Samia Andricia Souza da Silva
@ufal.br
Universidade Federal de Alagoas
RESEARCH, TEACHING, or OTHER INTERESTS
Drug Discovery, Organic Chemistry
Scopus Publications
Scopus Publications
Ariana da Silva Santos, Anderson Lopes Pimentel, João Victor Lessa de Oliveira, Michelle Teixeira da Silva, Fernanda Geny Calheiros Silva, Arthur Luy Tavares Ferreira Borges, Maria Aline Fidelis Barros de Moura, Sâmia Andrícia Souza da Silva, and Ticiano Gomes do Nascimento
FapUNIFESP (SciELO)
Abstract Moringa oleifera is an arboreal plant belonging to the family Moringaceae distributed in tropical areas and has gained enormous attention in the last decades. This research is a review on the association between aqueous extracts of M. oleifera leaves and diabetes mellitus and understanding its pharmacological functions and underlying mechanisms. The research refinement demonstrated the pharmaceutical potential of M. oleifera and its phytochemicals, given its antidiabetic effect. The prospective analysis showed the amount of application within IPC A61K in health area. The secondary metabolites present in M. oleifera, glucosinolates, flavonoids, and phenolic compounds may be responsible, in part, for the disease control hypoglycemic actions. Glucosinolates, when metabolized by salivary enzymes, give rise to sulforaphanes that act in preventing type 2 diabetes and in reducing insulin resistance. Flavonoids interact with intestinal enzymes by modifying carbohydrate metabolism by regulating glycemic levels, in addition to increasing insulin sensitivity. Phenolic compounds increase the expression of glucose transporters (GLUT4) and reduce the synthesis of fatty acids and cholesterol, contributing to the reduction of glucose resistance and blood sugar control. Moringa oleifera can be used as complementary therapy of the type-2 diabetes.
José Jailson Lima Bezerra, Ticiano Gomes do Nascimento, Regianne Umeko Kamiya, Ana Paula do Nascimento Prata, Patrícia Muniz de Medeiros, Sâmia Andrícia Souza da Silva, and Nathaly Esperidião de Melo
FapUNIFESP (SciELO)
Several factors contribute to the resistance of some pathogenic microorganisms and this fact requires the search for new therapeutic alternatives. The genus Cyperus (family Cyperaceae) groups species that present chemical compounds of pharmacological interest, mainly with antimicrobial action. Thus, the present work was carried out to investigate the antimicrobial activities, antioxidants and the phytochemical profile of Cyperus articulatus L. and Cyperus iria L. Hydroalcoholic extracts (1:1, v:v) of the aerial and underground parts of these species were used to analyze the total phenol content and to evaluate the in vitro antioxidant activity against the DPPH (2,2-diphenyl-1-picrylhydrazyl). The ethyl acetate and chloroform phases resulting from liquid-liquid partitioning of C. articulatus and C. iria extracts were evaluated in antimicrobial assays and subject to high performance liquid chromatography (HPLC-DAD) analysis. The chromatograms obtained by HPLC-DAD allowed us to identify four compounds: chlorogenic acid, catechin, quercetin, and quercitrin. The hydroalcoholic extracts of C. articulatus and C. iria showed a weak antioxidant activity with IC 50 of 395.57 and 321.33 μg/mL (aerial parts), and 1,114.01 and 436.82 μg/mL (underground parts), respectively. Regarding antimicrobial activity, the chloroform phase of C. iria showed the best result at the concentration of only 31.2 µg/mL against the pathogens Candida albicans and Staphylococcus aureus . The ethyl acetate phases of the aerial parts of C. articulatus and C. iria did not show antimicrobial activity.
Lais Farias Azevedo, Priscilla da Fonseca Silva, Marianna Porfírio Brandão, Louisianny Guerra da Rocha, Cícero Flávio Soares Aragão, Sâmia Andrícia Souza da Silva, Isabel Cristina Celerino Moraes Porto, Irinaldo Diniz Basílio-Júnior, Eduardo Jorge da Silva Fonseca, Maria Aline Barros Fidelis de Moura,et al.
Informa UK Limited
The aim of the present study was to compare two nanoparticle composition loaded with Brazilian red propolis extract regarding its physicochemical characteristics and its antioxidant and antileishmanial activities. The red propolis nanoparticles in an aqueous medium and in solid-state presented particle size in a nanometric scale with an apparent size of 100–288 nm for the NEPE and 175–380 nm for the NPPE. ATR-FTIR and thermal analysis revealed an encapsulation of flavonoids from the red propolis extract in polymeric matrices for the multidrug delivery system. UPLC-DAD identified red propolis markers (flavonoids) in EPE, NEPE and NPPE. The efficiency of encapsulation (28.0–55.0% for NEPE and 61.2–81.0% for NPPE) were determined and calculated using UPLC-DAD. DPPH method showed the antioxidant activity of both EPE and nanoparticle compositions of red propolis. These polymeric matrices systems were able to encapsulate flavonoids from red propolis extract with specific characteristics of solubility and polarity. EPE and nanoparticles loaded with red propolis extract in the multi-constituent co-delivery system presented leishmanicidal activity and a good correlation was established between IC50 and efficiency of encapsulation. Red propolis nanoparticles exhibited leishmanicidal activity but NEPE presented a lower leishmanicidal effect in relation to NPPE, which showed similar activity compared to EPE. The nanopolymeric matrices choice should be established in propolis nanoparticle compositions to avoid lack of efficacy of bioproducts. Red propolis nanoparticles were shown to be a potential final bulk product for the preparation of various pharmaceutical and cosmetics compositions in therapy against diseases such as leishmaniasis. Scanning Electron Microscopy of red propolis nanoparticles (NEPE 30) (A). ATR-FTIR spectra of NPPE 30 and NPPE placebo (B). Chromatogram of the NPPE 30 (C). Determination of IC using leishmanicidal assay against Leishmania braziliensis for EPE, NEPE and NPPE (D).
Ticiano Gomes do Nascimento, Adriana dos Santos Silva, Patrícia Beltrão Lessa Constant, Sâmia Andrícia Souza da Silva, Maria Aline Barros Fidelis de Moura, Clinston Paulino de Almeida, Valdemir da Costa Silva, Amanda Barbosa Wanderley, Irinaldo Diniz Basílio Júnior, and Pierre Barnabé Escodro
Informa UK Limited
This study investigated the chemical composition, flavonoids, phenolic compounds, antioxidant activity and antibacterial activity of commercial propolis extracts produced in the Sergipe and Alagoas States of Brazil as potential bioproducts for the food and pharmaceutical industries. Four samples were analyzed, three brown propolis extracts and one red propolis extract, and were characterized through phytochemical screening, chemical, chromatographic profile and antibacterial activity. Phytochemical analysis detected the presence of triterpenoids and phenolic compound in propolis extracts. Propolis extracts showed total phenolic content between 9 and 15% and total flavonoids >2%. Propolis extracts showed excellent antioxidant activity with inhibition of the Free radical DPPH˙ between 97 and 60%, which confirm the results obtained in total phenolics, total flavonoids content and antibacterial activity. The chromatographic profile showed differences for brown propolis samples and quite different from the red propolis extract, which present flavonoids as isoflavonoids, pterocarpans, chalcones and guttiferones. Commercial propolis extract (propolis extract C and propolis extract D) showed excellent activity for Staphylococcus aureus ATCC 25923 and moderate activity for Pseudomonas aeruginosa ATCC 27853. The chemical characterization of propolis extracts is fundamental in the process of standardization and monitoring of the chemical composition susceptible to geographic and seasonal variation. These results point to new possibilities of use as bio-preservative of processed foods as well as in the development of pharmaceuticals and nutraceuticals products from propolis extract C and D in its formulation actuate on the inhibition of some pathogenic microorganisms strains.
Sâmia Andricia S. da Silva, Maria de Fátima Agra, Josean F. Tavares, Emídio V. L. da-Cunha, José Maria Barbosa-Filho, and Marcelo S. da Silva
Springer Science and Business Media LLC
The phytochemical analysis of aerial parts of Cordia globosa, collected in the Municipality of Picui, State of Paraiba, Brazil, resulted in the isolation and structural identification of narigenin-4',7-dimethyl ether (0.025 g) and eriodictyol (0.015 g). These compounds are the first flavanones aglycones isolated from the genus Cordia.
Marcelo Sobral da Silva, Josean Fechine Tavares, Karine Formiga Queiroga, Maria de Fátima Agra, José Maria Barbosa Filho, Jackson Roberto Guedes da Silva Almeida, and Sâmia Andrícia Souza da Silva
FapUNIFESP (SciELO)
The phytochemical investigation of Xylopia langsdorffiana led to the isolation of corytenchine, xylopinine, discretamine, xylopine, ent-atisan-16α-hydroxy-18-oic acid, 132 (S) hydroxy-173-ethoxyphaephorbide and quercetin-3-α-rhamnoside. Their structures were assigned based on spectroscopic analyses, including two-dimensional NMR techniques. Antioxidant activities of discretamine were measured using the 1,2-diphenyl- 2-picryl-hydrazyl (DPPH) free radical scavenging assay.
Sâmia Andricia Souza da Silva, Marla Simone Lopes Rodrigues, Maria de Fátima Agra, Emídio Vasconcelos Leitão da-Cunha, José Maria Barbosa-Filho, and Marcelo Sobral da Silva
Elsevier BV