Milind Sharad Pande
@iimt.edu.in
Professor & Dean Pharmacy
IIMT UNIVERSITY MEERUT
EDUCATION
M Pharm PhD (Pharmacognosy)
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmaceutical Science, Pharmaceutical Science, Pharmacy, Pharmacology (medical)
Scopus Publications
Scopus Publications
Kanika Verma, Deepa Dhruvakumar, and Milind Pande
Medknow
Aim: A randomized controlled clinical trial was conducted to evaluate the effect of local drug delivery (LDD) of Acmella oleracea (Akarkara) and Acacia catechu (kattha) gels as an adjunct to scaling and root planing (SRP) in generalized chronic periodontitis patients. Materials and Methods: Thirty patients with ninety sites aged 25–65 years with generalized chronic periodontitis having pocket probing depth (PPD) of more than or equal to 5 mm on the basis of inclusion and exclusion criteria were selected. They were treated according to split-mouth design protocol. The placement of gel containing A. oleracea (1%) (Group 1) and A. catechu (1%) (Group 2) as LDD was placed at the two test sites, respectively, and only SRP was done in the control group (Group 3). Periodontal dressing was applied to all the three sites after procedure, and patients were given oral care guidelines. Evaluation of clinical parameters gingival index (GI), plaque index (PI), gingival bleeding index (GBI), PPD, clinical attachment level (CAL), and relative attachment level (RAL) was done at baseline, 1, 3, and 6 months, and microbiological parameter was assessed at baseline and 6 months. N-benzoyl-DL-arginine-2-napthylamide (BANA) test was used for the microbiological analysis. Results: Clinical parameters from baseline to 6 months at different time intervals demonstrated a significant reduction in mean GI, PI, GBI, and PPD and gain in CAL and RAL over a period of 6 months, and results were statistically significant in all the three treatment groups. However, on intergroup comparison, clinically significant difference was observed, but statistically, results were significant at few intervals. The microbiological analysis revealed a statistically nonsignificant reduction at the end of 6 months on intra- and intergroup comparison. Conclusion: The study concluded that the use of A. catechu gel and A. oleracea gel clinically showed improvement in clinical parameters when combined with SRP, attributing to better anti-inflammatory and healing properties.
Gaurav Garg, Milind Pande, Ambika Agrawal, Jie Li, and Rakesh Kumar
Elsevier BV
M. Pande, S. Ingale, S. Gupta and Sajjan Singh Nagar
The leaves of Murraya koenigii (L) Spreng (Rutaceae) are reported to have great medicinal value. Pharmacognostic evaluation including examinations of morphological and microscopic characters, determination of leaf content, ash value, powder analysis, and extractive values were carried out. Phytochemical screenings including qualitative chemical examinations were carried out. Phytoconstituent in various extracts gives us clue for further investigation.
Lipi Purwal, Surya Prakash B. N. Gupta, and S. Milind Pande
Wiley
Hair formulation of Emblica officinalis (Euphorbiaceae), Bacopa, monnieri (Scrophulariaceae), Trigonella foenumgraecum (Leguminosae), Murraya koenigii (Rutaceae) in various concentrations in the form of herbal oil were studied for their hair growth activity. Each drug was tested for their hair growth activity in a concentration range for 1‐10% separately. Based on these results mixture of crude drugs Murraya koeniigi, leaf (Rutaceae), Bacopa monnieri, leaf (Scrophulariaceae), Trigonella foenumgraecum (Leguminosae), Murraya koenigii (Rutaceae) were prepared in varying concentration in the form of herbal hair oil by three different oils preparation techniques and were tested for hair growth activity. The result revealed that the hair growth activity of each drug was found proportional to the concentration range tested. Similarly higher concentrations of drug in the formulation were found to have higher hair growth activities. But looking towards the formulation viscosity the maximum concentration of combined drug was found to be 30% at their maximum level. The formulation containing 7.5% of each drug used for the study and showed excellent hair growth activity with standard (2% minoxidil ethanolic solution) by an enlargement of follicular size and prolongation of the anagen phase. It holds the promise of potent herbal alternative for minoxidil. Excellent results of hair growth were seen in formulation prepared by cloth pouch decoction method of oils preparation technique.