Prashant Verma

RESEARCH, TEACHING, or OTHER INTERESTS

Management Information Systems, Management Science and Operations Research, General Decision Sciences

Scopus Publications

Translational Advances in Oncogene and Tumor-Suppressor Gene Research
Radoslav Stojchevski, Edward Agus Sutanto, Rinni Sutanto, Nikola Hadzi-Petrushev, Mitko Mladenov, Sajal Raj Singh, Jitendra Kumar Sinha, Shampa Ghosh, Bhuvaneshwar Yarlagadda, Krishna Kumar Singh,et al.
MDPI AG
Cancer, characterized by the uncontrolled proliferation of cells, is one of the leading causes of death globally, with approximately one in five people developing the disease in their lifetime. While many driver genes were identified decades ago, and most cancers can be classified based on morphology and progression, there is still a significant gap in knowledge about genetic aberrations and nuclear DNA damage. The study of two critical groups of genes—tumor suppressors, which inhibit proliferation and promote apoptosis, and oncogenes, which regulate proliferation and survival—can help to understand the genomic causes behind tumorigenesis, leading to more personalized approaches to diagnosis and treatment. Aberration of tumor suppressors, which undergo two-hit and loss-of-function mutations, and oncogenes, activated forms of proto-oncogenes that experience one-hit and gain-of-function mutations, are responsible for the dysregulation of key signaling pathways that regulate cell division, such as p53, Rb, Ras/Raf/ERK/MAPK, PI3K/AKT, and Wnt/β-catenin. Modern breakthroughs in genomics research, like next-generation sequencing, have provided efficient strategies for mapping unique genomic changes that contribute to tumor heterogeneity. Novel therapeutic approaches have enabled personalized medicine, helping address genetic variability in tumor suppressors and oncogenes. This comprehensive review examines the molecular mechanisms behind tumor-suppressor genes and oncogenes, the key signaling pathways they regulate, epigenetic modifications, tumor heterogeneity, and the drug resistance mechanisms that drive carcinogenesis. Moreover, the review explores the clinical application of sequencing techniques, multiomics, diagnostic procedures, pharmacogenomics, and personalized treatment and prevention options, discussing future directions for emerging technologies.


Sleep and Immune System Crosstalk: Implications for Inflammatory Homeostasis and Disease Pathogenesis
Krishna Kumar Singh, Shampa Ghosh, Anisha Bhola, Prashant Verma, Aparajita Dasgupta Amist, Hitaishi Sharma, Punya Sachdeva, and Jitendra Kumar Sinha
SAGE Publications
Background Sleep and immune function are interconnected aspects of health that mutually impact each other in disease development and inflammatory homeostasis. Different aspects of immunology are regulated by different sleep characteristics, impacting on specific aspects of immune function including cytokine production and T-cell activity. Ongoing disruptions of sleep have been linked to heightened inflammation and are suspected in the pathogenesis and disease course of a range of life-style-related illnesses, including diabetes and neurodegenerative diseases. Summary This review provides a comprehensive overview of knowledge on the interaction of sleep with the immune system, its modulation of inflammatory balance, and the pathogenesis of many diseases. It emphasizes how sleep deficiency compromises immune function by means of a systemic, low-grade inflammatory response, while adequate sleep promotes intense immune responses and thus enables efficient pathogen clearance and the maintenance of immune memory. The mutual influence of sleep on the immune system underlines its critical involvement in health preservation and the course of disease. Key Message Sleep plays an indispensable role in immune health, mediating the efficiency of immune responses and the course of the regulation of inflammation. Chronic sleep deprivation can result in a low-grade inflammation that substantially contributes to the onset and exacerbation of metabolic and neurodegenerative disorders. The intimate linkage between sleep and immune function can be one strategic approach to therapy, improving health outcomes by leveraging this sleep-immune connection.


Critical success factors for better healthcare: An MCDM approach
Prashant Verma and Subhash Dutta
Inderscience Publishers



Skills Augmenting Online Shopping Behavior: A Study of Need for Cognition Positive Segment
Prashant Verma and Shruti Jain
SAGE Publications
The present study takes into account “need for cognition” (NFC), which represents the tendency of individuals to engage in and enjoy thinking. The NFC has been described as the need to structure relevant situation into meaningful, integrated ways and a need to understand and make a reasonable understanding of the experiential world. The article attempts to identify the specific skill dimensions, which operate in respondents who shop online and are positive on NFC, and try to seek difference in online shopping behavior of the respondents with different level of these skills. Principal Component Analysis, ANOVA, and confirmatory factor analysis were the statistics used in the study. Six factors were identified explaining dimensions operating in NFC positive segment, namely, preference for being advance user, confident user of latest in information technology, using it as tool for knowledge exploration, ability to assess behavior of program, efficient end user and knowledge of hardware. Significant difference in online shopping behavior was identified for users having skills clubbed under the dimension of confident user of latest in information technology.


Fix factor structure of online shopping skills in NFC positive segment consumers
Prashant Verma and Shruti Jain
IGI Global
This article attempts to identify dimensions of online shopping skills, which operate in respondents positive on need for cognition (NFC). Both EFA and CFA suggests six factors; preference for being advance user, confident user of latest in information technology, using IT as tool for knowledge exploration, ability to assess behaviour of program, efficient end user and knowledge of hardware. Respondent under ‘confident users of latest in information technology' has shown significant difference in online shopping behaviour.


Organisational Role Stress among Women in the Private Sector
Shalini Srivastava and Prashant Verma
SAGE Publications
Employees, who are married, are part of a family with members having at least two different careers and influence of at least two different organisations. In the context of married women employees it is increasingly difficult for them to find time to fulfil their commitment towards home, spouse, children, parents and friends. They are increasingly recognizing that work is infringing on their personal lives, and they are not happy about it. Recent studies suggest that employees want jobs that give them flexibility in their work schedules or work culture which facilitates better management of work-life conflicts. Organisations now often find women employee a part of their best performing teams, if they cannot be helped to achieve work-life balance, it will become increasingly difficult for management to attract and retain this human resource, which otherwise are capable and motivated. The present study intends to identify the major causes and remedies of work-life conflict which a working married woman face in the current scenario. It also intends to evaluate the importance of family-friendly work arrangements towards a joyful organisation. This paper attempts to investigate the intensity of organisational role stress which a married woman perceives as compared to an unmarried one. It further attempts to study the differences in the level of stress between married and unmarried women on several role stressors.

RECENT SCHOLAR PUBLICATIONS

Hierarchical Healthcare Facility Location at the Subdistrict Level in Western Uttar Pradesh: A Heuristic Approach
P Verma, S Datta
Advances in Social Sciences Research Journal 8 (4) 2021



Critical success factors for better healthcare: an MCDM approach
P Verma, S Dutta
International Journal of Technology Marketing 15 (2-3), 287-315 2021



Is Volatility Uniform Across the Stock Market? Evidences from Select Indices of NSE
P Sarkar, S., & Verma
NMIMS Management Review 29, 23-51 2016



A Study of Factors Driving Indian Youth's Intention to Purchase Online
S Jain, P Verma
Online] Accessed May 2, 2018 2016



Skills augmenting online shopping behavior: A study of need for cognition positive segment
P Verma, S Jain
Business Perspectives and Research 3 (2), 126-145 2015



Fix factor structure of online shopping skills in nfc positive segment consumers
P Verma, S Jain
International Journal of Cyber Behavior, Psychology and Learning (IJCBPL) 4 2014



A study of general role stress among IT/ITeS professional in India
S Bhatt, P Verma
Asia Pacific Business Review 4 (1), 105-114 2008



A Study of Mental Well Being and Academic Anxiety among School Children In Relation to their Emotional Intelligence.
P Verma, S., Sharma, V., & Verma
MINDSCAPES-Global Perspectives on Psychology in Mental Health. Bangalore 2007



Food Grain Production in India and its Significance in GDP
P Verma, A Varma
Journal of Management Development and Information Technology 4 2006



An Analysis of Problems Faced by Private Professional Institutions of Western U.P.
N Gupta, P Verma
Indian Journal of Technical Education 28 (2) 2005

MOST CITED SCHOLAR PUBLICATIONS

Skills augmenting online shopping behavior: A study of need for cognition positive segment
P Verma, S Jain
Business Perspectives and Research 3 (2), 126-145 2015
Citations: 34



A study of general role stress among IT/ITeS professional in India
S Bhatt, P Verma
Asia Pacific Business Review 4 (1), 105-114 2008
Citations: 13



A Study of Factors Driving Indian Youth's Intention to Purchase Online
S Jain, P Verma
Online] Accessed May 2, 2018 2016
Citations: 3



Critical success factors for better healthcare: an MCDM approach
P Verma, S Dutta
International Journal of Technology Marketing 15 (2-3), 287-315 2021
Citations: 2



Is Volatility Uniform Across the Stock Market? Evidences from Select Indices of NSE
P Sarkar, S., & Verma
NMIMS Management Review 29, 23-51 2016
Citations: 2



Fix factor structure of online shopping skills in nfc positive segment consumers
P Verma, S Jain
International Journal of Cyber Behavior, Psychology and Learning (IJCBPL) 4 2014
Citations: 2