DAILIAH ROOPHA
@americancollege.edu.in
Assistant Professor, PG and Research Department of Zoology
The American College
RESEARCH INTERESTS
Toxicology, Endocrinology
Scopus Publications
Scopus Publications
Ibrahim H. Dursun, Z. B. Güvenç and E. Kasap
SAGE Publications
Jawahar B Samuel, Jone A Stanley, Ganapathy Vengatesh, Rajendran A Princess, Sridhar Muthusami, Dailiah P Roopha, Esakky Suthagar, Kathiresh M Kumar, Maria S Sebastian, and Michael M Aruldhas
SAGE Publications
At the request of the Editor and the Publisher, the following article: Samuel JB, Stanley JA, Vengatesh G, Princess RA, Muthusami S, Roopha DP, Suthagar E, Kumar KM, Sebastian MS, Aruldhas MM. (2012) Ameliorative effect of vitamin C on hexavalent chromium-induced delay in sexual maturation and oxidative stress in developing Wistar rat ovary and uterus, Toxicology and Industrial Health 28(8): 720-733. DOI: 10.1177/0748233711422728 http://tih.sagepub.com/content/28/8/720.abstract has been retracted from Toxicology and Industrial Health due to redundant publication by the same group of authors in another journal: Samuel JB, Stanley JA, Roopha DP, Vengatesh G, Anbalagan J, Banu SK, Aruldhas MM. (2011) Lactational hexavalent chromium exposure-induced oxidative stress in rat uterus is associated with delayed puberty and impaired gonadotropin levels, Human & Experimental Toxicology 30(2):91-101. DOI: 10.1177/0960327110364638 http://het.sagepub.com/content/30/2/91.abstract The two papers have used the same data and reporting with the Toxicology and Industrial Health manuscript inserting Vitamin C to differ the reporting. Additionally, the Toxicology and Industrial Health manuscript does not provide citations to original work by another author.
Jawahar B Samuel, Jone A Stanley, Dailiah P Roopha, Ganapathy Vengatesh, Jaganathan Anbalagan, Sakhila K Banu, and Michael M Aruldhas
SAGE Publications
Hexavalent chromium (CrVI) is a transition element utilized in many fields of modern industries. CrVI is a reproductive metal toxicant that can traverse the placental barrier and cause a wide range of fetal effects. Therefore, the present study was carried out to determine the CrVI-induced utero-toxicity. In the present study, lactating rats received drinking water containing CrVI (50 mg/L and 200 mg/L) from postnatal days (PND) 1-21. During PND 1-21, the pups received CrVI via the mother’s milk. Pups from both control and treatment groups were continued on regular diet and water from PND-21 onwards and euthanized on PND-45 and -65. Specific activities antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST) were estimated. Hydrogen peroxide (H 2O2), lipid peroxidation (LPO) and serum gonadotropins viz. Luteinizing hormone (LH) and follicle stimulating hormone (FSH) were also assayed. Specific activities of SOD, CAT, GPX, GR and GST and serum testosterone and progesterone were significantly decreased, while H2O2 , LPO and serum FSH was increased in 50—parts per million (ppm) and 200 ppm—treated rats in an age-dependent manner. These results suggest that lactational CrVI exposure induces oxidative stress in rat uterus by decreasing antioxidant enzymes, which were associated with delayed puberty and altered steroids and gonadotrophin levels.