Pharmacology, Toxicology and Pharmaceutics, Pharmaceutical Science, General Pharmacology, Toxicology and Pharmaceutics
25
Scopus Publications
825
Scholar Citations
16
Scholar h-index
16
Scholar i10-index
Scopus Publications
Antifungal activity of oily core PEGylated PLGA nanocapsules loaded with Penicillium oxalicum fungal extract: in vitro, in vivo, and in silico study Engy Elekhnawy, Dalia H. Abdelkader, Duaa Eliwa, Sarah Ibrahim, Moataz A. Shaldam, et al. Microbial Cell Factories, 2026 The rise of difficult-to-treat fungal infections necessitates novel therapeutic strategies. In this study, endophytic fungi were isolated from Acalypha hispida leaves and molecularly identified as Penicillium oxalicum via 18S rRNA sequencing. LC–MS/MS analysis of the fungal extract revealed major bioactive compounds, including linoleic acid, sinapinic acid, alternariol monomethyl ether, ellagic acid, and kaurenic acid. Oily-core poly (ethylene glycol) methyl ether-block-poly(lactide- co -glycolide) nanocapsules (PEGylated PLGA NCs) were developed to encapsulate the fungal extract, improving stability and bioavailability. The PEGylated PLGA NCs exhibited controlled particle size, positive surface charge, and spherical morphology. In vitro, the PEGylated PLGA NCs demonstrated antifungal activity against Candida albicans with inhibition zones of 10–14 mm. In vivo, treatment significantly improved histological features of the kidney, liver, and spleen, and reduced tumor necrosis factor-alpha and cyclooxygenase-2 expression. In silico studies further confirmed the potential of the major compounds of the fungal extract to inhibit C. albicans aspartic proteinases SAP4-6. These findings suggest that PEGylated PLGA NCs loaded with P. oxalicum extract represent a promising antifungal therapeutic strategy.
Controlled anti-solvent precipitation for enhanced dissolution rate and antiplatelet activity of ticagrelor Asmaa M. Eldeeb, Dalia H. Abdelkader, Gamal M. El Maghraby Pharmaceutical Development and Technology, 2025 The goal of our study is to augment ticagrelor (TC)'s dissolution rate and antiplatelet activity via controlled antisolvent precipitation. A saturated ethanolic solution of TC was prepared in the absence and presence of poloxamer 188 or gelucire 44/14. Aerosil 200 was added before controlled precipitation using water or water-containing poloxamer (1% w/v). The resulting precipitate was dried and characterized using Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and in vitro dissolution. FTIR showed hydrogen bonding after the processing of TC. DSC and PXRD reflected partial amorphization. A significant enhancement (p < 0.05) in dissolution efficiency and TC amount released after five minutes was also shown. The most effective composition was F6, which comprised TC, poloxamer, and Aerosil (5:5:2.5), or F9, utilizing gelucire instead of poloxamer at a similar ratio. Assessment of tail bleeding time (min) exhibited a significant (p < 0.05) prolongation for rat groups treated with F6 (24.71 ± 5.46) and F9 (30.06 ± 1.63) compared with negative control (3.43 ± 0.46) and unprocessed TC (5.78 ± 2.18). These results suggest an enhancement of TC's pharmacological activity probably due to enhanced bioavailability imparted with an enhanced dissolution rate. The study introduced controlled antisolvent precipitation as a simple tool for hastened TC's dissolution.
Muco-bioadhesive gel containing basil extract (Ocimum basilicum) in the management of recurrent aphthous stomatitis: a randomized clinical and immunological study Malak Y.M. Shoukheba, Amany E. Eagab, Nagwa A. Shoeib, Dalia H. Abdelkader, Mona M.W. Mahmoud, et al. Tanta Dental Journal, 2024 Background Recurrent aphthous ulcer (RAU) is a widespread highly prevalent disorder that impairs the life quality of the affected persons and leads to difficulties in daily activities such as talking, eating, and oral hygiene maintenance. Aim To evaluate the efficiency of basil extract (Ocimum basilicum) loaded in poly (vinylacohol)–borate hydrogel for topical application in the treatment of RAU. Patients and methods Twenty patients with a clear history of frequent eruption of RAU, their ages ranges between 18 and 45 years, and presented with mucosal ulcer (2 days or less duration and ≥4 mm in diameter). The patients were randomly allocated into two groups, group I (test group): 10 patients treated with mucoadhesive gel containing 2% of basil extract. Group II (placebo group): 10 patients treated with placebo gel. The healing period, pain scale, and the size of the ulcer were evaluated. Salivary endocan was collected at baseline and 5 days after materials application. Results There was no significant difference between the test and control group, while there were statistically significant differences between them and the healthy group at baseline clinically and immunologically. At 5 days there was a significant reduction in the degree of pain sensation, healing period, ulcer size, and decrease in the level of salivary endocan for both groups with statistically significant differences between them observed in the test group more than the control group in all tested parameters. Conclusion Using the muco-bioadhesive gel containing basil extract (O. basilicum) shows promise as a therapy for the management of patients with RAU.
Fabrication of Celecoxib PVP Microparticles Stabilized by Gelucire 48/16 via Electrospraying for Enhanced Anti-Inflammatory Action Samar Zuhair Alshawwa, Thanaa A. El-Masry, Engy Elekhnawy, Hadil Faris Alotaibi, Al-Sayed Sallam, et al. Pharmaceuticals, 2023 Electrospraying (ES) technology is considered an efficient micro/nanoparticle fabrication technique with controlled dimensions and diverse morphology. Gelurice® 48/16 (GLR) has been employed to stabilize the aqueous dispersion of Celecoxib (CXB) for enhancing its solubility and oral bioavailability. Our formula is composed of CXB loaded in polyvinylpyllodine (PVP) stabilized with GLR to formulate microparticles (MPs) (CXB-GLR-PVP MPs). CXB-GLR-PVP MPs display excellent in vitro properties regarding particle size (548 ± 10.23 nm), zeta potential (−20.21 ± 2.45 mV), and drug loading (DL, 1.98 ± 0.059 mg per 10 mg MPs). CXB-GLR-PVP MPs showed a significant (p < 0.05) higher % cumulative release after ten minutes (50.31 ± 4.36) compared to free CXB (10.63 ± 2.89). CXB exhibited good dispersibility, proved by X-ray diffractometry (XRD), adequate compatibility of all components, confirmed by Fourier-Transform Infrared Spectroscopy (FTIR), and spherical geometry as revealed in scanning electron microscopy (SEM). Concerning our anti-inflammatory study, there was a significant decrease in the scores of the inflammatory markers’ immunostaining in the CXB-GLR-PVP MPs treated group. Also, the amounts of the oxidative stress biomarkers, as well as mRNA expression of interleukins (IL-1β and IL-6), considerably declined (p < 0.05) in CXB-GLR-PVP MPs treated group alongside an enhancement in the histological features was revealed. CXB-GLR-PVP MPs is an up-and-coming delivery system that could be elucidated in future clinical investigations.
Metoclopramide loaded buccal films for potential treatment of migraine symptoms: in vitro and in vivo study Omar Mady, Sara Hussien, Dalia H. Abdelkader, Enas elZahaby Pharmaceutical Development and Technology, 2023 Objective Developing mucoadhesive buccal films loaded with metoclopramide for the treatment of migraine-associated vomiting. Methods Buccal films were prepared using the solvent casting method. Several tests were conducted, including measurement of film weight, thickness, drug content, moisture uptake, swelling index, and DSC analysis. The bioadhesion properties were also assessed. Furthermore, in vitro release profiles and in human bioavailability were studied. Results The developed films were transparent, homogeneous, and easy to remove. Film weight and thickness increased with higher drug content. The drug entrapment exceeded 90%. Film weight increased with moisture uptake, and DSC analysis indicated the absence of drug crystallinity. Bioadhesion properties and swelling index decreased with increasing drug content. In vitro release demonstrated that drug release depended on the drug-polymer ratio. The in vivo study showed significant improvements in Tmax (from 1.21 ± 0.33 to 0.50 ± 0.0) and Cmax (from 45.29 ± 14.66 to 63.27 ± 24.85) compared to conventional tablets. Conclusion The prepared mucoadhesive buccal films exhibited the desired characteristics and demonstrated enhanced drug absorption, evidenced by the significantly reduced Tmax and increased Cmax compared to conventional tablets. The results indicate the successful achievement of the study objectives in selecting and designing an effective pharmaceutical dosage form. as cm2
Capryol-Ethyl oleate self-microemulsifying system for improved intestinal absorption and hypoglycemic activity of empagliflozin EM Hathout, SS Eltokhy, DH Abdelkader, GME Maghraby Pharmaceutical Development and Technology, 1-21 , 2026 2026
Antifungal activity of oily core PEGylated PLGA nanocapsules loaded with Penicillium oxalicum fungal extract: in vitro, in vivo, and in silico study E Elekhnawy, DH Abdelkader, D Eliwa, S Ibrahim, MA Shaldam, ... Microbial Cell Factories 25, 37 , 2026 2026
Exploring solid dispersion approach to improve the dissolution of atorvastatin calcium trihydrate ME Mohamed, DH Abdelkader, EA Essa Bulletin of Pharmaceutical Sciences Assiut University , 2025 2025
Controlled anti-solvent precipitation for enhanced dissolution rate and antiplatelet activity of ticagrelor AM Eldeeb, DH Abdelkader, GM El Maghraby Pharmaceutical Development and Technology 30 (4), 463-473 , 2025 2025 Citations: 2
Pioglitazone repurposing via in-situ gelling system: An effective topical strategy for wound management DH Abdelkader, SM Elshaer, EA Elkordy, NI Sarhan, EA Essa Journal of Drug Delivery Science and Technology 106, 106723 , 2025 2025 Citations: 1
In-Vitro Characterization and In-Vivo Pharmacokinetic Study of Zolmitriptan Mucoadhesive Buccal Film for Expedited Migraine Relief EI El Zahaby, O Yasin Mady, DH Abdelkader, SG Hussien Journal of Advanced Medical and Pharmaceutical Research 6 (1), 22-31 , 2025 2025 Citations: 1
Fabrication and in-vivo evaluation of polyvinyl pyrrolidone/poloxamer 188 hybrid nanofibers of deflazacort DH Abdelkader, AM Belal, EA Elkordy, NI Sarhan, EA Essa International Journal of Pharmaceutics 655, 123997 , 2024 2024 Citations: 7
Muco-bioadhesive gel containing basil extract (Ocimum basilicum) in the management of recurrent aphthous stomatitis: a randomized clinical and immunological study MYM Shoukheba, AE Eagab, NA Shoeib, DH Abdelkader, ... Tanta Dental Journal 21 (1), 74-81 , 2024 2024
Antiviral and antibacterial potential of electrosprayed PVA/PLGA nanoparticles loaded with chlorogenic acid for the management of coronavirus and Pseudomonas aeruginosa lung … A Saleh, DH Abdelkader, TA El-Masry, D Eliwa, B Alotaibi, WA Negm, ... Artificial cells, nanomedicine, and biotechnology 51 (1), 255-267 , 2023 2023 Citations: 17
Green synthetized Cu-Oxide Nanoparticles: Properties and applications for enhancing healing of wounds infected with Staphylococcus aureus B Alotaibi, E Elekhnawy, TA El-Masry, A Saleh, MM El-Bouseary, ... International Journal of Pharmaceutics 645, 123415 , 2023 2023 Citations: 19
Metoclopramide loaded buccal films for potential treatment of migraine symptoms: in vitro and in vivo study O Mady, S Hussien, DH Abdelkader, E elZahaby Pharmaceutical Development and Technology 28 (7), 650-659 , 2023 2023 Citations: 7
Green synthesised zinc oxide nanoparticles reveal potent in vivo and in vitro antibacterial efficacy against Proteus mirabilis isolates E Elekhnawy, AS Almurshedi, DH Abdelkader, TA El-Masry, BN Aldosari, ... International Journal of Pharmaceutics 642, 123111 , 2023 2023 Citations: 8
Fabrication of Celecoxib PVP microparticles stabilized by Gelucire 48/16 via electrospraying for enhanced anti-inflammatory action SZ Alshawwa, TA El-Masry, E Elekhnawy, HF Alotaibi, AS Sallam, ... Pharmaceuticals 16 (2), 258 , 2023 2023 Citations: 9
Aqueous core epigallocatechin gallate PLGA nanocapsules: characterization, antibacterial activity against uropathogens, and in vivo reno-protective effect in … B Alotaibi, TA El-Masry, E Elekhnawy, AH El-Kadem, A Saleh, WA Negm, ... Drug Delivery 29 (1), 1848-1862 , 2022 2022 Citations: 50
Antibacterial activity of nano zinc oxide green-synthesised from Gardenia thailandica triveng. Leaves against Pseudomonas aeruginosa clinical isolates: in vitro … B Alotaibi, WA Negm, E Elekhnawy, TA El-Masry, ME Elharty, A Saleh, ... Artificial Cells, Nanomedicine, and Biotechnology 50 (1), 96-106 , 2022 2022 Citations: 62
Insight into fucoidan-based PEGylated PLGA nanoparticles encapsulating methyl anthranilic acid: in vitro evaluation and in vivo anti-inflammatory study DH Abdelkader, E Elekhnawy, WA Negm, TA El-Masry, M Almukainzi, ... Marine Drugs 20 (11), 694 , 2022 2022 Citations: 28
Co-delivery of gentiopicroside and thymoquinone using electrospun m-PEG/PVP nanofibers: In-vitro and In vivo studies for antibacterial wound dressing in diabetic rats M Almukainzi, TA El-Masry, WA Negm, E Elekhnawy, A Saleh, AE Sayed, ... International journal of pharmaceutics 625, 122106 , 2022 2022 Citations: 55
Zinc Oxide Nanoparticles as Potential Delivery Carrier: Green Synthesis by Aspergillus niger Endophytic Fungus, Characterization, and In Vitro/In Vivo Antibacterial … DH Abdelkader, WA Negm, E Elekhnawy, D Eliwa, BN Aldosari, ... Pharmaceuticals 15 (9), 1057 , 2022 2022 Citations: 92
Gentiopicroside PLGA nanospheres: fabrication, in vitro characterization, antimicrobial action, and in vivo effect for enhancing wound healing in diabetic rats M Almukainzi, T A El-Masry, W A Negm, E Elekhnawy, A Saleh, ... International Journal of Nanomedicine, 1203-1225 , 2022 2022 Citations: 63
Antimicrobial Activity of Brassica rapa L. Flowers Extract on Gastrointestinal Tract Infections and Antiulcer Potential Against Indomethacin-Induced Gastric Ulcer in … B Alotaibi, FA Mokhtar, TA El-Masry, E Elekhnawy, SA Mostafa, ... Journal of Inflammation Research, 7411-7430 , 2021 2021 Citations: 54
MOST CITED SCHOLAR PUBLICATIONS
Zinc Oxide Nanoparticles as Potential Delivery Carrier: Green Synthesis by Aspergillus niger Endophytic Fungus, Characterization, and In Vitro/In Vivo Antibacterial … DH Abdelkader, WA Negm, E Elekhnawy, D Eliwa, BN Aldosari, ... Pharmaceuticals 15 (9), 1057 , 2022 2022 Citations: 92
Enhanced cutaneous wound healing in rats following topical delivery of insulin-loaded nanoparticles embedded in poly (vinyl alcohol)-borate hydrogels DH Abdelkader, MM Tambuwala, CA Mitchell, MA Osman, SA El-Gizawy, ... Drug delivery and translational research 8 (5), 1053-1065 , 2018 2018 Citations: 69
Novel drug delivery systems AM Faheem, DH Abdelkader Engineering drug delivery systems, 1-16 , 2020 2020 Citations: 64
Gentiopicroside PLGA nanospheres: fabrication, in vitro characterization, antimicrobial action, and in vivo effect for enhancing wound healing in diabetic rats M Almukainzi, T A El-Masry, W A Negm, E Elekhnawy, A Saleh, ... International Journal of Nanomedicine, 1203-1225 , 2022 2022 Citations: 63
Antibacterial activity of nano zinc oxide green-synthesised from Gardenia thailandica triveng. Leaves against Pseudomonas aeruginosa clinical isolates: in vitro … B Alotaibi, WA Negm, E Elekhnawy, TA El-Masry, ME Elharty, A Saleh, ... Artificial Cells, Nanomedicine, and Biotechnology 50 (1), 96-106 , 2022 2022 Citations: 62
The Role of Insulin in Wound Healing Process: Mechanism of Action and Pharmaceutical Applications DMH Abdelkader Journal of Analytical & Pharmaceutical Research - MedCrave, Jan 13, 2016 , 2016 2016 Citations: 59
Co-delivery of gentiopicroside and thymoquinone using electrospun m-PEG/PVP nanofibers: In-vitro and In vivo studies for antibacterial wound dressing in diabetic rats M Almukainzi, TA El-Masry, WA Negm, E Elekhnawy, A Saleh, AE Sayed, ... International journal of pharmaceutics 625, 122106 , 2022 2022 Citations: 55
Antimicrobial Activity of Brassica rapa L. Flowers Extract on Gastrointestinal Tract Infections and Antiulcer Potential Against Indomethacin-Induced Gastric Ulcer in … B Alotaibi, FA Mokhtar, TA El-Masry, E Elekhnawy, SA Mostafa, ... Journal of Inflammation Research, 7411-7430 , 2021 2021 Citations: 54
Aqueous core epigallocatechin gallate PLGA nanocapsules: characterization, antibacterial activity against uropathogens, and in vivo reno-protective effect in … B Alotaibi, TA El-Masry, E Elekhnawy, AH El-Kadem, A Saleh, WA Negm, ... Drug Delivery 29 (1), 1848-1862 , 2022 2022 Citations: 50
Effect of process variables on formulation, in-vitro characterisation and subcutaneous delivery of insulin PLGA nanoparticles: an optimisation study DH Abdelkader, SA El-Gizawy, AM Faheem, PA McCarron, MA Osman Journal of Drug Delivery Science and Technology 43, 160-171 , 2018 2018 Citations: 45
A novel sustained anti-inflammatory effect of atorvastatin—calcium PLGA nanoparticles: in vitro optimization and in vivo evaluation DH Abdelkader, AK Abosalha, MA Khattab, BN Aldosari, AS Almurshedi Pharmaceutics 13 (10), 1658 , 2021 2021 Citations: 41
Effect of poly (ethylene glycol) on insulin stability and cutaneous cell proliferation in vitro following cytoplasmic delivery of insulin-loaded nanoparticulate carriers–A … DH Abdelkader, MA Osman, SA El-Gizawy, SJ Hawthorne, AM Faheem, ... European Journal of Pharmaceutical Sciences 114, 372-384 , 2018 2018 Citations: 35
Insight into fucoidan-based PEGylated PLGA nanoparticles encapsulating methyl anthranilic acid: in vitro evaluation and in vivo anti-inflammatory study DH Abdelkader, E Elekhnawy, WA Negm, TA El-Masry, M Almukainzi, ... Marine Drugs 20 (11), 694 , 2022 2022 Citations: 28
Characterisation and in vitro stability of low-dose, lidocaine-loaded poly(vinyl alcohol)-tetrahydroxyborate hydrogels DMH Abdelkader International Journal of Pharmaceutics, Jan 18, 2016 , 2016 2016 Citations: 20
Green synthetized Cu-Oxide Nanoparticles: Properties and applications for enhancing healing of wounds infected with Staphylococcus aureus B Alotaibi, E Elekhnawy, TA El-Masry, A Saleh, MM El-Bouseary, ... International Journal of Pharmaceutics 645, 123415 , 2023 2023 Citations: 19
Antiviral and antibacterial potential of electrosprayed PVA/PLGA nanoparticles loaded with chlorogenic acid for the management of coronavirus and Pseudomonas aeruginosa lung … A Saleh, DH Abdelkader, TA El-Masry, D Eliwa, B Alotaibi, WA Negm, ... Artificial cells, nanomedicine, and biotechnology 51 (1), 255-267 , 2023 2023 Citations: 17
Fabrication of Celecoxib PVP microparticles stabilized by Gelucire 48/16 via electrospraying for enhanced anti-inflammatory action SZ Alshawwa, TA El-Masry, E Elekhnawy, HF Alotaibi, AS Sallam, ... Pharmaceuticals 16 (2), 258 , 2023 2023 Citations: 9
Green synthesised zinc oxide nanoparticles reveal potent in vivo and in vitro antibacterial efficacy against Proteus mirabilis isolates E Elekhnawy, AS Almurshedi, DH Abdelkader, TA El-Masry, BN Aldosari, ... International Journal of Pharmaceutics 642, 123111 , 2023 2023 Citations: 8
Fabrication and in-vivo evaluation of polyvinyl pyrrolidone/poloxamer 188 hybrid nanofibers of deflazacort DH Abdelkader, AM Belal, EA Elkordy, NI Sarhan, EA Essa International Journal of Pharmaceutics 655, 123997 , 2024 2024 Citations: 7
Metoclopramide loaded buccal films for potential treatment of migraine symptoms: in vitro and in vivo study O Mady, S Hussien, DH Abdelkader, E elZahaby Pharmaceutical Development and Technology 28 (7), 650-659 , 2023 2023 Citations: 7