Salma Elsherbeni

Scopus Publications

Accessing Highly Substituted Indoles via B(C<inf>6</inf>F<inf>5</inf>)<inf>3</inf>-Catalyzed Secondary Alkyl Group Transfer
Salma A. Elsherbeni, Rebecca L. Melen, Alexander P. Pulis, and Louis C. Morrill
American Chemical Society (ACS)
Herein, we report a synthetic method to access a range of highly substituted indoles via the B(C6F5)3-catalyzed transfer of 2° alkyl groups from amines. The transition-metal-free catalytic approach has been demonstrated across a broad range of indoles and amine 2° alkyl donors, including various substituents on both reacting components, to access useful C(3)-alkylated indole products. The alkyl transfer process can be performed using Schlenk line techniques in combination with commercially available B(C6F5)3·nH2O and solvents, which obviates the requirement for specialized equipment (e.g., glovebox).


Recent Advances in Catalysis using Organoborane Mediated Hydride Abstraction
Rebecca L. Melen, Louis C. Morrill, Alexander P. Pulis, Joseph P. Gillions, Salma A. Elsherbeni, Laura Winfrey, and Lei Yun
Georg Thieme Verlag KG
AbstractC–H functionalization is widely regarded as an important area in the development of synthetic methodology, enabling the design of more time- and atom-efficient syntheses. The ability of electron-deficient organoboranes to mediate hydride abstraction from α-amino C–H bonds is therefore of great interest, as the reactive iminium and hydridoborate moieties generated are able to participate in a range of synthetically useful transformations. In this review, we cover the recent advances made in organoborane-mediated hydride abstraction, and focus on the catalytic applications of electron-deficient boranes in α- or β-functionalization, α,β-difunctionalization, and the dehydrogenation of amines.1 Introduction2 α-Functionalization of Amines3 β-Functionalization of Amines4 α,β-Difunctionalization of Amines5 Dehydrogenation of Amines6 Summary and Future Prospects


B(C<inf>6</inf>F<inf>5</inf>)<inf>3</inf>-Catalyzed E-Selective Isomerization of Alkenes
Betty A. Kustiana, Salma A. Elsherbeni, Thomas G. Linford‐Wood, Rebecca L. Melen, Matthew N. Grayson, and Louis C. Morrill
Wiley
AbstractHerein, we report the B(C6F5)3‐catalyzed E‐selective isomerization of alkenes. The transition‐metal‐free method is applicable across a diverse array of readily accessible substrates, giving access to a broad range of synthetically useful products containing versatile stereodefined internal alkenes. The reaction mechanism was investigated by using synthetic and computational methods.