Gutierrez Roman Ana Silvia

Scopus Publications

Secondary metabolites of mesoamerican plants castilleja tenuiflora benth. and baccharis conferta kunth with anti-inflammatory effects
Norma Elizabeth Moreno-Anzúrez, José Luis Trejo-Espino, Elizabeth Rubio-Rodríguez, Ana Silvia Gutiérrez-Román, and Gabriela Trejo-Tapia
CRC Press

Anti-arthritic and anti-inflammatory effects of Baccharis conferta Kunth in a kaolin/carrageenan-induced monoarthritis model
Ana Silvia Gutiérrez-Román, Gabriela Trejo-Tapia, Manasés González-Cortazar, Enrique Jiménez-Ferrer, José Luis Trejo-Espino, Alejandro Zamilpa, Ever A. Ble-González, Brenda Hildeliza Camacho-Díaz, and Maribel Herrera-Ruiz
Elsevier BV

Ellagitannin, Phenols, and Flavonoids as Antibacterials from Acalypha arvensis (Euphorbiaceae)
Ever A. Ble-González, Abraham Gómez-Rivera, Alejandro Zamilpa, Ricardo López-Rodríguez, Carlos Ernesto Lobato-García, Patricia Álvarez-Fitz, Ana Silvia Gutierrez-Roman, Ma Dolores Perez-García, Alejandro Bugarin, and Manasés González-Cortazar
MDPI AG
There is a significant need to gain access to new and better antibacterial agents. Acalypha arvensis, a plant from the Euphorbiaceae family, has been used in traditional medicine for centuries to treat infectious diseases. This manuscript reports the isolation, characterization, and antibacterial screening of 8 natural products extracted from maceration of aerial parts of Acalypha arvensis. Specifically, three extracts were assessed (n-hexane, ethyl acetate, and ethanol), in which antibacterial activity was evaluated against diverse bacterial strains. The ethanolic extract showed the best activity against methicillin-sensitive and methicillin-resistant Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa strains, which supports the medicinal properties attributed to this plant. The chromatographic fractions AaR4 and AaR5 were the most bioactive, in which the ellagitannin natural product known as corilagin (1) was identified for the first time in this plant. Therefore, it can be said that this is the main chemical responsible for the observed antibacterial activity. However, we also identified chlorogenic acid (2), rutin (3), quercetin-3-O-glucoside (4), caffeic acid (5), among others (6–8). Hence, this plant can be considered to be a good alternative to treat health-related issues caused by various bacteria.

Antidiabetic Activity of Xoconostle Fruit from Opuntia matudae Scheivar in Mice
Manasés González-Cortazar, Ana Silvia Gutiérrez-Román, Rodrigo Vargas-Ruiz, Rosa Mariana Montiel-Ruiz, Ever A. Ble-González, Yolanda Yamila Pérez-Terán, Jaime Tortoriello, and Enrique Jiménez-Ferrer
Mary Ann Liebert Inc
In Mexico, Cactaceae plants are widely used in folk medicine for the treatment of diabetes. The genus Opuntia spp. Opuntia matudae Sheinvar prickly pears are known as xoconostle and are used in Mexican cuisine for their acidic flavor. Currently there are few reports of pharmacological properties of this plant, which include antioxidant and antimicrobial activities. This study focuses on the chemical characterization of the methanolic (OmMe) and aqueous (OmAq) extracts and the evaluation of the antidiabetic activity of O. matudae fruits in two biological models. For the in vivo model, streptozotocin (STZ)-induced diabetic mice were used, and for the in vitro model, liver sections isolated from healthy mice were used. The OmAq (100 mg/kg, oral pathway [p.o.]) extract decreased postprandial glucose peak at 0.5 h after glucose uptake by 43.1%, similarly, OmMe (100 mg/kg, p.o.) extract reduced postprandial glucose peak at 0.5 h by 34.1% in healthy mice. The effect of the two extracts and the fraction of the mixture of unidentified betalains (OmB) of O. matudae evaluated in the isolated mouse liver slice model showed a concentration-dependent decrease in hepatic glucose output (HGO) with and without insulin administration with the OmMe extract. The OmAq extract, however, showed concentration-dependent increases of HGO with and without insulin, and the OmB fraction generally exhibited an insulin mimetic effect. Moreover, both OmAq and OmMe extracts were tested in mice with STZ-induced diabetes (160 mg/kg, intraperitoneal route), using a semichronic daily administration (2-28 days after diabetes onset) of OmAq extract was able to reduce blood glucose by 34.3%, meanwhile OmMe extract reduced blood glucose by 22.9%, 28 days after diabetes onset. We identified five compounds (1-5) in the two extracts, consisting of two phenolic acids (1, 2), three flavanols (3-5), as well as two unidentified betalains. Therefore, we conclude that the aqueous extract of the xoconostle fruit where betalains are present may be useful for the treatment of diabetes mellitus.

Angiotensin-converting enzyme inhibitors from Salvia elegans Vahl
Ana Silvia Gutiérrez-Román, Manasés Gonzalez-Cortazar, Gabriela Trejo-Tapia, Maribel Herrera-Ruiz, Alejandro Zamilpa, Ernesto Sanchéz-Mendoza, Natividad Giovana De la Cruz- Sanchez, and Enrique Jiménez-Ferrer
Informa UK Limited
Abstract Phytochemical research of the acetate and methanol extracts of the aerial parts (flowers, leaves and stems) of Salvia elegans allowed to obtain seventeen known compounds (1–17): three of them (4, 5, 14), had already been described for this species, while the others (1–3, 6–13, 15–17) are described for the first time for S. elegans. All isolated compounds were characterized using spectroscopic techniques and mass spectrometry and were evaluated in the Angiotensin I-converting enzyme (ACE) inhibition model, where the phenolic compounds (13, 14 and 15) had the same inhibitory effect as lisinopril at 0.02 mg/mL. The terpenes showed a moderate inhibitory capacity at a concentration of 0.2 mg/mL. Graphical Abstract

Effect of Terpenoids and Flavonoids Isolated from Baccharis conferta Kunth on TPA-Induced Ear Edema in Mice
Gutiérrez-Román Ana Silvia, Trejo-Tapia Gabriela, Herrera-Ruiz Maribel, Monterrosas-Brisson Nayeli, Trejo-Espino José Luis, Zamilpa Alejandro, and González-Cortazar Manasés
MDPI AG
In this study, we isolated from the aerial parts of Baccharis conferta Kunth (i) a new neoclerodane, denominated “bacchofertone”; (ii) four known terpenes: schensianol A, bacchofertin, kingidiol and oleanolic acid; and (iii) two flavonoids: cirsimaritin and hispidulin. All structures were identified by an exhaustive analysis of nuclear magnetic resonance (NMR) and mass spectroscopy (MS). Extracts from aerial parts were screened for anti-inflammatory activity in the mice ear edema model of 12-O-tetradecanoylforbol-13-acetate mice. Dichloromethane extract (BcD) exhibited 78.5 ± 0.72% inhibition of edema, followed by the BcD2 and BcD3 fractions of 71.4% and 82.9% respectively, at a dose of 1 mg/ear. Kingidiol and cirsimaritin were the most potent compounds identified, with a median effective dose of 0.12 and 0.16 mg/ear, respectively. A histological analysis showed that the topical application of TPA promoted intense cell infiltration, and this inflammatory parameter was reduced with the topical application of isolated compounds.

Antibacterial activity of Morinda citrifolia Linneo seeds against Methicillin-Resistant Staphylococcus spp
Natividad Giovana De La Cruz-Sánchez, Abraham Gómez-Rivera, Patricia Alvarez-Fitz, Elsa Ventura-Zapata, Ma Dolores Pérez-García, Margarita Avilés-Flores, Ana Silvia Gutiérrez-Román, and Manasés González-Cortazar
Elsevier BV

Gutierrez Roman Ana Silvia

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Scopus Publications