Corrosion inhibition mechanism of a functionalized schiff base–derived quaternary ammonium salt for carbon steel in 1 M HCl: electrochemical, adsorption, and theoretical studies Mohamed I. Ahmed, M. Abd-El-Raouf, M. A. Migahed, Magdy A.M. Ibrahim, Sameh A. Rizk, et al. Scientific Reports, 2026 To address costly corrosion and material degradation, we report the development of a new quaternary ammonium salt (Q-Ar) via functionalization of a Schiff base with benzyl chloride through a quaternization reaction, intended as a potential corrosion inhibitor for carbon steel (C-steel) in 1 M HCl. FT-IR and 1 H NMR spectroscopy confirmed the chemical structure of Q-Ar. Electrochemical potentiodynamic polarization (PDP) studies revealed that Q-Ar acted as mixed-type inhibitor and achieved corrosion inhibition efficiency 93.94% at 35 ppm. Electrochemical impedance spectroscopy (EIS) confirmed strong adsorption layer with charge transfer resistance (R ct ) of 737.3 Ω.cm 2 . The adsorption behavior followed the Langmuir isotherm model, suggesting chemical adsorption reaction of Q-Ar at room temperature over C-steel surface according to standard adsorption energy values (∆G ads ) of -43.2 kJ.mol − 1 for Q-Ar. Activation thermodynamic parameters of C-steel reaction in presence of Q-Ar suggested its inhibition action forming barrier film over C-steel surface as reflected by the increase in activation energy (Eₐ) from 21.60 kJ mol − 1 for the uninhibited system to 42.79 kJ mol − 1 in the presence of Q-Ar. Scanning electron microscopy (SEM) confirmed the protective effect of Q-Ar, showing that the C-steel surface remained largely free of corrosion products compared with the severely corroded blank sample. Energy-dispersive X-ray (EDX) analysis further verified this observation by revealing a marked reduction in iron oxide formation in the presence of Q-Ar. Theoretically, the lower energy gap (ΔE gap ) of the optimized Q-Ar molecule and the higher adsorption energy (E ads ) of the Q-Ar/Fe(110) system indicate strong interactions between the Q-Ar and the C-steel surface, corroborating the experimental observations.
Microwave/Ultrasound-Assisted Synthesis of an Fe(III) Coordination Polymer Derived From an Oxazolone Linker for Adsorptive Removal of 2,4,5-Trichlorophenoxyacetic Acid Abdulrahman A. Alsimaree, Saeed S. Samman, Asmaa M. Fahim, Saleh A. Ahmed, El‐Hady Rafat, et al. Chemistryselect, 2026 A novel Fe (III) coordination polymer, was synthesized rapidly via a microwave/ultrasonication method utilizing the organic linker O‐HetCur‐CO and characterized using FT‐IR, powder x‐ray diffraction (PXRD), scanning electron microscopy (SEM)/EDX, x‐ray photoelectron spectroscopy (XPS), TGA, and density functional theory (DFT) computations. The linker and polymer were produced with yields of > 70%. The reaction to form the polymer took place in approximately 5 min at 70°C. Structural characterization methods confirm that coordination has occurred between Fe and the linker (stronger than expected). TGA results indicate that the Fe‐(O‐HetCur‐CO) coordination polymer (FeCP) is stable to ∼340°C. EDX data (weight percentages) show that the final polymer composition consists of C (72.50%), N (9.64%), O (12.75%), and Fe (5.11%). DFT calculations show that coordination with Fe significantly alters electronic properties of the linker: Band gap changes from 2.1410 to 3.9002 eV; the dipole moment changes from 5.5337 to 8.4542 D. Thus, the Fe coordination increases the polarity and structural stability of the final polymer. FeCP adsorption studies of 2,4,5‐T showed rapid uptake to equilibrium within 60 min at concentrations ranging from 10 to 50 ppm. The Langmuir isotherm model produced an excellent fit of equilibrium data ( R 2 = 0.9999) with a maximum adsorption capacity of 54.9 mg g − 1 , K L = 0.1689 L mg − 1 and R L = 0.10 indicating a highly favorable monolayer adsorption process; whereas, the Freundlich model yielded K F = 1.175, n = 0.361 and R 2 = 0.9219 revealing that the surface is heterogeneous but with a dominant chemical adsorption phenomenon. Adsorption studies theoretically validated the experimental results in that FeCP/2,4,5‐T adducts displayed a significant reduction in their band gap (1.9100 eV), an increase in dipole moment (11.43 D), and an electrophilicity index (41.2571 eV). All indicative of strong interfacial electron coupling and donor/acceptor interaction. Also of note, FeCP maintained satisfactory adsorption efficiency after five consecutive adsorption cycles, indicating its great promise for herbicide remediation from pollutant‐laden water.
Novel Pyrazoline and Pyrazoline–Thiazole Derivatives Linked to Tetrahydronaphthalene Ring: Synthesis, Anticancer Evaluation, VEGFR-2 Inhibition Activity, and Molecular Docking Study Nehal A. Hamdy, Eman S. Zarie, Eman Kh. Hamza, Issa M. I. Fakhr, Hanem M. Awad, et al. Journal of Heterocyclic Chemistry, 2026 A new series of pyrazoline and pyrazoline–thiazole derivatives conjugated with tetralin ring 5a, b–19 was created starting with the chalcones 3a , b . The new compounds were tested as potential anticancer agents on three human cancer cell lines (HCT‐116, HepG‐2, and MCF‐7) and one human normal cell line (BJ‐1). The Compounds 5a , b , 7a , 9a , b , 10 , 13a , d , and 16b were identified as strong candidates against the MCF‐7 cell line (IC 50 = 2.0 ± 0.1–5.6 ± 0.2 μM), where all the compounds exhibited significant activity against the HCT‐116 cell line (IC 50 = 2.8 ± 0.1–6.5 ± 0.5 μM). Compounds 5b, 9b , and 10 were chosen to study VEGFR‐2 inhibitors in comparison with sorafenib (IC 50 = 2.9 ± 0.08, 8.6 ± 0.41, 1.1 ± 0.04, and 0.2 ± 0.01 nM, respectively). A molecular docking study was conducted to ascertain the latter compounds' binding interactions with VEGFR‐2 kinase.
Multifunctional PES-based nanocomposites: from water treatment membranes to effective radiation shielding materials Abdelmoniem E. Alahmer, Sameh A. Rizk, Atef S. Darwish, Abdelfatah T. Elgendy, Mohamed E. M. Ali, et al. Journal of Materials Science Materials in Electronics, 2025 In this study, novel composite membranes based on polyethersulfone (PES) reinforced with nano-copper (N-Cu) particles were developed using the phase inversion method. The primary aim was to enhance water treatment performance, while simultaneously evaluating their potential as lightweight radiation shielding materials, thus providing a dual-functional platform. The prepared membranes were systematically characterized using FTIR, SEM, TEM, EDX, TGA, as well as adsorption tests and contact angle measurements. Results revealed successful and homogeneous dispersion of N-Cu within the PES matrix, leading to significant improvements in surface and hydrophilic properties. The contact angle decreased from 59.7° to 36.5°, confirming enhanced wettability, while the pure water flux (PWF) increased dramatically from 28 LMH for pristine PES to 135 LMH for PES/N-Cu FSM, indicating nearly a fivefold enhancement. Additionally, the PES/N-Cu FSM exhibited superior adsorption capacity toward pollutants (methylene blue), achieving ~ 25% higher removal efficiency compared to pristine PES. Radiation shielding performance was further assessed using Monte Carlo (MCNP) simulations validated by EpiXS software. The results confirmed that PES/N-Cu FSM displayed significantly higher linear attenuation coefficients than pristine PES, with effective shielding against γ-rays and fast neutrons up to 15 MeV. The incorporation of nano-copper increased the effective density and photon interaction probability, thereby improving radiation attenuation while maintaining lightweight characteristics. Overall, PES/N-Cu FSM demonstrates a unique dual functionality by combining efficient water purification with effective radiation shielding. This positions it as a promising candidate for applications in medical, industrial, and environmental fields where both clean water and radiation protection are simultaneously required.
Synthesis of new zwitterionic surfactants and investigation of their surface active and thermodynamic properties Ahmed S. Mansour, M. M. Abo-Aly, S. A. Rizk, Abdellatif M. M. Abd El Rahman, N. F. Ghaly, et al. Scientific Reports, 2025 This study focused on the synthesis of six bio-based zwitterionic surfactants derived from oleic acid to assess their applicability in different petroleum fields. The final bi-zwitterionic surfactants were synthesized from oleic acid, utilizing the double bond and carboxylic group. Friedel–Crafts alkylation, sulfonation, chlorination, amidation, and quaternization were performed to synthesize six bi-zwitterionic surfactants. The bi-quaternary surfactants derived from benzene are represented by the general formula Bi Q 10, BOAS (Amide), with the symbols BE, BP, and BPh. In contrast, those derived from naphthalene are represented by Bi Q 10, NOAS (Amide), with the symbols NE, NP, and NPh. The structures of these surfactants were confirmed using FT-IR and H1-NMR techniques. The surface activity and thermodynamic properties of the synthesized surfactants were analyzed through surface tension measurements conducted at various temperatures (30, 40, 50, and 60°C). Additionally, CMC, γ CMC , π CMC , Γ max , A min, and Pc 20 were measured. The thermodynamic variables for micellization and adsorption were also measured. The structural effect of the obtained surfactants was assessed. The maximum value of the structural effect was 4.33 KJmol-1, corresponding to BE. The results indicated that the negative values of ΔGads were greater than the negative values of ΔGmic, indicating that these surfactants are absorbed in the interface prior to the formation of micelles. The more negative values of ΔGads suggest that these surfactants are strongly adsorbed onto solid particles, such as sands and rocks, indicating their potential utilization in oil production in different petroleum fields.
Flat sheet membrane of modified PES with metal organic framework for dying wastewater treatment AE Alahmer, MEM Ali, SA Rizk, AS Darwish, AT Elgendy, AS El-Kalliny Journal of Materials Science: Materials in Engineering 21 (1), 60 , 2026 2026
Quinoline Removal via Rice Husk-Chitosan Composite: Adsorption Isotherms and kinetic Studies, and Alignment with (SDGs) MFEA Alashry, SA Rizk, MTH Abou Kana, NA Negm Egyptian Journal of Chemistry , 2026 2026
Multitarget bioactive benzo [f] quinoline heterocycles from a thiocarbohydrazone scaffold: synthesis, biological assays, and in silico mechanistic rationale EM Saleh, MG El-Banna, AM Fahim, ME El Awady, SA Rizk, EAE El-Helw Bioorganic Chemistry, 109867 , 2026 2026
Corrosion inhibition mechanism of a functionalized schiff base–derived quaternary ammonium salt for carbon steel in 1 M HCl: electrochemical, adsorption, and theoretical studies MI Ahmed, M Abd-El-Raouf, MA Migahed, MAM Ibrahim, SA Rizk, ... Scientific Reports , 2026 2026
Microwave/Ultrasound‐Assisted Synthesis of an Fe (III) Coordination Polymer Derived From an Oxazolone Linker for Adsorptive Removal of 2, 4, 5‐Trichlorophenoxyacetic Acid AA Alsimaree, SS Samman, AM Fahim, SA Ahmed, EH Rafat, SA Rizk, ... ChemistrySelect 11 (14), e07102 , 2026 2026
Green synthesis and biological assessment of curcumin-based heterocycles via a microwave-ultrasonic-ultraviolet reactor: DFT, docking, and MD insights EM Saleh, EAE El Helw, AM Fahim, ME El Awady, MG El-Banna, SA Rizk Journal of Molecular Structure, 146002 , 2026 2026 Citations: 2
Curcumin Biowaste Valorization with Microwave–Ultrasonic Energy-Efficient Irradiation Techniques Afford Sustainable Heterocyclic Compounds as Antibacterial and Anticancer … MM Al-Rooqi, SS Samman, SA Ahmed, AM Omeman, AM Abdo, SA Rizk Polycyclic Aromatic Compounds, 1-20 , 2026 2026 Citations: 2
Green MW/US route from lignocellulose to FDCA-based thiadiazol scaffolds: DPP-4/COX-1 inhibition and antioxidant evaluation SA Rizk, ME Salem, AM Fahim Bioorganic Chemistry, 109692 , 2026 2026 Citations: 4
Novel Pyrazoline and Pyrazoline–Thiazole Derivatives Linked to Tetrahydronaphthalene Ring: Synthesis, Anticancer Evaluation, VEGFR‐2 Inhibition Activity, and Molecular Docking … NA Hamdy, ES Zarie, EK Hamza, IMI Fakhr, HM Awad, SA Rizk Journal of Heterocyclic Chemistry 63 (2), 209-227 , 2026 2026 Citations: 1
Multifunctional PES-based nanocomposites: from water treatment membranes to effective radiation shielding materials AE Alahmer, SA Rizk, AS Darwish, AT Elgendy, MEM Ali, AS El-Kalliny, ... Journal of Materials Science: Materials in Electronics 36 (36), 2263 , 2025 2025
Enzymatic Changes in the Larvae of Culex pipiens L., 1758 (Diptera: Culicidae) Induced by Nanoemulsion of Pimpinella anisum L. Essential Oil E Abdel-Nasser, JA Hafez, RM Badawy, SA Rizk, HH Hefny, RM Azmy Egyptian Academic Journal of Biological Sciences, E. Medical Entomology … , 2025 2025
Microwave (MW) and ultrasound-ultraviolet (US/UV) energy-assisted green synthesis of Spiro heterocycles for high-yield efficiency and agrochemical applications AM Elgohary, EH Rafat, SM Alhunayhin, YO Al-Ghamdi, MG El-Banna, ... Results in Chemistry, 102796 , 2025 2025 Citations: 4
Chemical viz biological method for the extraction of chitin and chitosan from adults of the black soldier fly (Hermetia illucens) AA AbdelQader, HF Abd-Elkhalek, SA Rizk, MF Abd-EL Aziz, AA Ibrahim Journal of Basic and Environmental Sciences 12 (4), 241-263 , 2025 2025
Enhanced biomedical performance of magnetic Fe3O4@ chitosan nanocomposites: A comparative study of synthesis methods for hyperthermia and chemotherapy applications AF Aman, OA Ghazy, H Saleh, IA Ali, NH Ahmed, SA Rizk, ZI Ali JCIS Open 19, 100142 , 2025 2025 Citations: 3
Effective 2, 4, 5-T Removal from Wastewater Using M53F Adsorbent: Synthesis, Characterization, Kinetics, and Isotherm Investigations R Mohammed, O Abuzalat, SA Rizk, AS Darwish, MEM Ali Water Conservation Science and Engineering 10 (2), 1-17 , 2025 2025 Citations: 3
Synthesis, characterization, antimicrobial activity and DFT studies of novel phthalazine-5, 10-dione derivatives MYA Abuderbala, MG El-Banna, SA Rizk, AM El-Naggar, AMA Hassan Egyptian Journal of Chemistry 68 (8), 567-576 , 2025 2025
Green tea extract coated magnetite nanoparticle as chimosensetive and hyperthermice responsive material. AF Aman, OA Ghazy, HH Saleh, IA Ali, NH Ahmed, SA Rizk, ZI Ali Digest Journal of Nanomaterials & Biostructures (DJNB) 20 (3) , 2025 2025
Synthesis of new zwitterionic surfactants and investigation of their surface active and thermodynamic properties AS Mansour, MM Abo-Aly, SA Rizk, AMM Abd El Rahman, NF Ghaly, ... Scientific Reports 15 (1), 15737 , 2025 2025 Citations: 10
Investigation of Newly Prepared Chitosan Derivatives as a Corrosion Inhibitor of Low-Carbon Steel During Sulfuric Acid Pickling MNM Ismail, NA Barghout, SA Rizk, A El Nemr Journal of Bio-and Tribo-Corrosion 11 (1), 13 , 2025 2025 Citations: 1
Synthesis, design, biological activity, DFT study and molecular docking of new 1, 2, 4-triazine and 1, 2, 4-triazol derivatives bearing the phthalazine moiety MA Kadhim, MG Mukhlif, EW Gayadh, EKM Zangana, MA Mohaisen, ... Journal of Molecular Structure 1322, 140384 , 2025 2025 Citations: 22
MOST CITED SCHOLAR PUBLICATIONS
Synthesis, reactions and application of chalcones: a systematic review MA Shalaby, SA Rizk, AM Fahim Organic & biomolecular chemistry 21 (26), 5317-5346 , 2023 2023 Citations: 127
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Synthesis, characterization and computational chemical study of novel pyrazole derivatives as anticorrosion and antiscalant agents FET Heakal, SK Attia, SA Rizk, MA Abou Essa, AE Elkholy Journal of Molecular Structure 1147, 714-724 , 2017 2017 Citations: 61
Synthesis of some novel heterocyclic and schiff base derivatives as antimicrobial agents ME Azab, SA Rizk, AEGE Amr Molecules 20 (10), 18201-18218 , 2015 2015 Citations: 57
Synthesis and regioselective reaction of some unsymmetrical heterocyclic chalcone derivatives and spiro heterocyclic compounds as antibacterial agents MA El-Hashash, SA Rizk, SR Atta-Allah Molecules 20 (12), 22069-22083 , 2015 2015 Citations: 55
Antioxidant activity of novel nitrogen scaffold with docking investigation and correlation of DFT stimulation MA Shalaby, AM Fahim, SA Rizk RSC advances 13 (21), 14580-14593 , 2023 2023 Citations: 53
Enhancing lubricating oil properties using novel quinazolinone derivatives: DFT study and molecular dynamics simulation AE Elkholy, SA Rizk, AM Rashad Journal of Molecular Structure 1175, 788-796 , 2019 2019 Citations: 51
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Synthesis, spectroscopic characterization and computational chemical study of 5-cyano-2-thiouracil derivatives as potential antimicrobial agents SA Rizk, AM El-Naggar, AA El-Badawy Journal of Molecular Structure 1155, 720-733 , 2018 2018 Citations: 44
Rodenticidal activity of some Quinoline-Based heterocycles derived from Hydrazide–Hydrazone derivative MM Kaddah, AA Fahmi, MM Kamel, SA Rizk, SK Ramadan Polycyclic Aromatic Compounds 43 (5), 4231-4241 , 2023 2023 Citations: 40
Synthesis, DFT study, molecular docking and insecticidal evaluation of some pyrazole-based tetrahydropyrimidine derivatives KNM Halim, SK Ramadan, SA Rizk, MA El-Hashash Synthetic Communications 50 (8), 1159-1175 , 2020 2020 Citations: 40
Efficient Green Synthesis and Computational Chemical Study of Some Interesting Heterocyclic Derivatives as Insecticidal Agents AFM Fahmy, SA Rizk, MM Hemdan, AA El‐Sayed, AI Hassaballah Journal of Heterocyclic Chemistry , 2019 2019 Citations: 40
One‐pot Synthesis of Novel Spirooxindoles as Antibacterial and Antioxidant Agents MA El‐Hashash, SA Rizk Journal of Heterocyclic Chemistry 54 (3), 1776-1784 , 2017 2017 Citations: 40
Facile Synthesis, Characterization, and Antimicrobial Evaluation of Novel Heterocycles, Schiff Bases, and N-Nucleosides Bearing Phthalazine Moiety NFM Mohamed Emad Azab, Sameh Ahmed Rizk Chem. Pharm. Bull. 64 (5), 439-450 , 2016 2016 Citations: 40
42 Utility of β-aroyl acrylic acid in heterocyclic synthesis SA Rizk, MA El-Hashash, KK Mostafa Egyptian Journal of Chemistry 51 (5), 611 , 2008 2008 Citations: 39
Photosensitization of TiO 2 microspheres by novel Quinazoline-derivative as visible-light-harvesting antenna for enhanced Rhodamine B photodegradation MA Hamza, SA Rizk, EEM Ezz-Elregal, SAA El-Rahman, SK Ramadan, ... Scientific Reports 13 (1), 12929 , 2023 2023 Citations: 38
Synthesis and biological activity on IBD virus of diverse heterocyclic systems derived from 2-cyano- N '-((2-oxo-1,2-dihydroquinolin-3-yl)methylene)acetohydrazide MM Kaddah, ARI Morsy, AA Fahmi, MM Kamel, MM Elsafty, SA Rizk, ... Synthetic Communications 51 (22), 3366-3378 , 2021 2021 Citations: 38
Straightforward synthesis, antiproliferative screening, and density functional theory study of some pyrazolylpyrimidine derivatives KNM Halim, SA Rizk, MA El‐Hashash, SK Ramadan Journal of Heterocyclic Chemistry 58 (2), 636-645 , 2021 2021 Citations: 38
A new approach to chromeno [4, 3-b] pyridine: Synthesis, X-ray, spectral investigations, hirshfeld surface analysis, and computational studies MA Shalaby, HM Al-Matar, AM Fahim, SA Rizk Journal of Physics and Chemistry of Solids 170, 110933 , 2022 2022 Citations: 37
Cytotoxic activity and density functional theory studies of some 1, 3-diphenylpyrazolyltetrahydropyrimidine derivatives SK Ramadan, KNM Halim, SA Rizk, MA El-Hashash Journal of the Iranian Chemical Society 17 (7), 1575-1589 , 2020 2020 Citations: 37