Maria Priscila Quinonez Angulo

Scopus Publications

Enhanced Cell Proliferation and Maturation Using Carboxylated Bacterial Nanocellulose Scaffolds for 3D Cell Culture
Elizabeth Mavil-Guerrero, José Manuel Romo-Herrera, Priscila Quiñonez-Angulo, Francisco J. Flores-Ruiz, Edén Morales-Narváez, J. Félix Armando Soltero, Josué D. Mota-Morales, and Karla Juarez-Moreno
American Chemical Society (ACS)
Developing scaffolds for three-dimensional (3D) cell culture and tissue regeneration with biopolymers requires the creation of an optimal nanobiointerface. This interface must possess suitable surface chemistry, biomechanical properties, and fibrillar morphology across nano- to microscale levels to support cell attachment and growth, enabling a biomimetic arrangement. In this study, we developed a hydrogel scaffold made from bacterial nanocellulose (BNC) functionalized with carboxylic acid groups (BNC-COOH) through a reactive deep eutectic solvent (DES), offering a sustainable approach. The surface properties and fibrillar structure of BNC-COOH facilitated the formation of hydrogels with significantly enhanced water uptake (1.4-fold) and adhesion force (2.3-fold) compared to BNC. These hydrogels also demonstrated tissue-like rheological properties in both water with G' exceeding G″, suggesting predominantly elastic (solid-like) characteristics and viscosities in the range of 8- 15 Pa·s. The BNC-COOH hydrogel scaffold demonstrated excellent biocompatibility, supporting significant cell growth and anchorage for the 3D growth of mammalian cells and enhancing preadipocyte growth by up to 7.3 times. Furthermore, the BNC-COOH hydrogel facilitates the maturation of 3T3-L1 preadipocytes into mature adipocytes, inducing typical morphology changes, such as decreased filopodia extensions, rounded cell shape, and lipid droplet accumulation without any additional chemical induction stimulus. Therefore, we demonstrated that a reactive DES composed of oxalic acid and choline chloride represents a mild reaction medium and a suitable approach for designing biocompatible 3D hydrogel scaffolds with improved physicochemical properties and biological activities for 3D cell culture.

Ring-opening polymerization of emulsion-templated deep eutectic system monomer for macroporous polyesters with controlled degradability
Martín Castillo-Santillan, Priscila Quiñonez-Angulo, Dina Maniar, José Román Torres-Lubian, María C. Gutiérrez, Théophile Pelras, Albert J. J. Woortman, Qi Chen, María Guadalupe Pérez-García, Katja Loos,et al.
Royal Society of Chemistry (RSC)
Multifunctional macroinitiators in the ROP of a DESm allow fine-tuning the properties of the resulting polyesters. This capability enables control over the degradability, Mn, and polymer architectures of macroporous polyesters for oil sorption.

PEGMAs with short and long side chains: what is the effect in the formation of stars and brushes by RAFT polymerization?
Priscila Quiñonez-Angulo, Claude St. Thomas, Hortensia Maldonado-Textle, Ángel Licea-Claveríe, Enrique Saldívar-Guerra, and Iván Zapata-González
Royal Society of Chemistry (RSC)
PEGMA RAFT polymerization presents diverse kinetic characteristics, such as initiation rate (acceleration or inhibition), retardation effect, and dispersity, according to the length of the PEG side chain.

Low-Temperature and Solventless Ring-Opening Polymerization of Eutectic Mixtures of l-Lactide and Lactones for Biodegradable Polyesters
Martín Castillo-Santillan, Dina Maniar, María C. Gutiérrez, Priscila Quiñonez-Angulo, José Román Torres-Lubian, Katja Loos, and Josué D. Mota-Morales
American Chemical Society (ACS)

The influences of monomer structure and solvent on the radical copolymerization of tertiary amine and PEGylated methacrylates
Priscila Quiñonez-Angulo, Robin A. Hutchinson, Ángel Licea-Claveríe, Enrique Saldívar-Guerra, and Iván Zapata-González
Royal Society of Chemistry (RSC)
This work presents a meticulous and rigorous investigation of reactivity ratios of commonly used monomers (PEGMA, DEAEMA, and DMAEMA) with high importance for stimuli-responsive materials; a copolymerization mini-library with 9 systems is reported.

Ethylene polymerization via zirconocene catalysts and organoboron activators: An experimental and kinetic modeling study
Luis Valencia, Francisco Enríquez-Medrano, Ricardo López-González, Priscila Quiñonez-Ángulo, Enrique Saldívar-Guerra, José Díaz-Elizondo, Iván Zapata-González, and Ramón Díaz de León
MDPI AG
Forty years after the discovery of metallocene catalysts, there are still several aspects that remain unresolved, especially when the “conventional” alkylaluminum activators are not used. Herein, we systematically investigated the synthesis of polyethylene (PE) via three different zirconocene catalysts, with different alkyl substituents, activated via different organoboron compounds. The polymerization behavior, as well as the properties of the materials, were evaluated. The results demonstrate that the highest catalytic activity is shown by bis(cyclopentadienyl)dimethylzirconium activated by trityl tetra(pentafluorophenyl)borate. Additionally, it was found that toluene is the optimum solvent for these systems and at these reaction conditions. Moreover, to validate our experimental results, a comprehensive mathematical model was developed on the basis of thermodynamic and kinetic principles. The concentration of ethylene transferred to the solvent phase (toluene) in a liquid–vapor equilibrium (LVE) system was estimated based on Duhem’s theorem. Arrhenius expressions for the kinetic rate constants of a proposed kinetic mechanism were estimated by a kinetic model, in which the rate of polymerization was fitted by a least-square optimization procedure and the molecular weight averages by the method of moments. The simulations of the coordination polymerization suggest the presence of two types of active sites, principally at low temperatures, and the reactivation of the deactivated sites via a boron-based activator. However, the effect of the temperature on the reactivation step was not clear; a deeper understanding via designed experiments is required.

A kinetic study, thermal analysis and kinetic modeling on homo and copolymerization of 2-(N,N-diethylamino)ethyl methacrylate and PEGMA
Priscila Quiñonez-Angulo, Jesús Ruiz-Villegas, Ángel Licea-Claveríe, Alejandro Ramirez-Jiménez, Valentín Miranda-Soto, and Iván Zapata-González
Elsevier BV

Synthesis of flocculants based on responsive polymers and its use in solids removal from river water and wastewater

Maria Priscila Quinonez Angulo

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