Mona El-Aasr

Scopus Publications

Unveiling the wound-healing potential of Pisum sativum aerial biomass through integrated bioassay-guided, LC–MS/MS, and network pharmacology approaches
Noha M. Kadash, Abdullah A. Elgazar, Mona El-Aasr, Ramadan A. El-Domany, Marwa Balaha, et al.
BMC Complementary Medicine and Therapies, 2026
Molecular networking based on UPLC-MS/MS fingerprinting for evaluation of Atriplex lindleyi Moq. subsp. inflata's renoprotective potential
Abdelrahman A. Ziada, Amal Kabbash, Mona El-Aasr, Mohamed A. Selim, Rehab F. Abdel-Rahman, et al.
South African Journal of Botany, 2026
Phytochemicals of Vitis vinifera L. var. King Ruby protect mice from benzo(a)pyrene-induced lung injury
Gehad S. Ahmedy, Hend M. Selim, Mona El-Aasr, Souzan M. Ibrahim, Suzy A. El-Sherbeni
Scientific Reports, 2025
The world’s concern about smoking hazards, chronic obstructive pulmonary disease (COPD) and lung cancer was the motivation to investigate plants as a source of new drugs with lung protective effect. The phytochemical profile of Vitis vinifera L. var. King Ruby leaves methanol extract (VLME) was tentatively recognized by liquid chromatography electrospray ionization tandem mass spectrometric (LC-ESI-MS/MS). Fifty-two and forty-seven compounds were identified by negative and positive ESI modes, respectively. Taraxerol (1), β-sitosterol (2), daucosterol (3), quercetin-3-O-β-D-glucuronoide-6″-methyl ester (4) and isoquercetin (5) were isolated from VLME. The sulforhodamine B (SRB) assay of the different fractions against A-549 cell line revealed that the methylene chloride fraction (MCF) had the lowest cell viability at 300 µg/mL (4.54 ± 0.19%). Mice of 10 groups (n = 6) was treated as follows: Group I (negative control group), group II (disease control, mice received B(a)P 125 mg/kg, orally), groups III-V (mice received 100, 200, and 300 mg/kg of VLME, followed by B(a)P), group VI (mice received only 300 mg/kg of VLME), groups VII-XI (mice received 100, 200, and 300 mg/kg of MCF, followed by B(a)P), group X (mice received only 300 mg/kg of MCF). On the seventh day, all groups received a single oral dose of B(a)P 125 mg/kg body, except group I, VI and X. In vivo studies showed VLME and MCF (300 mg/kg body weight) effectively mitigated benzo(a)pyrene-induced lung injuries in mice. The anti-inflammatory effects were confirmed by the downregulation of cyclooxygenase-2 (COX-2) and CD34, alongside reduced nuclear factor-kappa B (NF-κB) expression. Antioxidant activity was indicated by decreased malondialdehyde (MDA) levels and inducible nitric oxide synthase (iNOS) expression with the remarkable increase in glutathione (GSH). Histological improvements further support the potential of Vitis vinifera L. leaves as a natural lung protectant. Further pre-clinical and clinical investigations will be required to deliver a new drug with promising protection effect.
Phytochemical content of Cycas rumphii n-butanol fraction and antiprotozoal activity against Toxoplasma gondii in vivo
Hosam M. El-Seadawy, Amany E. Ragab, Mona El-Aasr, Kamilia A. Abo El-Seoud, Ayat A. Elblihy, et al.
Scientific Reports, 2025
Toxoplasmosis treatments are currently limited due to their ineffectiveness against the chronic stage and potential adverse effects. The search for novel medications that possess characteristics such as non-toxicity, and efficacy on all stages of the parasite, particularly the cystic form, is important. The n-butanol (n-BuOH) fraction of Cycas rumphii has shown promising potency against Toxoplasma gondii (RH strain) in vitro, and this study aimed to evaluate its efficacy against T. gondii in mice models. Therefore, mice were infected with 20 cysts (acute infection model) or 10 cysts (chronic infection model) of T. gondii (ME49 strain). The infected mice were treated with C. rumphii n-BuOH fraction and cotrimoxazole at 200 mg/kg/day and 370 mg/kg/day, respectively, divided into 2 doses/12 h, starting the 4th day (acute stage) or the 6th week (chronic model) post-infection, and continued for 14 consecutive days. Mice were sacrificed at 56, and 70 days post-infection for acute and chronic models, respectively, to assess the efficacy of treatment. Evaluations included size and count of brain cysts, histopathological examinations of the brain and liver, inflammatory scoring, and immunological studies to assess the levels of nitric oxide (NO), interferon-gamma (INF-γ), and tumor necrosis factor-alpha (TNF-α) in serum. Oral administration of the n-BuOH fraction at a daily dose of 200 mg/kg for two weeks significantly reduced the cyst count in the brains of infected mice and improved the survival rate. The results were comparable to those observed in subgroups treated with cotrimoxazole in both acute and chronic models. The histopathological findings indicated that C. rumphii n-BuOH alleviated T. gondii-induced brain and liver lesions. Furthermore, the serum levels of NO, and IFN-γ were significantly elevated in the C. rumphii n-BuOH fraction-treated subgroups. High-performance liquid chromatography analysis indicated that this fraction is rich in phenolic acids, including caffeic acid, gallic acid, and chlorogenic acid which have been linked to anti-oxidant, anti-inflammatory, antiparasitic, and anti-Toxoplasma properties. Experimental results demonstrated that the n-BuOH fraction of C. rumphii exhibits anti-Toxoplasma effects, making it a promising candidate for the development of complementary therapies or use in combination with other drugs.
Investigating the Efficacy of Amoxicillin-Broccoli Combination in Combating Multidrug-Resistant Staphylococcus aureus Infection
Habiba Mosaad, Engy Elekhnawy, Walaa A. Negm, Salwa S. Younis, Mona El-Aasr
Current Microbiology, 2025
Drosophila melanogaster as a model organism for diabetes II treatment by the ethyl acetate fraction of Atriplex halimus L.
Omnia Montaser, Mona El‐Aasr, Haytham O. Tawfik, Wesam S. Meshrif, Hanaa Elbrense
Journal of Experimental Zoology Part A Ecological and Integrative Physiology, 2024
Type 2 diabetes (T2D) is the most common metabolic disorder. The undesirable effects of synthetic drugs demand a search for safe antidiabetic agents. This study aimed to assess the antidiabetic activity of different fractions of Atriplex halimus (petroleum ether 60–80, methylene chloride, ethyl acetate, and n‐butanol) using Drosophila melanogaster larvae. Titers of total glucose and trehalose, as well as larval weight, were measured and compared with those of control and diabetic larvae. The expression of Drosophila insulin‐like peptides (DILP2 and DILP3) and adipokinetic hormone (AKH) was evaluated. The results revealed a significant increase in total glucose, trehalose, and a decrease in body weight in the larvae fed a high‐sugar diet compared with those in the control. When larvae fed diets containing the tested fractions, the total glucose and trehalose decreased to the control level, and the body weight increased. DILP2, DILP3, and AKH exhibited significant decreases upon treatment with A. halimus ethyl acetate. Metabolomic profiling of the ethyl acetate fraction of A. halimus revealed the presence of flavonoids and flavonoid glycosides. After docking screening to predict the most powerful moiety, we discovered that flavonoid glycosides (especially eriodictyol‐7‐O‐neohesperidoside) have a greater affinity for the pocket than the other moieties. The results indicated the therapeutic activity of the A. halimus ethyl acetate fraction against induced T2D in Drosophila larvae. The antidiabetic activity may be attributed to flavonoids, which are the main components of the A. halimus ethyl acetate fraction.
LC-MS/MS metabolomics approach for chemical characterization of Beta vulgaris subspecies maritima extract through untargeted molecular networking, in correlation to its renoprotective activity in renal ischemia/reperfusion induced injury model in rats
Abdelrahman A. Ziada, Amal Kabbash, Mona El-Aasr, Mohamed A. Selim, Rehab F. Abdel-Rahman, et al.
Food Bioscience, 2024
Anticancerous sulfides from onion, Welsh onion, and garlic
Studies in Natural Products Chemistry, 2024
Microbiota-derived short chain fatty acids in fermented Kidachi Aloe promote antimicrobial, anticancer, and immunomodulatory activities
Lamiaa A. Al-Madboly, Akira Yagi, Amal Kabbash, Mona A. El-Aasr, Rasha M. El-Morsi
BMC Microbiology, 2023
Background Fermented Aloe leaf juice is a commonly used food supplement in Japan. In a previous study, fermentation of A. arborescence juice was performed and the presence of short-chain fatty acids (SCFAs) was confirmed and quantified. Samples were collected before and after the fermentation process to be subjected, in the present study, to DNA extraction, 16S rRNA gene (V3–V4 regions) amplification, and sequencing by the next-generation Illumina MiSeq sequencer. Our work aims to analyze the sequences to assess the bacterial diversity in the juice before and after fermentation, identify the beneficial microbes responsible for the production of SCFAs, and evaluate some of the biological activities of the fermented juice. Results Data revealed the richness and diversity of the bacterial community in the fermented juice compared to the unfermented control. Relative abundance of bacterial phyla showed that the majority of the microbial community in the test samples corresponded to Pseudomonadota (unfermented; 10.4%, fermented; 76.36%), followed by Bacillota (unfermented; 4.71%, fermented; 17.13%) and then Bacteroidota (unfermented; 0.57%, fermented; 1.64%). For the fermented sample, 84% of Bacillota were lactobacilli. A hierarchically clustered heatmap revealed that Lactobacillus was the most abundant genus in both samples suggesting its involvement in the production of SCFAs. To assess potential health benefits, the anticancer efficacy of the fermented product of A. arborescens was investigated against colorectal cancer (IC50 = 3.5 µg/ml) and liver cancer (IC50 = 6.367 µg/ml) compared to the normal peripheral blood mononuclear cells (PBMCs). Flow cytometric analysis of the cell cycle pattern revealed remarkable population arrest in G0 and G1, however, the highest percentages were mainly in the G1 phase for Hep-G2 (40.1%) and HCT-116 (53.2%) cell lines. This effect was accompanied by early apoptotic profiles of HCT-116 (36.9%) and late apoptosis for Hep-G2 (17.3%). Furthermore, immunomodulatory properties demonstrated a significantly (p < 0.001) reduced percentage of induced TNF-α while enhancing IFN-γ dramatically. For antimicrobial activities, marked broad-spectrum activities were recorded against some bacterial and fungal pathogens (17–37 mm inhibition zone diameter range). Conclusion Therefore, this study affords the basis of bacterial community composition in fermented A. arborescens juice as well as its potential biological benefits.
Papaverinol-N-Oxide: A Microbial Biotransformation Product of Papaverine with Potential Antidiabetic and Antiobesity Activity Unveiled with In Silico Screening
Duaa Eliwa, Amal Kabbash, Mona El-Aasr, Haytham O. Tawfik, Gaber El-Saber Batiha, et al.
Molecules, 2023
Bioconversion of biosynthetic heterocyclic compounds has been utilized to produce new semisynthetic pharmaceuticals and study the metabolites of bioactive drugs used systemically. In this investigation, the biotransformation of natural heterocyclic alkaloid papaverine via filamentous fungi was explored. Molecular docking simulations, using protein tyrosine phosphatase 1B (PTP1B), α-glucosidase and pancreatic lipase (PL) as target enzymes, were performed to investigate the antidiabetic potential of papaverine and its metabolites in silico. The metabolites were isolated from biotransformation of papaverine with Cunninghamella elegans NRRL 2310, Rhodotorula rubra NRRL y1592, Penicillium chrysogeneum ATCC 10002 and Cunninghamella blackesleeana NRRL 1369 via reduction, demethylation, N-oxidation, oxidation and hydroxylation reactions. Seven metabolites were isolated: namely, 3,4-dihydropapaverine (metabolite 1), papaveroline (metabolite 2), 7-demethyl papaverine (metabolite 3), 6,4′-didemethyl papaverine (metabolite 4), papaverine-3-ol (metabolite 5), papaverinol (metabolite 6) and papaverinol N-oxide (metabolite 7). The structural elucidation of the metabolites was investigated with 1D and 2D NMR and mass spectroscopy (EI and ESI). The molecular docking studies showed that metabolite 7 exhibited better binding interactions with the target enzymes PTP1B, α-glucosidase and PL than did papaverine. Furthermore, papaverinol-N-oxide (7) also displayed inhibition of α-glucosidase and lipase enzymes comparable to that of their ligands (acarbose and orlistat, respectively), as unveiled with an in silico ADMET profile, molecular docking and molecular dynamics studies. In conclusion, this study provides evidence for enhanced inhibition of PTP1B, α-glucosidase and PL via some papaverine fungal transformation products and, therefore, potentially better antidiabetic and antiobesity effects than those of papaverine and other known therapeutic agents.
Elucidation of Natural Components of Gardenia thunbergia Thunb. Leaves: Effect of Methanol Extract and Rutin on Non-Alcoholic Fatty Liver Disease
Eman M. EL-Shial, Amal Kabbash, Mona El-Aasr, Ola A. El-Feky, Suzy A. El-Sherbeni
Molecules, 2023
Evaluation of Zamia floridana A. DC. Leaves and Its Isolated Secondary Metabolites as Natural Anti-Toxoplasma and Anti-Cancer Agents Using In Vitro and In Silico Studies
Hosam M. El-Seadawy, Kamilia A. Abo El-Seoud, Mona El-Aasr, Haytham O. Tawfik, Wagdy M. Eldehna, et al.
Metabolites, 2023
LC-MS/MS metabolomics profiling of Glechoma hederacea L. methanolic extract; in vitro antimicrobial and in vivo with in silico wound healing studies on Staphylococcus aureus infected rat skin wound
Mona El-Aasr, Toshihiro Nohara, Tsuyushi Ikeda, Sally E. Abu-Risha, Engy Elekhnawy, et al.
Natural Product Research, 2023
Histological assessment, anti-quorum sensing, and anti-biofilm activities of Dioon spinulosum extract: in vitro and in vivo approach
Engy Elekhnawy, Walaa A. Negm, Mona El-Aasr, Amal Abo Kamer, Mohammed Alqarni, et al.
Scientific Reports, 2022
Toxoplasmocidal and Cytotoxic Activities Guided Isolation and Characterization of an Undescribed Bioflavonoid-di-C-glucoside from Cycas rumphii Miq. Cultivated in Egypt
Hosam M. El-Seadawy, Kamilia A. Abo El-Seoud, Mona El-Aasr, Haytham O. Tawfik, Amany E. Ragab
Plants, 2022
Biotransformation of Modified Benzylisoquinoline Alkaloids: Boldine and Berberine and In Silico Molecular Docking Studies of Metabolites on Telomerase and Human Protein Tyrosine Phosphatase 1B
Duaa Eliwa, Abdel-Rahim S. Ibrahim, Amal Kabbash, Mona El-Aasr, Michał Tomczyk, et al.
Pharmaceuticals, 2022
Sulfated Galactofucans: An Outstanding Class of Fucoidans with Promising Bioactivities
Ahmed Zayed, Jose Avila-Peltroche, Mona El-Aasr, Roland Ulber
Marine Drugs, 2022
Promising Antifungal Activity of Encephalartos laurentianus de Wild against Candida albicans Clinical Isolates: In Vitro and In Vivo Effects on Renal Cortex of Adult Albino Rats
Walaa A. Negm, Mona El-Aasr, Ghada Attia, Moneerah J. Alqahtani, Rania Ibrahim Yassien, et al.
Journal of Fungi, 2022
Thiolane-type sulfides from garlic, onion, and Welsh onion
Toshihiro Nohara, Yukio Fujiwara, Mona El-Aasr, Tsuyoshi Ikeda, Masateru Ono, et al.
Journal of Natural Medicines, 2021
Microbial transformation of some simple isoquinoline and benzylisoquinoline alkaloids and in vitro studies of their metabolites
Mona El-Aasr, Duaa Eliwa, Mohamed Albadry, Abdel-Rahim S. Ibrahim, Amal Kabbash, et al.
Phytochemistry, 2021
Investigation of the antibacterial activity and efflux pump inhibitory effect of cycas thouarsii r.Br. extract against klebsiella pneumoniae clinical isolates
Walaa A. Negm, Mona El-Aasr, Amal Abo Kamer, Engy Elekhnawy
Pharmaceuticals, 2021
Biotransformation of papaverine and in silico docking studies of the metabolites on human phosphodiesterase 10a
Duaa Eliwa, Mohamed A. Albadry, Abdel-Rahim S. Ibrahim, Amal Kabbash, Kumudini Meepagala, et al.
Phytochemistry, 2021
The plausible mechanisms of tramadol for treatment of COVID-19
Nahla E. El-Ashmawy, Abdel-Halim A. Lashin, Kamal M. Okasha, Amal M. Abo Kamer, Tarek M. Mostafa, et al.
Medical Hypotheses, 2021
Fucoidan characterization: Determination of purity and physicochemical and chemical properties
Ahmed Zayed, Mona El-Aasr, Abdel-Rahim S. Ibrahim, Roland Ulber
Marine Drugs, 2020
Hepatoprotective, cytotoxic, antimicrobial and antioxidant activities of Dioon spinulosum leaves Dyer Ex Eichler and its isolated secondary metabolites
Walaa A. Negm, Kamilia A. Abo El-Seoud, Amal Kabbash, Amira A. Kassab, Mona El-Aasr
Natural Product Research, 2020
Effect of avocado pulp extract on chlorpyrifos-induced thyroid gland injury in rats: A histological and morphometric study
Amira Kassab, Mona El-Aasr
Egyptian Journal of Histology, 2018
Antitumor Allium sulfides
Toshihiro Nohara, Yukio Fujiwara, Mona El-Aasr, Tsuyoshi Ikeda, Masateru Ono, et al.
Chemical and Pharmaceutical Bulletin, 2017
Atypical cyclic sulfides, garlicnins G, I, and J, extracted from Allium sativum
Masateru Ono, Yukio Fujiwara, Tsuyoshi Ikeda, Cheng Pan, Mona El-Aasr, et al.
Chemical and Pharmaceutical Bulletin, 2017
Antimicrobial and immunomodulatory activities of flavonol glycosides isolated from Atriplex halimus L. Herb
Journal of Pharmaceutical Sciences and Research, 2016
Two new bicyclic sulfoxides from Welsh onion
Toshihiro Nohara, Yukio Fujiwara, Tsuyoshi Ikeda, Kotaro Murakami, Masateru Ono, et al.
Journal of Natural Medicines, 2016
In vitro and In vivo hepatoprotective study of Inula crithmoides L.,Pluchea dioscoridis (L.) Desf. and Phyllanthus reticulates poir
Journal of Pharmaceutical Sciences and Research, 2015
Saponins, esculeosides B-1 and B-2, in tomato juice and sapogenol, esculeogenin B1
Toshihiro Nohara, Yukio Fujiwara, Jian-Rong Zhou, Jun Urata, Tsuyoshi Ikeda, et al.
Chemical and Pharmaceutical Bulletin, 2015
New spirostanol glycosides from Solanum nigrum and S. jasminoides
Mizuho Ohno, Kotaro Murakami, Mona El-Aasr, Jian-Rong Zhou, Kazumi Yokomizo, et al.
Journal of Natural Medicines, 2012
Garlicnin a from the fraction regulating macrophage activation of Allium sativum
Mona El-Aasr, Yukio Fujiwara, Motohiro Takeya, Masateru Ono, Daisuke Nakano, et al.
Chemical and Pharmaceutical Bulletin, 2011
Content variations of the tomato saponin esculeoside A in various processed tomatoes
Hideyuki Manabe, Yoshihiro Murakami, Mona El-Aasr, Tsuyoshi Ikeda, Yukio Fujiwara, et al.
Journal of Natural Medicines, 2011
Study of the chemical constituents of Pruni Cortex and its related parts
Nanae Matsuoka, Tsuyoshi Ikeda, Mona El-Aasr, Hideyuki Manabe, Yoshihiro Murakami, et al.
Journal of Natural Medicines, 2011
The tomato saponin, esculeoside A
Toshihiro Nohara, Masateru Ono, Tsuyoshi Ikeda, Yukio Fujiwara, Mona El-Aasr
Journal of Natural Products, 2010
Study of constituents of Veronicastrum villosulum
Toshihiro Nohara, Ai Nakano, Mona El-Aasr, Tsuyoshi Ikeda, Hiroyuki Miyashita, et al.
Journal of Natural Medicines, 2010
Onionin a from allium cepa inhibits macrophage activation
Mona El-Aasr, Yukio Fujiwara, Motohiro Takeya, Tsuyoshi Ikeda, Sachiko Tsukamoto, et al.
Journal of Natural Products, 2010
Two new cucurbitane-type glycosides obtained from roots of Siraitia grosvenori SWINGLE
Dian-Peng Li, Mona El-Aasr, Tsuyoshi Ikeda, Misato Ogata, Hiroyuki Miyashita, et al.
Chemical and Pharmaceutical Bulletin, 2009
A new spirostanol glycoside from fruits of Solanum indicum L.
Mona El-Aasr, Hiroyuki Miyashita, Tsuyoshi Ikeda, Jong-Hyun Lee, Hitoshi Yoshimitsu, et al.
Chemical and Pharmaceutical Bulletin, 2009
Two new acyclic diterpene glycosides from fruits of habanero, Capsicum chinense
Jong-Hyun Lee, Mona El-Aasr, Tsuyoshi Ikeda, Kana Oda, Hiroyuki Miyashita, et al.
Chemical and Pharmaceutical Bulletin, 2009
Studies on the constituents of whole plants of Youngia japonica
Emiko Yae, Shoji Yahara, Mona El-Aasr, Tsuyoshi Ikeda, Hitoshi Yoshimitsu, et al.
Chemical and Pharmaceutical Bulletin, 2009
Conversion of esculeoside A into esculeogenin B
Mona El Aasr, Yukino Oshiro, Yukio Fujiwara, Hiroyuki Miyashita, Tsuyoshi Ikeda, et al.
Chemical and Pharmaceutical Bulletin, 2008

RECENT SCHOLAR PUBLICATIONS

Unveiling the wound-healing potential of Pisum sativum aerial biomass through integrated bioassay-guided, LC–MS/MS, and network pharmacology approaches
NM Kadash, AA Elgazar, M El-Aasr, RA El-Domany, M Balaha, ...
BMC Complementary Medicine and Therapies , 2026
2026
Anti-ulcer and Antibiofilm Activities of Abelmoschus esculentus L. Leaves: Biological and In-Silico Insights
HI Ghanem, SA El-Sherbeni, AR Azzam, E Elekhnawy, HO Tawfik, ...
Journal of Advanced Medical and Pharmaceutical Research, 26-37 , 2026
2026
Molecular networking based on UPLC-MS/MS fingerprinting for evaluation of Atriplex lindleyi Moq. subsp. inflata's renoprotective potential
AA Ziada, A Kabbash, M El-Aasr, MA Selim, RF Abdel-Rahman, HA Ogaly, ...
South African Journal of Botany 189, 565-573 , 2026
2026
Investigating the Efficacy of Amoxicillin-Broccoli Combination in Combating Multidrug-Resistant Staphylococcus aureus Infection
H Mosaad, E Elekhnawy, WA Negm, SS Younis, M El-Aasr
Current Microbiology 82 (8), 338 , 2025
2025
Phytochemical content of Cycas rumphii n -butanol fraction and antiprotozoal activity against Toxoplasma gondii in vivo
HM El-Seadawy, AE Ragab, M El-Aasr, KAA El-Seoud, AA Elblihy, ...
Scientific Reports 15 (1), 15697 , 2025
2025
Citations: 3
Phytochemicals of Vitis vinifera L. var. King Ruby protect mice from benzo(a)pyrene-induced lung injury
GS Ahmedy, HM Selim, M El-Aasr, SM Ibrahim, SA El-Sherbeni
Scientific Reports 15 (1), 4536 , 2025
2025
Citations: 1
A Comparative Study of Cytotoxic Effect in Three Vitis vinifera L. Varieties: King Ruby, Thompson and Crimson Against A-549 Lung Cancer Cell Line
GS Ahmedy, SA El-Sherbeni, M El-Aasr, SM Ibrahim
Journal of Advanced Medical and Pharmaceutical Research, 1-9 , 2024
2024
Drosophila melanogaster as a model organism for diabetes II treatment by the ethyl acetate fraction of Atriplex halimus L.
O Montaser, M El‐Aasr, HO Tawfik, WS Meshrif, H Elbrense
Journal of Experimental Zoology Part A: Ecological and Integrative … , 2024
2024
Citations: 5
LC-MS/MS metabolomics approach for chemical characterization of Beta vulgaris subspecies maritima extract through untargeted molecular networking, in correlation to its …
AA Ziada, A Kabbash, M El-Aasr, MA Selim, RF Abdel-Rahman, HA Ogaly, ...
Food Bioscience 59, 104004 , 2024
2024
Citations: 7
Anticancerous sulfides from onion, Welsh onion, and garlic
T Nohara, Y Fujiwara, M El-Aasr, T Ikeda, M Ono, D Nakano, J Kinjo
Studies in Natural Products Chemistry 83, 69-94 , 2024
2024
Phytochemical profile, ethnobotanical and biological impacts of various Zamia species: A mini-review
HM El-Seadawy, KA Abo El-Seoud, M El-Aasr, AE Ragab
Journal of Advanced Medical and Pharmaceutical Research 4 (2), 63-73 , 2023
2023
Citations: 3
Cycadaceae: An important source for biflavonoids and various pharmacological effects of different Cycas species
HM El-Seadawy, KA Abo El-Seoud, M El-Aasr, AE Ragab
Journal of Advanced Medical and Pharmaceutical Research 4 (2), 35-41 , 2023
2023
Citations: 6
Microbiota-derived short chain fatty acids in fermented Kidachi Aloe promote antimicrobial, anticancer, and immunomodulatory activities
LA Al-Madboly, A Yagi, A Kabbash, MA El-Aasr, RM El-Morsi
BMC microbiology 23 (1), 240 , 2023
2023
Citations: 8
LC-MS/MS metabolomics profiling of Glechoma hederacea L. methanolic extract; in vitro antimicrobial and in vivo with in silico wound healing studies on Staphylococcus aureus …
M El-Aasr, T Nohara, T Ikeda, SE Abu-Risha, E Elekhnawy, HO Tawfik, ...
Natural Product Research 37 (10), 1730-1734 , 2023
2023
Citations: 14
GC-MS Analysis of Bioactive Compounds of Gardenia thunbergia Thunb. Leaves and Antibiofilm Potential against Staphylococcus aureus Clinical Isolates
EM EL-Shial, A Kabbash, M El-Aasr, E Elekhnawy, SA El-Sherbeni
Journal of Advanced Medical and Pharmaceutical Research 4 (1), 11-18 , 2023
2023
Citations: 2
Papaverinol- N -Oxide: A Microbial Biotransformation Product of Papaverine with Potential Antidiabetic and Antiobesity Activity Unveiled with In Silico Screening
D Eliwa, A Kabbash, M El-Aasr, HO Tawfik, GES Batiha, MH Mahmoud, ...
Molecules 28 (4), 1583 , 2023
2023
Citations: 3
Elucidation of Natural Components of Gardenia thunbergia Thunb. Leaves: Effect of Methanol Extract and Rutin on Non-Alcoholic Fatty Liver Disease
EM El-Shial, A Kabbash, M El-Aasr, OA El-Feky, SA El-Sherbeni
Molecules 28 (2), 879 , 2023
2023
Citations: 19
Evaluation of Zamia floridana A. DC. Leaves and Its Isolated Secondary Metabolites as Natural Anti-Toxoplasma and Anti-Cancer Agents Using In Vitro and In …
HM El-Seadawy, KA Abo El-Seoud, M El-Aasr, HO Tawfik, WM Eldehna, ...
Metabolites 13 (1), 10 , 2022
2022
Citations: 5
Toxoplasmocidal and Cytotoxic Activities Guided Isolation and Characterization of an Undescribed Bioflavonoid-di- C -glucoside from Cycas rumphii Miq. Cultivated …
HM El-Seadawy, KA Abo El-Seoud, M El-Aasr, HO Tawfik, AE Ragab
Plants 11 (21), 2867 , 2022
2022
Citations: 8
Biotransformation of modified benzylisoquinoline alkaloids: boldine and berberine and in silico molecular docking studies of metabolites on telomerase and human protein …
D Eliwa, ARS Ibrahim, A Kabbash, M El-Aasr, M Tomczyk, YA Bin Jardan, ...
Pharmaceuticals 15 (10), 1195 , 2022
2022
Citations: 4

MOST CITED SCHOLAR PUBLICATIONS

Fucoidan characterization: Determination of purity and physicochemical and chemical properties
A Zayed, M El-Aasr, ARS Ibrahim, R Ulber
Marine Drugs 18 (11), 571 , 2020
2020
Citations: 242
Onionin A from Allium cepa Inhibits Macrophage Activation
M El-Aasr, Y Fujiwara, M Takeya, T Ikeda, S Tsukamoto, M Ono, ...
Journal of natural products 73 (7), 1306-1308 , 2010
2010
Citations: 131
The tomato saponin, esculeoside A
T Nohara, M Ono, T Ikeda, Y Fujiwara, M El-Aasr
Journal of Natural Products 73 (10), 1734-1741 , 2010
2010
Citations: 64
Histological assessment, anti-quorum sensing, and anti-biofilm activities of Dioon spinulosum extract: in vitro and in vivo approach
E Elekhnawy, WA Negm, M El-Aasr, AA Kamer, M Alqarni, GES Batiha, ...
Scientific Reports 12 (1), 180 , 2022
2022
Citations: 52
Investigation of the Antibacterial Activity and Efflux Pump Inhibitory Effect of Cycas thouarsii R.Br. Extract against Klebsiella pneumoniae Clinical Isolates
WA Negm, M El-Aasr, AA Kamer, E Elekhnawy
Pharmaceuticals 14 (8), 756 , 2021
2021
Citations: 51
Antitumor allium sulfides
T Nohara, Y Fujiwara, M El-Aasr, T Ikeda, M Ono, D Nakano, J Kinjo
Chemical and Pharmaceutical Bulletin 65 (3), 209-217 , 2017
2017
Citations: 51
Antimicrobial and Immunomodulatory Activities of Flavonol Glycosides Isolated From Atriplex halimus L. Herb.
M El-Aasr, A Kabbash, KAA El-Seoud, LA Al-Madboly, T Ikeda
Journal of Pharmaceutical Sciences and Research 8 (10), 1159 , 2016
2016
Citations: 41
Studies on the constituents of whole plants of Youngia japonica
E Yae, S Yahara, M El-Aasr, T Ikeda, H Yoshimitsu, C Masuoka, M Ono, ...
Chemical and pharmaceutical bulletin 57 (7), 719-723 , 2009
2009
Citations: 41
Sulfated galactofucans: an outstanding class of fucoidans with promising bioactivities
A Zayed, J Avila-Peltroche, M El-Aasr, R Ulber
Marine drugs 20 (7), 412 , 2022
2022
Citations: 36
The plausible mechanisms of tramadol for treatment of COVID-19
MAAS Nahla E. El-Ashmawy, Abdel-Halim A. Lashin, Kamal M. Okasha, Amal M ...
Medical Hypotheses 146 , 2021
2021
Citations: 36
Hepatoprotective, cytotoxic, antimicrobial and antioxidant activities of Dioon spinulosum leaves Dyer Ex Eichler and its isolated secondary metabolites
WA Negm, KA Abo El-Seoud, A Kabbash, AA Kassab, M El-Aasr
Natural product research 35 (23), 5166-5176 , 2021
2021
Citations: 34
Garlicnin A from the fraction regulating macrophage activation of Allium sativum
M El-Aasr, Y Fujiwara, M Takeya, M Ono, D Nakano, M Okawa, J Kinjo, ...
Chemical and Pharmaceutical Bulletin 59 (11), 1340-1343 , 2011
2011
Citations: 33
Thiolane-type sulfides from garlic, onion, and Welsh onion
T Nohara, Y Fujiwara, M El-Aasr, T Ikeda, M Ono, D Nakano, J Kinjo
Journal of natural medicines 75 (4), 741-751 , 2021
2021
Citations: 29
Promising Antifungal Activity of Encephalartos laurentianus de Wild against Candida albicans Clinical Isolates: In Vitro and In Vivo Effects on Renal Cortex of Adult …
WA Negm, M El-Aasr, G Attia, MJ Alqahtani, RI Yassien, A Abo Kamer, ...
Journal of Fungi 8 (5), 426 , 2022
2022
Citations: 28
Content variations of the tomato saponin esculeoside A in various processed tomatoes
H Manabe, Y Murakami, M El-Aasr, T Ikeda, Y Fujiwara, M Ono, T Nohara
Journal of natural medicines 65 (1), 176-179 , 2011
2011
Citations: 22
A new spirostanol glycoside from fruits of Solanum indicum L.
M El-Aasr, H Miyashita, T Ikeda, JH Lee, H Yoshimitsu, T Nohara, ...
Chemical and Pharmaceutical Bulletin 57 (7), 747-748 , 2009
2009
Citations: 20
Elucidation of Natural Components of Gardenia thunbergia Thunb. Leaves: Effect of Methanol Extract and Rutin on Non-Alcoholic Fatty Liver Disease
EM El-Shial, A Kabbash, M El-Aasr, OA El-Feky, SA El-Sherbeni
Molecules 28 (2), 879 , 2023
2023
Citations: 19
Biotransformation of papaverine and in silico docking studies of the metabolites on human phosphodiesterase 10a
D Eliwa, MA Albadry, ARS Ibrahim, A Kabbash, K Meepagala, IA Khan, ...
Phytochemistry 183, 112598 , 2020
2020
Citations: 19
Two new bicyclic sulfoxides from Welsh onion
T Nohara, Y Fujiwara, T Ikeda, K Murakami, M Ono, M El-Aasr, D Nakano, ...
Journal of natural medicines 70 (2), 260-265 , 2016
2016
Citations: 19
Saponins, esculeosides B-1 and B-2, in tomato juice and sapogenol, esculeogenin B1
T Nohara, Y Fujiwara, JR Zhou, J Urata, T Ikeda, K Murakami, M El-Aasr, ...
Chemical and Pharmaceutical Bulletin 63 (10), 848-850 , 2015
2015
Citations: 18

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