Dr. Sapna Patel M.C is an MD in Pathology with 18 years of service in the department of pathology at JSS medical College and Hospital. She is alumni of PG in Pathology of the same institution. As an academician, pathologist, and teacher by profession she is passionate towards diagnostic pathology and teaching. Skilled in teaching, designing curriculum and teaching schedule for undergraduates (MBBS, BDS), postgraduates (MD) and various paramedical courses (BSc allied health sciences).
She has 36 publications in national and international journals with poster and paper presentations in various national CMEs and conferences. She has guided two UG students for STS projects funded by ICMR, New Delhi and many Post graduate students. Her areas of special interest are Bone marrow aspiration and biopsies, histopathology, forensic pathology, fetal autopsies, and cytology with research work in the same field. She is actively involved as NAAC Coordinator, NABL Coordinator in cytopathology, Member
EDUCATION
MBBS, MD Pathology
RESEARCH, TEACHING, or OTHER INTERESTS
Pathology and Forensic Medicine, Multidisciplinary, Multidisciplinary, Multidisciplinary
17
Scopus Publications
11873
Scholar Citations
38
Scholar h-index
56
Scholar i10-index
Scopus Publications
A fetal autopsy study on congenital malformations among stillbirths in a tertiary care hospital Narayanappa D, Sinchana N, Vinutha S. P, Sapna Patel M. C, Shrisagar R. A, Manjunath G. V Scientific Reports, 2026 The present study was conducted to determine the pattern of distribution of congenital anomalies based on the system of involvement through fetal autopsy. A descriptive, cross-sectional study was performed on 50 stillborn fetuses. The objective of this study is to find out the association between congenital anomalies and maternal factors, congenital anomalies and fetal factors, and the association between autopsy findings and antenatal ultrasound reports. Each stillborn fetus was classified based on birth weight, gestational age, maternal age, gravidity of the mother, and socioeconomic status of the parents. The central nervous system anomalies (36%) are the most commonly observed congenital anomalies. The chi-square test showed a significant association between maternal medical disorders and congenital anomalies (p < 0.05). The chi-square test showed a significant association between maternal medical disorders and congenital anomalies (p < 0.05). The autopsy confirmed the antenatal ultrasound findings in 40 (80%) of the cases. There were significant additional findings observed in 7 (14%) cases, and ultrasound diagnosis was completely changed in 3 (6%) cases, after the final autopsy procedure. It should be mandatory to have an autopsy study for all the stillborn fetuses to predict and counsel for safe future pregnancy outcomes.
When Stress Strikes the Heart: A Case of Post-Myocardial Infarction Ventricular Rupture Leading to Cardiac Tamponade Smitha Rani, Sapna Patel, M. Jayakshimman, S Atma Bivin, Kaustubh Gaur Medical Journal of Dr D Y Patil Vidyapeeth, 2026 A BSTRACT Myocardial infarction (MI), a common cardiac event, is often associated with various complications. This case report unveils a unique and intriguing instance of post-MI ventricular rupture leading to cardiac tamponade, a condition attributed to emotional stress as a precipitating factor. While MI complications are well-documented, this case highlights the remarkable role of emotional stress as a potential trigger for catastrophic events in the aftermath of an MI. This case report underscores the intricate interplay between physiological and psychological factors in cardiovascular health. While MI and its complications are frequently studied and well-understood, the influence of emotional stress on cardiovascular events remains an area of ongoing research and clinical interest.
Unravelling Venom: Histopathological Changes After Snake Envenomation Saravana Prasanth, Smitha Rani, Pooja V Menon, Sapna Patel M C Journal of Forensic Medicine and Toxicology, 2025 This case study presents a detailed clinical account of a patient suffering from Snakebite envenoming (SBE), outlining the clinical symptoms, diagnostic approaches, focusing on histopathological changes seen in such cases. Histopathological changes following snake envenomation are crucial for understanding the mechanisms of venom toxicity and developing effective therapeutic interventions. These changes vary depending on the snake species, the venom composition, and the envenomation site. Locally, venom induces tissue necrosis, myonecrosis, and haemorrhage often accompanied by inflammation, vascular damage, and edema. In skeletal muscles, histological observations frequently reveal degenera tion, loss of myofibers, and infiltration of inflammatory cells. Venom’s proteolytic enzymes—particularly metallopro teinases—contribute significantly to the degradation of tissue and basement membranes, further exacerbating damage. Systemically, snake venom can target multiple organs, with histopathological changes observed in the liver, kidney, heart, and lungs. Hepatic injury often manifests as hepatocyte degeneration, sinusoidal congestion, and vacuolization. Renal histopathology shows acute tubular necrosis, glomerular damage, and interstitial inflammation—often a result of ven om-induced hemolysis, myoglobinuria, or direct nephrotoxic effects. Cardiotoxicity is evidenced by myocardial fiber damage, interstitial oedema, and inflammatory cell infiltration. Additionally, in pulmonary tissues, venom can lead to alveolar hemorrhage, congestion, and inflammation. These changes are further amplified by coagulopathies, dissem inated intravascular coagulation (DIC), and immune responses triggered by venom components. Understanding the histopathological changes not only highlights the mechanisms of venom toxicity but also aids in the development of antivenoms and adjunct therapies aimed at mitigating local and systemic damage.
Patterns of Histopathological Changes in Kidney in Phosphorus Poisoning-An Autopsy Finding Sapna Patel, Pallavi BR, Smitha Rani, Kushala P Journal of Forensic Medicine and Toxicology, 2025 Background Yellow phosphorus is a toxic, nonmetallic inorganic substance used in various sectors, such as fireworks, firecrackers, rodenticides, ammunition, match industries and fertilizers. We report a case of phosphorus poisoning with histopathological changes in the kidney. Case description An 18 years old male died from the consumption of rat poison (contains yellow phosphorous). On postmortem examination, yellowish discoloration was seen all over the body. Internal examination showed edematous brain. Yellowish discoloration with hemorrhagic areas was seen in the cerebellum along with yellowish discoloration of both liver and kidney. On histopathological examination of kidney, the proximal tubular epithelial cells were predominantly affected by diffuse cytoplasmic vacuolation. Glomerular epithelial cells showed cloudy swelling. No significant interstitial inflammation/tubulitis was seen.
Hybrid Lesion: Extrapulmonary Sequestration with Cystic Adenomatoid Malformation: A Rare Case Report Sapna Patel, Pallavi BR, Sheela Dev CS, Devi Sreelakshmi Indian Journal of Forensic Medicine and Pathology, 2024 Background: 10-25% of bronchopulmonary sequestration comprises extralobar sequestration (ELS). ELS are usually found between the left lower lobe and diaphragm and rarely infra-diaphragmatically. Case Description: 25 years old young female with 24 weeks of gestation was diagnosed with left supra adrenal mass in fetal anomaly scan. On fetal autopsy, the supra adrenal mass showed lung parenchyma with multiple cystic spaces which are lined by columnar to cuboidal cells. Bronchi and bronchioles were dilated. Skeletal muscle and cartilage were absent. Both grossly and microscopically, lungs and other organs were normal. Diagnosed as extralobar intraabdominal bronchopulmonary sequestration with cystic adenomatoid malformation suggestive of hybrid lesion. Hybrid lesion is a combination of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM). Clinical Relevance: Diagnosis of hybrid lesion during pregnancy is important for prenatal counselling, fetal intervention and birth planning.
A Case Report of Pulmonary Alveolar Proteinosis with Associated Opportunistic Infection of Pneumocystis jirovecii and Molluscum Contagiosum Sapna Patel, Deepika Gurumurthy, Smitha Rani, Sheela Devi Journal of Forensic Science and Medicine, 2024 Pulmonary alveolar proteinosis (PAP) is an idiopathic rare diffuse pulmonary disease, first described in 1958 by Rosen et al. Its estimated prevalence is about 1 in 3.7–6.9 × 106 with a male: female ratio of 1:1–2:1. Majority of the patient’s age ranges between 20 and 50 years. PAP on microscopy is characterized by the presence of massive insoluble, amorphous, phospholipid-rich protein deposits in the bronchial and alveolar cavities. Most patients with acquired PAP present with cough and exertional dyspnea. It has been studied that there is increased risk of superinfection in PAP with opportunistic organisms like pneumocystis and vice versa. Definitive diagnosis of Pneumocystis jirovecii pneumonia rests on the demonstration of the organism within the alveoli by special stains like Grocott Methenamine Silver stain. Molluscum contagiosum (MC) is a common superficial skin infection caused by the poxvirus. MC is characterized by painless papules commonly seen in children and immunocompromised individuals. Here, we present a 34-year-old female who had complaints of severe difficulty in breathing and was brought dead to our hospital. On external examination, she had multiple warts over chest, abdomen, and over genitalia. Internal examination was unremarkable. Specimens of kidney, lung, and skin biopsy of genital warts sent for histopathological examination revealed acute tubular necrosis, P. jirovecii with PAP, and MC respectively.
DEATH DUE TO TRAUMA OR DISEASE?-A CASE REPORT Smitha Rani, Gowri S Nair, Suraj S Shetty, MC Sapna Patel, M Arun Journal of Forensic Medicine and Toxicology, 2023 One of the complex problems encountered in forensic practice is the death of an individual who has suffered trauma but has an either pre-existing natural disease or where some natural disease has supervened after trauma. In such circumstances, ascertaining the relative role of trauma and disease and their contributions to death may become an acute medico-legal problem. Herein, we report a case of a 65-year-old male who sustained several injuries in a road traffic accident and died at the hospital after 14 days of treatment. The autopsy, histopathological examination, and review of hospital case records revealed a combination of injuries and diseases that could have contributed to his death. This case report discusses the apportionment of the contribution of trauma and/or disease to death and highlights the need to analyse the percentage of the contribution made by the trauma/ disease to the mortality in cases wherein both trauma and disease co-exist.
Spectrum of Neural Tube Defects Among the Fetal Autopsies in a Tertiary Care Hospital in Southern India Indian Journal of Forensic Medicine and Pathology, 2021
The Spectrum of Congenital Central Nervous System Anomalies Among Stillborn: An Autopsy Based Study S. P. Vinutha, D. Narayanappa, G. V. Manjunath, M. S. Sujatha, M. C. Sapna Patel, Deepa Bhat Annals of Neurosciences, 2020 Background: Congenital central nervous system (CNS) anomalies are the structural or functional abnormalities of the brain and spinal cord that occur during the intrauterine developmental process. Purpose: The present study aims to detect the prevalence of congenital CNS anomalies among stillborn fetuses, the association between congenital anomalies and maternal factors, and also the association between autopsy and ultrasound findings. Methods: This study was conducted on 50 stillborn fetuses, obtained from the Department of Obstetrics and Gynecology at JSS Medical College and Hospital, Mysuru. The fetuses were fixed in 10% formalin and autopsies were performed as per the standard fetal autopsy protocol. The congenital CNS anomalies were studied in detail. Results: CNS anomalies were the most common congenital anomalies observed. Out of the total 50 stillborn fetuses studied, CNS anomalies were found in 17 fetuses and their occurrence was more common among male stillborn than females. Meningomyelocele was the most common anomaly, followed by anencephaly. The other anomalies documented were meningocele, encephalocele, meningoencephalocele, agenesis of the corpus callosum, craniorachischisis, bifid cerebellum with hypoplastic vermis, holoprosencephaly, and sirenomelia. Fisher’s exact test showed a significant association between maternal hypothyroidism and congenital CNS anomalies ( P < .05). The autopsy confirmed the ultrasound findings in 40 (80%) fetuses. There were significant additional findings observed in seven (14%) fetal autopsies and ultrasound diagnosis completely changed in three (6%) cases, after the final autopsy procedure. Conclusion: The fetal autopsy is the single most directly evident investigation, which gives information that changes or significantly improves the clinical diagnosis. A multidisciplinary holistic approach toward pregnancy will help to detect any kind of abnormality in the fetus and thus to take a timely decision toward the management.
Influence of external magnetic field on the excitation of lower hybrid wave by beating of two different profile laser beams in spherical nanoparticles UK Tiwari, A Ansari, MS Patel, A Yadav, SP Mishra, A Kumar, A Kumar, ... Journal of the Korean Physical Society, 1-16 , 2026 2026
Resonant absorption of surface plasma wave over different metal and dielectric surface embedded with vertically aligned arrays of cylindrical shaped nanoparticles UK Tiwari, A Ansari, MS Patel, SP Mishra, A Yadav, A Kumar, A Kumar, ... The European Physical Journal Plus 140 (12), 1249 , 2025 2025 Citations: 1
Excitation of large-amplitude electron plasma wave by counterpropagation of two laser beams in spherical nanoparticles A Ansari, MS Patel, SP Mishra, A Kumar, A Kumar, A Varma Laser Physics 35 (4), 045402 , 2025 2025 Citations: 10
SYNTHESIS OF THE NOVEL COUMARIN PROBES AND SENSITIVE DETECTION AND SEPARATION OF CATIONS USING RP-LC AND THEORETICAL INVESTIGATIONS NH Ali, MT Abdulrahman, SH Ahmed, MS Patel, H Panwar, S Chetana, ... Rasayan Journal of Chemistry 18 (2) , 2025 2025 Citations: 1
Synthesis of a Series of Quinoline-Based New Chiral Reagent and Its Application in Separation of Racemic Mexiletine Followed by Liquid Chromatography and Confirmation of … M Solanki, S Sehlangia, VS Talismanov, A Damayanthi, MS Patel, ... Asian J. Chem 36 (2), 404-410 , 2024 2024 Citations: 5
AJ Csian OURNALOF HEMISTRY AJ Csian OURNALOF HEMISTRY GO OBAIAH, MA ABDULZAHRA, A TEWARI, MS PATEL, ... Asian Journal of Chemistry 36 (7), 1571-1578 , 2024 2024
MA19. 09 AI-Based Early Detection and Subtyping of Non-Small Cell Lung Cancer from Blood Samples Using Orphan Noncoding RNAs M Karimzadeh, TB Cavazos, J Wang, M Multhaup, Y Fang, J Ku, X Zhao, ... Journal of Thoracic Oncology 18 (11), S173 , 2023 2023 Citations: 1
Ipilimumab with or without nivolumab in PD-1 or PD-L1 blockade refractory metastatic melanoma: a randomized phase 2 trial A VanderWalde, SL Bellasea, KL Kendra, NI Khushalani, KM Campbell, ... Nature medicine 29 (9), 2278-2285 , 2023 2023 Citations: 182
Gusev Y and Shameer K (2022) StarGazer: A Hybrid Intelligence Platform for Drug Target Prioritization and Digital Drug Repositioning Using Streamlit C Lee, J Lin, A Prokop, V Gopalakrishnan, RN Hanna, E Papa, ... Application of Network Theoretic Approaches in Biology 45 (1), 37 , 2023 2023
Concurrent intrathecal and intravenous nivolumab in leptomeningeal disease: phase 1 trial interim results IC Glitza Oliva, SD Ferguson, R Bassett Jr, AP Foster, I John, ... Nature medicine 29 (4), 898-905 , 2023 2023 Citations: 83
Neoadjuvant–adjuvant or adjuvant-only pembrolizumab in advanced melanoma SP Patel, M Othus, Y Chen, GP Wright Jr, KJ Yost, JR Hyngstrom, ... New England Journal of Medicine 388 (9), 813-823 , 2023 2023 Citations: 926
Advances in the clinical management of uveal melanoma RD Carvajal, JJ Sacco, MJ Jager, DJ Eschelman, R Olofsson Bagge, ... Nature reviews Clinical oncology 20 (2), 99-115 , 2023 2023 Citations: 288
Death due to trauma or disease?-A case report S Rani, GS Nair, SS Shetty, MCS Patel, M Arun Journal of Forensic Medicine and Toxicology 40 (1), 121-124 , 2023 2023 Citations: 1
Neoadjuvant relatlimab and nivolumab in resectable melanoma RN Amaria, M Postow, EM Burton, MT Tetzlaff, MI Ross, C Torres-Cabala, ... Nature 611 (7934), 155-160 , 2022 2022 Citations: 377
Increased long-term bleeding complications in females undergoing endovascular revascularization for peripheral arterial disease K Marulanda, E Duchesneau, S Patel, SE Browder, DM Caruso, CB Agala, ... Journal of vascular surgery 76 (4), 1021-1029. e3 , 2022 2022 Citations: 7
Intermittent MEK inhibition for the treatment of metastatic uveal melanoma S Khan, SP Patel, AN Shoushtari, G Ambrosini, S Cremers, S Lee, ... Frontiers in Oncology 12, 975643 , 2022 2022 Citations: 10
Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy CP Vellano, MG White, MC Andrews, M Chelvanambi, RG Witt, ... Nature 606 (7915), 797-803 , 2022 2022 Citations: 127
Distinct molecular and immune hallmarks of inflammatory arthritis induced by immune checkpoint inhibitors for cancer therapy ST Kim, Y Chu, M Misoi, ME Suarez-Almazor, JH Tayar, H Lu, M Buni, ... Nature communications 13 (1), 1970 , 2022 2022 Citations: 119
The vaccine-site microenvironment: impacts of antigen, adjuvant, and same-site vaccination on antigen presentation and immune signaling MO Meneveau, P Kumar, KT Lynch, SP Patel, CL Slingluff Journal for immunotherapy of cancer 10 (3), e003533 , 2022 2022 Citations: 27
Photocatalytic Degradation of Rhodamine B Dye by Using Tin-Doped CeO 2 -Fe 2 O 3 Nanocomposite HS Al-Shehri, MS Patel, S Alwera, V Alwera, VS Talismanov, ... Asian Journal of Chemistry 34 (3), 673-680 , 2022 2022 Citations: 8
MOST CITED SCHOLAR PUBLICATIONS
B cells and tertiary lymphoid structures promote immunotherapy response BA Helmink, SM Reddy, J Gao, S Zhang, R Basar, R Thakur, K Yizhak, ... Nature 577 (7791), 549-555 , 2020 2020 Citations: 2753
Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response CN Spencer, JL McQuade, V Gopalakrishnan, JA McCulloch, M Vetizou, ... Science 374 (6575), 1632-1640 , 2021 2021 Citations: 952
Neoadjuvant–adjuvant or adjuvant-only pembrolizumab in advanced melanoma SP Patel, M Othus, Y Chen, GP Wright Jr, KJ Yost, JR Hyngstrom, ... New England Journal of Medicine 388 (9), 813-823 , 2023 2023 Citations: 926
Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma RN Amaria, SM Reddy, HA Tawbi, MA Davies, MI Ross, IC Glitza, ... Nature medicine 24 (11), 1649-1654 , 2018 2018 Citations: 921
Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance W Roh, PL Chen, A Reuben, CN Spencer, PA Prieto, JP Miller, ... Science translational medicine 9 (379), eaah3560 , 2017 2017 Citations: 915
Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients LG Radvanyi, C Bernatchez, M Zhang, PS Fox, P Miller, J Chacon, R Wu, ... Clinical Cancer Research 18 (24), 6758-6770 , 2012 2012 Citations: 541
Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade MC Andrews, CPM Duong, V Gopalakrishnan, V Iebba, WS Chen, ... Nature medicine 27 (8), 1432-1441 , 2021 2021 Citations: 449
Neoadjuvant relatlimab and nivolumab in resectable melanoma RN Amaria, M Postow, EM Burton, MT Tetzlaff, MI Ross, C Torres-Cabala, ... Nature 611 (7934), 155-160 , 2022 2022 Citations: 377
Neoadjuvant plus adjuvant dabrafenib and trametinib versus standard of care in patients with high-risk, surgically resectable melanoma: a single-centre, open-label, randomised … RN Amaria, PA Prieto, MT Tetzlaff, A Reuben, MC Andrews, MI Ross, ... The lancet oncology 19 (2), 181-193 , 2018 2018 Citations: 352
Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses K Robinson, R Kenefeck, EL Pidgeon, S Shakib, S Patel, RJ Polson, ... Gut 57 (10), 1375-1385 , 2008 2008 Citations: 302
Advances in the clinical management of uveal melanoma RD Carvajal, JJ Sacco, MJ Jager, DJ Eschelman, R Olofsson Bagge, ... Nature reviews Clinical oncology 20 (2), 99-115 , 2023 2023 Citations: 288
Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome A Torrelo, S Patel, I Colmenero, D Gurbindo, F Lendínez, A Hernández, ... Journal of the American Academy of Dermatology 62 (3), 489-495 , 2010 2010 Citations: 251
Hypoxia-driven immunosuppressive metabolites in the tumor microenvironment: new approaches for combinational immunotherapy Y Li, SP Patel, J Roszik, Y Qin Frontiers in immunology 9, 1591 , 2018 2018 Citations: 213
Ipilimumab with or without nivolumab in PD-1 or PD-L1 blockade refractory metastatic melanoma: a randomized phase 2 trial A VanderWalde, SL Bellasea, KL Kendra, NI Khushalani, KM Campbell, ... Nature medicine 29 (9), 2278-2285 , 2023 2023 Citations: 182
The tardigrade Hypsibius dujardini, a new model for studying the evolution of development WN Gabriel, R McNuff, SK Patel, TR Gregory, WR Jeck, CD Jones, ... Developmental biology 312 (2), 545-559 , 2007 2007 Citations: 182
First-in-human study of mivebresib (ABBV-075), an oral pan-inhibitor of bromodomain and extra terminal proteins, in patients with relapsed/refractory solid tumors SA Piha-Paul, JC Sachdev, M Barve, P LoRusso, R Szmulewitz, SP Patel, ... Clinical Cancer Research 25 (21), 6309-6319 , 2019 2019 Citations: 172
Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy CP Vellano, MG White, MC Andrews, M Chelvanambi, RG Witt, ... Nature 606 (7915), 797-803 , 2022 2022 Citations: 127
Aloe–emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells M Acevedo-Duncan, C Russell, S Patel, R Patel International immunopharmacology 4 (14), 1775-1784 , 2004 2004 Citations: 120
Distinct molecular and immune hallmarks of inflammatory arthritis induced by immune checkpoint inhibitors for cancer therapy ST Kim, Y Chu, M Misoi, ME Suarez-Almazor, JH Tayar, H Lu, M Buni, ... Nature communications 13 (1), 1970 , 2022 2022 Citations: 119
Helicobacter pylori dupA Is Polymorphic, and Its Active Form Induces Proinflammatory Cytokine Secretion by Mononuclear Cells NR Hussein, RH Argent, CK Marx, SR Patel, K Robinson, JC Atherton The Journal of infectious diseases 202 (2), 261-269 , 2010 2010 Citations: 104
Publications
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Industry, Institute, or Organisation Collaboration
