Umamaheshwari S

@jssuni.edu.in

Assistant Professor and Department of Microbiology
JSS Academy of Higher Education & Research

Umamaheshwari S


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https://researchid.co/uma_s1980

RESEARCH, TEACHING, or OTHER INTERESTS

Microbiology, Microbiology (medical), General Immunology and Microbiology, Microbiology (medical)
17

Scopus Publications

82

Scholar Citations

6

Scholar h-index

3

Scholar i10-index

Scopus Publications

  • Pyridine embedded 1,3,4-oxadiazole derivatives: Design, synthesis, molecular docking and antitubercular activity evaluation
    Deepak Devadiga, T.N. Ahipa, S. Umamaheshwari, Chinmay Bhat, S.K. Keerthi, D. Deepika, Santosh L. Gaonkar
    Tuberculosis, 2026
  • Biopolymers: An Overview and Progressive Phases in Biomedical Sciences
    Sudipta Choudhury, Shivaswamy Umamaheshwari, Kanthesh M. Basalingappa
    Materials Horizons from Nature to Nanomaterials, 2026
  • The impact of photodynamic therapy in root canal disinfection and smear layer removal using phytocompounds
    R. Sumukh Bharadwaj, Ashwini Tumkur Shivakumar, Umamaheshwari Shivaswamy, Sowmya Halasabalu Kalgeri, Supreeth S. Gowda, Dheeraj Lokesh, H. R. Pragath, S. Sneha
    Endodontology, 2025
    Aim: The study aims to assess the antibacterial properties of Psidium guajava and Citrus sinensis on Enterococcus faecalis, compare their effectiveness as irrigating solutions, compare their effectiveness with photodynamic therapy (PDT), and evaluate their ability to remove smear layer from the root canal using scanning electron microscopy (SEM). Methods: The study examined the antibacterial efficacy of sweet orange peel and guava leaf extracts on 90 single roots from permanent teeth with closed apices. The roots were stored in a 0.9% saline solution, cleaned, and disinfected. The root canals were prepared using a Protaper rotary file system and irrigated with sodium hypochlorite, ethylenediaminetetraacetic acid, and normal saline. Samples were grouped into two groups – Group I (without PDT) and Group II (with PDT). The samples were irrigated with guava, sweet orange extracts, and 2% chlorhexidine, and the apical third specimen was subjected to SEM to evaluate the smear layer removing ability of the irrigants. Results: The study found that guava extract showed the highest colony-forming unit reduction compared to sweet orange extract. In the experimental Group I without PDT, guava extracts (Group IA) and chlorhexidine (Group IC) were found to remove the maximum smear layer, whereas sweet orange extract (Group IB) did not. Statistical significance was observed between the subgroups. Conclusion: The study found that guava extract maximum smear layer removal from root canal specimens, with or without PDT and chlorhexidine. Sweet orange did not show significant reduction in bacterial count or effectively remove the smear layer. Further research is needed to confirm this.
  • Corrigendum to “Clinical profile, antifungal susceptibility, and molecular characterization of Candida auris isolated from patients in a South Indian surgical ICU.” [J Mycol Med (2021) 101176] (Journal of Medical Mycology (2021) 31(4), (S1156523321000664), (10.1016/j.mycmed.2021.101176))
    S. Umamaheshwari, S.M. Neelambike, S.A. Shankarnarayan, K.S. Kumarswamy, S. Gopal, H. Prakash, S.M. Rudramurthy
    Journal of Medical Mycology, 2025
  • Probiotics with Preventive and Therapeutic Potential for Colorectal Cancer: An Emphasis on Immunomodulatory and Anticancer Properties
    Taparia Saloni, Jalahalli M. Siddesha, Basalingappa M. Kanthesh, Shivaswamy Umamaheshwari
    Microbiota and Dietary Mediators in Colon Cancer Prevention and Treatment, 2025
  • The Role of Magnetic Microbots in Colorectal Cancer
    KR Arjun, Avipsa Hazra, R Mythreyi, D Mutthuraj, BM Kanthesh, S Umamaheshwari
    Colorectal Cancer Diagnosis Advancements and Applications, 2025
    Colorectal cancer is one of the leading causatives in today's world which is due to various external factors. The treatment of cancer is a big challenge in today's therapeutics. Though there are numerous ways to treat cancer such as drugs, plant sources, combination therapy, radiation therapy, etc., there is still research going on for a way to permanently cure it with fewer side effects. To boost these therapeutics, the robotic fields have moved into cancer research. Microbots can be controlled through external devices and, in the study of treating cancer patients, they can enter the body and remove the affected tumor cells effectively. Magnetic microbots which can be used to reach the desired target are at the forefront of current research to treat cancer. These microbots are designed small in size, will have fewer side effects, and can also be highly effective compared to other existing therapies, leading to a huge impact in the field of biomedical and therapeutics. There are numerous research findings going on in this aspect to remove the abnormal cancer cells with the help of magnetic microbots. The potential of biohybrid bacteria-based microbots as externally programmable carriers for targeted cancer treatment is becoming more widely acknowledged. In particular, magnetic fields have been employed as a secure method of directing and transferring energy. In this chapter we will be discussing the working of magnetic microbots particularly in the treatment of colon cancer. We also have a look in depth about the betterment and future aspect oriented applications of magnetic microbots in the eradication of colon cancer, the capacity of hydrogel microbots powered by magnetism to transport Lycorine hydrochloride, which inhibits the growth of colorectal cancer cells. This chapter also discusses different drugs which can be used for preparation of magnetic microbots and can be targeted for the betterment of colorectal cancer therapeutics.
  • Probiotic, Prebiotic, and Gut-Brain Connection in Cancer Development
    K. R. Arjun, D. Mutthuraj, Neha Foferkar, Dhanush Nagendra, R. Mythreyi, S. Umamaheshwari, Kanthesh M. Basalingappa
    Microbiota and Dietary Mediators in Colon Cancer Prevention and Treatment, 2025
  • Pharmacokinetics and Pharmacodynamics of a Nanostructured Lipid Carrier Co-Encapsulating Artemether and miRNA for Mitigating Cerebral Malaria
    Veera Venkata Nishanth Goli, Spandana Tatineni, Umme Hani, Mohammed Ghazwani, Sirajunisa Talath, Sathvik Belagodu Sridhar, Yahya Alhamhoom, Farhat Fatima, Riyaz Ali M. Osmani, Umamaheshwari Shivaswamy, Vichitra Chandrasekaran, Bannimath Gurupadayya
    Pharmaceuticals, 2024
    Cerebral malaria (CM), a severe neurological pathology caused by Plasmodium falciparum infection, poses a significant global health threat and has a high mortality rate. Conventional therapeutics cannot cross the blood–brain barrier (BBB) efficiently. Therefore, finding effective treatments remains challenging. The novelty of the treatment proposed in this study lies in the feasibility of intranasal (IN) delivery of the nanostructured lipid carrier system (NLC) combining microRNA (miRNA) and artemether (ARM) to enhance bioavailability and brain targeting. The rational use of NLCs and RNA-targeted therapeutics could revolutionize the treatment strategies for CM management. This study can potentially address the challenges in treating CM, allowing drugs to pass through the BBB. The NLC formulation was developed by a hot-melt homogenization process utilizing 3% (w/w) precirol and 1.5% (w/v) labrasol, resulting in particles with a size of 94.39 nm. This indicates an effective delivery to the brain via IN administration. The results further suggest the effective intracellular delivery of encapsulated miRNAs in the NLCs. Investigations with an experimental cerebral malaria mouse model showed a reduction in parasitaemia, preservation of BBB integrity, and reduced cerebral haemorrhages with the ARM+ miRNA-NLC treatment. Additionally, molecular discoveries revealed that nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) and Interleukin-6 (IL-6) levels were reduced in the treated groups in comparison to the CM group. These results support the use of nanocarriers for IN administration, offering a viable method for mitigating CM through the increased bioavailability of therapeutics. Our findings have far-reaching implications for future research and personalized therapy.
  • Fluorescence-based Evaluation of the Efficacy of Augmented Reality-assisted Toothbrush on Oral Hygiene Practices Among 6–8 Years Old Children
    S Dey, S Deshmukh, Umamaheshwari S, Dheeraj L, Sinchan HG
    Journal of Advanced Oral Research, 2023
    Aim: Effective toothbrushing is the most simple way to maintain a child’s oral hygiene for a cavity-free mouth. Yet, most children find it an uninteresting task and they fail to understand its scientific basis. Augmented reality (A-R)-assisted toothbrushes for pediatric population are commercially available to make toothbrushing interactive, interesting, and educative for the child, aided by gamification providing an interactive videogame platform between the real and the virtual world. The aim of the study was to evaluate the efficacy of A-R-assisted brushing experience of children with respect to fluorescence imaging data and plaque Streptococcus mutans count at clinical and microbiological levels, respectively. Materials and Methods: A total of 32 children in the age group of 6-8 years were included and allocated in two study groups (A-R-assisted toothbrushing and manual toothbrushing). Fluorescence-based lesion area scoring was done using FC, Duerr Dental, Vistaproof, Germany. Microbiological analysis of plaque Streptococcus mutans was done to evaluate change in bacterial count. The parameters were recorded again after two weeks. Pre- and post-intervention scores were subjected to statistical analysis. Results: Significantly higher reduction of fluorescent scores and mean bacterial count were found in A-R-assisted tooth-brushing group when compared to that of manual toothbrushing. Conclusion: Based on the findings of the study, A-R-assisted toothbrushing proves to be an effective tool for motivating and maintaining oral hygiene among children and efforts should be made in incorporating this practice in daily domestic healthcare.
  • Retrospective analysis on distribution and antifungal susceptibility profile of Candida in clinical samples: a study from Southern India
    Umamaheshwari S., M. N. Sumana
    Frontiers in Public Health, 2023
    IntroductionCandida is one of the rising primary causes of infections connected with health care. However, their distribution and susceptibility patterns vary widely amongst different regions.MethodThe study was carried out to retrospectively analyze the distribution of Candida in various clinical samples, their species types and susceptibility, in a tertiary care hospital, in India for 4 years using the Vitek-2 database.ResultsCandida infection was identified in 751 clinical samples, and the major source of infection was found to be urine samples accounting for about 58.32%. A total of 18 different Candida species were recorded. Non-albicans Candida (NAC) 73.64% (n = 553) predominated Candida albicans 26.36% (n = 198). Candida tropicalis was found to be identified at a higher frequency followed by C. albicans, Candida glabrata and Candida parapsilosis. Candida tropicalis was the only species which were recovered from bile; Candida pelliculosa was recorded merely from blood and Candida lipolytica from urine and blood and not in any other samples. In vaginal swabs, C. albicans accounted for 63.64% (n = 14) compared to NAC 36.36% (n = 8). The susceptibility test revealed that 75.44% (n = 559) isolates were susceptible and 24.56% (n = 182) were resistant to one or more drugs tested. Major resistance was exhibited to flucytosine by C. tropicalis 77.46% (n = 55) compared to C. albicans 11.27% (n = 8). Apart from C. albicans, NAC-C. tropicalis, C. glabrata and Candida krusei showed resistance to echinocandins, and Candida haemulonii to amphotericin-B.ConclusionThe knowledge of the incidence, resistance and emergence of different species might guide clinicians to select an appropriate antifungal therapy and plan effective strategies to control invasive and systemic Candida infections.
  • Clinical profile, antifungal susceptibility, and molecular characterization of Candida auris isolated from patients in a South Indian surgical ICU.
    Shivaswamy Umamaheshwari, Sumana Mahadevaiah Neelambike, Shamanth Adekhandi Shankarnarayan, Keerthi Sravanur Kumarswamy, Shubha Gopal, Hariprasath Prakash, Shivaprakash Mandya Rudramurthy
    Journal of Medical Mycology, 2021
  • Reply to Letter to Editor regarding the article, 'Idiopathic CD4+ T lymphocytopenia: A case report
    S Umamaheshwari, MN Sumana, MS Shetty, S Gopal
    Journal of Postgraduate Medicine, 2020
  • Antifungal resistance of candida species isolated from HIV patients in a tertiary care hospital, Mysuru, Karnataka
    MN Sumana, Umamaheshwari Shivaswamy
    Indian Journal of Dermatology, 2020
  • Idiopathic CD4+ T lymphocytopenia: A case report
    S Umamaheshwari, S Gopal, MN Sumana, MS Shetty
    Journal of Postgraduate Medicine, 2020
  • Drug resistance pattern of mycobacterial isolates in HIV and non-HIV population in South India
    SumanaM Neelambike, Umamaheshwari Shivaswamy
    Lung India, 2016
  • A study of candidiasis in HIV reactive patients in a tertiary care hospital, Mysore - South India
    SumanaMahadevaiah Neelambike, Umamaheshwari Shivaswamy
    Indian Journal of Dermatology Venereology and Leprology, 2014
  • Algal diversity in a group of fifteen small lakes of T. Narasipur taluk, Mysore district, Karnataka state
    Nature Environment and Pollution Technology, 2011

RECENT SCHOLAR PUBLICATIONS

  • Applications of Fungi in Waste Water
    KR Dhanushree, S Umamaheshwari
    Fungi in Wastewater Treatment: Volume 2 2, 125 , 2026
    2026
  • Applications of Fungi in Waste Water Treatment in Remediation of Radioactive Wastewater
    KR Dhanushree, S Umamaheshwari
    Fungi in Wastewater Treatment: Volume 2, 125-146 , 2026
    2026
  • Pyridine embedded 1, 3, 4-oxadiazole derivatives: Design, synthesis, molecular docking and antitubercular activity evaluation
    D Devadiga, TN Ahipa, S Umamaheshwari, C Bhat, SK Keerthi, ...
    Tuberculosis, 102735 , 2026
    2026
  • Biopolymers: An Overview and Progressive Phases in Biomedical Sciences
    S Choudhury, S Umamaheshwari, KM Basalingappa
    Biopolymers: Green and Sustainable Approaches for Drug Delivery, Food … , 2026
    2026
  • The Role of Magnetic Microbots in Colorectal Cancer
    KR Arjun, A Hazra, R Mythreyi, D Mutthuraj, BM Kanthesh, ...
    Colorectal Cancer Diagnosis, 128-140 , 2026
    2026
  • The impact of photodynamic therapy in root canal disinfection and smear layer removal using phytocompounds
    RS Bharadwaj, AT Shivakumar, U Shivaswamy, SH Kalgeri, SS Gowda, ...
    Endodontology 37 (3), 312-318 , 2025
    2025
  • Corrigendum to “Clinical profile, antifungal susceptibility, and molecular characterization of Candida auris isolated from patients in a South Indian surgical ICU.”[J Mycol Med …
    S Umamaheshwari, SM Neelambike, SA Shankarnarayan, ...
    Journal of Medical Mycology 35 (2), 101552 , 2025
    2025
  • Probiotics with Preventive and Therapeutic Potential for Colorectal Cancer: An Emphasis on Immunomodulatory and Anticancer Properties
    T Saloni, JM Siddesha, BM Kanthesh, S Umamaheshwari
    Microbiota and Dietary Mediators in Colon Cancer Prevention and Treatment … , 2025
    2025
  • Probiotic, Prebiotic, and Gut–Brain Connection in Cancer Development
    KR Arjun, D Mutthuraj, N Foferkar, D Nagendra, R Mythreyi, ...
    Microbiota and Dietary Mediators in Colon Cancer Prevention and Treatment … , 2025
    2025
  • Pharmacokinetics and pharmacodynamics of a nanostructured lipid carrier co-encapsulating artemether and miRNA for mitigating cerebral malaria
    VVN Goli, S Tatineni, U Hani, M Ghazwani, S Talath, SB Sridhar, ...
    Pharmaceuticals 17 (4), 466 , 2024
    2024
    Citations: 10
  • Fluorescence-based evaluation of the efficacy of augmented reality-assisted toothbrush on oral hygiene practices among 6–8 years old children
    S Dey, S Deshmukh, S Umamaheshwari, L Dheeraj, HG Sinchan
    Journal of Advanced Oral Research 14 (2), 183-189 , 2023
    2023
    Citations: 5
  • Retrospective analysis on distribution and antifungal susceptibility profile of Candida in clinical samples: a study from Southern India
    S Umamaheshwari, MN Sumana
    Frontiers in Public Health 11, 1160841 , 2023
    2023
    Citations: 9
  • Retrospective analysis on distribution and antifungal susceptibility profile of Candida in clinical samples: a study from Southern India
    MN Sumana
    Frontiers in Public Health 11, 1160841 , 2023
    2023
    Citations: 12
  • Clinical profile, antifungal susceptibility, and molecular characterization of Candida auris isolated from patients in a South Indian surgical ICU.
    S Umamaheshwari, SM Neelambike, SA Shankarnarayan, ...
    Journal of Medical Mycology 31 (4), 101176 , 2021
    2021
    Citations: 8
  • Antifungal resistance of candida species isolated from HIV patients in a tertiary care hospital, Mysuru, Karnataka
    U Shivaswamy, MN Sumana
    Indian Journal of Dermatology 65 (5), 423-425 , 2020
    2020
    Citations: 5
  • Reply to Letter to Editor "Idiopathic CD4+ T lymphocytopenia: A case report
    GS Umamaheshwari S, Sumana MN, Shetty MS
    Journal of Postgraduate Medicine 66, 227 , 2020
    2020
    Citations: 5
  • Detection of Aspartyl Proteinases and Esterase activities of Candida auris isolated at a tertiary care hospital in Karnataka, South India.
    SMN Umamaheshwari S, Shubha Gopal, Keerthi SK
    BMC Infectious Diseases , 2020
    2020
  • Do Not Neglect Global Threatening Yeast: Candida auris
    U S
    ACTA SCIENTIFIC MICROBIOLOGY 2 (10), 34 , 2019
    2019
  • CCME water quality index in river Cauvery Basin at Talakadu, South India
    S Umamaheshwari
    International Journal of Plant, Animal and Environmental Sciences 6 (1), 148-151 , 2016
    2016
    Citations: 5
  • A study of candidiasis in HIV reactive patients in a tertiary care hospital, Mysore-South India
    U Shivaswamy, SM Neelambike
    Indian Journal of Dermatology, Venereology and Leprology 80, 278 , 2014
    2014
    Citations: 8

MOST CITED SCHOLAR PUBLICATIONS

  • Retrospective analysis on distribution and antifungal susceptibility profile of Candida in clinical samples: a study from Southern India
    MN Sumana
    Frontiers in Public Health 11, 1160841 , 2023
    2023
    Citations: 12
  • Antibacterial activity of root of Aristolochia indica on Bacillus subtilis
    S Umamaheshwari, SM Murthy
    RGUHS Journal of Pharmaceutical Sciences 2 (2), 82-85 , 2012
    2012
    Citations: 11
  • Pharmacokinetics and pharmacodynamics of a nanostructured lipid carrier co-encapsulating artemether and miRNA for mitigating cerebral malaria
    VVN Goli, S Tatineni, U Hani, M Ghazwani, S Talath, SB Sridhar, ...
    Pharmaceuticals 17 (4), 466 , 2024
    2024
    Citations: 10
  • Retrospective analysis on distribution and antifungal susceptibility profile of Candida in clinical samples: a study from Southern India
    S Umamaheshwari, MN Sumana
    Frontiers in Public Health 11, 1160841 , 2023
    2023
    Citations: 9
  • Clinical profile, antifungal susceptibility, and molecular characterization of Candida auris isolated from patients in a South Indian surgical ICU.
    S Umamaheshwari, SM Neelambike, SA Shankarnarayan, ...
    Journal of Medical Mycology 31 (4), 101176 , 2021
    2021
    Citations: 8
  • A study of candidiasis in HIV reactive patients in a tertiary care hospital, Mysore-South India
    U Shivaswamy, SM Neelambike
    Indian Journal of Dermatology, Venereology and Leprology 80, 278 , 2014
    2014
    Citations: 8
  • Fluorescence-based evaluation of the efficacy of augmented reality-assisted toothbrush on oral hygiene practices among 6–8 years old children
    S Dey, S Deshmukh, S Umamaheshwari, L Dheeraj, HG Sinchan
    Journal of Advanced Oral Research 14 (2), 183-189 , 2023
    2023
    Citations: 5
  • Antifungal resistance of candida species isolated from HIV patients in a tertiary care hospital, Mysuru, Karnataka
    U Shivaswamy, MN Sumana
    Indian Journal of Dermatology 65 (5), 423-425 , 2020
    2020
    Citations: 5
  • Reply to Letter to Editor "Idiopathic CD4+ T lymphocytopenia: A case report
    GS Umamaheshwari S, Sumana MN, Shetty MS
    Journal of Postgraduate Medicine 66, 227 , 2020
    2020
    Citations: 5
  • CCME water quality index in river Cauvery Basin at Talakadu, South India
    S Umamaheshwari
    International Journal of Plant, Animal and Environmental Sciences 6 (1), 148-151 , 2016
    2016
    Citations: 5
  • Screening health care personnel for detection of methicillin resistant of Staphylococcus aureus carrier state at a tertiary care hospital in Mysore
    A Theagrajan, S Mahadevaiah, S Umamaheshwari
    IJPSI 2, 12-15 , 2013
    2013
    Citations: 2
  • Diagnosis of mycobacterial drug resistance in HIV reactive patients by phenotypic and genotypic assay-a comparative study
    S Umamaheshwari, SM Neelambike, K Anuradha, B Sumangala
    BMC Infectious Diseases 14 (Suppl 3), P58 , 2014
    2014
    Citations: 1
  • Algal Diversity in a Group of Fifteen Small Lakes of T.NarasipurTaluk,Mysore District,Karnataka State”. Nat. Environ. Poll. Technol Journal Vol 2011; Vol 10(1); 45-50.
    Umamaheshwari
    Nat.Environ.Poll.Technol 10 (1), 45-50 , 2011
    2011
    Citations: 1
  • Applications of Fungi in Waste Water
    KR Dhanushree, S Umamaheshwari
    Fungi in Wastewater Treatment: Volume 2 2, 125 , 2026
    2026
  • Applications of Fungi in Waste Water Treatment in Remediation of Radioactive Wastewater
    KR Dhanushree, S Umamaheshwari
    Fungi in Wastewater Treatment: Volume 2, 125-146 , 2026
    2026
  • Pyridine embedded 1, 3, 4-oxadiazole derivatives: Design, synthesis, molecular docking and antitubercular activity evaluation
    D Devadiga, TN Ahipa, S Umamaheshwari, C Bhat, SK Keerthi, ...
    Tuberculosis, 102735 , 2026
    2026
  • Biopolymers: An Overview and Progressive Phases in Biomedical Sciences
    S Choudhury, S Umamaheshwari, KM Basalingappa
    Biopolymers: Green and Sustainable Approaches for Drug Delivery, Food … , 2026
    2026
  • The Role of Magnetic Microbots in Colorectal Cancer
    KR Arjun, A Hazra, R Mythreyi, D Mutthuraj, BM Kanthesh, ...
    Colorectal Cancer Diagnosis, 128-140 , 2026
    2026
  • The impact of photodynamic therapy in root canal disinfection and smear layer removal using phytocompounds
    RS Bharadwaj, AT Shivakumar, U Shivaswamy, SH Kalgeri, SS Gowda, ...
    Endodontology 37 (3), 312-318 , 2025
    2025
  • Corrigendum to “Clinical profile, antifungal susceptibility, and molecular characterization of Candida auris isolated from patients in a South Indian surgical ICU.”[J Mycol Med …
    S Umamaheshwari, SM Neelambike, SA Shankarnarayan, ...
    Journal of Medical Mycology 35 (2), 101552 , 2025
    2025