Marta Rivera Viloria

@unileon.es

PhD Student. Instituto Universitario de Biomedicina (IBIOMED). Departamento de Ciencias Biomédicas
Universidad de León

Marta Rivera Viloria


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https://researchid.co/martarv98

EDUCATION

Biology Degree. Universidad de León
Master in Innovation in biomedical and health sciences. Universidad de León
PhD student in Biomedicine and health sciences. Universidad de León

RESEARCH, TEACHING, or OTHER INTERESTS

Molecular Biology
3

Scopus Publications

27

Scholar Citations

3

Scholar h-index

1

Scholar i10-index

Scopus Publications

  • Influence of Klotho Protein Levels in Obesity and Sarcopenia: A Systematic Review
    Diana G. Ariadel-Cobo, Brisamar Estébanez, Elena González-Arnáiz, María Pilar García-Pérez, Marta Rivera-Viloria, et al.
    International Journal of Molecular Sciences, 2025
    The Klotho gene is recognized for its anti-aging properties. Its downregulation leads to aging-like phenotypes, whereas overexpression can extend lifespan. Klotho protein exists in three forms: α-klotho, β-klotho and γ-klotho. The α-klotho has two isoforms: a membrane-bound form, primarily in the kidney and brain, and a secreted klotho protein present in blood, urine, and cerebrospinal fluid. Klotho functions as a co-receptor for fibroblast growth factor-23 (FGF23), regulating phosphate metabolism. The membrane-bound form controls various ion channels and receptors, while the secreted form regulates endocrine FGFs, including FGF19 and FGF21. The interaction between β-klotho and FGF21 in muscle is critical in the development of sarcopenic obesity. This systematic review, registered in PROSPERO and conducted following PRISMA guidelines, evaluates klotho levels in individuals with obesity or sarcopenic obesity. The study includes overweight, obese, and sarcopenic obese adults compared to those with a normal body mass index. After reviewing 713 articles, 20 studies were selected, including observational, cross-sectional, cohort studies, and clinical trials. Significant associations between klotho levels and obesity, metabolic syndrome (MS), and cardiovascular risk were observed. Exercise and dietary interventions positively influenced klotho levels, which were linked to improved muscle strength and slower decline. Klotho is a potential biomarker for obesity, MS, and sarcopenic obesity. Further research is needed to explore its mechanisms and therapeutic potential.
  • Resistance Training Modulates Reticulum Endoplasmic Stress, Independent of Oxidative and Inflammatory Responses, in Elderly People
    Brisamar Estébanez, Nishant P. Visavadiya, José E. Vargas, Marta Rivera-Viloria, Andy V. Khamoui, et al.
    Antioxidants, 2022
    Aging is related to changes in the redox status, low-grade inflammation, and decreased endoplasmic reticulum unfolded protein response (UPR). Exercise has been shown to regulate the inflammatory response, balance redox homeostasis, and ameliorate the UPR. This work aimed to investigate the effects of resistance training on changes in the UPR, oxidative status, and inflammatory responses in peripheral blood mononuclear cells of elderly subjects. Thirty elderly subjects volunteered to participate in an 8-week resistance training program, and 11 youth subjects were included for basal assessments. Klotho, heat shock protein 60 (HSP60), oxidative marker expression (catalase, glutathione, lipid peroxidation, nuclear factor erythroid 2-related factor 2, protein carbonyls, reactive oxygen species, and superoxide dismutase 1 and 2), the IRE1 arm of UPR, and TLR4/TRAF6/pIRAK1 pathway activation were evaluated before and following training. No changes in the HSP60 and Klotho protein content, oxidative status markers, and TLR4/TRAF6/pIRAK1 pathway activation were found with exercise. However, an attenuation of the reduced pIRE1/IRE1 ratio was observed following training. Systems biology analysis showed that a low number of proteins (RPS27A, SYVN1, HSPA5, and XBP1) are associated with IRE1, where XBP1 and RPS27A are essential nodes according to the centrality analysis. Additionally, a gene ontology analysis confirms that endoplasmic reticulum stress is a key mechanism modulated by IRE1. These findings might partially support the modulatory effect of resistance training on the endoplasmic reticulum in the elderly.
  • Exercise Outcomes in Childhood Obesity-Related Inflammation and Oxidative Status
    Brisamar Estébanez, Chun-Jung Huang, Marta Rivera-Viloria, Javier González-Gallego, María J. Cuevas
    Frontiers in Nutrition, 2022
    Childhood obesity is identified as one of the major public health issues to increase the risk for cardiometabolic diseases and related complications in adulthood. The literature has supported inflammation and oxidative stress as the primary underlying mechanisms involved in the pathogenesis of obesity-related diseases. Epidemiological evidence consistently shows the benefits of physical activity in the improvement of obesity-mediated inflammation and oxidative stress status. In this narrative mini-review, the available scientific evidence on the potential effects of exercise in alleviating these susceptibilities in childhood obesity will be assessed.

RECENT SCHOLAR PUBLICATIONS

  • Influence of klotho protein levels in obesity and sarcopenia: a systematic review
    DG Ariadel-Cobo, B Estébanez, E González-Arnáiz, MP García-Pérez, ...
    International Journal of Molecular Sciences 26 (5), 1915 , 2025
    2025
    Citations: 11
  • Role of exosome markers, FGF-Klotho-system and cfDNA as potential biomarker of premature-aging in adults with obesity
    M Rivera-Viloria, DG Ariadel Cobo, BP de la Maza, P Garcia Perez, ...
    ACTA PHYSIOLOGICA 240, 65-65 , 2024
    2024
  • Resistance Training Modulates Reticulum Endoplasmic Stress, Independent of Oxidative and Inflammatory Responses, in Elderly People
    B Estébanez, NP Visavadiya, JE Vargas, M Rivera-Viloria, AV Khamoui, ...
    Antioxidants 11 (11), 2242 , 2022
    2022
    Citations: 9
  • Abstracts of the XL Congress of the Spanish Society of Physiological Sciences (SECF)
    MJC Brisamar Estébanez, Sergio Maroto-Izquierdo, Marta Rivera-Viloria, José ...
    Journal of Physiology and Biochemistry 2022 (10.1007/s13105-022-00923-3), 83 , 2022
    2022
  • Abstracts of the XL Congress of the Spanish Society of Physiological Sciences (SECF)
    MJC Brisamar Estébanez, Francisco Amaro-Gahete, Cristina Gil-González, Marta ...
    Journal of Physiology and Biochemistry 2022 (10.1007/s13105-022-00923-3), 82-83 , 2022
    2022
  • Exercise Outcomes in Childhood Obesity-Related Inflammation and Oxidative Status
    B Estébanez, CJ Huang, M Rivera-Viloria, J González-Gallego, ...
    Frontiers in Nutrition 9, 886291 , 2022
    2022
    Citations: 7
  • Efecto de un programa de ejercicio físico sobre la respuesta a proteínas mal plegadas en las células mononucleares de la sangre periférica de pacientes pediátricos con obesidad
    M Pérez-Pérez, MJ Cuevas, R Quiroga, M Rivera-Villoria, ...
    AmbioCiencias: revista de divulgación 19, 141-150 , 2021
    2021
  • Neuroinflamación. la vía de la interleucina 1 (Neuroinflammation. the Interleukin-1 Pathway)
    M Rivera Viloria
    2020

MOST CITED SCHOLAR PUBLICATIONS

  • Influence of klotho protein levels in obesity and sarcopenia: a systematic review
    DG Ariadel-Cobo, B Estébanez, E González-Arnáiz, MP García-Pérez, ...
    International Journal of Molecular Sciences 26 (5), 1915 , 2025
    2025
    Citations: 11
  • Resistance Training Modulates Reticulum Endoplasmic Stress, Independent of Oxidative and Inflammatory Responses, in Elderly People
    B Estébanez, NP Visavadiya, JE Vargas, M Rivera-Viloria, AV Khamoui, ...
    Antioxidants 11 (11), 2242 , 2022
    2022
    Citations: 9
  • Exercise Outcomes in Childhood Obesity-Related Inflammation and Oxidative Status
    B Estébanez, CJ Huang, M Rivera-Viloria, J González-Gallego, ...
    Frontiers in Nutrition 9, 886291 , 2022
    2022
    Citations: 7
  • Role of exosome markers, FGF-Klotho-system and cfDNA as potential biomarker of premature-aging in adults with obesity
    M Rivera-Viloria, DG Ariadel Cobo, BP de la Maza, P Garcia Perez, ...
    ACTA PHYSIOLOGICA 240, 65-65 , 2024
    2024
  • Abstracts of the XL Congress of the Spanish Society of Physiological Sciences (SECF)
    MJC Brisamar Estébanez, Sergio Maroto-Izquierdo, Marta Rivera-Viloria, José ...
    Journal of Physiology and Biochemistry 2022 (10.1007/s13105-022-00923-3), 83 , 2022
    2022
  • Abstracts of the XL Congress of the Spanish Society of Physiological Sciences (SECF)
    MJC Brisamar Estébanez, Francisco Amaro-Gahete, Cristina Gil-González, Marta ...
    Journal of Physiology and Biochemistry 2022 (10.1007/s13105-022-00923-3), 82-83 , 2022
    2022
  • Efecto de un programa de ejercicio físico sobre la respuesta a proteínas mal plegadas en las células mononucleares de la sangre periférica de pacientes pediátricos con obesidad
    M Pérez-Pérez, MJ Cuevas, R Quiroga, M Rivera-Villoria, ...
    AmbioCiencias: revista de divulgación 19, 141-150 , 2021
    2021
  • Neuroinflamación. la vía de la interleucina 1 (Neuroinflammation. the Interleukin-1 Pathway)
    M Rivera Viloria
    2020