Daniela Catanzaro
Verified @gmail.com
LTCA-ULSS8
Scopus Publications
- Impact of mesenchymal stromal/stem cell infusions on circulating inflammatory biomarkers in COVID-19 patients: analysis of a phase I-IIa trial
Roberto Tonelli, Francesca Pischiutta, Francesca Elice, Elisa R Zanier, Giulia Grisendi, et al.
Cytotherapy, 2025 - A rescue approach in refractory diffuse large B-cell lymphoma with obinutuzumab-redirected cytokine-induced killer cells: a first-in-human case report
Francesca Elice, Roberta Sommaggio, Elisa Cappuzzello, Marcello Riva, Maria Chiara Tisi, et al.
Haematologica, 2024
Not available. - Correction: Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy (Cell Death & Disease, (2022), 13, 4, (398), 10.1038/s41419-022-04741-9)
Caterina Vianello, Veronica Cocetta, Daniela Catanzaro, Gerald W Dorn, Angelo De Milito, et al.
Cell Death and Disease, 2024 - Correction: Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy (Cell Death & Disease, (2022), 13, 4, (398), 10.1038/s41419-022-04741-9)
Caterina Vianello, Veronica Cocetta, Daniela Catanzaro, Gerald W Dorn, Angelo De Milito, et al.
Cell Death and Disease, 2023 - Enalaprilat and losartan decrease erythroid precursors frequency in cells from patients with polycythemia vera
Angela Bozza, Martina Bernardi, Daniela Catanzaro, Katia Chieregato, Anna Merlo, et al.
Hematology United Kingdom, 2023
OBJECTIVE Polycythemia Vera (PV) is a myeloproliferative neoplasm characterized by the overproduction of red blood cells. First-line therapies are directed at lowering hematocrit levels. After the discovery of a mutation in the Janus kinase 2 (JAK2V617F), JAK2 inhibitors have been tested as second-line therapies. Despite these approaches, there is still the need for a major comprehension of the mechanisms involved in PV erythrocytosis and of more effective therapies. Angiotensin-converting enzyme (ACE) stimulates hematopoietic precursors proliferation and erythroid differentiation. We thus hypothesized that ACE inhibition could help in controlling erythrocytosis in PV. METHODS We assessed the clonogenic potential by colony-forming unit (CFU) assay of mononuclear cells isolated from PV JAK2 positive or JAK2 negative patients with erythrocytosis treated with enalaprilat or losartan. RESULTS Treatment with drugs led to a decrease of erythroid precursor frequency both in the presence and absence of JAK2 mutation, with a high extent in JAK2 positive cells and without affecting other types of precursors. No dose-dependent effect was observed. CONCLUSIONS Our results demonstrate that ACE inhibition reduces erythroid precursor frequency, confirming the involvement of ACE in erythrocytosis despite the presence of JAK2 mutation and encouraging the hypothesis that ACE inhibitors and AT1R antagonists could help in directly managing erythrocytosis in PV. - Correction: Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy (Cell Death & Disease, (2022), 13, 4, (398), 10.1038/s41419-022-04741-9)
Caterina Vianello, Veronica Cocetta, Daniela Catanzaro, Gerald W Dorn, Angelo De Milito, et al.
Cell Death and Disease, 2022 - Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy
Caterina Vianello, Veronica Cocetta, Daniela Catanzaro, Gerald W Dorn, Angelo De Milito, et al.
Cell Death and Disease, 2022
Cisplatin (CDDP) is commonly used to treat a multitude of tumors including sarcomas, ovarian and cervical cancers. Despite recent investigations allowed to improve chemotherapy effectiveness, the molecular mechanisms underlying the development of CDDP resistance remain a major goal in cancer research. Here, we show that mitochondrial morphology and autophagy are altered in different CDDP resistant cancer cell lines. In CDDP resistant osteosarcoma and ovarian carcinoma, mitochondria are fragmented and closely juxtaposed to the endoplasmic reticulum; rates of mitophagy are also increased. Specifically, levels of the mitophagy receptor BNIP3 are higher both in resistant cells and in ovarian cancer patient samples resistant to platinum-based treatments. Genetic BNIP3 silencing or pharmacological inhibition of autophagosome formation re-sensitizes these cells to CDDP. Our study identifies inhibition of BNIP3-driven mitophagy as a potential therapeutic strategy to counteract CDDP resistance in ovarian carcinoma and osteosarcoma. - Selective cell cycle arrest in glioblastoma cell lines by quantum molecular resonance alone or in combination with temozolomide
Daniela Catanzaro, Gloria Milani, Angela Bozza, Martina Bernardi, Katia Chieregato, et al.
British Journal of Cancer, 2022
Background Glioblastoma is the most aggressive form of brain cancer, characterised by high proliferation rates and cell invasiveness. Despite advances in surgery and radio-chemotherapy, patients continue to have poor prognoses, with a survival rate of 14–15 months. Thus, new therapeutic strategies are needed. Non-ionising electromagnetic fields represent an emerging option given the potential advantages of safety, low toxicity and the possibility to be combined with other therapies. Methods Here, the anticancer activity of quantum molecular resonance (QMR) was investigated. For this purpose, three glioblastoma cell lines were tested, and the QMR effect was evaluated on cancer cell proliferation rate and aggressiveness. To clarify the QMR mechanism of action, the proteomic asset after stimulation was delineated. Mesenchymal stromal cells and astrocytes were used as healthy controls. Results QMR affected cancer cell proliferation, inducing a significant arrest of cell cycle progression and reducing cancer tumorigenicity. These parameters were not altered in healthy control cells. Proteomic analysis suggested that QMR acts not only on DNA replication but also on the machinery involved in the mitotic spindle assembly and chromosome segregation. Moreover, in a combined therapy assessment, QMR significantly enhanced temozolomide efficacy. Conclusions QMR technology appears to be a promising tool for glioblastoma treatment. - Cannabidiol Isolated From Cannabis sativa L. Protects Intestinal Barrier From In Vitro Inflammation and Oxidative Stress
Veronica Cocetta, Paolo Governa, Vittoria Borgonetti, Mattia Tinazzi, Gregorio Peron, et al.
Frontiers in Pharmacology, 2021
The relevance and incidence of intestinal bowel diseases (IBD) have been increasing over the last 50 years and the current therapies are characterized by severe side effects, making essential the development of new strategies that combine efficacy and safety in the management of human IBD. Herbal products are highly considered in research aimed at discovering new approaches for IBD therapy and, among others, Cannabis sativa L. has been traditionally used for centuries as an analgesic and anti-inflammatory remedy also in different gastrointestinal disorders. This study aims to investigate the effects of different C. sativa isolated compounds in an in vitro model of intestinal epithelium. The ability of treatments to modulate markers of intestinal dysfunctions was tested on Caco-2 intestinal cell monolayers. Our results, obtained by evaluation of ROS production, TEER and paracellular permeability measurements and tight junctions evaluation show Cannabidiol as the most promising compound against intestinal inflammatory condition. Cannabidiol is able to inhibit ROS production and restore epithelial permeability during inflammatory and oxidative stress conditions, suggesting its possible application as adjuvant in IBD management. - Further assessment of Salvia haenkei as an innovative strategy to counteract skin photo-aging and restore the barrier integrity
Veronica Cocetta, Jessica Cadau, Miriam Saponaro, Isabella Giacomini, Stefano Dall’Acqua, et al.
Aging, 2021
Skin is the essential barrier of the human body which performs multiple functions. Endogenous factors, in concert with external assaults, continuously affect skin integrity, leading to distinct structural changes that influence not only the skin appearance but also its various physiological functions. Alterations of the barrier functions lead to an increased risk of developing disease and side reactions, thus the importance of maintaining the integrity of the epidermal barrier and slowing down the skin aging process is evident. Salvia haenkei (SH) has been recently identified as a potential anti-senescence agent; its extract is able to decrease the level of senescent cells by affecting the IL1α release and reducing reactive oxygen species (ROS) generation. In this study, SH extract was tested on human keratinocyte cell line (HaCaT) exposed to stress factors related to premature aging of cells such as free radicals and ultraviolet B radiation. We confirmed that SH acts as scavenger of ROS and found its ability to restore the skin barrier integrity by reinforcing the cytoskeleton structure, sealing the tight junctions and increasing the migration rate of cells. Given these results, this work becomes relevant, identifying Salvia haenkei as a compound useful for anti-aging skin treatment in clinical performance. - Logistics of an advanced therapy medicinal product during COVID-19 pandemic in Italy: successful delivery of mesenchymal stromal cells in dry ice
Giuseppe Astori, Martina Bernardi, Angela Bozza, Daniela Catanzaro, Katia Chieregato, et al.
Journal of Translational Medicine, 2020 - A fixed combination of probiotics and herbal extracts attenuates intestinal barrier dysfunction from inflammatory stress in an in vitro model using caco-2 cells
Veronica Cocetta, Daniela Catanzaro, Vittoria Borgonetti, Eugenio Ragazzi, Maria C. Giron, et al.
Recent Patents on Food Nutrition and Agriculture, 2019 - Effects of boswellia serrata roxb. And curcuma longa l. in an in vitro intestinal inflammation model using immune cells and caco-2
Paolo Governa, Maddalena Marchi, Veronica Cocetta, Bianca De Leo, Philippa Saunders, et al.
Pharmaceuticals, 2018 - Cisplatin liposome and 6-amino nicotinamide combination to overcome drug resistance in ovarian cancer cells
Daniela Catanzaro, Silvia Nicolosi, Veronica Cocetta, Marika Salvalaio, Andrea Pagetta, et al.
Oncotarget, 2018 - Silybin counteracts doxorubicin resistance by inhibiting GLUT1 expression
Daniela Catanzaro, Daniela Gabbia, Veronica Cocetta, Marco Biagi, Eugenio Ragazzi, et al.
Fitoterapia, 2018 - Chlorogenic acid interaction with cisplatin and oxaliplatin: Studies in cervical carcinoma cells
Daniela Catanzaro, Raffaella Filippini, Caterina Vianello, Maria Carrara, Eugenio Ragazzi, et al.
Natural Product Communications, 2016 - Protective effects of ψ taraxasterol 3-O-myristate and arnidiol 3-O-myristate isolated from Calendula officinalis on epithelial intestinal barrier
Stefano Dall'Acqua, Daniela Catanzaro, Veronica Cocetta, Nadine Igl, Eugenio Ragazzi, et al.
Fitoterapia, 2016 - Effect of quercetin on cell cycle and cyclin expression in ovarian carcinoma and osteosarcoma cell lines
Daniela Catanzaro, Eugenio Ragazzi, Caterina Vianello, Laura Caparrotta, Monica Montopoli
Natural Product Communications, 2015 - Boswellia serrata preserves intestinal epithelial barrier from oxidative and inflammatory damage
Daniela Catanzaro, Serena Rancan, Genny Orso, Stefano Dall’Acqua, Paola Brun, et al.
Plos One, 2015 - Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death
Daniela Catanzaro, Edoardo Gaude, Genny Orso, Carla Giordano, Giulia Guzzo, et al.
Oncotarget, 2015 - Cell cycle control by natural phenols in cisplatin-resistant cell lines
Daniela Catanzaro, Caterina Vianello, Eugenio Ragazzi, Laura Caparrotta, Monica Montopoli
Natural Product Communications, 2014 - Isoleucyl-tRNA synthetase levels modulate the penetrance of a homoplasmic m.4277T>C mitochondrial tRNA Ile mutation causing hypertrophic cardiomyopathy
Elena Perli, Carla Giordano, Helen A.L. Tuppen, Monica Montopoli, Arianna Montanari, et al.
Human Molecular Genetics, 2012
