Syeda Aaliya
@iiu.edu.pk
Assistant Professor at Center for Interdisciplinary Research in Basic Sciences (CIRBS), Faculty of Sciences, International Islamic University, H-10 Sector campus, Islamabad (IIUI) Pakistan.
International Islamic University, Islamabad
RESEARCH, TEACHING, or OTHER INTERESTS
Chemistry, Organic Chemistry, Catalysis, Spectroscopy
Scopus Publications
Scopus Publications
Mian Muhammad, Sikandar Khan, Syeda Aaliya Shehzadi, Zarif Gul, Hamed M. Al-Saidi, Abdul Waheed Kamran, and Fahad A. Alhumaydhi
Elsevier BV
Syeda Aaliya Shehzadi, Aamer Saeed, Fouzia Perveen, Pervaiz Ali Channar, Ifzan Arshad, Qamar Abbas, Saima Kalsoom, Sammer Yousaf, and Jim Simpson
Elsevier BV
Iqbal Ahmad, Jawad Ahmed, Saima Batool, Muhammad Nadeem Zafar, Amna Hanif, Zahidullah, Muhammad Faizan Nazar, Anwar Ul-Hamid, Uzma Jabeen, Alaa Dahshan,et al.
Elsevier BV
Rabail Ujan, Nasima Arshad, Fouzia Perveen, Pervaiz Ali Channar, Bhajan Lal, Mumtaz Hussain, Zahid Hussain, Aamer Saeed, and Syeda Aaliya Shehzadi
Springer Science and Business Media LLC
Pervaiz Ali Channar, Aamer Saeed, Saira Afzal, Dilawar Hussain, Markus Kalesse, Syeda Aaliya Shehzadi, and Jamshed Iqbal
Springer Science and Business Media LLC
Shafiq-ur-Rehman, Shaista Ghafoor, Shamsa BiBi, Abida Kausar, Shaukat Ali, Sadia Asim, Asim Mansha, Syeda Aaliya Shehzadi, and Ran Jia
Springer Science and Business Media LLC
Ifzan Arshad, Aamer Saeed, Pervaiz Ali Channar, Syeda Aaliya Shehzadi, Muhammad Naeem Ahmed, and Muhammad Siddiq
Royal Society of Chemistry (RSC)
The inhibitory effect of three new bis-Schiff bases on mild steel corrosion in 0.5 M HCl was studied by the weight loss method and the electrochemical method.
Mumtaz Hussain, Tahir Qadri, Zahid Hussain, Aamer Saeed, Pervaiz Ali Channar, Syeda Aaliya Shehzadi, Mubashir Hassan, Fayaz Ali Larik, Tarique Mahmood, and Arif Malik
Elsevier BV
Pervaiz Ali Channar, Nasima Arshad, Shahid Iqbal Farooqi, Fayaz Ali Larik, Aamer Saeed, Tuncer Hökelek, Syeda Aaliya Shehzadi, Nasir Abbas, and Ulrich Flörke
Springer Science and Business Media LLC
Aamer Saeed, Syeda Aaliya Shehzadi, Michael Bolte, Carlos A. Franca, and Mauricio F. Erben
Wiley
AbstractThe 2‐(prop‐2‐yn‐1‐yloxy)naphthalene (compound I) and 1‐nitro‐2‐(prop‐2‐yn‐1‐yloxy)benzene (compound II) were prepared in excellent yields by the reaction of propargyl bromide with 2‐naphthol and 2‐nitrophenol, respectively. Structural and conformational properties of both compounds have been analyzed using a combined approach including single‐crystal X‐ray diffraction and quantum chemical calculations. Two forms are found to be stable and nearly isoenergetic conformers, depending on the mutual orientation of the C≡C triple bond and the O–C single bond of the prop‐2‐yn‐1‐yloxy group. The gauche conformation is the most stable form for the vacuum isolated species, with the anti conformation higher in energy by 1.00 and 1.89 kcal/mol computed at the M06‐2X/6‐311++G(d,p) level of approximation, for I and II, respectively. The gauche form is observed in the crystal of I but the nearly planar anti conformation is adopted in the crystalline phase of compound II. The occurrence of C–H⋅⋅⋅π and C–H⋅⋅⋅O intermolecular interactions involving the acidic ‐C≡C–H hydrogen donor and ‐C≡C‐ and ‐OCH2– acceptors is discussed. Furthermore, vibrational features of the prop‐2‐yn‐1‐yloxy moiety are analyzed by infrared and Raman spectroscopy. The UV‐Vis spectrum shows the presence of well‐defined absorption at ca. 280 and 320 nm assigned to the π→π* transitions in the naphtyl/benzyl and prop‐2‐yn‐1‐yloxy groups, respectively.
Syeda Aaliya Shehzadi, Imtiaz Khan, Aamer Saeed, Fayaz Ali Larik, Pervaiz Ali Channar, Mubashir Hassan, Hussain Raza, Qamar Abbas, and Sung-Yum Seo
Elsevier BV
Imtiaz Khan, Aliya Ibrar, and Syeda Aaliya Shehzadi
Elsevier BV
Tanzeela A. Fattah, Aamer Saeed, and Syeda A. Shehzadi
Bentham Science Publishers Ltd.
Cardiovascular diseases are among the most threatening problems being faced by twenty-first century humans. The core cause of these diseases is high cholesterol level. Simvastatin (1: Synvinolin) is a well-known cholesterol-lowering drug marketed under the trade name Zocor®, which significantly reduces the risk of cardiovascular diseases related to hypercholesterolemia and is effective in lowering the total plasma cholesterol, low-density and very low-density lipoprotein cholesterol. It also enhances the high-density lipoprotein cholesterol. This review article aims to provide an overview of several chemical and biological methods utilized for the production of simvastatin in high yields and purity. Many robust and scalable methods have been described using lovastatin (2: Mevinolin) as a starting material, produced by the fungal strain of Aspergelius terreus. Enzymatic synthesis of simvastatin is also highlighted in this review. In addition, detailed experimental conditions, as well as the compatibility for industrial-scale preparations of simvastatin are also discussed.
Ifzan Arshad, Aamer Saeed, Pervaiz Ali Channar, Syeda Aaliya Shehzadi, and Rana Muhammad Irfan
Georg Thieme Verlag KG
A contrapositionally substituted derivative of cyclohexa-meta-phenylene ([6]CMP) was synthesized by an intramolecular Yamamoto coupling reaction of an appropriate terphenyl unit containing a trimethylsilyl substituent. Iododesilylation of the trimethylsilyl groups of the product with iodine monochloride was used to incorporate iodo groups, an important functionality for metal-catalyzed coupling reactions. The iodo groups were also converted into a (pinacolato)boryl groups, another important functionality for coupling reactions. The diborylated [6]CMP is expected to be a versatile potential comonomer and a precursor for the synthesis of CMP-based materials. The synthetic route to the disubstituted [6]CMP included lithiation, Pd-catalyzed borylation, Suzuki coupling, and Yamamoto coupling. The structure of the product was established by NMR spectroscopy and mass spectrometry.
Syeda Aaliya Shehzadi, Khushbu Kushwaha, Hans Sterckx, and Kourosch Abbaspour Tehrani
Wiley
AbstractA zinc(II) triflate catalyzed reaction of β‐chloro aldimines with terminal alkynes leading to a rapid and efficient formation of 2‐alkynylazetidines in good to excellent yield has been described. The catalytic hydrogenation of the 2‐alkynylazetidines resulted in acyclic secondary amines by reductive cleavage of the 2‐alkynylazetidine. Further, these non‐activated 2‐alkynylazetidines were ring expanded in a reaction with dimethyl acetylenedicarboxylate in the presence of zinc(II) triflate to give 4‐alkynyltetrahydropyridines. Catalytic reduction of these 4‐alkynyltetrahydropyridines led to an efficient conversion to 4‐alkyltetrahydropyridine carboxylates.magnified image
Aliya Ibrar, Syeda Aaliya Shehzadi, Faiq Saeed, and Imtiaz Khan
Elsevier BV
Syeda Aaliya Shehzadi, Aamer Saeed, Filip Lemière, Bert U. W. Maes, and Kourosch Abbaspour Tehrani
Wiley
A ZnII‐catalyzed reaction between imines, which were derived from unactivated aldehydes or ketones and primary amines or α‐amino acid esters, and terminal alkynes has led to the rapid and efficient formation of tri‐ and tetrasubstituted propargylamines (from aldimines and ketimines, respectively) in good to excellent yields. No additives or extra Lewis acid reagents were required for the imine‐alkyne coupling reaction.
Syeda Aaliya Shehzadi, Christophe M. L. Vande Velde, Aamer Saeed, and Kourosch Abbaspour Tehrani
Royal Society of Chemistry (RSC)
One pot Zn(ii)-catalyzed imine–alkyne–alkyne coupling.
Syeda Aaliya Shehzadi and Aamer Saeed
Wiley
A series of novel N‐alkylcarbazol–propargylamine hybrids were designed and synthesized by CuIBr‐catalyzed A3‐coupling of N‐octylcarbazol‐3‐carbaldehyde, amines, and alkynes. The tri‐substituted propargyl amines decorated with carbazole moiety were obtained under solvent‐free conditions in good to moderate yields. Furthermore, the scope of the method was studied, which was found to be applicable to primary aliphatic and aromatic amines. Also, a large variety of substituents both on alkynes and anilines are well tolerated.
Farukh Jabeen, Syeda Aaliya Shehzadi, Muhammad Qaiser Fatmi, Sobia Shaheen, Lubna Iqbal, Nighat Afza, Siva S. Panda, and Farzana Latif Ansari
Elsevier BV
Aamer Saeed, Ghulam Shabir, and Syeda Aaliya Shehzadi
Wiley
This work investigated the synthesis of biphenyl-3,3′,4,4′-tetracarboxylic dianhydride and benzophenone-3,3′,4,4′-tetracarboxylic dianhydride derivatives (3a–e and 6a–e) with different substituted phenols via Friedel-Crafts acylation reaction in the presence of dilute sulfuric acid. Dianhydride derivatives with 3-N,N′-dimethylamino phenol (3d and 6d) and resorcinol (3e and 6e) have been found to be highly fluorescent. The structures of all newly synthesized compounds were confirmed by the chromatographic, spectral and elemental data. Electrochemical study was done to determine to band gap energy, LUMO and HOMO levels energy. Band gap and LUMO energy levels were found to be lowest in xanthene derivatives substituted with 3-N,N′-dimethylamino group having value 2.24 and 4.85 eV respectively.
Khushbu Kushwaha, Balazs Pinter, Syeda A. Shehzadi, Chandi C. Malakar, Christophe M. L. Vande Velde, Frank de Proft, and Kourosch Abbaspour Tehrani
Wiley
AbstractThe metal‐free reaction of terminal arylacetylenes with α,α‐dichloroaldimines in 1,1,1,3,3,3‐hexafluoro‐2‐propanol as the sole solvent results in the rapid and selective formation of γ,γ‐dichloro‐β‐amino ketones. In this solvent the expected dichlorinated propargylamines and/or allylic amines are not formed. The dichloromethylene moiety of the aldimine acts as an activating group and is essential to accomplish this transformation. Electron‐rich acetylenes lead to the best results and work well with all imines (with or without α′‐H at the nitrogen substituent), while electron‐deficient acetylenes only reacted with N‐tert‐butylaldimines (no α′‐H). The mechanistic pathway showed 1,1,1,3,3,3‐hexafluoro‐2‐propanol to protonate the aldimine, which in the rate‐determining step will react with the arylacetylene to form a resonance‐stabilized allene cation, which is trapped by a HFIP molecule giving rise to an enol ether, which promptly hydrolyzes to furnish exclusively the β‐amino ketones. Using DFT techniques we found that the first CC bond forming step is the rate‐determining step and is associated with a barrier of about 21 kcal mol−1.magnified image