Ana Maria Brezoiu

@upb.ro

Assistant Professor/ Chemical and Biochemical Engineering/Chemical Engineering and Biotechnology
University POLITEHNICA of Bucharest

Ana Maria Brezoiu


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https://researchid.co/anamaria_brezoiu

RESEARCH, TEACHING, or OTHER INTERESTS

Bioengineering, Food Science, Materials Science, Spectroscopy
26

Scopus Publications

670

Scholar Citations

14

Scholar h-index

20

Scholar i10-index

Scopus Publications

  • Compositional data and properties of Romanian wine varieties - A statistical analysis
    A.-M. Brezoiu, I. Rosca, M. Deaconu, V. Artem, D. Berger
    Journal of Food Composition and Analysis, 2026
  • Optimization of Ultrasound-Assisted Extraction of Phenolic Compounds from Romanian Blackthorn (Prunus spinosa L.) Fruits
    Ana-Maria Drăghici-Popa, Oana Cristina Pârvulescu, Raluca Stan, Ana-Maria Brezoiu
    Antioxidants, 2025
    Selecting factors that significantly affect the extraction process and optimizing them are essential to obtain high extraction efficiency. This study aimed at optimizing the ultrasonic-assisted extraction (UAE) of polyphenols from Romanian blackthorn fruits using aqueous solutions of ethanol as green extraction solvents. Six process factors, including solvent/plant material ratio (RLS = 4.95–15.1 cm3/g), ethanol concentration in the extraction solvent (cet = 16.4–83.6%), extraction temperature (t = 30–70 °C), pH of the solvent (pH = 2–7), amplitude of the ultrasonic probe (A = 30–70%), and extraction time (τ = 5–15 min), were screened and optimized based on a Plackett–Burman design (PBD) and a central composite design (CCD). Statistical analysis indicated that RLS, cet, and t significantly affected the process response variables in terms of total phenolic content (TPC), total anthocyanin content (TAC), and antioxidant capacity (AC). Under optimal conditions (RLS,opt = 15.1 cm3/g, cet,opt = 33.2%, topt = 66.8 °C, pHopt = 7, Aopt = 50%, and τopt = 10 min), the following levels of response variables were experimentally determined: TPCopt = 14.45 ± 0.718 mg GAE/g DM, TACopt = 0.405 ± 0.057 mg C3GE/g DM, and ACopt = 16.75 ± 1.144 mg TE/g DM. Six phenolic compounds were identified in the extract obtained at optimal levels of process factors, i.e., rutin (7.12 ± 0.06 mg/100 g DM), protocatechuic acid (6.83 ± 0.01 mg/100 g DM), neochlorogenic acid (4.88 ± 0.01 mg/100 g DM), vanillic acid (3.70 ± 0.01 mg/100 g DM), chlorogenic acid (1.93 ± 0.02 mg/100 g DM), and caffeic acid (1.51 ± 0.01 mg/100 g DM).
  • Mesoporous Titania Nanoparticles for a High-End Valorization of Vitis vinifera Grape Marc Extracts
    Anil Abduraman, Ana-Maria Brezoiu, Rodica Tatia, Andreea-Iulia Iorgu, Mihaela Deaconu, et al.
    Inorganics, 2024
    Mesoporous titania nanoparticles (NPs) can be used for encapsulation polyphenols, with applications in the food industry, cosmetics, or biomedicine. TiO2 NPs were synthesized using the sol-gel method combined with solvothermal treatment. TiO2 NPs were characterized through X-ray diffraction, FTIR spectroscopy, the N2 adsorption method, scanning and transmission electron microscopy, and thermal analysis. The sample prepared using Pluronic F127 presented a higher surface area and less agglomerated NPs than the samples synthesized with Pluronic P123. Grape marc (GM), a by-product from wine production, can be exploited for preparing extracts with good antioxidant properties. In this regard, we prepared hydroethanolic and ethanolic GM extracts from two cultivars, Feteasca Neagra (FN) and Pinot Noir. The extract components were determined by spectrometric analyses and HPLC. The extract with the highest radical scavenging activity, the hydroethanolic FN extract, was encapsulated in titania (FN@TiO2) and compared with SBA-15 silica support. Both resulting materials showed biocompatibility on the NCTC fibroblast cell line in a 50–300 µg/mL concentration range after 48 h of incubation and even better radical scavenging potential than the free extract. Although titania has a lower capacity to host polyphenols than SBA-15, the FN@TiO2 sample shows better cytocompatibility (up to 700 µmg/mL), and therefore, it could be used for skin-care products.
  • Anti-Inflammatory, Antidiabetic, and Antioxidant Properties of Extracts Prepared from Pinot Noir Grape Marc, Free and Incorporated in Porous Silica-Based Supports
    Mihaela Deaconu, Anil Abduraman, Ana-Maria Brezoiu, Nada K. Sedky, Simona Ioniță, et al.
    Molecules, 2024
    This study presents properties of hydroethanolic extracts prepared from Pinot Noir (PN) grape pomace through conventional, ultrasound-assisted or solvothermal extraction. The components of the extracts were identified by HPLC. The total content of polyphenols, flavonoids, anthocyanins, and condensed tannins, as well as antioxidant activity and α-glucosidase inhibitory activity of extracts were evaluated using UV-vis spectroscopy. All extracts were rich in phenolic compounds, proving a good radical scavenging activity. The extract obtained by conventional extraction at 80 °C showed the best α-glucosidase inhibitory activity close to that of (-)-epigallocatechin gallate. To improve the chemical stability of polyphenols, the chosen extract was incorporated in porous silica-based supports: amine functionalized silica (MCM-NH2), fucoidan-coated amine functionalized silica (MCM-NH2-Fuc), MCM-41, and diatomite. The PN extract exhibited moderate activity against Gram-positive S. aureus (MIC = 156.25 μg/mL) better than against Gram-negative E. coli (MIC = 312.5 μg/mL). The biocompatibility of PN extract, free and incorporated in MCM-NH2 and MCM-NH2-Fuc, was assessed on RAW 264.7 mouse macrophage cells, and the samples showcased a good cytocompatibility at 10 µg/mL concentration. At this concentration, PN and PN@MCM-NH2-Fuc reduced the inflammation by inhibiting NO production. The anti-inflammatory potential against COX and LOX enzymes of selected samples was evaluated and compared with that of Indomethacin and Zileuton, respectively. The best anti-inflammatory activity was observed when PN extract was loaded on MCM-NH2-Fuc support.
  • The Antioxidant and Anti-Inflammatory Properties of Wild Bilberry Fruit Extracts Embedded in Mesoporous Silica-Type Supports: A Stability Study
    Ana-Maria Brezoiu, Mihaela Deaconu, Raul-Augustin Mitran, Nada K. Sedky, Frédéric Schiets, et al.
    Antioxidants, 2024
    Polyphenolic extracts from wild bilberries (Vaccinium myrtillus L.) have shown antioxidant and anti-inflammatory effects, but they are prone to degradation when exposed to environmental factors, limiting their use in biomedical applications. To overcome this issue, this study proposed the embedding of wild bilberry fruit ethanolic extracts in pristine mesoporous silica functionalized with organic groups (mercaptopropyl and propionic acid), as well as coated with fucoidan, a biopolymer. Herein, we report a stability study of free and incorporated extracts in mesoporous silica-type supports in high-humidity atmospheres at 40 °C up to 28 days, using HPLC analysis, thermal analysis, and radical scavenging activity determination. Better chemical and thermal stability over time was observed when the extracts were incorporated in mesoporous silica-type supports. After 12 months of storage, higher values of antioxidant activity were determined for the extract embedded in the supports, silica modified with mercaptopropyl groups (MCM-SH), and fucoidan-coated silica (MCM-SH-Fuc) than that of the free extract due to a synergistic activity between the support and extract. All encapsulated extracts demonstrated remarkable effects in reducing NO production in LPS-stimulated RAW 264.7 cells. The treatment with extract embedded in MCM-SH-Fuc in a dose of 10 μg/mL surpassed the effect of free extract in the same concentration. For the extract encapsulated in an MCM-SH support, a lower IC50 value (0.69 μg/mL) towards COX-2 was obtained, comparable with that of Indomethacin (0.6 μg/mL). Also, this sample showed a higher selectivity index (2.71) for COX-2 than the reference anti-inflammatory drug (0.98). The developed formulations with antioxidant and anti-inflammatory properties could be further used in nutraceuticals.
  • Design of Scaffolds Based on Zinc-Modified Marine Collagen and Bilberry Leaves Extract-Loaded Silica Nanoparticles as Wound Dressings
    Mihaela Deaconu, Ana-Maria Prelipcean, Ana-Maria Brezoiu, Raul-Augustin Mitran, Ana-Maria Seciu-Grama, et al.
    International Journal of Nanomedicine, 2024
    Purpose In this study, wound dressings were designed using zinc-modified marine collagen porous scaffold as host for wild bilberry (WB) leaves extract immobilized in functionalized mesoporous silica nanoparticles (MSN). These new composites were developed as an alternative to conventional wound dressings. In addition to the antibacterial activity of classic antibiotics, a polyphenolic extract could act as an antioxidant and/or an anti-inflammatory agent as well. Methods Wild bilberry leaves extract was prepared by ultrasound-assisted extraction in ethanol and its properties were evaluated by UV-Vis spectroscopy (radical scavenging activity, total amount of polyphenols, flavonoids, anthocyanins, and condensed tannins). The extract components were identified by HPLC, and the antidiabetic properties of the extract were evaluated via α-glucosidase inhibitory activity. Spherical MSN were modified with propionic acid or proline moieties by post-synthesis method and used as carriers for the WB leaves extract. The textural and structural features of functionalized MSN were assessed by nitrogen adsorption/desorption isotherms, small-angle XRD, SEM, TEM, and FTIR spectroscopy. The composite porous scaffolds were prepared by freeze drying of the zinc-modified collagen suspension containing WB extract loaded silica nanoparticles. Results The properties of the new composites demonstrated enhanced properties in terms of thermal stability of the zinc-collagen scaffold, without altering the protein conformation, and stimulation of NCTC fibroblasts mobility. The results of the scratch assay showed contributions of both zinc ions from collagen and the polyphenolic extract incorporated in functionalized silica in the wound healing process. The extract encapsulated in functionalized MSN proved enhanced biological activities compared to the extract alone: better inhibition of P. aeruginosa and S. aureus strains, higher biocompatibility on HaCaT keratinocytes, and anti-inflammatory potential demonstrated by reduced IL-1β and TNF-α levels. Conclusion The experimental data shows that the novel composites can be used for the development of effective wound dressings.
  • Effects of Extraction Process Factors on the Composition and Antioxidant Activity of Blackthorn (Prunus spinosa L.) Fruit Extracts
    Ana-Maria Drăghici-Popa, Aurelian Cristian Boscornea, Ana-Maria Brezoiu, Ștefan Theodor Tomas, Oana Cristina Pârvulescu, et al.
    Antioxidants, 2023
    This study aimed at establishing the optimal conditions for the classic extraction of phenolic compounds from Prunus spinosa L. fruits. The effects of different parameters, i.e., ethanol concentration in the extraction solvent (mixture of ethanol and water), operation temperature, and extraction time, on process responses were evaluated. Total phenolic content (TPC), total anthocyanin content (TAC), antioxidant capacity (AC), and contents of protocatechuic acid (PA), caffeic acid (CA), vanillic acid (VA), rutin hydrate (RH), and quercetin (Q) of fruit extracts were selected as process responses. A synergistic effect of obtaining high values of TPC, TAC, AC, PA, and VA was achieved for the extraction in 50% ethanol at 60 °C for 30 min. At a higher level of process temperature, the extraction of protocatechuic acid and vanillic acid was enhanced, but the flavonoids, i.e., rutin hydrate and quercetin, were degraded. A lower temperature should be used to obtain a higher amount of flavonoids. TPC, TAC, AC, and phenolic acid contents (PA, CA, and VA) in the extract samples obtained at an ethanol concentration of 50–100%, a temperature of 30–60 °C, and an extraction time of 30 min were strongly directly correlated.
  • Optimisation of Polyphenols Extraction from Wild Bilberry Leaves—Antimicrobial Properties and Stability Studies
    Ana-Maria Brezoiu, Mihaela Deaconu, Raul-Augustin Mitran, Ana-Maria Prelipcean, Cristian Matei, et al.
    Molecules, 2023
    Polyphenolic extracts from natural sources have received great interest due to their beneficial properties for human health. A method to reduce their variability is to use the design of experiments which allows a limited number of experiments to be performed while exploring the experimental space. Firstly, a 23-full factorial model was used to investigate the polyphenols extraction from wild bilberry leaves. Spectrophotometric data (the content of polyphenols, flavonoids, chlorophyll and radical scavenger activity) and extraction yield were used as responses, and six statistical models were determined depending on the two numerical factors (temperature and alcohol % of ethanol–water mixture) being significant (p < 0.05) in all cases. Numerical optimisation performed by Design Expert 13 software correlates well with the chemical profile determined by high-performance liquid chromatography and the amount of the polyphenol. Afterwards, under the optimised conditions, an extract was prepared in three extraction steps for which composition, chemical stability and antimicrobial properties were evaluated. The antimicrobial potential of the extract was compared with that of the standard compounds (rutin and chlorogenic acid), and the results supported a synergistic effect of the extract components.
  • Ultrasound-Assisted Extraction of Blackberry Seed Oil: Optimization and Oil Characterization
    Petronela L. Matei, Iuliana Deleanu, Ana M. Brezoiu, Nicoleta A. Chira, Cristina Busuioc, et al.
    Molecules, 2023
    Ultrasound-assisted extraction (UAE) was applied to extract oil from blackberry (BB) seeds. The effect of UAE conditions on oil recovery and quality was investigated. Favorable experimental conditions (ultrasound intensity (UI), extraction temperature, and time) were investigated using response surface methodology (RSM). A Box–Behnken design was used to predict optimized conditions for BB seed oil extraction. These conditions were as follows: 13.77 W/cm2 UI, 45 °C extraction temperature, and 15 min extraction time. The experimental value obtained for extraction efficiency under optimal conditions was 87 ± 0.34%, in good agreement with the optimized predicted value. UAE does not affect the oil composition and confers higher antioxidant values in BB seed oil in comparison with Soxhlet extraction.
  • Novel Collagen-Polyphenols-Loaded Silica Composites for Topical Application
    Mihaela Deaconu, Ana-Maria Prelipcean, Ana-Maria Brezoiu, Raul-Augustin Mitran, Gabriela Isopencu, et al.
    Pharmaceutics, 2023
    Lesions can affect skin functions and cause a simple issue, such as dehydration, or more challenging complications, such as bacterial infections. The purpose of this study was to design composites for topical application that can prevent and/or assist in bacterial infections and support cell regeneration using natural components. A polyphenolic extract obtained from Salvia officinalis was embedded in functionalized mesoporous silica nanoparticles for better stability, followed by their distribution into a collagen porous scaffold. The resulting polyphenols-loaded MSN exhibited enhanced antibacterial activity and good cytocompatibility. Improved thermal stability of the collagen porous scaffold was obtained due to the presence of the functionalized MSN. For the first time, collagen-polyphenols-loaded silica composites were reported in the literature as potential wound dressings. The newly developed composites showed excellent sterility.
  • Nanoplatforms for Irinotecan Delivery Based on Mesoporous Silica Modified with a Natural Polysaccharide
    Ana-Maria Brezoiu, Ana-Maria Prelipcean, Daniel Lincu, Mihaela Deaconu, Eugeniu Vasile, et al.
    Materials, 2022
  • Evaluation of intracellular distribution of folate functionalized silica nanoparticles using fluorescence and hyperspectral enhanced dark field microscopy
    Luminita Claudia Miclea, Mona Mihailescu, Nicolae Tarba, Ana-Maria Brezoiu, Ana Maria Sandu, et al.
    Nanoscale, 2022
  • Resveratrol Encapsulation and Release from Pristine and Functionalized Mesoporous Silica Carriers
    Simona Ioniţă, Daniel Lincu, Raul-Augustin Mitran, Laila Ziko, Nada K. Sedky, et al.
    Pharmaceutics, 2022
  • Mesoporous silica and titania-based materials for stability enhancement of polyphenols
    Mioara Prundeanu, Ana-Maria Brezoiu, Mihaela Deaconu, Gratiela Gradisteanu Pircalabioru, Daniel Lincu, et al.
    Materials, 2021
  • Chemical profiling of polyphenols from salvia officinalis and thymus serpyllum extracts during a three-stage extraction process
    UPB Scientific Bulletin Series B Chemistry and Materials Science, 2021
  • Exploiting the zwitterionic properties of lomefloxacin to tailor its delivery from functionalized MCM-41 silica
    Mihaela Deaconu, Ana-Maria Brezoiu, Raul-Augustin Mitran, Ioana Nicu, Bogdan Manolescu, et al.
    Microporous and Mesoporous Materials, 2020
  • Biological evaluation of black chokeberry extract free and embedded in two mesoporous silica-type matrices
    Valentina Buda, Ana-Maria Brezoiu, Daniela Berger, Ioana Zinuca Pavel, Delia Muntean, et al.
    Pharmaceutics, 2020
  • Effect of nanoconfinement of polyphenolic extract from grape pomace into functionalized mesoporous silica on its biocompatibility and radical scavenging activity
    Ana-Maria Brezoiu, Laura Bajenaru, Daniela Berger, Raul-Augustin Mitran, Mihaela Deaconu, et al.
    Antioxidants, 2020
  • Properties of salvia offcinalis l. And thymus serpyllum l. extracts free and embedded into mesopores of silica and titania nanomaterials
    Ana-Maria Brezoiu, Mioara Prundeanu, Daniela Berger, Mihaela Deaconu, Cristian Matei, et al.
    Nanomaterials, 2020
  • Enhanced stability of polyphenolic extracts from grape pomace achieved by embedding into mesoporous silica-type matrices
    UPB Scientific Bulletin Series B Chemistry and Materials Science, 2020
  • Polyphenols extract from grape pomace. Characterization and valorisation through encapsulation into mesoporous silica-type matrices
    Ana-Maria Brezoiu, Cristian Matei, Mihaela Deaconu, Ana-Maria Stanciuc, Adrian Trifan, et al.
    Food and Chemical Toxicology, 2019
  • Heteroatom modified MCM-41-silica carriers for Lomefloxacin delivery systems
    Ana-Maria Brezoiu, Mihaela Deaconu, Ioana Nicu, Eugeniu Vasile, Raul-Augustin Mitran, et al.
    Microporous and Mesoporous Materials, 2019
  • Tailored doxycycline delivery from MCM-41-type silica carriers
    Mihaela Deaconu, Ioana Nicu, Robert Tincu, Ana-Maria Brezoiu, Raul-Augustin Mitran, et al.
    Chemical Papers, 2018
  • Mesostructured silica–titania composites for improved oxytetracycline delivery systems
    Doina Georgescu, Ana-Maria Brezoiu, Raul-Augustin Mitran, Daniela Berger, Cristian Matei, et al.
    Comptes Rendus Chimie, 2017
  • Organic layers via aryl diazonium electrochemistry: Towards modifying platinum electrodes for interference free glucose biosensors
    Matei D. Raicopol, Corina Andronescu, Ruxandra Atasiei, Anamaria Hanganu, Eugeniu Vasile, et al.
    Electrochimica Acta, 2016
  • Amperometric glucose biosensors based on functionalized electrochemically reduced graphene oxide
    UPB Scientific Bulletin Series B Chemistry and Materials Science, 2016

RECENT SCHOLAR PUBLICATIONS

  • Compositional data and properties of Romanian wine varieties-A statistical analysis
    AM Brezoiu, I Rosca, M Deaconu, V Artem, D Berger
    Journal of Food Composition and Analysis, 109096 , 2026
    2026
  • Optimization of Ultrasound-Assisted Extraction of Phenolic Compounds from Romanian Blackthorn ( Prunus spinosa L.) Fruits
    AM Drăghici-Popa, OC Pârvulescu, R Stan, AM Brezoiu
    Antioxidants 14 (6), 680 , 2025
    2025
    Citations: 11
  • Design of scaffolds based on zinc-modified marine collagen and bilberry leaves extract-loaded silica nanoparticles as wound dressings
    M Deaconu, AM Prelipcean, AM Brezoiu, RA Mitran, AM Seciu-Grama, ...
    International Journal of Nanomedicine, 7673-7689 , 2024
    2024
    Citations: 10
  • Mesoporous Titania Nanoparticles for a High-End Valorization of Vitis vinifera Grape Marc Extracts
    A Abduraman, AM Brezoiu, R Tatia, AI Iorgu, M Deaconu, RA Mitran, ...
    Inorganics 12 (10), 263 , 2024
    2024
    Citations: 4
  • Anti-inflammatory, antidiabetic, and antioxidant properties of extracts prepared from pinot noir grape marc, free and incorporated in porous silica-based supports
    M Deaconu, A Abduraman, AM Brezoiu, NK Sedky, S Ioniță, C Matei, ...
    Molecules 29 (13), 3122 , 2024
    2024
    Citations: 8
  • The antioxidant and anti-inflammatory properties of wild bilberry fruit extracts embedded in mesoporous silica-type supports: a stability study
    AM Brezoiu, M Deaconu, RA Mitran, NK Sedky, F Schiets, P Marote, ...
    Antioxidants 13 (2), 250 , 2024
    2024
    Citations: 12
  • Effects of Extraction Process Factors on the Composition and Antioxidant Activity of Blackthorn ( Prunus spinosa L.) Fruit Extracts
    AM Drăghici-Popa, AC Boscornea, AM Brezoiu, ȘT Tomas, ...
    Antioxidants 12 (10), 1897 , 2023
    2023
    Citations: 41
  • Optimisation of polyphenols extraction from wild bilberry leaves—Antimicrobial properties and stability studies
    AM Brezoiu, M Deaconu, RA Mitran, AM Prelipcean, C Matei, D Berger
    Molecules 28 (15), 5795 , 2023
    2023
    Citations: 7
  • Ultrasound-assisted extraction of blackberry seed oil: Optimization and oil characterization
    PL Matei, I Deleanu, AM Brezoiu, NA Chira, C Busuioc, G Isopencu, ...
    Molecules 28 (6), 2486 , 2023
    2023
    Citations: 32
  • Novel collagen-polyphenols-loaded silica composites for topical application
    M Deaconu, AM Prelipcean, AM Brezoiu, RA Mitran, G Isopencu, C Matei, ...
    Pharmaceutics 15 (2), 312 , 2023
    2023
    Citations: 15
  • Novel Collagen-Polyphenols-Loaded Silica Composites for Topical Application. Pharmaceutics 2023, 15, 312
    M Deaconu, AM Prelipcean, AM Brezoiu, RA Mitran, G Isopencu, C Matei, ...
    2023
  • Nanoplatforms for irinotecan delivery based on mesoporous silica modified with a natural polysaccharide
    AM Brezoiu, AM Prelipcean, D Lincu, M Deaconu, E Vasile, R Tatia, ...
    Materials 15 (19), 7003 , 2022
    2022
    Citations: 15
  • Design of Nanoplatforms for Targeted Delivery of Irinotecan
    AM Brezoiu, AM Prelipcean, L Miclea, M Moisescu, M Deaconu, C Matei, ...
    Chemistry Proceedings 7 (1), 58 , 2022
    2022
  • Resveratrol encapsulation and release from pristine and functionalized mesoporous silica carriers
    S Ioniţă, D Lincu, RA Mitran, L Ziko, NK Sedky, M Deaconu, AM Brezoiu, ...
    Pharmaceutics 14 (1), 203 , 2022
    2022
    Citations: 39
  • Evaluation of intracellular distribution of folate functionalized silica nanoparticles using fluorescence and hyperspectral enhanced dark field microscopy
    LC Miclea, M Mihailescu, N Tarba, AM Brezoiu, AM Sandu, RA Mitran, ...
    Nanoscale 14 (35), 12744-12756 , 2022
    2022
    Citations: 14
  • Mesoporous Silica and Titania-Based Materials for Stability Enhancement of Polyphenols
    M Prundeanu, AM Brezoiu, M Deaconu, G Gradisteanu Pircalabioru, ...
    Materials 14 (21), 6457 , 2021
    2021
    Citations: 11
  • CHEMICAL PROFILING OF POLYPHENOLS FROM SALVIA OFFICINALIS AND THYMUS SERPYLLUM EXTRACTS DURING A THREE-STAGE EXTRACTION PROCESS
    BD Prundeanu Mioara , Brezoiu Ana-Maria, Deaconu Mihaela
    Upb Sci. Bull. 83 (1), 3-16 , 2021
    2021
    Citations: 3
  • Acknowledgment to Reviewers of Medicines in 2020
    A Adhikari-Devkota, E Costantini, S Aghanavesi, B Criado, F Alconchel, ...
    2021
  • Properties of Free and Embedded Extracts from Different Grape Pomace into Mesoporous Inorganic Matrices
    A Abduraman, AM Brezoiu, R Tatia, M Deaconu, D Lincu, S Minea, ...
    Proceedings 57 (1), 78 , 2020
    2020
    Citations: 2
  • Exploiting the zwitterionic properties of lomefloxacin to tailor its delivery from functionalized MCM-41 silica
    M Deaconu, AM Brezoiu, RA Mitran, I Nicu, B Manolescu, C Matei, ...
    Microporous and Mesoporous Materials 305, 110323 , 2020
    2020
    Citations: 17

MOST CITED SCHOLAR PUBLICATIONS

  • Polyphenols extract from grape pomace. Characterization and valorisation through encapsulation into mesoporous silica-type matrices
    AM Brezoiu, C Matei, M Deaconu, AM Stanciuc, A Trifan, ...
    Food and Chemical Toxicology 133, 110787 , 2019
    2019
    Citations: 135
  • Heteroatom modified MCM-41-silica carriers for Lomefloxacin delivery systems
    AM Brezoiu, M Deaconu, I Nicu, E Vasile, RA Mitran, C Matei, D Berger
    Microporous and Mesoporous Materials 275, 214-222 , 2019
    2019
    Citations: 60
  • Properties of Salvia officinalis L. and Thymus serpyllum L. Extracts Free and Embedded into Mesopores of Silica and Titania Nanomaterials
    AM Brezoiu, M Prundeanu, D Berger, M Deaconu, C Matei, O Oprea, ...
    Nanomaterials 10 (5), 820 , 2020
    2020
    Citations: 52
  • Effect of nanoconfinement of polyphenolic extract from grape pomace into functionalized mesoporous silica on its biocompatibility and radical scavenging activity
    AM Brezoiu, L Bajenaru, D Berger, RA Mitran, M Deaconu, D Lincu, ...
    Antioxidants 9 (8), 696 , 2020
    2020
    Citations: 45
  • Biological evaluation of black chokeberry extract free and embedded in two mesoporous silica-type matrices
    V Buda, AM Brezoiu, D Berger, IZ Pavel, D Muntean, D Minda, ...
    Pharmaceutics 12 (9), 838 , 2020
    2020
    Citations: 44
  • Effects of Extraction Process Factors on the Composition and Antioxidant Activity of Blackthorn ( Prunus spinosa L.) Fruit Extracts
    AM Drăghici-Popa, AC Boscornea, AM Brezoiu, ȘT Tomas, ...
    Antioxidants 12 (10), 1897 , 2023
    2023
    Citations: 41
  • Resveratrol encapsulation and release from pristine and functionalized mesoporous silica carriers
    S Ioniţă, D Lincu, RA Mitran, L Ziko, NK Sedky, M Deaconu, AM Brezoiu, ...
    Pharmaceutics 14 (1), 203 , 2022
    2022
    Citations: 39
  • Organic layers via aryl diazonium electrochemistry: towards modifying platinum electrodes for interference free glucose biosensors
    MD Raicopol, C Andronescu, R Atasiei, A Hanganu, E Vasile, AM Brezoiu, ...
    Electrochimica Acta 206, 226-237 , 2016
    2016
    Citations: 34
  • Tailored doxycycline delivery from MCM-41-type silica carriers
    M Deaconu, I Nicu, R Tincu, AM Brezoiu, RA Mitran, E Vasile, C Matei, ...
    Chemical Papers 72 (8), 1869-1880 , 2018
    2018
    Citations: 33
  • Ultrasound-assisted extraction of blackberry seed oil: Optimization and oil characterization
    PL Matei, I Deleanu, AM Brezoiu, NA Chira, C Busuioc, G Isopencu, ...
    Molecules 28 (6), 2486 , 2023
    2023
    Citations: 32
  • Exploiting the zwitterionic properties of lomefloxacin to tailor its delivery from functionalized MCM-41 silica
    M Deaconu, AM Brezoiu, RA Mitran, I Nicu, B Manolescu, C Matei, ...
    Microporous and Mesoporous Materials 305, 110323 , 2020
    2020
    Citations: 17
  • Novel collagen-polyphenols-loaded silica composites for topical application
    M Deaconu, AM Prelipcean, AM Brezoiu, RA Mitran, G Isopencu, C Matei, ...
    Pharmaceutics 15 (2), 312 , 2023
    2023
    Citations: 15
  • Nanoplatforms for irinotecan delivery based on mesoporous silica modified with a natural polysaccharide
    AM Brezoiu, AM Prelipcean, D Lincu, M Deaconu, E Vasile, R Tatia, ...
    Materials 15 (19), 7003 , 2022
    2022
    Citations: 15
  • Evaluation of intracellular distribution of folate functionalized silica nanoparticles using fluorescence and hyperspectral enhanced dark field microscopy
    LC Miclea, M Mihailescu, N Tarba, AM Brezoiu, AM Sandu, RA Mitran, ...
    Nanoscale 14 (35), 12744-12756 , 2022
    2022
    Citations: 14
  • The antioxidant and anti-inflammatory properties of wild bilberry fruit extracts embedded in mesoporous silica-type supports: a stability study
    AM Brezoiu, M Deaconu, RA Mitran, NK Sedky, F Schiets, P Marote, ...
    Antioxidants 13 (2), 250 , 2024
    2024
    Citations: 12
  • Optimization of Ultrasound-Assisted Extraction of Phenolic Compounds from Romanian Blackthorn ( Prunus spinosa L.) Fruits
    AM Drăghici-Popa, OC Pârvulescu, R Stan, AM Brezoiu
    Antioxidants 14 (6), 680 , 2025
    2025
    Citations: 11
  • Mesoporous Silica and Titania-Based Materials for Stability Enhancement of Polyphenols
    M Prundeanu, AM Brezoiu, M Deaconu, G Gradisteanu Pircalabioru, ...
    Materials 14 (21), 6457 , 2021
    2021
    Citations: 11
  • Design of scaffolds based on zinc-modified marine collagen and bilberry leaves extract-loaded silica nanoparticles as wound dressings
    M Deaconu, AM Prelipcean, AM Brezoiu, RA Mitran, AM Seciu-Grama, ...
    International Journal of Nanomedicine, 7673-7689 , 2024
    2024
    Citations: 10
  • Mesostructured silica–titania composites for improved oxytetracycline delivery systems
    D Georgescu, AM Brezoiu, RA Mitran, D Berger, C Matei, ...
    Comptes Rendus Chimie 20 (11-12), 1017-1025 , 2017
    2017
    Citations: 10
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