Cassia Goncalves Magalhaes
@uepg.br
Departamento de Química
Universidade Estadual de Ponta Grossa
EDUCATION
PHD in Ciências - Química - by Universidade Federal de Minas Gerais; MSc. in Agroquímica by Universidade Federal de Viçosa
RESEARCH, TEACHING, or OTHER INTERESTS
Chemistry, Organic Chemistry
FUTURE PROJECTS
Phytochemical study of species found in Paraná, Brazil
Applications Invited
Green chemistry in undergraduated labs
Applications Invited
Green synthesis of metal nanoparticles
Applications Invited
Scopus Publications
Scopus Publications
Tarsila Rodrigues Arruda, Bruno Ricardo de Castro Leite Junior, Clara Suprani Marques, Patrícia Campos Bernardes, Cássia Gonçalves Magalhães, and Patrícia Fontes Pinheiro
Elsevier
Francielle Schremeta Humacayo, Joel Toribio Espinoza, Josiane de Fatima Padilha De Paula, Luma Clarindo Lopes, Christiana Andrade Pessoa, and Cassia Gon�alves Magalhaes
Ecletica Quimica
This work reports a new application for a well-known medicinal plant used in Brazil. The green synthesis of silver nanoparticles (AgNPs) using the aqueous extract of Monteverdia ilicifolia (MI) leaves as stabilizing and reducing agent is described. The AgNPs-MI obtained were characterized by UV-VIS, FTIR, and Raman spectroscopies, DLS, zeta potential and FEG-SEM, which demonstrated that M. ilicifolia was effective at capping the AgNPs, yielding stable suspensions. These nanoparticles were deposited on glassy carbon electrodes, and they were efficiently applied as electrochemical sensors for the determination of dopamine (DA) using square wave voltammetry (SWV). The AgNPs-MI improved the electrochemical properties of the electrodes and enhanced their electroanalytical performance. The developed sensing device presented detection and quantification limits equal to 0.52 and 1.74 ?mol�L�1, respectively, towards DA determination. The proposed electrochemical sensor quantified this neurotransmitter successfully, confirming its potential as a new promising analytical detection tool for DA quality control.
Elton Kazmierczak, C�ssia Gon�alves Magalh�es, and Romaiana Picada Pereira
Ecletica Quimica
Species from the Garcinia genus (Clusiaceae family) are used in the treatment of many diseases and metabolic disorders frequently associated with the oxidative stress. The characteristic metabolites found in this genus are xanthones and benzophenones, which have antioxidant properties, among relevant biological potentials. This review provides a specific vision about antioxidant activity of Garcinia species, reporting in vitro and in vivo assays, described from the last five years. The research about antioxidant properties of Garcinia species and their constituents can be directed in the development of new medicines and drugs.
Maria Eduarda Tech, C�ssia Gon�alves Magalhães, and Sidney Augusto Vieira Filho
Ecletica Quimica Journal
Species from Thuja genus (Cupressaceae) are found in Brazil, North America and Asia. In the traditional medicine, these plants are used in the treatment of cough, skin allergies, and asthma. In Brazil, Thuja species are also used in the ornamentation of urban areas. Different parts of these plants displayed insecticidal, antitumor, and antioxidant activities. The essential oil of the leaves from Thuja spp. are constituted by monoterpenes and sesquiterpenes. The main substances found in the extracts of these species are flavonoids, which display relevant biological activities. This brief review shows recent phytochemical studies involving T. orientalis and T. occidentalis, as well as 40 constituents isolated from these species. The existing pharmacological potential justifies the growing scientific interest in this genus.
Lincon Bordignon Somensi, Philipe Costa, Thaise Boeing, Luísa Nathália Bolda Mariano, Elizama de Gregório, Aline Teixeira Maciel E Silva, Bruna Longo, Claudriana Locatelli, Priscila de Souza, Cássia Gonçalves Magalhães,et al.
Hindawi Limited
Objective. The focus of this study was to evaluate the gastric healing effect of lupeol stearate (LS) and its ability to minimize ulcer recurrence in rodents. Methods. To evaluate the gastric healing properties of LS, rats were subjected to 80% acetic acid-induced ulcer model and treated with vehicle, LS (1 mg/kg, p.o.), or omeprazole (20 mg/kg, p.o.), twice daily by seven days. The gastric ulcers were evaluated macroscopically, histologically, and biochemically. To evaluate the effects of LS in gastric ulcer recurrence, mice were ulcerated with 10% acetic acid and treated with vehicle, LS (1 mg/kg, p.o.), or ranitidine (100 mg/kg, p.o.), twice a day for ten days. Then, ulcer recurrence in these animals was induced by IL-1β at five days after the treatment period. Results. The oral treatment with LS accelerated gastric healing by 63% in rats compared to the vehicle group, evidenced by histological improvement and increased gastric mucin levels. Moreover, the gastric healing effects of LS in rats were accompanied by an elevation in glutathione S-transferase activity and a reduction in myeloperoxidase activity. Furthermore, the LS treatment reduced the recurred lesions in mice. Conclusions. The oral treatment of LS accelerates gastric healing in rats by favoring mucus production and reducing neutrophil migration, and it also can reduce ulcer recurrence. These data highlighted this compound as promising for developing new pharmacological strategies for the management of gastric ulcer.
Jociani Ascari, Marcos Felipe Maciel Pereira, Vinicius Monteiro Schaffka, Domingos Sávio Nunes, Cássia Gonçalves Magalhães, Jânio Sousa Santos, Daniel Granato, Mariana Araújo Vieira do Carmo, Luciana Azevedo, Marcos Vinicio Lopes Rodrigues Archilha,et al.
Molecules (Basel, Switzerland) MDPI AG
The sesquiterpenes selina-1,3,7(11)-trien-8-one and oxidoselina-1,3,7(11)-trien-8-one were isolated from the essential oil of Eugenia uniflora L. leaves. The structures were elucidated using spectrometric methods (UV, GC–MS, NMR, and specific optical rotation). The relationship between antioxidant activity, as determined by DPPH assay, and the cytotoxic effect was evaluated using tumor cells, namely lung adenocarcinoma epithelial cells (A549) and human hepatoma carcinoma cells (HepG2), as well as a model of normal human lung fibroblast cells (IMR90). Both compounds did not show prominent free-radical scavenging activity according to DPPH assay, and did not inhibit lipid peroxidation in Wistar rat brain homogenate. The isolated compounds showed pro-oxidative effects and cytotoxicity in relation to the IMR90 cell line.
Sandra Grzygorczyk, Joel Toribio Ezpinoza, Josiane De Fátima Padinha De Paula, Patricia Mathias Doll Boscardin, Domingos Sávio Nunes, Marilei Casturina Mendes Sandri, and Cássia Gonçalves Magalhães
Instituto de Quimica - Univ. Federal do Mato Grosso do Sul
Plant extracts are a good alternative of reducing agents in the synthesis of metal nanoparticles. In this paper, we report the evaluation of the cytotoxic activity against T3 cell lines of the ethanolic extract of Monteverdia salicifolia (Mart ex. Reissek) Biral roots (MS) as well as a green one-pot route of synthesis of silver nanoparticles (AgNPs) using that extract as reducing and stabilizing agent. The extract exhibited dose dependent activity. The smallest particle size (48.01 nm) was achieved in just 25 minutes by employing a temperature of 65 °C and AgNO 3 and MS concentrations equal to 0.9 mmol.L −1 and 0.67 mg.mL −1 , respectively. The AgNPs-MS nanocomposite was characterized by UV–vis spectroscopy, FEG microscope and zeta potential, which proved that MS was effective at reducing and capping the AgNPs. In order to emphasize the advantage of the methodology applied in this synthesis, it was compared to a usual procedure using NaBH 4 as a reducing agent and the greenness analysis was also carried out, using the Green Star. DOI: http://dx.doi.org/10.17807/orbital.v13i2.1545
Lincon Bordignon Somensi, Philipe Costa, Thaise Boeing, Luísa Nathália Bolda Mariano, Bruna Longo, Cássia Gonçalves Magalhães, Lucenir Pain Duarte, Aline Teixeira Maciel e Silva, Priscila de Souza, Sérgio Faloni de Andrade,et al.
Elsevier BV
Joel Toribio Espinoza, Robson Schimandeiro Novak, Cássia Gonçalves Magalhães, Jane Manfron Budel, Barbara Justus, Melissa Marques Gonçalves, Patricia Mathias Döll Boscardin, Paulo Vitor Farago, and Josiane de Fátima Padiha De Paula
FapUNIFESP (SciELO)
The objective of this work was to develop and characterize liposomes loaded with silver nanoparticles (LAgNPs) to show improvement in stability characteristics. AgNPs were prepared by the green synthesis method with Aloe vera gel extract and exposure to sunlight. Liposomes were prepared by the modified reverse phase method. Particle size, polydispersity index, zeta potential, as well as the scanning electron microscopy (SEM) morphological aspects of AgNPs and LAgNPs were evaluated. In addition, was used flame atomic absorption spectroscopy to determine the amount of AgNP that was encapsulated in liposomes. The AgNPs presented as amorphous and polydisperse structures, with a mean diameter of 278.46 nm and zeta potential of -18.3 mV. LAgNPs had a mean diameter between 321 and 373 nm, the polydispersity index close to 0.2 and a zeta potential around -40 mV, which indicates greater stability to the AgNPs. The images obtained by SEM show semicircular structures for AgNPs and well-defined spherical shape for LAgNPs. The percentage of encapsulation was between 51.81 to 58.83%. These results showed that LAgNPs were obtained with adequate physicochemical characteristics as a release system.
Aline Teixeira Maciel e Silva, Cássia Gonçalves Magalhães, Lucienir Pains Duarte, Wagner da Nova Mussel, Ana Lucia Tasca Gois Ruiz, Larissa Shiozawa, João Ernesto de Carvalho, Izabel Cristina Trindade, and Sidney Augusto Vieira Filho
FapUNIFESP (SciELO)
1Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil, 2Departamento de Química, Centro de Ciências Exatas e Naturais,Universidade Estadual de Ponta Grossa, Ponta Grossa, Paraná, Brasil,3Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil, 4Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas, Universidade Estadual de Campinas, Paulínia, São Paulo, Brasil, 5Faculdade de Ciências Farmacêuticas, Universidade Estadual de Campinas, Campinas, São Paulo, Brasil, 6Departamento de Farmácia, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil
Cássia G. Magalhães, Grácia D. de Fátima Silva, Lucienir P. Duarte, Jacqueline A. Takahashi, Vagner R. Santos, Rute C. Figueiredo, and Sidney A. Vieira Filho
Sociedade Brasileira de Quimica (SBQ)
Maytenus salicifolia Reissek e conhecida como "cafezinho" em Minas Gerais, Brasil. Suas folhas sao utilizadas na medicina popular no tratamento de ulceras estomacais. Neste trabalho e reportado o isolamento de 4´- O -metilepigalocatequina ( 1 ) e proantocianidina A ( 2 ) dos extratos polares da raiz ( 1 ; 4,36%; 2 , 2,17%) e tronco ( 1 , 4,16%; 2 , 0,26%) de M. salicifolia . Pela primeira vez, esses compostos foram encontrados na raiz dessa especie. Esses constituintes foram encontrados em quantidades expressivas, o que torna M. salicifolia uma fonte alternativa desses compostos. Alem disto, a atividade antimicrobiana de extratos polares (etanolico das raizes, etanolico e acetato-etilico dos galhos) e apolares (hexânico das raizes) dessa planta foi avaliada in vitro contra os patogenos da cavidade oral: Candida albicans , Streptococcus mutans , Streptococcus sanguinis e Staphylococcus aureus . Todos os extratos exibiram atividade antimicrobiana e C. albicans foi o micro-organismo mais sensivel. Os triterpenos nepeticina, rigidenol, gloquidona , 11- a- hidroxigloquidona e 16- b -hidroxipristimerina, previamente isolados desta especie, tambem foram testados contra Helicobacter pylori . R igidenol e 16- b -hidroxipristimerina foram ativos contra essa bacteria. Os resultados contribuem para confirmar o uso na medicina popular de M. salicifolia no tratamento de ulceras e outros problemas estomacais e indicam que extratos dessa planta apresentam grande potencial para o uso no tratamento de doencas infecciosas da cavidade oral.
Cássia G. Magalhães, Grácia D. de Fátima Silva, Lucienir P. Duarte, Isabel L. Bazzocchi, Antonio J. Diaz, Laila Moujir, Manuel R. López, Rute C. Figueiredo, and Sidney A. Vieira Filho
Wiley
AbstractIn continuation of our work on Maytenus salicifolia, we report herein the isolation and structural elucidation of two new compounds, salicassin (1), a diterpene‐chalcone adduct with an unprecedented C‐framework, and (16β)‐16‐hydroxypristimerin (2), a quinone methide triterpenoid. Their structures were elucidated on the basis of spectroscopic analysis, including 1D‐ and 2D‐NMR techniques (COSY, ROESY, HSQC, and HMBC). In addition, 22 known compounds were isolated and characterized by comparison of their spectra with reported data. Compound 2, structurally related to the well known cytotoxic quinone methide triterpenoids, exhibited an antiproliferative effect on HeLa, A‐549, and HL‐60 human cell lines, with IC50 values of 2.2, 3.2, and 2.7 μM, respectively.
Antonio Jacinto Demuner, Luiz Claudio Almeida Barbosa, Cassia Gonçalves Magalhaes, Cleber Jose Da Silva, Celia Regina Alvares Maltha, and Antonio Lelis Pinheiro
MDPI AG
This study investigates the seasonal variation of three species of Leptospermum (Myrtaceae) grown in Brazil. The chemical composition of the volatile oils of L. flavescens and L. petersonii did not show any significant seasonal variation in the major components, while for Leptospermum madidum subsp. sativum the levels of major constituents of the volatile oils varied with the harvest season. Major fluctuations in the composition of L. madidum subsp. sativum oil included α-pinene (0–15.2%), β-pinene (0.3–18.5%), α-humulene (0.8–30%), 1,8-cineole (0.4–7.1%) and E-caryophyllene (0.4–11.9%). Levels of β-pinene (0.3–5.6%), terpinen-4-ol (4.7–7.2%) and nerolidol (55.1–67.6%) fluctuated seasonally in the L. flavescens oil. In L. petersonii, changes were noted for geranial (29.8–32.8%), citronellal (26.5–33.9%) and neral (22.7–23.5%). The activity of the volatile oils against the tested bacteria differed, depending on season the oils were obtained. In general, the volatile oils were more active against Gram-positive bacteria.
Cássia G. Magalhães, Fernanda C. Ferrari, Dênia A. S. Guimarâes, Grácia D. F. Silva, Lucienir P. Duarte, Rute C. Figueiredo, and Sidney A. V. Filho
Springer Science and Business Media LLC
Six pentacyclic triterpenes were isolated from hexane extract of stems of Maytenus salicifolia Reissek, Celastraceae: 30-hydroxyfriedelan-3-one (1), 3,16-dioxofriedelane (2), friedeline (3), lupeol (4), betuline (5) and lup-20(29)-en-3,30-diol (6). The structure each one was established on the basis of detailed 1H and 13C NMR spectral investigation and by comparison with the respective literature values. For compound 1, the complete 2D NMR (HMBC, HMQC and NOESY) spectral data were herein reported for the first time. Compounds 1, 2, 5 and 6 were isolated for the first time from this plant. Antioxidant activity is described for some extracts from species of the Celastraceae family, then, the extracts from aerial parts of M. salicifolia were evaluated in relation to antioxidant potential using the DPPH method. Compared to quecertin, the AcEt extract (EAF) from leaves, AcEt (EAPF) and MeOH (EMPF) from pulp fruit and AcEt (EAT) and MeOH (EMT) from stems showed significant antioxidant property.