PREPARATION AND IN VITRO EVALUATION OF BUTENAFINE HCL NANOSUSPENSION NIBRAS MAHDI NAEEM, OMAR SAEB SALIH International Journal of Applied Pharmaceutics, 2026 Objective One of the significant problems associated with poorly soluble drugs is low bioavailability. Butenafine HCl is classified as BCS Class II by the biopharmaceutical classification system, with low solubility and high permeability. Objectives: Formulation as a nanosuspension is an attractive and promising alternative to solve low solubility problems and low bioavailability Methods: A nanosuspension of Butenafine HCL was generated utilizing a bottom-up method through the solvents/anti-solvents procedure characterized by particle size analysis, polydisperse index, and entrapment efficacy, and then the selected formula was described by dissolution testing, differential scanning calorimetry, X-ray powder diffraction, FTIR, and FESEM. Nanosuspensions were prepared via the solvent/anti-solvent procedure, using different polymer types and ratios. Results: Butenafine solubilized in PBS with 1% soluplus, PVP, PEG 400, and poloxamer was 14.32 ±0.011,6±0.01,10.48±0.012, and 2.025±0.001.To form a nanosuspension with particle sizes ranging from 78 to 516 ±0.01 nm, entrapment up to 96%, and a Drug content of 99%. Particle size of optimum formula, consisting of Butenafine HCL and soluplus® in a ratio of drug: stabilizer (Soluplus®):co-stabilizer (PEG400) is (1:8:2.5) measured in nanostructure, and it was equal to 78.3±0.03 with a PDI 0.2511±0.13, which is in the nanosized range, drug content of optimum formula 99.6±0.013, and entrapment was 96±0.012. Osmolarity adjusted to a range of 280 to 310 mOsm/Kg. The release of the drug after 120 min was 95%. FTIR spectra show a distinct peak for the drug, indicating no chemical interaction between BF and Soluplus®.DSC shows a slight shift in the melting point to 220.50 °C due to the presence of cryoprotectants. PXRD shows amorphous formation due to nanosuspension, and FESEM shows the size and shape of the nanosuspension, in which the size of the particle by FESEM was 72.9nm, which is close to the measured particle size. The stability study of the optimal formula after three months showed a particle size of 78 nm at 5 °C and 80nm at 25 °C . Conclusions: Using soluplus as a stabilizer at various concentrations successfully produced a nanosuspension of Butenafine HCl.The best formula, consisting of Butenafine HCL and soluplus® in a ratio of drug: stabilizer (Soluplus®):co-stabilizer (PEG400) is 1:8:2.5,
Impact of preparation techniques on formulation and characterization of captopril effervescent granules Ishraq K. Abbas, Marwah M. Hareeja, Saba Abdulhadi Jaber, Adnan Burhan Qader, Raffah Khamis Mahal, et al. Journal of Advanced Pharmacy Education and Research, 2025 Captopril aqueous solution prepared using the drug as a powder dissolved in water was stable only for approximately twenty-seven days. The present work aimed to prepare captopril as stable dry solid effervescent granules that form a suitable swallowing aqueous liquid dosage for pediatrics. Six formulas were prepared, by wet, and; fusion methods, using different ratios of citric acid and tartaric acid with potassium bicarbonate as the effervescent base. The granules evaluation was done concerning their flowability, tapped density, bulk density
Preparation, In vitro, and Ex vivo Evaluation of Ondansetron Loaded Invasomes for Transdermal Delivery Omar Saeb Salih, Entidhar J. Al-Akkam Iraqi Journal of Pharmaceutical Sciences, 2023 Invasomes are newly developed types of nanovesicles. A vesicular drug delivery system is considered one of the approaches for transdermal delivery to enhance permeation and improve drug bioavailability. Ondansetron is a serotonin receptor antagonist used for treating vomiting associated with different clinical cases. The study aimed to prepare invasomal dispersions for improving permeation of ondansetron across the skin with a controlled release pattern. Twenty-seven formulas of ondansetron-loaded invasomes were prepared by a modified mechanical dispersion method. These formulas were optimized by studying the effect of variables on entrapment efficiency. Vesicle size, polydispersity, zeta potential, in-vitro release and ex-vivo permeation studies were done for the optimized formulas. The selected formula was )F25( had )88.24%±0.04 (entrapment, (317.7 nm) vesicle size, (0.29) polydispersity, and (-31.5mV) zeta potential. In-vitro release study showed That (F25) had 75% release after (12) hrs., and dissolution followed the Korsmeyer-Peppas model with anomalous diffusion. Ex-vivo permeation study showed steady-state flux was 340.2 µg/cm2.hr with no lag time using rat skin tissue. A transmission electron microscope was done to visualize the selected formula. Invasomes are considered promising drug delivery systems for transdermal delivery of ondansetron, ensuring efficient permeation with a sustained release pattern.
Study the sustain release effect of different polymers used in the formulation of aspirin-rosuvastatin tablets International Journal of Pharmacy and Pharmaceutical Sciences, 2015
Formulation and in vitro evaluation of rosuvastatin calcium niosomes International Journal of Pharmacy and Pharmaceutical Sciences, 2013
Effects of mucoadhesive polymers combination on the properties of lisinpril buccal tablets prepared by wet granulation method International Journal of Pharmacy and Pharmaceutical Sciences, 2013
RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)
FORMULATION AND IN VITRO EVALUATION OF ROSUVASTATIN CALCIUM NIOSOMES.
