Brindha Rethinam

@aubit.edu.in

Assistant Professor (Senior Grade) and Biotechnology
University College of Engineering, BIT Campus, Anna university, Tiruchirappalli

Brindha Rethinam


                  Download Compact PDF  
https://researchid.co/brindharethinam

RESEARCH, TEACHING, or OTHER INTERESTS

Biotechnology, Environmental Engineering, Waste Management and Disposal, Water Science and Technology
11

Scopus Publications

150

Scholar Citations

5

Scholar h-index

4

Scholar i10-index

Scopus Publications

  • Correction to: Understanding integrative approach of translational bioinformatics on cardiovascular disease: Myocardial Ischemia (Egyptian Journal of Medical Human Genetics, (2024), 25, 1, (153), 10.1186/s43042-024-00622-2)
    Yeswanth Ranganathan, Saayaa Nazar, Ravi Shankar Krishnan, Yuvaraj Dinakarkumar, Vijayalakshmi Varadarajan, Lenita Sebastian, Brindha Rethinam
    Egyptian Journal of Medical Human Genetics, 2025
  • Identifying the major research trends in algae polysaccharides: a scientometric analysis from 1989 to 2023
    Mohana Priya Eswaramoorthi, Geetha Subramanian, Rajeswari Shanmugam, Jennet Debora John Britto, Vijayalakshmi Varadarajan, Gracy Angel Karunakaran, Brindha Rethinam
    Biologia, 2025
  • Understanding integrative approach of translational bioinformatics on cardiovascular disease: Myocardial Ischemia
    Yeswanth Ranganathan, Saayaa Nazar, Ravi Shankar Krishnan, Yuvaraj Dinakarkumar, Vijayalakshmi Varadarajan, Lenita Sebastian, Brindha Rethinam
    Egyptian Journal of Medical Human Genetics, 2024
    Background Myocardial ischemia is a significant problem in cardiovascular health caused by the obstruction or constriction of coronary arteries, resulting in diminished blood supply to the heart muscle. Translational bioinformatics bridges the gap between biological discoveries and clinical applications, enabling early disease identification, therapy response confirmation, and prognosis prediction. It facilitates the integration and analysis of vast amounts of clinical data, hence advancing clinical research and enhancing therapeutic approaches. Main body This review explores the role of translational bioinformatics in understanding and treating cardiovascular disease, specifically Myocardial Ischemia. It covers the discovery of novel biomarkers (miRNA, lncRNA, and tsRNA), analysis of genes and proteins, and integrated bioinformatics to identify differentially expressed genes. The study highlights the impact of personalized medicine, drug discovery, and repurposing through bioinformatics. Additionally, it examines the application of systems biology and network analysis to understand biological networks, and the use of clinical decision support systems to enhance patient care. This integrative approach demonstrates the potential of bioinformatics to improve cardiovascular health outcomes. Conclusions Combining clinical and omics data using translational bioinformatics is critical for refining treatment regimens and speeding up medication repurposing. This comprehensive study emphasizes the necessity of combining interdisciplinary data to enhance patient outcomes in myocardial ischemia, minimize the global burden of cardiovascular-related deaths, and improve cardiovascular disease management. Graphical abstract
  • Antibiotic Resistance Genes – An Emerging Genetic Pollutant of LFL
    Jennet Debora J., Vijayalakshmi V., Rajaguru P., Rajeswari S., Brindha R.
    Water Air and Soil Pollution, 2024
  • Analysis of Batch Kinetic Data of Biodecolorization Reaction: Theoretical Approach for the Design of Packed Bed Reactor
    Brindha Rethinam, Rajaguru Palanichamy, Jennet Debora John Britto
    Journal of Environmental Engineering United States, 2023
    The degradation of azo dyes by conventional methods has proven ineffective due to their complex structure and synthetic nature. Bioremediation of azo dye containing textile wastewater requires an appropriate selection of potential strains to address its potential hazards. This study focuses on the biodegradation of azo dyes containing textile wastewater by isolating halotolerant bacterial strains from marine coastal soil. The rapid degradation of model dye Mordant Yellow 10 (MY10) was monitored spectrophotometrically and it was found that decolorization of MY10 by isolated strains Bacillus firmus (BA01), Pseudomonas aeroginosa (BRPO3), and Bacillus cereus (BRPO4) and mixed consortium CMBS follows zero-, second-, first-, and one-and-a-half-order kinetics, respectively. Through the batch kinetic analysis of MY10 degradation, it was observed that bacterial strain Pseudomonas aeroginosa BRPO3 was more effective with reaction rate constant and half-life as 1,024±213×10−2 mM−1 day−1 and 0.3±0.1 day, respectively. Further kinetic analysis using BRPO3 helps describe that initial dye and glucose concentration were the driving forces of the dye degradation reaction and thus were used to construct kinetic rate equation. Using a stepwise protocol, this kinetic model was applied to calculate the design parameters including optimal height and working volume of an upflow anaerobic packed bed (UAPB) reactor as 0.95 m and 4.78 L, respectively, for 85% dye conversion. Design was validated by evaluating the performance of the newly fabricated UAPB reactor for treatment of simulated wastewater containing MY10 and real textile wastewater. Complete dye removal and 94.5% total organic carbon (TOC) reduction were observed with simulated wastewater, whereas in real textile effluent 82.5% dye removal and 89% TOC reduction were achieved. Thus, the predicted results corresponded satisfactorily with the experimental data in both wastewater treatments. This study highlights the usefulness of analyzing biodegradation kinetics to improve both the construction of microbial consortia and the development of reactors for wastewater treatments in the context of bioeconomy.
  • Evaluation of global research trends in photocatalytic degradation of dye effluents using scientometrics analysis
    R. Brindha, S. Rajeswari, J. Jennet Debora, P. Rajaguru
    Journal of Environmental Management, 2022
  • Pure and Al-Bi Co-doped SnO2 nanoparticles as bacterial growth inhibitors
    Anuja E., Pramothkumar A., R. Brindha, Vetha Potheher I.
    Toxicological and Environmental Chemistry, 2022
    The present work is aimed to prepare un-doped and aluminium-bismuth co-doped tin-oxide nanoparticles with 2 weight percentages (each co-dopant 2 wt %) and 4 weight percentages (each 4 wt %) by employing a co-precipitation method. Tetragonal rutile crystal structure of the synthesized materials was confirmed by powder X-ray diffraction, bandgap energy by UV-Vis diffuse reflectance spectral analysis, chemical bonding and the position of O-Sn-O by Fourier transform infrared spectrum and morphology through scanning electron microscopy. The photoluminescence spectrum of synthesized nanoparticles shows emission peaks at 490, 520 and 536 nm. Antibacterial activity of Al-Bi co-doped (4 wt %) SnO2 nanoparticles shows a higher zone of inhibition in the range of 20–36 mm against Staphyllococcus aureus, 25–34 against Bacillus cereus and 30–41 against Escherichia Coli than pure SnO2 nanoparticles. The developed oxygen vacancies due to the addition of dopants increase the generation of reactive oxygen species which increases the inhibition capability of tin-oxide nanoparticles against various bacterial species.
  • Biodegradation of aniline from textile industry waste using salt tolerant Bacillus firmus BA01
    A. Anli Dino, R. Brindha, J. Jayamuthunagai, B. Bharathiraja
    Engineering in Agriculture Environment and Food, 2019
    In the present investigation, aromatic compound of aniline acquired from textile industry waste was degraded by isolated bacterial species from the source of contaminant by using acclimatization and enrichment techniques. The isolated bacterial species were further identified as Bacillus firmus BA01 by 16S rRNA sequencing. The growth kinetics of bacteria was validated over the entire concentration range by Haldane's growth kinetics model. Further, the specific growth rate and the decay coefficients have been found to be 0.024 h−1 and 0.006 h−1 respectively. The salt tolerance of potent degrading strain was analyzed through dose response assessment showing IC50 value of 1.7%. The specific turnover rate was obtained to be 0.047 μM h−1 mg of protein−1. The intermediates of aniline were identified by GC/MS analysis before and after treatment.
  • Integrated bio-chemo degradation of Mordant Yellow 10 using upflow anaerobic packed bed reactor (UAPBR) and tray type photo-Fenton reactor (TPFR)
    R. Brindha, S. Santhosh, P. Rajaguru
    Journal of Cleaner Production, 2019
  • Effect of different retting processes on yield and quality of banana pseudostem fiber
    R Brindha, C.K Narayana, V Vijayalakshmi, R.P Nachane
    Journal of Natural Fibers, 2019
    The main objective of this study is to develop a suitable technology to utilize banana pseudostem waste in an effective manner. The choice of a specific extraction method depends on the intended end uses of the fibers and hence different methods (mechanical, microbial, chemical, and enzymatic) were carried out to extract cellulosic fibers from Poovan variety and the chemical properties were investigated. The flexural and tensile properties of fibers were explored to analyze the suitability of fibers for different applications. Results obtained from these analyses confirmed that the tex value of chemical retted fiber was lesser than others. Scanning electron micrographs revealed that the surfaces of the chemically retted fibers were rougher than mechanically extracted fibers with an average diameter of 180 µm. The elemental composition of the chemical-treated banana pseudostem fibers was investigated by energy-dispersive X-ray analysis. Fourier transform infrared spectrum indicated the presence of similar functional groups in all the fiber samples.
  • Fe0 catalyzed photo-Fenton process to detoxify the biodegraded products of azo dye Mordant Yellow 10
    R. Brindha, P. Muthuselvam, S. Senthilkumar, P. Rajaguru
    Chemosphere, 2018

RECENT SCHOLAR PUBLICATIONS

  • Tracing Toxicity: A Scientometric Perspective on Three Decades of Metallic Pollutants Research
    PD Balachandran, R Shanmugam, V Varadarajan, B Rethinam, ...
    Journal of Toxicology 2026 (1), 8884503 , 2026
    2026
  • Identifying the major research trends in algae polysaccharides: a scientometric analysis from 1989 to 2023
    MP Eswaramoorthi, G Subramanian, R Shanmugam, JDJ Britto, ...
    Biologia 80 (7), 1605-1624 , 2025
    2025
  • Correction: Understanding integrative approach of translational bioinformatics on cardiovascular disease: Myocardial Ischemia
    Y Ranganathan, S Nazar, RS Krishnan, Y Dinakarkumar, V Varadarajan, ...
    Egyptian Journal of Medical Human Genetics 26 (1), 21 , 2025
    2025
  • Understanding integrative approach of translational bioinformatics on cardiovascular disease: myocardial ischemia
    Y Ranganathan, S Nazar, RS Krishnan, Y Dinakarkumar, V Varadarajan, ...
    Egyptian Journal of Medical Human Genetics 25 (1), 153 , 2024
    2024
    Citations: 3
  • Antibiotic Resistance Genes–An Emerging Genetic Pollutant of LFL
    V Vijayalakshmi, P Rajaguru, S Rajeswari, R Brindha
    Water, Air and Soil Pollution 235 (6), 348 , 2024
    2024
    Citations: 4
  • Analysis of Batch Kinetic Data of Biodecolorization Reaction: Theoretical Approach for the Design of Packed Bed Reactor
    B Rethinam, R Palanichamy, JD John Britto
    Journal of Environmental Engineering 149 (10), 04023056 , 2023
    2023
    Citations: 3
  • Pure and Al-Bi Co-doped SnO2 Nanoparticles as Bacterial Growth Inhibitors
    VPI Anuja E., Pramothkumar A., R. Brindha
    Toxicological & Environmental Chemistry , 2022
    2022
    Citations: 3
  • Evaluation of global research trends in photocatalytic degradation of dye effluents using scientometrics analysis
    PR R. Brindha, S. Rajeswari, J. Jennet Debora
    Journal of Environmental Management 318 , 2022
    2022
    Citations: 15
  • Integrated bio-chemo degradation of Mordant Yellow 10 using upflow anaerobic packed bed reactor (UAPBR) and tray type photo-Fenton reactor (TPFR)
    R Brindha, S Santhosh, P Rajaguru
    Journal of Cleaner Production 208, 602-611 , 2019
    2019
    Citations: 20
  • Effect of different retting processes on yield and quality of banana pseudostem fiber
    RP Brindha, R., Narayana, C. K., Vijayalakshmi, V., and Nachane
    Journal of Natural Fibers 16 (1), 58-67 , 2019
    2019
    Citations: 60
  • Biodegradation of aniline from textile industry waste using salt tolerant Bacillus firmus BA01
    AA Dino, R Brindha, J Jayamuthunagai, B Bharathiraja
    Engineering in Agriculture, Environment and Food 12 (3), 360-366 , 2019
    2019
    Citations: 9
  • Fe0 catalyzed photo-Fenton process to detoxify the biodegraded products of azo dye Mordant Yellow 10
    R Brindha, P Muthuselvam, S Senthilkumar, P Rajaguru
    Chemosphere 201, 77-95 , 2018
    2018
    Citations: 33

MOST CITED SCHOLAR PUBLICATIONS

  • Effect of different retting processes on yield and quality of banana pseudostem fiber
    RP Brindha, R., Narayana, C. K., Vijayalakshmi, V., and Nachane
    Journal of Natural Fibers 16 (1), 58-67 , 2019
    2019
    Citations: 60
  • Fe0 catalyzed photo-Fenton process to detoxify the biodegraded products of azo dye Mordant Yellow 10
    R Brindha, P Muthuselvam, S Senthilkumar, P Rajaguru
    Chemosphere 201, 77-95 , 2018
    2018
    Citations: 33
  • Integrated bio-chemo degradation of Mordant Yellow 10 using upflow anaerobic packed bed reactor (UAPBR) and tray type photo-Fenton reactor (TPFR)
    R Brindha, S Santhosh, P Rajaguru
    Journal of Cleaner Production 208, 602-611 , 2019
    2019
    Citations: 20
  • Evaluation of global research trends in photocatalytic degradation of dye effluents using scientometrics analysis
    PR R. Brindha, S. Rajeswari, J. Jennet Debora
    Journal of Environmental Management 318 , 2022
    2022
    Citations: 15
  • Biodegradation of aniline from textile industry waste using salt tolerant Bacillus firmus BA01
    AA Dino, R Brindha, J Jayamuthunagai, B Bharathiraja
    Engineering in Agriculture, Environment and Food 12 (3), 360-366 , 2019
    2019
    Citations: 9
  • Antibiotic Resistance Genes–An Emerging Genetic Pollutant of LFL
    V Vijayalakshmi, P Rajaguru, S Rajeswari, R Brindha
    Water, Air and Soil Pollution 235 (6), 348 , 2024
    2024
    Citations: 4
  • Understanding integrative approach of translational bioinformatics on cardiovascular disease: myocardial ischemia
    Y Ranganathan, S Nazar, RS Krishnan, Y Dinakarkumar, V Varadarajan, ...
    Egyptian Journal of Medical Human Genetics 25 (1), 153 , 2024
    2024
    Citations: 3
  • Analysis of Batch Kinetic Data of Biodecolorization Reaction: Theoretical Approach for the Design of Packed Bed Reactor
    B Rethinam, R Palanichamy, JD John Britto
    Journal of Environmental Engineering 149 (10), 04023056 , 2023
    2023
    Citations: 3
  • Pure and Al-Bi Co-doped SnO2 Nanoparticles as Bacterial Growth Inhibitors
    VPI Anuja E., Pramothkumar A., R. Brindha
    Toxicological & Environmental Chemistry , 2022
    2022
    Citations: 3
  • Tracing Toxicity: A Scientometric Perspective on Three Decades of Metallic Pollutants Research
    PD Balachandran, R Shanmugam, V Varadarajan, B Rethinam, ...
    Journal of Toxicology 2026 (1), 8884503 , 2026
    2026
  • Identifying the major research trends in algae polysaccharides: a scientometric analysis from 1989 to 2023
    MP Eswaramoorthi, G Subramanian, R Shanmugam, JDJ Britto, ...
    Biologia 80 (7), 1605-1624 , 2025
    2025
  • Correction: Understanding integrative approach of translational bioinformatics on cardiovascular disease: Myocardial Ischemia
    Y Ranganathan, S Nazar, RS Krishnan, Y Dinakarkumar, V Varadarajan, ...
    Egyptian Journal of Medical Human Genetics 26 (1), 21 , 2025
    2025