Francisco Jose Diaz-Galiano
@ual.es
Department of Chemistry and Physics
University of Almería
RESEARCH, TEACHING, or OTHER INTERESTS
Analytical Chemistry, Food Science
Scopus Publications
Scopus Publications
Francisco José Díaz-Galiano, María Murcia-Morales, Víctor Cutillas, and Amadeo R. Fernández-Alba
Elsevier BV
María Murcia-Morales, Francisco José Díaz-Galiano, María José Gómez-Ramos, and Amadeo R. Fernández-Alba
Elsevier BV
Francisco José Díaz‐Galiano, María Murcia‐Morales, and Amadeo Rodríguez Fernández‐Alba
Wiley
AbstractThis manuscript presents a comprehensive review of high‐resolution mass spectrometry in the field of food analysis and metabolomics. We have followed the historical evolution of metabolomics, its associated techniques and technologies, and its increasing role in food science and research. The review provides a critical comparison and synthesis of tentative identification guidelines proposed for over 15 years, offering a condensed resource for researchers in the field. We have also examined a wide range of recent metabolomics studies, showcasing various methodologies and highlighting key findings as a testimony of the versatility of the field and the possibilities it offers. In doing so, we have also carefully provided a compilation of the software tools that may be employed in this type of studies. The manuscript also explores the prospects of high‐resolution mass spectrometry and metabolomics in food science. By covering the history, guidelines, applications, and tools of metabolomics, this review attempts to become a comprehensive guide for researchers in a rapidly evolving field.
Francisco José Díaz-Galiano, María Murcia-Morales, María José Gómez-Ramos, María del Mar Gómez-Ramos, and Amadeo R. Fernández-Alba
Elsevier BV
Alicia Hernández-Lara, Margarita Ros, Almudena Giménez, Diego A. Moreno, Francisco J. Díaz-Galiano, María Jesús Martínez-Bueno, Pedro Lozano-Pastor, and José Antonio Pascual
MDPI AG
Solar radiation and the incorporation of compost into soil is a practice for disinfecting soil that could have some other effects on spinach cultivation. The quality of spinach leaves after two types of soil disinfection, non-amended soil (NAS) and compost-amended soil (CAS), was compared in order to find biomarkers of both types of disinfection. These practices did not show significant differences in nutrient composition (N-P-K) compared to the control soil (CS). However, the amount of harmful nutrients such as NO2− was significantly lower in CAS (65.74 mg kg−1 FW) and NAS (49.99 mg kg−1 FW) than in CS (114.39 mg kg−1 FW). In addition, NO3− levels did not exceed the EU-recommended limit (<3500 mg kg−1 FW). Both types of disinfected soils produced higher concentrations of total phenols and more individual flavonoids in spinach leaves than the control. Combined chemometric analysis of the HRAMS data showed different clustering depending on the type of disinfection (NAS and CAS). Fifteen metabolite compounds could be identified, seven of which are beneficial for health and were more abundant in spinach grown in CAS compared to that grown in NAS or CS. Such beneficial metabolites measured with non-target analysis as markers of CAS-grown spinach. However, more studies are necessary in order to determine the differences between the metabolites of spinach grown in NAS or CAS.
Icíar Beraza-Gómez, María José Gómez-Ramos, Francisco José Díaz-Galiano, and Amadeo R. Fernández Alba
Elsevier BV
Francisco José Díaz-Galiano, María José Gómez-Ramos, Icíar Beraza, María Murcia-Morales, and Amadeo R. Fernández-Alba
Elsevier BV
Francisco José Díaz-Galiano, Horacio Heinzen, María José Gómez-Ramos, María Murcia-Morales, and Amadeo R. Fernández-Alba
Elsevier BV
Francisco José Díaz-Galiano, María Murcia-Morales, Fabrice Monteau, Bruno Le Bizec, and Gaud Dervilly
Elsevier BV
L. Kharbouche, M. Martínez Galera, F.J. Díaz Galiano, and M.D. Gil García
Elsevier BV
Francisco José Díaz-Galiano, Horacio Heinzen, María Jesús Martínez-Bueno, Łukasz Rajski, and Amadeo R. Fernández-Alba
Elsevier BV
Laura V Morales, Andrés S Salinas, Ivonne A González, Katherin Holguin, Diana C Sinuco, Francisco J Díaz-Galiano, Diego A Ahumada, and Amadeo R Fernández-Alba
Oxford University Press (OUP)
Abstract Background Pesticide quantitation in foods relies on the availability of matrix reference materials, which, however, are scarce because of the general instability of pesticides. In particular, no avocado reference material has been developed. Objective This research aimed to develop a reference material to support the determination of pesticide residues in avocado. Method Avocado was spiked with 11 selected pesticides at levels of 0.01–0.35 mg/kg. The production process included the assessment of between-unit heterogeneity, stability during dispatch, and best storage conditions according to ISO 17034. Reference values were estimated through an interlaboratory comparison study involving laboratories of demonstrated competence and adhering to ISO/IEC 17025. The corresponding expanded uncertainties were calculated as 4–19% in compliance with the Guide to the Expression of Uncertainty in Measurement. Results The reference material was sufficiently homogeneous and stable at 4°C during the entire study period (365 days) for most of the pesticides, and at 40°C during 10 days, but it was unstable at 50 and 60°C during 10 days. Four pesticides showed downward trends; however, this behavior was considered in the uncertainty budget. As this material complied with all requirements of proficiency testing, it was used in an interlaboratory proficiency test designed to investigate analytical performance and assist laboratories in improving the quality of measurement results. Conclusions The presented material can be used for the development of novel analytical methods or in-house reference materials and adds to the scarce supply of reference materials for the determination of pesticides in vegetable matrixes with high oil contents and intermediate water contents. Highlights A novel reference material has been developed for the reliable and accurate quantitation of multiple pesticides in avocado, allowing researchers to avoid the preparation of in-house reference materials for this purpose.
María Murcia-Morales, Francisco José Díaz-Galiano, Flemming Vejsnæs, Ole Kilpinen, Jozef J.M. Van der Steen, and Amadeo R. Fernández-Alba
Elsevier BV
Francisco José Díaz-Galiano, Łukasz Rajski, Carmen Ferrer, Piedad Parrilla Vázquez, and Amadeo Rodríguez Fernández-Alba
Elsevier BV
María Murcia-Morales, Francisco José Díaz-Galiano, Inmaculada Guitérrez-Tirado, José Manuel Flores, Jozef J.M. Van der Steen, and Amadeo R. Fernández-Alba
Elsevier BV
Łukasz Rajski, Styliani Petromelidou, Francisco José Díaz-Galiano, Carmen Ferrer, and Amadeo Rodríguez Fernández-Alba
Elsevier BV
Francisco José Díaz-Galiano, Maria Murcia-Morales, María del Mar Gómez-Ramos, Carmen Ferrer, and Amadeo R. Fernández-Alba
Royal Society of Chemistry (RSC)
The developed method prevents the occurrence of matrix interferences in the analysis of anthraquinone in coffee and tea.
Mar García Valverde, María Jesús Martínez Bueno, María del Mar Gómez-Ramos, Francisco José Díaz-Galiano, and Amadeo R. Fernández-Alba
Elsevier BV
Łukasz Rajski, Florencia Jesús, Francisco José Díaz-Galiano, and Amadeo Rodríguez Fernández-Alba
Elsevier BV
María Murcia-Morales, Jozef J.M. Van der Steen, Flemming Vejsnæs, Francisco José Díaz-Galiano, José Manuel Flores, and Amadeo R. Fernández-Alba
Elsevier BV
Víctor Cutillas, Mar García-Valverde, María del Mar Gómez-Ramos, Francisco José Díaz-Galiano, Carmen Ferrer, and Amadeo R. Fernández-Alba
Elsevier BV
María Murcia Morales, María José Gómez Ramos, Piedad Parrilla Vázquez, Francisco José Díaz Galiano, Mar García Valverde, Victoria Gámiz López, José Manuel Flores, and Amadeo R. Fernández-Alba
Elsevier BV
María Jesús Martínez Bueno, Francisco José Díaz-Galiano, Łukasz Rajski, Víctor Cutillas, and Amadeo R. Fernández-Alba
Elsevier BV
E. Hakme, A. Lozano, C. Ferrer, F.J. Díaz-Galiano, and A.R. Fernández-Alba
Elsevier BV
Łukasz Rajski, Francisco José Díaz Galiano, Víctor Cutillas, and Amadeo R Fernández-Alba
Oxford University Press (OUP)
Abstract Ion chromatography coupled to a quadrupole Orbitrap mass analyzer was used to develop a multiresidue method for the determination of highly polar pesticides and their metabolites (chlorate, perchlorate, fosetyl-aluminum, glyphosate, aminomethylphosphonic acid (AMPA), phosphonic acid, N-acetyl AMPA, and N-acetyl glyphosate) in fruits and vegetables. After extraction with methanol, samples were diluted 5× with water. No derivatization was applied. Pesticides were separated in an anion-exchange column. Water was used as the ion chromatography mobile phase. A gradient was created by increasing the concentration of KOH in the mobile phase. Ion chromatography provided good and stable retention and separation for all studied compounds. All investigated pesticides had an LOQ of 0.01 mg/kg and a linear range of 0.01–0.50 mg/kg. The ion ratio of the m/z ions produced was stable and adequate (deviation &lt;30%) in all cases. The obtained mass errors (always in full-scan MS and MS2 mode) were &lt;0.2 mDa. The high resolution (&gt;100 000) provided by the Orbitrap analyzer with the low m/z ions obtained (e.g., m/z 80) was effective in obtaining low background matrix signals. The influence of postcolumn infusion of organic solvent on sensitivity was investigated. Acetonitrile was found to be more effective than methanol, increasing the sensitivity 3× with respect to water. The method was validated for five vegetable-based matrixes. Both the sample processing and the analytical measurement were very fast. Hence, the methodology is ideal for high-throughput work.