Sudipta Bhowmik

Scopus Publications

Nickel-Catalyzed Construction of Dibenzoxathiepine and Dibenzothiazepine Frameworks as H-Telo G-Quadruplex DNA Binders
Sk Shamim Ahamed, Sagar Bag, Raj Kumar Chinnadurai, Sudipta Bhowmik, Tapas Ghosh
Chemmedchem, 2026
A series of medium‐ring heterocycles, including dibenzoxathiepine and dibenzothiazepine derivatives bearing tetra‐substituted exocyclic olefins, were synthesized via a ligand‐free nickel‐catalyzed one‐pot cyclocarbonickelation‐arylation cascade of functionalized bromoalkyne substrates. In this study, these synthesized ligands were evaluated for their binding affinity toward various G‐quadruplex (GQ) and duplex DNA structures using biophysical such as UV–Vis absorption, fluorescence spectroscopy, fluorescence anisotropy, time‐resolved decay, circular dichroism, thermal melting, thermodynamic analysis, and in silico studies (molecular docking and simulation studies). Owing to their biological significance, GQ‐DNA motifs have emerged as attractive targets for anticancer drug development. Among the tested compounds, ligand 3i demonstrated high selectivity for the H‐Telo GQ‐DNA over other GQ forms and duplex DNA. The thermodynamic and spectroscopic data collectively reveal that hydrophobic and π–π stacking interactions drive the ligand‐GQ association. This recognition suggests that ligand 3i may serve as a promising ligand and also potential candidates for further investigation in cancer cells. Overall, the findings provide valuable insights into ligand‐GQ interactions and may support the development of GQ‐targeted agents, contributing to the broader understanding of GQ‐DNA recognition and therapeutic design. These findings also establish a structure‐function relationship linking the heterocyclic framework to GQ recognition.
Impact of Polystyrene Microplastics on Human Alternative DNA Structures
Sagar Bag, Souvik Ghosal, Sudipta Bhowmik
Chemistryselect, 2026
The widespread contamination of the environment by microplastics (MPs), particularly polystyrene (PS) and polyethylene (PE), poses significant ecological and health concerns. While much attention has been given to the physical impact of MPs, their molecular interactions, particularly with genetic material, remain largely unexplored. This study examines how PS and PE MPs influence the structure and stability of human alternative i‐motif (iM) DNA, which plays a key role in regulating gene expression and maintaining genomic integrity. Using biophysical techniques, our results have demonstrated the effects of PS‐MPs and PE‐MPs of different sizes on HRAS2 iM DNA. Our results reveal that PS‐MPs, particularly those with a 100 nm diameter, strongly interact with HRAS2 iM DNA, causing hypochromism and shifts in the UV‐Vis spectra, along with changes in secondary structure observed by CD. FT‐IR spectroscopy confirmed alterations in DNA conformation, and thermal melting data showed increased stability of the HRAS2 iM DNA in the presence of PS‐MPs. These findings suggest that PS‐MPs, due to their small size, may disrupt the structural integrity of iM DNA, potentially affecting gene regulation. This work highlights the need to consider both the physical and biochemical properties of MPs in assessing their environmental and health risks.
Synthesis of tris-indolylmethanealkaloids by harnessing the nucleophilic reactivity of Indole-BX and studying their interactions with hemoglobin
Sukanya Das, Mangal Deep Burman, Sagar Bag, Ranjit Soren, Brindaban Roy, et al.
New Journal of Chemistry, 2026
In this investigation, we have synthesized tris-indolylmethanealkaloid (TIMs) from Indole-BX and also described the nature of the interaction between hemoglobin (Hb) with TIMs using different multi-spectroscopic studies.
An Amino Acid-Based Self-Shrinking Supramolecular Bioactive Hydrogel - A Sustainable Platform for Wastewater Treatment and Water Purification
Swaraj Ganesh Gaonkar, Pandey Priya Arun, S. Daisy Precilla, Hirak Kumar Basak, Meenakshi Singh, et al.
Chemistry A European Journal, 2025
This study investigates the unique syneresis (self‐shrinking) behavior of N‐Terminally Fmoc‐protected amino acid, Fmoc‐hPhe‐OH (Fmoc‐homo‐L‐phenylalanine, abbreviated in this work as hF)‐based hydrogel, and its potential in environmental remediation applications. Fmoc‐hPhe‐OH (hF) forms a hydrogel in 50 mM phosphate buffer (PB) of pH 7.4. Interestingly, hF‐based hydrogel shows syneresis behavior with controlled release of residual water from the hydrogel matrix. Moreover, this hydrogelator can form co‐assembled hydrogels with various dyes, including Congo Red and Rhodamine B; natural water samples, including natural mud water and sea water; and heavy metal ions aqueous solutions, including CdII, PbII, and HgII separately in 50 mM PB of pH 7.4. Interestingly, after 2 to 3 hours for shake gel and 5–6 hours for nonshake gel, the released waters have been tested and it has been found that these co‐assembled hydrogels are capable of retaining almost all the contaminants within the shrink hydrogels matrix and releasing almost pure water along with the presence of hydrogel nanofibers. Syneresis is augmented to purify the contaminated water with dyes, mud, dissolved salts, and toxic heavy metal ions. These co‐assembled hydrogels, leading to distinct structural and functional changes, which have been characterized by using Fourier‐Transform Infrared Spectroscopy (FTIR), X‐ray Diffraction (XRD), and Field Emission Scanning Electron Microscopy (FE‐SEM), suggesting various supramolecular interactions including π‐π stacking, hydrogen bonding, and electrostatic interactions are responsible for stable hydrogelations. The rheological study evaluates the hydrogel's mechanical and thixotropic properties and spectroscopic techniques, including UV‐visible spectroscopy and fluorescence spectroscopy, to monitor structural transition. This novel class of amino acid‐based hydrogel shows antibacterial activity against both Gram‐positive and Gram‐negative bacteria, likely through membrane‐disruptive mechanisms, and also shows promising antioxidant properties. The native hF hydrogel is biocompatible and shows anticancer activity toward the pancreatic cancer cell line. The research finding bestows the biomedically relevant hydrogel's potential use in green and sustainable environmental remediation.
Smart drug in cancer treatment: Design, synthesis and biophysical characterization of uracil-containing cyclic hypervalent iodine (Uracil-BX) reagent with G-quadruplex DNA structures
Sukanya Das, Sagar Bag, Md. Abbasuddin Sk, Raj K. Nandi, Sudipta Bhowmik
Bioorganic Chemistry, 2025
Naphthalene Diimide-Based Soft Materials Exhibiting High-Performance, Tunable Electrical Properties Through Side-Chain Engineering and Strong Binding Interactions with Human Hemoglobin
Sk Shamim Ahamed, Nargis Khatun, Mangal Deep Burman, Sagar Bag, Rajdeep Chakraborty, et al.
Small, 2025
Herein the design and synthesis of naphthalene diimide (NDI) derivatives aminated at the core with N1,N1‐dimethylpropane‐1,3‐diamine, and 6‐aminocoumarin are reported. Accommodating amine substituents on the electron‐poor NDI scaffold yielded notable electronic characteristics of interest. These aminated NDIs exhibited two distinct absorption bands: one at a high‐energy band (350–450 nm) associated with π–π* transitions and the other one (450–600 nm) due to intramolecular charge transfer absorption. The obtained bandgaps, ranging from 2.69 to 3.34 eV depending on side‐chain modifications, demonstrated tunability, indicating varied semiconducting properties. Electrical studies revealed that all the side‐chain‐modified molecules exhibited high electrical conductivity and displayed characteristics of Schottky diodes. Notably, different Schottky parameters are found to vary systematically based on side‐chain engineering, aligning well with their optical characteristics. Complementarily, AFM, and XRR investigations revealed unique crystalline morphologies associated with molecular architecture, highlighting the efficacy of molecular engineering in optimizing materials for electrical devices. Selective compounds underwent a series of biophysical analyses, including UV–vis absorption‐, fluorescence‐, and circular dichroism spectroscopy, all of which demonstrated a strong binding affinity, highlighting their potential interactions with human hemoglobin (Hb). In‐depth computational studies like TDDFT and frontier molecular orbital analysis cemented the experimental observations.
Nickel-Catalyzed Regioselective Access to Dibenzo[b,e]Azepinones: Mechanistic Study, Docking, and Biophysical Exploration of Binding Interactions with Human Hemoglobin
Sk Shamim Ahamed, Uma Sankar Mandal, Sagar Bag, Mangal Deep Burman, Rabindranath Lo, et al.
Chemistry an Asian Journal, 2025
A nickel‐catalyzed intramolecular acetylene hydroarylation process has been described to produce dibenzo[b,e]azepin‐6‐one derivatives in an effective, regioselective manner. This procedure demonstrates a broad substrate scope and exceptional tolerance to various functional groups. Mechanistic insights were confirmed through the use of the density functional theory method. Selective synthesized compounds were subjected to biophysical analysis such as UV–vis absorption spectroscopy, fluorescence spectroscopy, stoichiometric analysis, thermal melting, and circular dichroism spectroscopic analysis revealing strong binding affinity to exploit their interactions with human hemoglobin (Hb). Additionally, molecular docking studies provided insights into the interactions between the synthesized molecule and human Hb.
Poly(vinyl chloride) microplastics induce structural and functional alterations in myoglobin
Souvik Ghosal, Sagar Bag, Sudipta Bhowmik
Rsc Advances, 2025
Microplastics (MPs) pollution represents a global concern for biodiversity conservation, ecosystem and public health.
Modulation of the HRAS1 I-motif DNA Promoter Region by Dietary Plant Flavonoid Kaempferol
Sagar Bag, Souvik Ghosal, Mangal Deep Burman, Moupriya Mukherjee, Goutam Pramanik, et al.
ACS Omega, 2025
External stimuli responsive syneresis of amino acid-based bioactive hydrogels: a sustainable platform for environmental remediation
Abhinandan Bera, Ritu Raj Patel, S. Daisy Precilla, Meenakshi Singh, B. Agiesh Kumar, et al.
Materials Advances, 2025
Fmoc-3-(1-naphthyl)-l-alanine and Fmoc-3-(2-naphthyl)-l-alanine form stable bioactive hydrogels individually. Removal of toxic heavy metal ions (HgII) and toxic dye (Thioflavin T) from waste-water by stimuli responsive syneresis has been portrayed.
Structural Diversity and Mechanistic Insights on Preferential Interaction of Small Molecule Ligands with i-Motif DNA Structures: Unlocking New Blueprint for Drug Discovery
Sagar Bag, Souvik Ghosal, Mangal Deep Burman, Atanu Manna, Sudipta Bhowmik
Chemistryselect, 2025
Understanding the impact of the molecular crowding environment on the glyoxal-mediated glycation of hemoglobin
Mangal Deep Burman, Sagar Bag, Souvik Ghosal, Sudipta Bhowmik
Physical Chemistry Chemical Physics, 2025
Glycation of Proteins and Its End Products: From Initiation to Natural Product-Based Therapeutic Preventions
Mangal Deep Burman, Sagar Bag, Souvik Ghosal, Sudipta Bhowmik
ACS Pharmacology and Translational Science, 2025
Microplastics can alter structural configurations of human non-canonical G-quadruplex DNA
Sagar Bag, Souvik Ghosal, Sudipta Bhowmik
Environmental Toxicology and Pharmacology, 2025
Exploring i-Motif DNA binding with benzothiazolino Coumarins: Synthesis, Screening, and spectroscopic insights
Sagar Bag, Karam Chand, Mangal Deep Burman, Steven Vertueux, Erik Chorell, et al.
Bioorganic Chemistry, 2025
Differential binding of curcumin with chair and basket type anti-parallel DNA G-quadruplexes
Pabitra Mandal, Priyabrata Das, Sudipta Bhowmik, Smritimoy Pramanik
Journal of Photochemistry and Photobiology A Chemistry, 2025
Decoding the Potential of HRAS2 i-Motif DNA Promoter to Become a Pinpoint Target by Phytomedicine Naringenin
Sagar Bag, Souvik Ghosal, Sudipta Bhowmik
Chemistryselect, 2025
Artificial Intelligence in Cellular and Biomolecular Spectroscopy: A New Horizon
Sagar Bag, Atanu Manna, Sudipta Bhowmik
Methods in Molecular Biology, 2025
Deciphering Preferential Binding Interaction of Synthetic Pyrido[2,3-c]Carbazole Alkaloid Derivative (PCAD) with Pu24T G-quadruplex DNA
Pamela Pal, Sagar Bag, Mangal Deep Burman, Raj Kumar Nandi, Sudipta Bhowmik
Chemistryselect, 2024
Investigating the preferential interaction between imatinib mesylate and VEGF G-quadruplex DNA as therapeutic strategies for cancer treatment: Biophysical and molecular modelling approaches
Souvik Ghosal, Sagar Bag, Raj Kumar Chinnadurai, Moupriya Mukherjee, Goutam Pramanik, et al.
Computers in Biology and Medicine, 2024
Insights into the Binding Interactions between Microplastics and Human α-Synuclein Protein by Multispectroscopic Investigations and Amyloidogenic Oligomer Formation
Souvik Ghosal, Sagar Bag, Sudipta Bhowmik
Journal of Physical Chemistry Letters, 2024
Quercetin Exhibits Preferential Binding Interaction by Selectively Targeting HRAS1 I-Motif DNA-Forming Promoter Sequences
Sagar Bag, Souvik Ghosal, Moupriya Mukherjee, Goutam Pramanik, Sudipta Bhowmik
Langmuir, 2024
Revealing the Improved Binding Interaction of Plant Alkaloid Harmaline with Human Hemoglobin in Molecular Crowding Condition
Mangal Deep Burman, Sagar Bag, Souvik Ghosal, Moupriya Mukherjee, Goutam Pramanik, et al.
ACS Omega, 2024
Fluorescence Spectroscopy: A Useful Method to Explore the Interactions of Small Molecule Ligands with DNA Structures
Sagar Bag, Sudipta Bhowmik
Methods in Molecular Biology, 2024
Exposure to polyethylene microplastics exacerbate inflammatory bowel disease tightly associated with intestinal gut microflora
Souvik Ghosal, Sagar Bag, S. R. Rao, Sudipta Bhowmik
Rsc Advances, 2024
Theranostic approach to specifically targeting the interloop region of BCL2 i-motif DNA by crystal violet
Sinjan Das, Shuntaro Takahashi, Tatsuya Ohyama, Sudipta Bhowmik, Naoki Sugimoto
Scientific Reports, 2023
Multispectroscopic Investigations of the Binding Interaction between Polyethylene Microplastics and Human Hemoglobin
Souvik Ghosal, Sagar Bag, Mangal Deep Burman, Sudipta Bhowmik
Journal of Physical Chemistry Letters, 2023
Exploring the Structural Importance of the C3═C4 Double Bond in Plant Alkaloids Harmine and Harmaline on Their Binding Interactions with Hemoglobin
Mangal Deep Burman, Sagar Bag, Souvik Ghosal, Sudip Karmakar, Goutam Pramanik, et al.
ACS Omega, 2023
Uncovering the Contrasting Binding Behavior of Plant Flavonoids Fisetin and Morin Having Subsidiary Hydroxyl Groups (−OH) with HRAS1 and HRAS2 i-Motif DNA Structures: Decoding the Structural Alterations and Positional Influences
Sagar Bag, Souvik Ghosal, Sudip Karmakar, Goutam Pramanik, Sudipta Bhowmik
ACS Omega, 2023
Unravelling the Drug Encapsulation Ability of Functional DNA Origami Nanostructures: Current Understanding and Future Prospects on Targeted Drug Delivery
Souvik Ghosal, Sagar Bag, Sudipta Bhowmik
Polymers, 2023
Structural insights and shedding light on preferential interactions of dietary flavonoids with G-quadruplex DNA structures: A new horizon
Sagar Bag, Mangal Deep Burman, Sudipta Bhowmik
Heliyon, 2023
Replication Control of Human Telomere G-Quadruplex DNA by G-Quadruplex Ligands Dependent on Solution Environment
Shuntaro Takahashi, Sudipta Bhowmik, Shinobu Sato, Shigeori Takenaka, Naoki Sugimoto
Life, 2022
Volumetric Strategy for Quantitatively Elucidating a Local Hydration Network around a G‑Quadruplex
Saki Matsumoto, Shuntaro Takahashi, Sudipta Bhowmik, Tatsuya Ohyama, Naoki Sugimoto
Analytical Chemistry, 2022
Chemical Modulation of DNA Replication along G-Quadruplex Based on Topology-Dependent Ligand Binding
Shuntaro Takahashi, Anita Kotar, Hisae Tateishi-Karimata, Sudipta Bhowmik, Zi-Fu Wang, et al.
Journal of the American Chemical Society, 2021
Preferential interaction with c-MYC quadruplex DNA mediates the cytotoxic activity of a nitro-flavone derivative in A375 cells
Anindita Mitra, Sudipta Bhowmik, Rita Ghosh
Journal of Photochemistry and Photobiology, 2021
Preferential targeting cancer-related i-motif DNAs by the plant flavonol fisetin for theranostics applications
Shuntaro Takahashi, Snehasish Bhattacharjee, Saptarshi Ghosh, Naoki Sugimoto, Sudipta Bhowmik
Scientific Reports, 2020
Subtle structural alterations in G-quadruplex DNA regulate site specificity of fluorescence light-up probes
Rajendra Kumar, Karam Chand, Sudipta Bhowmik, Rabindra Nath Das, Snehasish Bhattacharjee, et al.
Nucleic Acids Research, 2020
Lighting Up of Thiazole Orange on G-Quadruplex DNA by High Pressure
Sudipta Bhowmik, Shuntaro Takahashi, Naoki Sugimoto
ACS Omega, 2019
Importance of the hydroxyl substituents in the B–ring of plant flavonols on their preferential binding interactions with VEGF G–quadruplex DNA: Multi-spectroscopic and molecular modeling studies
Snehasish Bhattacharjee, Sandipan Chakraborty, Erik Chorell, Pradeep K. Sengupta, Sudipta Bhowmik
International Journal of Biological Macromolecules, 2018
Flexible Versus Rigid G-Quadruplex DNA Ligands: Synthesis of Two Series of Bis-indole Derivatives and Comparison of Their Interactions with G-Quadruplex DNA
Bagineni Prasad, Jan Jamroskovic, Sudipta Bhowmik, Rajendra Kumar, Tajanena Romell, et al.
Chemistry A European Journal, 2018
Encapsulation of pharmaceutically active dietary polyphenols in cyclodextrin-based nanovehicles: Insights from spectroscopic studies
Pradeep K. Sengupta, Snehasish Bhattacharjee, Sandipan Chakraborty, Sudipta Bhowmik
Design of Nanostructures for Versatile Therapeutic Applications, 2018
Volumetric analysis of formation of the complex of G-quadruplex DNA with hemin using high pressure
Shuntaro Takahashi, Sudipta Bhowmik, Naoki Sugimoto
Journal of Inorganic Biochemistry, 2017
Exploring the preferential interaction of quercetin with VEGF promoter G-quadruplex DNA and construction of a pH-dependent DNA-based logic gate
Snehasish Bhattacharjee, Pradeep K. Sengupta, Sudipta Bhowmik
Rsc Advances, 2017
Exploring the Interactions of the Dietary Plant Flavonoids Fisetin and Naringenin with G-Quadruplex and Duplex DNA, Showing Contrasting Binding Behavior: Spectroscopic and Molecular Modeling Approaches
Snehasish Bhattacharjee, Sandipan Chakraborty, Pradeep K. Sengupta, Sudipta Bhowmik
Journal of Physical Chemistry B, 2016
Influence of ultraviolet C bystander effect on inflammatory response in A 375. Cell on subsequent exposure to ultraviolet C or hydrogen peroxide
Indian Journal of Biochemistry and Biophysics, 2014
A small molecule peptidomimetic that binds to c-KIT1 G-quadruplex and exhibits antiproliferative properties in cancer cells
Ajay Chauhan, Sushovan Paladhi, Manish Debnath, Samir Mandal, Rabindra Nath Das, et al.
Bioorganic and Medicinal Chemistry, 2014
Antioxidant enzymes and the mechanism of the bystander effect induced by ultraviolet C irradiation of A375 human melanoma cells
Rita Ghosh, Dipanjan Guha, Sudipta Bhowmik, Sayantani Karmakar
Mutation Research, 2013
Antioxidant enzymes and the mechanism of the bystander effect induced by ultraviolet C irradiation of A375 human melanoma cells
Rita Ghosh, Dipanjan Guha, Sudipta Bhowmik, Sayantani Karmakar
Mutation Research Genetic Toxicology and Environmental Mutagenesis, 2013
A fluorescent guanosine dinucleoside as a selective switch-on sensor for c-myc G-quadruplex DNA with potent anticancer activities
Y. Pavan Kumar, Sudipta Bhowmik, Rabindra Nath Das, Irene Bessi, Sushovan Paladhi, et al.
Chemistry A European Journal, 2013
Design and synthesis of an on-off "click" fluorophore that executes a logic operation and detects heavy and transition metal ions in water and living cells
Ganesh Chandra Midya, Sushovan Paladhi, Sudipta Bhowmik, Subhadeep Saha, Jyotirmayee Dash
Organic and Biomolecular Chemistry, 2013
pH dependent multifunctional and multiply-configurable logic gate systems based on small molecule G-quadruplex DNA recognition
Sudipta Bhowmik, Rabindra Nath Das, Bibudha Parasar, Jyotirmayee Dash
Chemical Communications, 2013
Some UV-bystander effects are mediated through induction of antioxidant defense in mammalian cells
Indian Journal of Biochemistry and Biophysics, 2012
UV released factors induce antioxidant defense in A375 cells
Rita Ghosh, Dipanjan Guha, Sudipta Bhowmik
Photochemistry and Photobiology, 2012
9-phenyl acridine exhibits antitumour activity by inducing apoptosis in A375 cells.
Rita Ghosh, Sudipta Bhowmik, Dipanjan Guha
Molecular and Cellular Biochemistry, 2012
Chemotherapeutic potential of 9-phenyl acridine: Biophysical studies on its binding to DNA
Rita Ghosh, Sudipta Bhowmik, Angshuman Bagchi, Dipankar Das, Somnath Ghosh
European Biophysics Journal, 2010
Molecular modelling studies of some 9-arylacridines to elucidate their possible roles in Topoisomerase I inhibition
International Journal of Integrative Biology, 2008

RECENT SCHOLAR PUBLICATIONS

Microplastics-Induced Binding and Structural Changes in the Milk Proteins: α-Lactalbumin and β-Lactoglobulin
S Ghosal, S Bag, MD Burman, S Bhowmik
2026
Selective Stabilization of HRAS2 i-Motif DNA by TMPyP4: A Multimodal Biophysical and Thermodynamic Investigation
S Bag, S Ghosal, MD Burman, E Chorell, S Bhowmik
bioRxiv, 2026.04. 08.717182 , 2026
2026
Synthesis of tris-indolylmethanealkaloids by harnessing the nucleophilic reactivity of Indole-BX and studying their interactions with hemoglobin
S Das, MD Burman, S Bag, R Soren, B Roy, S Bhowmik, RK Nandi
New Journal of Chemistry 50 (1), 98-108 , 2026
2026
Impact of polystyrene microplastics on human alternative DNA structures
S Bag, S Ghosal, S Bhowmik
ChemistrySelect 11 (4), e02999 , 2026
2026
An Amino Acid‐Based Self‐Shrinking Supramolecular Bioactive Hydrogel‐A Sustainable Platform for Wastewater Treatment and Water Purification
SG Gaonkar, PP Arun, SD Precilla, HK Basak, M Singh, BA Kumar, ...
Chemistry–A European Journal 31 (58), e01895 , 2025
2025
Citations: 2
Smart drug in cancer treatment: Design, synthesis and biophysical characterization of uracil-containing cyclic hypervalent iodine (Uracil-BX) reagent with G-quadruplex DNA …
S Das, S Bag, MA Sk, RK Nandi, S Bhowmik
Bioorganic Chemistry, 109021 , 2025
2025
Citations: 1
Naphthalene Diimide‐Based Soft Materials Exhibiting High‐Performance, Tunable Electrical Properties Through Side‐Chain Engineering and Strong Binding Interactions with Human …
SS Ahamed, N Khatun, MD Burman, S Bag, R Chakraborty, B Panda, ...
Small 21 (33), 2504759 , 2025
2025
Citations: 2
Nickel‐Catalyzed Regioselective Access to Dibenzo[ b , e ]Azepinones: Mechanistic Study, Docking, and Biophysical Exploration of Binding Interactions with Human …
SS Ahamed, US Mandal, S Bag, MD Burman, R Lo, D Manna, S Bhowmik, ...
Chemistry–An Asian Journal 20 (16), e00030 , 2025
2025
Citations: 2
Modulation of the HRAS1 I-motif DNA Promoter Region by Dietary Plant Flavonoid Kaempferol
S Bag, S Ghosal, MD Burman, M Mukherjee, G Pramanik, S Bhowmik
ACS omega 10 (29), 31381-31392 , 2025
2025
Artificial Intelligence in Cellular and Biomolecular Spectroscopy: A New Horizon
S Bag, A Manna, S Bhowmik
Artificial Intelligence (AI) in Cell and Genetic Engineering, 59-72 , 2025
2025
Structural Diversity and Mechanistic Insights on Preferential Interaction of Small Molecule Ligands with i‐Motif DNA Structures: Unlocking New Blueprint for Drug Discovery
S Bag, S Ghosal, MD Burman, A Manna, S Bhowmik
ChemistrySelect 10 (24), e01985 , 2025
2025
Citations: 3
Breaking barriers: A new phytomedicine based treatment approach for targeted unrevealed non-canonical DNA structures in tuberculosis bacteria
S Bhowmik, T Shroff, S Bag, P Kadam, N Mistry
bioRxiv, 2025.04. 08.647720 , 2025
2025
Exploring i-Motif DNA binding with benzothiazolino Coumarins: Synthesis, Screening, and spectroscopic insights
S Bag, K Chand, MD Burman, S Vertueux, E Chorell, S Bhowmik
Bioorganic chemistry 156, 108227 , 2025
2025
Citations: 3
Microplastics can alter structural configurations of human non-canonical G-quadruplex DNA
S Bag, S Ghosal, S Bhowmik
Environmental Toxicology and Pharmacology 114, 104626 , 2025
2025
Citations: 7
Glycation of proteins and its end products: from initiation to natural product-based therapeutic preventions
MD Burman, S Bag, S Ghosal, S Bhowmik
ACS Pharmacology & Translational Science 8 (3), 636-653 , 2025
2025
Citations: 12
Differential binding of curcumin with chair and basket type anti-parallel DNA G-quadruplexes
P Mandal, P Das, S Bhowmik, S Pramanik
Journal of Photochemistry and Photobiology A: Chemistry 459, 116075 , 2025
2025
Citations: 1
Uracil-BX: A new class of cyclic hypervalent iodine reagents for unraveling approach towards umpolung functionalization and VEGF G-quadruplex DNA identification
S Das, S Bag, MA Sk, P Majumdar, UK Das, S Bhowmik, RK Nandi
ChemRxiv 2025 (0130) , 2025
2025
Citations: 3
Poly (vinyl chloride) microplastics induce structural and functional alterations in myoglobin
S Ghosal, S Bag, S Bhowmik
RSC advances 15 (34), 27576-27585 , 2025
2025
Citations: 2
External stimuli responsive syneresis of amino acid-based bioactive hydrogels: a sustainable platform for environmental remediation
A Bera, RR Patel, SD Precilla, M Singh, BA Kumar, S Bhowmik, ...
Materials Advances 6 (15), 5184-5195 , 2025
2025
Citations: 2
Understanding the impact of the molecular crowding environment on the glyoxal-mediated glycation of hemoglobin
MD Burman, S Bag, S Ghosal, S Bhowmik
Physical Chemistry Chemical Physics 27 (22), 11821-11829 , 2025
2025

MOST CITED SCHOLAR PUBLICATIONS

Exploring the interactions of the dietary plant flavonoids fisetin and naringenin with G-quadruplex and duplex DNA, showing contrasting binding behavior: spectroscopic and …
S Bhattacharjee, S Chakraborty, PK Sengupta, S Bhowmik
The Journal of Physical Chemistry B 120 (34), 8942-8952 , 2016
2016
Citations: 60
Chemical modulation of DNA replication along G-quadruplex based on topology-dependent ligand binding
S Takahashi, A Kotar, H Tateishi-Karimata, S Bhowmik, ZF Wang, ...
Journal of the American Chemical Society 143 (40), 16458-16469 , 2021
2021
Citations: 56
Subtle structural alterations in G-quadruplex DNA regulate site specificity of fluorescence light-up probes
R Kumar, K Chand, S Bhowmik, RN Das, S Bhattacharjee, M Hedenström, ...
Nucleic acids research 48 (3), 1108-1119 , 2020
2020
Citations: 48
Preferential targeting cancer-related i-motif DNAs by the plant flavonol fisetin for theranostics applications
S Takahashi, S Bhattacharjee, S Ghosh, N Sugimoto, S Bhowmik
Scientific Reports 10 (1), 2504 , 2020
2020
Citations: 47
Design and synthesis of an on–off “click” fluorophore that executes a logic operation and detects heavy and transition metal ions in water and living cells
GC Midya, S Paladhi, S Bhowmik, S Saha, J Dash
Organic & Biomolecular Chemistry 11 (18), 3057-3063 , 2013
2013
Citations: 45
Exploring the preferential interaction of quercetin with VEGF promoter G-quadruplex DNA and construction of a pH-dependent DNA-based logic gate
S Bhattacharjee, PK Sengupta, S Bhowmik*
RSC Advances 7 (59), 37230-37240 , 2017
2017
Citations: 42
Chemotherapeutic potential of 9-phenyl acridine: biophysical studies on its binding to DNA
R Ghosh, S Bhowmik, A Bagchi, D Das, S Ghosh
European Biophysics Journal 39 (8), 1243-1249 , 2010
2010
Citations: 35
Importance of the hydroxyl substituents in the B–ring of plant flavonols on their preferential binding interactions with VEGF G–quadruplex DNA: Multi-spectroscopic and …
S Bhattacharjee, S Chakraborty, E Chorell, PK Sengupta, S Bhowmik
International journal of biological macromolecules 118, 629-639 , 2018
2018
Citations: 33
A small molecule peptidomimetic that binds to< i> c-KIT1</i> G-quadruplex and exhibits antiproliferative properties in cancer cells
A Chauhan, S Paladhi, M Debnath, S Mandal, RN Das, S Bhowmik, ...
Bioorganic & Medicinal Chemistry , 2014
2014
Citations: 33
Structural insights and shedding light on preferential interactions of dietary flavonoids with G-quadruplex DNA structures: A new horizon
S Bag, MD Burman, S Bhowmik
Heliyon 9 (3) , 2023
2023
Citations: 31
pH dependent multifunctional and multiply-configurable logic gate systems based on small molecule G-quadruplex DNA recognition
S Bhowmik, R Das, B Parasar, J Dash
Chem. Commun. 49, 1817-1819 , 2013
2013
Citations: 31
9-phenyl acridine exhibits antitumour activity by inducing apoptosis in A375 cells
R Ghosh, S Bhowmik, D Guha
Molecular and cellular biochemistry 361 (1), 55-66 , 2012
2012
Citations: 31
Antioxidant enzymes and the mechanism of the bystander effect induced by ultraviolet C irradiation of A375 human melanoma cells
R Ghosh, D Guha, S Bhowmik, S Karmakar
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 757 (1 … , 2013
2013
Citations: 29
A Fluorescent Guanosine Dinucleoside as a Selective Switch‐On Sensor for c‐myc G‐Quadruplex DNA with Potent Anticancer Activities
YP Kumar, S Bhowmik, RN Das, I Bessi, S Paladhi, R Ghosh, H Schwalbe, ...
Chemistry–A European Journal 19 (35), 11502-11506 , 2013
2013
Citations: 27
Insights into the binding interactions between microplastics and human α-synuclein protein by multispectroscopic investigations and amyloidogenic oligomer formation
S Ghosal, S Bag, S Bhowmik
The Journal of Physical Chemistry Letters 15 (25), 6560-6567 , 2024
2024
Citations: 24
Exposure to polyethylene microplastics exacerbate inflammatory bowel disease tightly associated with intestinal gut microflora
S Ghosal, S Bag, SR Rao, S Bhowmik
RSC advances 14 (35), 25130-25148 , 2024
2024
Citations: 24
Flexible versus rigid G‐quadruplex DNA ligands: synthesis of two series of bis‐indole derivatives and comparison of their interactions with G‐quadruplex DNA
B Prasad, J Jamroskovic, S Bhowmik, R Kumar, T Romell, N Sabouri, ...
Chemistry–A European Journal 24 (31), 7926-7938 , 2018
2018
Citations: 24
Volumetric analysis of formation of the complex of G-quadruplex DNA with hemin using high pressure
S Takahashi, S Bhowmik, N Sugimoto
Journal of Inorganic Biochemistry 166, 199-207 , 2017
2017
Citations: 24
Unravelling the drug encapsulation ability of functional DNA origami nanostructures: current understanding and future prospects on targeted drug delivery
S Ghosal, S Bag, S Bhowmik
Polymers 15 (8), 1850 , 2023
2023
Citations: 23
Quercetin exhibits preferential binding interaction by selectively targeting HRAS1 I-Motif DNA-forming promoter sequences
S Bag, S Ghosal, M Mukherjee, G Pramanik, S Bhowmik
Langmuir 40 (19), 10157-10170 , 2024
2024
Citations: 17

Sudipta Bhowmik

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