Alanda (Ephedra foeminea) nanoparticles as a modulator of genomic DNA degradation in mice: new inspiration for treating Ehrlich solid tumour-induced kidney and liver toxicity R. M. Elgharabawy, E. Tousson, I. E. El Sayed, A. H. A. Abd El-Aleim, M. Elabd, et al. European Review for Medical and Pharmacological Sciences, 2023 OBJECTIVE The limitations faced by conventional drug delivery systems are being overcome through the use of rapidly evolving cancer nanotherapeutics. Determining the manner in which the Ehrlich solid tumor (EST) is impacted by the new bioactive Alanda-loaded flax seed gum nanoparticles (Alanda NPs) functioning as an anti-carcinogenic agent represents the research objective of this paper. MATERIALS AND METHODS Identification of the functional groups, surface morphology, particle size, and zeta potential were among the characterizations and preparations made for the prepared nanoparticles. A Control group, a Flax Seed Gum group, a raw Alanda group, an Alanda NPs group, an EST group, and an induced EST treated with Alanda NPs group comprised the six groups respectively which the 60 female mice were separated into in this in vivo study. RESULTS Toxicity assessments for kidneys and liver were performed alongside the detection of total genomic DNA degradation. The zeta potential and the particle sizes for Alanda NPs were -25.60±0.38 mv and 40±0.28 nm, respectively, where the latter demonstrated a monodisperse spherical shape, per the findings. The use of Alanda NPs to treat EST was found to alle te the DNA damage, apoptosis, and renal and hepatic toxicity that EST induces. Additionally, the activation of oxidative stress and apoptosis causing the renal and hepatic toxicity induced by EST is counteracted by the scavenging of free radicals by the Alanda NPs. CONCLUSIONS A high degree of safety for effective cancer treatment was displayed by the newly developed oral nanoparticles while also demonstrating strong potential in vivo.
Ambroxol, a mucolytic agent, boosts HO-1, suppresses NF-κB, and decreases the susceptibility of the inflamed rat colon to apoptosis: A new treatment option for treating ulcerative colitis Simona Cavalu, Hossam Sharaf, Sameh Saber, Mahmoud E. Youssef, Amir Mohamed Abdelhamid, et al. FASEB Journal, 2022 Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown etiology that increases the risk of developing colorectal cancer and imposes a lifelong healthcare burden on millions of patients worldwide. Current treatment strategies are associated with significant risks and have been shown to be fairly effective. Hence, discovering new therapies that have better efficacy and safety profiles than currently exploited therapeutic strategies is challenging. It has been well delineated that NF‐κB/Nrf2 crosstalk is a chief player in the interplay between oxidative stress and inflammation. Ambroxol hydrochloride, a mucolytic agent, has shown antioxidant and anti‐inflammatory activity in humans and animals and has not yet been examined for the management of UC. Therefore, our approach was to investigate whether ambroxol could be effective to combat UC using the common acetic acid rat model. Interestingly, a high dose of oral ambroxol (200 mg/kg/day) reasonably improved the microscopic and macroscopic features of the injured colon. This was linked to low disease activity and a reduction in the colonic weight/length ratio. In the context of that, ambroxol boosted Nrf2 activity and upregulated HO‐1 and catalase to augment the antioxidant defense against oxidative damage. Besides, ambroxol inactivated NF‐κB signaling and its consequent target pro‐inflammatory mediators, IL‐6 and TNF‐α. In contrast, IL‐10 is upregulated. Consistent with these results, myeloperoxidase activity is suppressed. Moreover, ambroxol decreased the susceptibility of the injured colon to apoptosis. To conclude, our findings highlight the potential application of ambroxol to modify the progression of UC by its anti‐inflammatory, antioxidant, and antiapoptotic properties.
Carbocisteine as a Modulator of Nrf2/HO-1 and NFκB Interplay in Rats: New Inspiration for the Revival of an Old Drug for Treating Ulcerative Colitis Amir Mohamed Abdelhamid, Mahmoud E. Youssef, Simona Cavalu, Gomaa Mostafa-Hedeab, Amal Youssef, et al. Frontiers in Pharmacology, 2022 Ulcerative colitis (UC), an inflammatory bowel disease, is a chronic condition of a multifaceted pathophysiology. The incidence of UC is increasing internationally. The current therapies for UC lack relative effectiveness and are associated with adverse effects. Therefore, novel therapeutic options should be developed. It has been well documented that modulating the Nrf2/NFκB is a promising therapeutic target in inflammation. Carbocisteine is a mucoregulatory medication and its efficacy in COPD was found to be more closely related to its antioxidant and anti-inflammatory properties. Carbocisteine has not yet been examined for the management of UC. Hence, our approach was to investigate the potential coloprotective role of carbocisteine in acetic acid-induced colitis in rats. Our results revealed that carbocisteine improved colon histology and macroscopic features and subdued the disease activity as well. Additionally, carbocisteine attenuated colon shortening and augmented colon antioxidant defense mechanisms via upregulating catalase and HO-1 enzymes. The myeloperoxidase activity was suppressed indicating inhibition of the neutrophil infiltration and activation. Consistent with these findings, carbocisteine boosted Nrf2 expression along with NFκB inactivation. Consequently, carbocisteine downregulated the proinflammatory cytokines IL-6 and TNF-α and upregulated the anti-inflammatory cytokine IL-10. Concomitant to these protective roles, carbocisteine displayed anti-apoptotic properties as revealed by the reduction in the Bax: BCL-2 ratio. In conclusion, carbocisteine inhibited oxidative stress, inflammatory response, and apoptosis in acetic acid-induced UC by modulating the Nrf2/HO-1 and NFκB interplay in rats. Therefore, the current study provides a potential basis for repurposing a safe and a commonly used mucoregulator for the treatment of UC.
Retraction notice to" Innovative challenge for the inhibition of hepatocellular carcinoma progression by combined targeting of HSP90 and STAT3/HIF-1α signaling"[Biomedicine … S Saber, EE Abd El-Fattah, AM Abdelhamid, AAE Mourad, ... Biomedicine & Pharmacotherapy, 119233 , 2026 2026
Alanda (Ephedra foeminea) nanoparticles as a modulator of genomic DNA degradation in mice: new inspiration for treating Ehrlich solid tumour-induced kidney and liver toxicity. RM Elgharabawy, E Tousson, IE El Sayed, AHABD EL-ALEIM, M Elabd, ... European Review for Medical & Pharmacological Sciences 27 (19) , 2023 2023 Citations: 4
Suppressing NLRP3 activation and PI3K/AKT/mTOR signaling ameliorates amiodarone-induced pulmonary fibrosis in rats: a possible protective role of nobiletin: MM El Tabaa et al. MM El Tabaa, MM El Tabaa, RM Elgharabawy, WG Abdelhamid Inflammopharmacology 31 (3), 1373-1386 , 2023 2023 Citations: 35
Mirtazapine, an atypical antidepressant, mitigates lung fibrosis by suppressing NLPR3 inflammasome and fibrosis-related mediators in endotracheal bleomycin rat model R Abdelhady, S Cavalu, S Saber, R Elmowafy, NE Morsy, S Ibrahim, ... Biomedicine & Pharmacotherapy 161, 114553 , 2023 2023 Citations: 27
A novel therapeutic combination of dapagliflozin, Lactobacillus and crocin attenuates diabetic cardiomyopathy in rats: role of oxidative stress, gut microbiota, and PPARγ … EM Khalaf, HM Hassan, AM El-Baz, A Shata, AE Khodir, ME Yousef, ... European Journal of Pharmacology 931, 175172 , 2022 2022 Citations: 28
Ambroxol, a mucolytic agent, boosts HO‐1, suppresses NF‐κB, and decreases the susceptibility of the inflamed rat colon to apoptosis: a new treatment option for treating … S Cavalu, H Sharaf, S Saber, ME Youssef, AM Abdelhamid, AAE Mourad, ... The FASEB Journal 36 (9), e22496 , 2022 2022 Citations: 52
GLP-1 mediates the neuroprotective action of crocin against cigarette smoking-induced cognitive disorders via suppressing HMGB1-RAGE/TLR4-NF-κB pathway MM El Tabaa, MM El Tabaa, A Anis, RM Elgharabawy, NB El-Borai International Immunopharmacology 110, 108995 , 2022 2022 Citations: 28
Carbocisteine as a modulator of Nrf2/HO-1 and NFκB interplay in rats: new inspiration for the revival of an old drug for treating ulcerative colitis AM Abdelhamid, ME Youssef, S Cavalu, G Mostafa-Hedeab, A Youssef, ... Frontiers in pharmacology 13, 887233 , 2022 2022 Citations: 41
Ellagic acid regulates hyperglycemic state through modulation of pancreatic IL-6 and TNF-α immunoexpression MM Elbandrawy, O Sweef, D Elgamal, TM Mohamed, RM Elgharabawy Saudi Journal of Biological Sciences 29 (5), 3871-3880 , 2022 2022 Citations: 33
Nifuroxazide-loaded cubosomes exhibit an advancement in pulmonary delivery and attenuate bleomycin-induced lung fibrosis by regulating the STAT3 and NF-κB signaling: A new … S Saber, M Nasr, MMY Kaddah, G Mostafa-Hedeab, S Cavalu, ... Biomedicine & Pharmacotherapy 148, 112731 , 2022 2022 Citations: 32
In Vitro Conditioning of Antigen-Reactive CD8 + T Cells with Toll-Like Receptor Agonists Enhances Their Expansion In Vivo in an Adoptive Transfer Mouse Model ML Salem, A Sobh, RM Elgharabawy Vitro , 2022 2022
Therapeutic Impact of Costus ( Saussurea lappa ) Against Ehrlich Solid Tumor-Induced Cardiac Toxicity and DNA Damage in Female Mice RM Elgharabawy, I El Tantawy El Sayed, N Abd-Allah Rezk, E Tousson Frontiers in pharmacology 12, 708785 , 2021 2021 Citations: 35
The impact of chicory (Cichoriumintybus L.) on hemodynamic functions and oxidative stress in cardiac toxicity induced by lead oxide nanoparticles in male rats RM Elgharabawy, AH Alhowail, AM Emara, MA Aldubayan, AS Ahmed Biomedicine & Pharmacotherapy 137, 111324 , 2021 2021 Citations: 38
Alpha-2 beta-adrenergic receptor (301–303 I/D) gene polymorphism in hypertension and type 2 diabetes mellitus diseases among Saudi cases in the Qassim region HM Eldeeb, RM Elgharabawy, AE Abd Elmoniem, AA Ahmed Science progress 104 (2), 00368504211012162 , 2021 2021 Citations: 7
Impact of smoking on heavy metal contamination and DNA fragmentation AS Ahmed, MA Aldubayan, HA Ahmed, AM Refaat, AS Alsalloumi, ... Environmental Science and Pollution Research 28 (11), 13931-13941 , 2021 2021 Citations: 17
Clinical Significance of Helicobacter pylori Infection on Psoriasis Severity AS Ahmed, AH Al-Najjar, H Alshalahi, WM Altowayan, RM Elgharabawy Journal of Interferon & Cytokine Research 41 (2), 44-51 , 2021 2021 Citations: 11
Effect of inhaled anesthetic gases on immune status alterations in health care workers AM Emara, KA Alrasheedi, SD Alrashidi, RM Elgharabawy Journal of Immunotoxicology 18 (1), 13-22 , 2021 2021 Citations: 7
Factors affecting the incidence, progression, and severity of COVID‐19 in type 1 diabetes mellitus AS Ahmed, WS Alotaibi, MA Aldubayan, AH Alhowail, AH Al-Najjar, ... BioMed research international 2021 (1), 1676914 , 2021 2021 Citations: 15
Co-administration of imipramine and doxorubicin reduces the survival rate and body weight of mice A Alhowail, S Chigurupati, R Elgharabawy, M Aldubayan Eur Rev Med Pharmacol Sci 24 (24), 12978-12982 , 2020 2020 Citations: 4
Evaluation of the testicular protection conferred by damiana (Turnera diffusa Willd.) against amitriptyline-induced testicular toxicity, DNA damage and apoptosis in rats E Tousson, E Hafez, S Zaki, A Gad, RM Elgharabawy Biomedicine & Pharmacotherapy 132, 110819 , 2020 2020 Citations: 32
MOST CITED SCHOLAR PUBLICATIONS
Antineoplastic activity and curative role of avenanthramides against the growth of ehrlich solid tumors in mice MA Aldubayan, RM Elgharabawy, AS Ahmed, E Tousson Oxidative medicine and cellular longevity 2019 (1), 5162687 , 2019 2019 Citations: 140
Zinc oxide nanoparticles and a standard antidiabetic drug restore the function and structure of beta cells in Type-2 diabetes RM El-Gharbawy, AM Emara, SES Abu-Risha Biomedicine & Pharmacotherapy 84, 810-820 , 2016 2016 Citations: 139
Knowledge, attitude and practice (KAP) study about middle east respiratory syndrome coronavirus (MERS-CoV) among population in Saudi Arabia N ALdowyan, AS Abdallah, R El-Gharabawy International Archives of Medicine 10 , 2017 2017 Citations: 108
Grape seed proanthocyanidin ameliorates cardiac toxicity induced by boldenone undecylenate through inhibition of NADPH oxidase and reduction in the expression of NOX2 and NOX4 E Tousson, RM Elgharabawy, TA Elmasry Oxidative medicine and cellular longevity 2018 (1), 9434385 , 2018 2018 Citations: 65
The art of crypto currencies: A comprehensive analysis of popular crypto currencies S Hameed, S Farooq arXiv preprint arXiv:1711.11073 , 2017 2017 Citations: 55
Ambroxol, a mucolytic agent, boosts HO‐1, suppresses NF‐κB, and decreases the susceptibility of the inflamed rat colon to apoptosis: a new treatment option for treating … S Cavalu, H Sharaf, S Saber, ME Youssef, AM Abdelhamid, AAE Mourad, ... The FASEB Journal 36 (9), e22496 , 2022 2022 Citations: 52
Carbocisteine as a modulator of Nrf2/HO-1 and NFκB interplay in rats: new inspiration for the revival of an old drug for treating ulcerative colitis AM Abdelhamid, ME Youssef, S Cavalu, G Mostafa-Hedeab, A Youssef, ... Frontiers in pharmacology 13, 887233 , 2022 2022 Citations: 41
The impact of chicory (Cichoriumintybus L.) on hemodynamic functions and oxidative stress in cardiac toxicity induced by lead oxide nanoparticles in male rats RM Elgharabawy, AH Alhowail, AM Emara, MA Aldubayan, AS Ahmed Biomedicine & Pharmacotherapy 137, 111324 , 2021 2021 Citations: 38
Mechanism of action and effect of immune-modulating agents in the treatment of psoriasis RM El-Gharabawy, AS Ahmed, AH Al-Najjar Biomedicine & Pharmacotherapy 85, 141-147 , 2017 2017 Citations: 36
Suppressing NLRP3 activation and PI3K/AKT/mTOR signaling ameliorates amiodarone-induced pulmonary fibrosis in rats: a possible protective role of nobiletin: MM El Tabaa et al. MM El Tabaa, MM El Tabaa, RM Elgharabawy, WG Abdelhamid Inflammopharmacology 31 (3), 1373-1386 , 2023 2023 Citations: 35
Therapeutic Impact of Costus ( Saussurea lappa ) Against Ehrlich Solid Tumor-Induced Cardiac Toxicity and DNA Damage in Female Mice RM Elgharabawy, I El Tantawy El Sayed, N Abd-Allah Rezk, E Tousson Frontiers in pharmacology 12, 708785 , 2021 2021 Citations: 35
Ellagic acid regulates hyperglycemic state through modulation of pancreatic IL-6 and TNF-α immunoexpression MM Elbandrawy, O Sweef, D Elgamal, TM Mohamed, RM Elgharabawy Saudi Journal of Biological Sciences 29 (5), 3871-3880 , 2022 2022 Citations: 33
Awareness, Prevalence and Determinants of Birth Control Methods Use among Women in Saudi Arabia. RAA Rehab M. El-Gharabawy, Amira S. Ahmed International Archives of Medicine 8, 1-11 , 2015 2015 Citations: 33
Nifuroxazide-loaded cubosomes exhibit an advancement in pulmonary delivery and attenuate bleomycin-induced lung fibrosis by regulating the STAT3 and NF-κB signaling: A new … S Saber, M Nasr, MMY Kaddah, G Mostafa-Hedeab, S Cavalu, ... Biomedicine & Pharmacotherapy 148, 112731 , 2022 2022 Citations: 32
Evaluation of the testicular protection conferred by damiana (Turnera diffusa Willd.) against amitriptyline-induced testicular toxicity, DNA damage and apoptosis in rats E Tousson, E Hafez, S Zaki, A Gad, RM Elgharabawy Biomedicine & Pharmacotherapy 132, 110819 , 2020 2020 Citations: 32
A novel therapeutic combination of dapagliflozin, Lactobacillus and crocin attenuates diabetic cardiomyopathy in rats: role of oxidative stress, gut microbiota, and PPARγ … EM Khalaf, HM Hassan, AM El-Baz, A Shata, AE Khodir, ME Yousef, ... European Journal of Pharmacology 931, 175172 , 2022 2022 Citations: 28
GLP-1 mediates the neuroprotective action of crocin against cigarette smoking-induced cognitive disorders via suppressing HMGB1-RAGE/TLR4-NF-κB pathway MM El Tabaa, MM El Tabaa, A Anis, RM Elgharabawy, NB El-Borai International Immunopharmacology 110, 108995 , 2022 2022 Citations: 28
Sinapic acid attenuates cardiovascular disorders in rats by modulating reactive oxygen species and angiotensin receptor expression MA Aldubayan, AS Ahmed, AM Emara, AA Ahmed, RM Elgharabawy Oxidative Medicine and Cellular Longevity 2020 (1), 1436858 , 2020 2020 Citations: 28
Mirtazapine, an atypical antidepressant, mitigates lung fibrosis by suppressing NLPR3 inflammasome and fibrosis-related mediators in endotracheal bleomycin rat model R Abdelhady, S Cavalu, S Saber, R Elmowafy, NE Morsy, S Ibrahim, ... Biomedicine & Pharmacotherapy 161, 114553 , 2023 2023 Citations: 27
Knowledge, attitude and practice about breast cancer among women in Saudi Arabia AS Abdallah, RM El-Gharabawy, HO Al-suhaibany International Archives of Medicine 8 , 2015 2015 Citations: 27