypertension of the neonates.
  • 2-Aminoethyldiphenylborinate modifies the pulmonary circulation in pulmonary hypertensive newborn lambs partially gestated at high altitude
    S. Castillo-Galán, S. Quezada, F. Moraga, G. Ebensperger, E. A. Herrera, et al.
    American Journal of Physiology Lung Cellular and Molecular Physiology, 2016

RECENT SCHOLAR PUBLICATIONS

  • Gestational hypoxia increases brain-blood barrier permeability in the neonatal cerebral cortex of guinea pigs
    EG Figueroa, AA Paz, TA Jiménez, O Meza-Vilches, D Palma C, ...
    Pediatric Research 99 (2), 748-758 , 2026
    2026
    Citations: 1
  • Prenatal Melatonin Modulates Cardiovascular Function and Oxidative Stress in Guinea Pig Neonates Under Normoxic and Hypoxic Gestation
    AA Paz, TA Jiménez, P Herrera, J Carreño, D Cornejo, J Ibarra-González, ...
    Antioxidants 15 (2), 162 , 2026
    2026
    Citations: 2
  • Long-lasting cardiovascular responses to gestation at high altitude: lessons from a sheep model
    EA Herrera, A Paz, A Gonzalez-Candia, T Jimenez, F Beñaldo, ...
    Philosophical Transactions of the Royal Society B: Biological Sciences 380 … , 2025
    2025
    Citations: 2
  • Gestational hypoxia elicits long-term cardiovascular dysfunction in female guinea pigs
    AA Paz, TA Jiménez, J Ibarra-Gonzalez, C Astudillo-Maya, FA Beñaldo, ...
    Life Sciences 361, 123282 , 2025
    2025
    Citations: 9
  • Deciphering the gasotransmitters' function on the cardiovascular programming induced by intrauterine chronic hypoxia
    EA Herrera, AA Paz, TA Jimenez, F Benaldo, P Herrera, ...
    ACTA PHYSIOLOGICA 240, 12-12 , 2024
    2024
  • Gestational Hypoxia Induces Deleterious Cardiovascular Programming in Adult Female Guinea Pigs.
    AA Paz, TA Jimenez, J Ibarra, C Astudillo, F Benaldo, J Frey, E Figueroa, ...
    REPRODUCTIVE SCIENCES 31, 142A-143A , 2024
    2024
  • Hypobaric Hypoxia during Gestation Differentially Alters the Gasotransmitters Vascular Function throughout the Lifetime in Guinea Pigs.
    EA Herrera, AA Paz, TA Jimenez, J Frey, F Benaldo, C Marambio, ...
    REPRODUCTIVE SCIENCES 31, 142A-142A , 2024
    2024
  • Developmental ultrasound characteristics in guinea pigs: similarities with human pregnancy
    AA Candia, T Jiménez, Á Navarrete, F Beñaldo, P Silva, C García-Herrera, ...
    Veterinary Sciences 10 (2), 144 , 2023
    2023
    Citations: 15
  • Cinaciguat (BAY-582667) Modifies Cardiopulmonary and Systemic Circulation in Chronically Hypoxic and Pulmonary Hypertensive Neonatal Lambs in the Alto Andino. Front. Physiol …
    FA Beñaldo, C Araya-Quijada, G Ebensperger, EA Herrera, RV Reyes, ...
    Frontiers in Physiology| www. frontiersin. org 13 , 2022
    2022
    Citations: 1
  • Cinaciguat (BAY-582667) modifies cardiopulmonary and systemic circulation in chronically hypoxic and pulmonary hypertensive neonatal lambs in the alto andino
    FA Beñaldo, C Araya-Quijada, G Ebensperger, EA Herrera, RV Reyes, ...
    Frontiers in Physiology 13, 864010 , 2022
    2022
    Citations: 9
  • Cinaciguat (BAY-582667) modifies cardiopulmonary and systemic circulation in chronically hypoxic and pulmonary hypertensive neonatal lambs in the alto andino
    FA Beñaldo Fuentes, CE Araya Quijada, G Ebensperger Darrouy, ...
    Frontiers Media , 2022
    2022
  • Study of the effect of treatment with atrial natriuretic peptide (ANP) and cinaciguat in chronic hypoxic neonatal lambs on residual strain and microstructure of the arteries
    A Navarrete, Z Chen, P Aranda, D Poblete, A Utrera, CM García-Herrera, ...
    Frontiers in Bioengineering and Biotechnology 8, 590488 , 2020
    2020
    Citations: 14
  • Cinaciguat Reduces Prolyl Hydroxylase 2 (PHD2) Protein Expression in Chronically Hypoxic and Pulmonary Hypertensive Newborn Lambs
    FA Beñaldo, C Araya-Quijada, M Seron-Ferre, E Herrera, G Ebensperger, ...
    The FASEB Journal 34 (S1), 1-1 , 2020
    2020
  • Cinaciguat Reduces Prolyl Hydroxylase 2 (PHD2) protein expression in chronically hypoxic and pulmonary hypertensive newborn lambs.
    F Beñaldo Fuentes, C Araya Quijada, M Serón Ferre, E Herrera Videla, ...
    Wiley , 2020
    2020
  • Effects of melatonin on the defense to acute hypoxia in newborn lambs
    FA Beñaldo, AJ Llanos, C Araya-Quijada, A Rojas, A Gonzalez-Candia, ...
    Frontiers in Endocrinology 10, 433 , 2019
    2019
    Citations: 11
  • Cinaciguat (BAY-582667), un activador de la guanilil ciclasa soluble (sGC) modifica la función cardiopulmonar en corderos recién nacidos hipóxicos e hipertensos pulmonares en …
    FA Beñaldo Fuentes
    Universidad de Chile , 2019
    2019
  • Circulation in neonatal llamas and sheep: a tale of two species
    AJ Llanos, FA Beñaldo, CE Araya-Quijada, M Serón-Ferré, EA Herrera, ...
    Iatreia 31 (1-S), S32-S32 , 2018
    2018
  • Mecanismos regulatorios del tono vascular pulmonar neonatal. Una perspectiva molecular
    FA Beñaldo, JC Ferrada, S Castillo, G Ebensperger
    Revista chilena de enfermedades respiratorias 33 (4), 308-315 , 2017
    2017
    Citations: 8
  • Treatment with cinaciguat improved the vasoactive properties of lamb small pulmonary arteries
    FA Beñaldo, C Araya-Quijada, G Ebensperger, CP Guzmán-Silva, ...
    Placenta 100 (51), 112-113 , 2017
    2017
    Citations: 1
  • 2-Aminoethyldiphenylborinate modifies the pulmonary circulation in pulmonary hypertensive newborn lambs partially gestated at high altitude
    S Castillo-Galán, S Quezada, F Moraga, G Ebensperger, EA Herrera, ...
    American Journal of Physiology-Lung Cellular and Molecular Physiology 311 (4 … , 2016
    2016
    Citations: 28

MOST CITED SCHOLAR PUBLICATIONS

  • Role of the RhoA/ROCK pathway in high-altitude associated neonatal pulmonary hypertension in lambs
    NC Lopez, G Ebensperger, EA Herrera, RV Reyes, G Calaf, G Cabello, ...
    American Journal of Physiology-Regulatory, Integrative and Comparative … , 2016
    2016
    Citations: 37
  • 2-Aminoethyldiphenylborinate modifies the pulmonary circulation in pulmonary hypertensive newborn lambs partially gestated at high altitude
    S Castillo-Galán, S Quezada, F Moraga, G Ebensperger, EA Herrera, ...
    American Journal of Physiology-Lung Cellular and Molecular Physiology 311 (4 … , 2016
    2016
    Citations: 28
  • Developmental ultrasound characteristics in guinea pigs: similarities with human pregnancy
    AA Candia, T Jiménez, Á Navarrete, F Beñaldo, P Silva, C García-Herrera, ...
    Veterinary Sciences 10 (2), 144 , 2023
    2023
    Citations: 15
  • Study of the effect of treatment with atrial natriuretic peptide (ANP) and cinaciguat in chronic hypoxic neonatal lambs on residual strain and microstructure of the arteries
    A Navarrete, Z Chen, P Aranda, D Poblete, A Utrera, CM García-Herrera, ...
    Frontiers in Bioengineering and Biotechnology 8, 590488 , 2020
    2020
    Citations: 14
  • Effects of melatonin on the defense to acute hypoxia in newborn lambs
    FA Beñaldo, AJ Llanos, C Araya-Quijada, A Rojas, A Gonzalez-Candia, ...
    Frontiers in Endocrinology 10, 433 , 2019
    2019
    Citations: 11
  • Gestational hypoxia elicits long-term cardiovascular dysfunction in female guinea pigs
    AA Paz, TA Jiménez, J Ibarra-Gonzalez, C Astudillo-Maya, FA Beñaldo, ...
    Life Sciences 361, 123282 , 2025
    2025
    Citations: 9
  • Cinaciguat (BAY-582667) modifies cardiopulmonary and systemic circulation in chronically hypoxic and pulmonary hypertensive neonatal lambs in the alto andino
    FA Beñaldo, C Araya-Quijada, G Ebensperger, EA Herrera, RV Reyes, ...
    Frontiers in Physiology 13, 864010 , 2022
    2022
    Citations: 9
  • Mecanismos regulatorios del tono vascular pulmonar neonatal. Una perspectiva molecular
    FA Beñaldo, JC Ferrada, S Castillo, G Ebensperger
    Revista chilena de enfermedades respiratorias 33 (4), 308-315 , 2017
    2017
    Citations: 8
  • Enfermedades del período de transición posparto y sus efectos en la producción de leche y la fertilidad en un sistema productivo de leche
    FA Beñaldo Fuentes
    Universidad de Chile , 2012
    2012
    Citations: 6
  • Prenatal Melatonin Modulates Cardiovascular Function and Oxidative Stress in Guinea Pig Neonates Under Normoxic and Hypoxic Gestation
    AA Paz, TA Jiménez, P Herrera, J Carreño, D Cornejo, J Ibarra-González, ...
    Antioxidants 15 (2), 162 , 2026
    2026
    Citations: 2
  • Long-lasting cardiovascular responses to gestation at high altitude: lessons from a sheep model
    EA Herrera, A Paz, A Gonzalez-Candia, T Jimenez, F Beñaldo, ...
    Philosophical Transactions of the Royal Society B: Biological Sciences 380 … , 2025
    2025
    Citations: 2
  • Gestational hypoxia increases brain-blood barrier permeability in the neonatal cerebral cortex of guinea pigs
    EG Figueroa, AA Paz, TA Jiménez, O Meza-Vilches, D Palma C, ...
    Pediatric Research 99 (2), 748-758 , 2026
    2026
    Citations: 1
  • Cinaciguat (BAY-582667) Modifies Cardiopulmonary and Systemic Circulation in Chronically Hypoxic and Pulmonary Hypertensive Neonatal Lambs in the Alto Andino. Front. Physiol …
    FA Beñaldo, C Araya-Quijada, G Ebensperger, EA Herrera, RV Reyes, ...
    Frontiers in Physiology| www. frontiersin. org 13 , 2022
    2022
    Citations: 1
  • Treatment with cinaciguat improved the vasoactive properties of lamb small pulmonary arteries
    FA Beñaldo, C Araya-Quijada, G Ebensperger, CP Guzmán-Silva, ...
    Placenta 100 (51), 112-113 , 2017
    2017
    Citations: 1
  • Deciphering the gasotransmitters' function on the cardiovascular programming induced by intrauterine chronic hypoxia
    EA Herrera, AA Paz, TA Jimenez, F Benaldo, P Herrera, ...
    ACTA PHYSIOLOGICA 240, 12-12 , 2024
    2024
  • Gestational Hypoxia Induces Deleterious Cardiovascular Programming in Adult Female Guinea Pigs.
    AA Paz, TA Jimenez, J Ibarra, C Astudillo, F Benaldo, J Frey, E Figueroa, ...
    REPRODUCTIVE SCIENCES 31, 142A-143A , 2024
    2024
  • Hypobaric Hypoxia during Gestation Differentially Alters the Gasotransmitters Vascular Function throughout the Lifetime in Guinea Pigs.
    EA Herrera, AA Paz, TA Jimenez, J Frey, F Benaldo, C Marambio, ...
    REPRODUCTIVE SCIENCES 31, 142A-142A , 2024
    2024
  • Cinaciguat (BAY-582667) modifies cardiopulmonary and systemic circulation in chronically hypoxic and pulmonary hypertensive neonatal lambs in the alto andino
    FA Beñaldo Fuentes, CE Araya Quijada, G Ebensperger Darrouy, ...
    Frontiers Media , 2022
    2022
  • Cinaciguat Reduces Prolyl Hydroxylase 2 (PHD2) Protein Expression in Chronically Hypoxic and Pulmonary Hypertensive Newborn Lambs
    FA Beñaldo, C Araya-Quijada, M Seron-Ferre, E Herrera, G Ebensperger, ...
    The FASEB Journal 34 (S1), 1-1 , 2020
    2020
  • Cinaciguat Reduces Prolyl Hydroxylase 2 (PHD2) protein expression in chronically hypoxic and pulmonary hypertensive newborn lambs.
    F Beñaldo Fuentes, C Araya Quijada, M Serón Ferre, E Herrera Videla, ...
    Wiley , 2020
    2020