Jithesh Kottur

@iav.kerala.gov.in

Scientist C, Department of Antiviral Drug Research
Institute of Advanced Virology, Trivandrum

Jithesh Kottur


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https://researchid.co/jitheshkottur

RESEARCH, TEACHING, or OTHER INTERESTS

Molecular Biology, Structural Biology, Biophysics, Biochemistry
21

Scopus Publications

903

Scholar Citations

14

Scholar h-index

18

Scholar i10-index

Scopus Publications

  • Discovery of a Potent, Selective, and In Vivo Efficacious Covalent Inhibitor for Lysine Methyltransferase SETD8
    He Chen, Rudra Prasad Dutta, Zhizhong Li, Yue Zhong, Anqi Ma, Kwang-Su Park, Jithesh Kottur, Alison Park, Nicolas Babault, Ke Wang, Dandan Wang, Yan Xiong, H. Ümit Kaniskan, Minkui Luo, Samir Parekh, Jian Jin
    Journal of Medicinal Chemistry, 2026
    Dysregulated signaling of SET domain-containing protein 8 (SETD8) has been implicated in tumorigenesis, yet most SETD8 inhibitors exhibited limited cellular efficacy. Herein, we developed a potent and selective SETD8 covalent inhibitor, MS2928 ( 3 ), featuring a propiolamide covalent warhead. Compound 3 potently and selectively inhibited SETD8 methyltransferase activity. The covalent inhibition mechanism of 3 was confirmed by mass spectrometry and X-ray crystallography. Moreover, 3 significantly reduced the histone H4 lysine 20 monomethylation (H4K20me1) levels in cells and robustly inhibited the proliferation of SETD8-overexpressing multiple myeloma (MM) cell lines with no significant antiproliferative effect on SETD8-low expressing MM cells and normal cells. Importantly, 3 effectively inhibited tumor growth in vivo in two xenograft mouse models of SETD8-overexpressing MM cell lines. Collectively, our results establish 3 as a valuable chemical tool for exploring the biological functions of SETD8 and pave the way for further development of novel epigenetic therapies for MM.
  • Measuring public health integrity in India: Kerala's COVID-19 undercount as a benchmark for excellence
    Shaiju S. Nazeer, Jithesh Kottur, Jagadeesh Bayry
    Frontiers in Public Health, 2026
    Kerala has long stood apart in India for its exceptional health and human development indicators. With one of the lowest infant mortality rates and highest life expectancy figures in the country, Kerala's health outcomes are comparable to those in many middle-and highincome countries (1). These achievements are rooted in decades of investment in primary health care, education, and social equity, built on a foundation of decentralized governance and strong community participation. These features define the so-called "Kerala Model" of development and also shaped the state's distinctive pandemic response.Kerala was the first Indian state to report a COVID-19 case in January 2020, yet it rapidly became a global example of effective pandemic containment. Even before confirming its first case, the state-initiated containment measures, drawing on lessons from its 2018 Nipah virus outbreak (2,3). With early contact tracing, quarantine enforcement, and the deployment of community kitchens and care centres, the state's response was swift, decentralized, and humane. Kerala's pandemic management evolved through multiple waves, including a unique third wave resulting from lower initial seroprevalence and high population mobility. Despite surging case numbers, its health system remained functional, largely due to a tiered care model that prioritized hospital admissions for those in greatest need (4). Kerala's long-standing traditions of public action and participatory democracy initially fuelled a coordinated statesociety response. While later waves exposed challenges like bureaucratic tensions, political interference, and public fatigue, the state's transparency, community trust, and resilience largely endured (5).In contrast, India's broader COVID-19 response faltered due to systemic weaknesses.A Lancet editorial described the crisis as a "self-inflicted catastrophe," citing premature optimism, mass gatherings, and vaccine mismanagement. The devastating second wave, driven by the Delta variant, laid bare the inadequacies of India's public health infrastructure such as oxygen shortages, overwhelmed hospitals, and limited transparency (6). Poor death certification practices, chronic underfunding of public health systems, and weak community engagement were further highlighted. States like Bihar, Uttar Pradesh, and Madhya Pradesh, identified as highly vulnerable, experienced particularly high excess mortality and extreme undercounting (7).Meanwhile, Kerala's health infrastructure remained resilient. Field hospitals, decentralized care delivery, and surplus oxygen supplies allowed the state to manage surges effectively. Though Kerala reported high case numbers during a third wave, this reflected robust testing and transparent data, often misread as failure rather than a sign of public health integrity (2,4,5). Notably, the Economic Survey (2020-21) identified Kerala as the only state in the country that met the recommended norms for healthcare workforce density, whereas all other states failed to reach this benchmark (8).Excess mortality is measured as the difference between observed all-cause deaths and expected historical baselines. Its ratio to officially reported COVID-19 fatalities, known as the undercount ratio, serves as a reliable indicator of the accuracy and integrity of mortality reporting during the pandemic. Unlike reported case or death counts, excess mortality provides a more reliable measure of the pandemic's true impact, as it accounts for inconsistencies in testing, cause-of-death attribution, and political interference in reporting (9). India's Civil Registration System data for 2021 revealed 10.2 million deaths, far exceeding historical baselines (10). Figure 1 starkly illustrates the reporting gaps: states like Gujarat (undercount ratio of 43.3), Uttar Pradesh (28.4), and Madhya Pradesh (19) reported only a fraction of their actual COVID-19 fatalities. In sharp contrast, Kerala's undercount ratio was just 1.57, meaning that for every confirmed COVID death, fewer than two went unreported. This level of accuracy aligns closely with developed countries such as the United States (1.1), the United Kingdom (0.9), and Italy (1.1), underscoring Kerala's relative transparency and robust data integrity (9,11).An important consideration in interpreting Kerala's comparatively better COVID-19 outcomes is the role of economic factors. While economic capacity can influence health system preparedness, Kerala is not the richest state in India by conventional economic measures. For the financial year 2024-25, Kerala ranked seventh in per capita Net State Domestic Product, eleventh in Gross State Domestic Product, and ninth in Net State Domestic Product, placing it behind several economically stronger states (12). Despite this, Kerala has recently become the first Indian state to eradicate extreme poverty, an achievement not yet realised in many higherincome regions (13). This highlights the importance of equitable social investment, rather than absolute economic wealth, in shaping population health outcomes. Kerala's COVID-19 performance is better explained by long-term public health policies and governance choices than by economic affluence alone. Sustained investment in primary health care, a strong public sector hospital network, and the mobilisation of grassroots health workers enabled early detection, timely reporting, effective contact tracing, and isolation. High literacy and decentralised governance further supported risk communication and local accountability. These factors distinguish Kerala from several economically stronger states that nonetheless experienced health system strain, substantial underreporting, and high excess mortality, underscoring that governance quality and social investment matter more than income rankings alone. Kerala's extensive medical certification of COVID-19 deaths, strong death registration systems, and willingness to revise mortality figures in response to judicial and expert recommendations, reflect a clear commitment to data accuracy. This reflects not merely administrative competence, but the operationalization of ethical standards within public health governance. While states like Maharashtra and Tamil Nadu also had significant excess deaths, their undercount ratios remained above 3 and 8 respectively. Kerala alone mirrored the transparent practices of developed nations, reflecting its structural strengths and public accountability mechanisms.Importantly, Kerala's reporting integrity challenges the myth that high case or death counts reflect governance failure. On the contrary, visibility becomes a virtue when combined with responsive health services and informed citizens. Kerala's undercount ratio thus becomes not just a statistic, but a benchmark for public health integrity.As India and Southeast Asia confront with the long-term consequences of the COVID-19 pandemic, future health governance must be grounded in transparency, public trust, and institutional accountability. Timely reporting of cases is crucial and far preferable to concealing or failing to disclose a disease. Kerala's experience, rooted in strong local governance, community engagement, and a commitment to data integrity, offers a compelling model. While imperfect, it illustrates that resilience is shaped not only by capacity but also by values. Kerala's case thus underscores the importance of robust civil registration systems, independent media, and a culture of accountability in shaping pandemic outcomes.
  • Mechanism of DNA degradation by CBASS Cap5 endonuclease immune effector
    Olga Rechkoblit, Daniela Sciaky, Mi Ni, Yangmei Li, Jithesh Kottur, Gang Fang, Aneel K. Aggarwal
    Nature Communications, 2025
    Bacterial CBASS immune defense systems commonly kill virally infected cells by degrading genomic DNA in a form of cell suicide or abortive infection. We present a high-resolution structure of the CBASS effector Cap5, activated by a cyclic nucleotide, in the act of digesting DNA via tetrameric HNH endonuclease domains. Two HNH domains are in a catalytically active state for cleavage of the DNA strands, whereas the other two HNH domains are in a topologically distinct catalytically inactive state for simply DNA binding. The four HNH domains track one face of the DNA and mark an enzyme that acts as a stand-alone non-specific nuclease. We also show that chromosomally encoded CBASS Cap5 can be extrinsically activated by a cyclic nucleotide, as a step towards potential antibiotics. Bacterial CBASS systems commonly kill virally infected cells by degrading genomic DNA. Here the authors present a structure of the CBASS effector Cap5 degrading DNA and demonstrate that Cap5 can be externally activated to limit bacterial growth.
  • Nucleic acid mediated activation of a short prokaryotic Argonaute immune system
    Jithesh Kottur, Radhika Malik, Aneel K. Aggarwal
    Nature Communications, 2024
    A short prokaryotic Argonaute (pAgo) TIR-APAZ (SPARTA) defense system, activated by invading DNA to unleash its TIR domain for NAD(P)+ hydrolysis, was recently identified in bacteria. We report the crystal structure of SPARTA heterodimer in the absence of guide-RNA/target-ssDNA (2.66 Å) and a cryo-EM structure of the SPARTA oligomer (tetramer of heterodimers) bound to guide-RNA/target-ssDNA at nominal 3.15–3.35 Å resolution. The crystal structure provides a high-resolution view of SPARTA, revealing the APAZ domain as equivalent to the N, L1, and L2 regions of long pAgos and the MID domain containing a unique insertion (insert57). Cryo-EM structure reveals regions of the PIWI (loop10-9) and APAZ (helix αN) domains that reconfigure for nucleic-acid binding and decrypts regions/residues that reorganize to expose a positively charged pocket for higher-order assembly. The TIR domains amass in a parallel-strands arrangement for catalysis. We visualize SPARTA before and after RNA/ssDNA binding and uncover the basis of its active assembly leading to abortive infection.
  • Burkholderia cenocepacia epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation
    Richard Quintana-Feliciano, Jithesh Kottur, Mi Ni, Rikhia Ghosh, Leslie Salas-Estrada, Goran Ahlsen, Olga Rechkoblit, Lawrence Shapiro, Marta Filizola, Gang Fang, Aneel K. Aggarwal
    Nature Communications, 2024
    Burkholderia cenocepacia is an opportunistic and infective bacterium containing an orphan DNA methyltransferase called M.BceJIV with roles in regulating gene expression and motility of the bacterium. M.BceJIV recognizes a GTWWAC motif (where W can be an adenine or a thymine) and methylates N6 of the adenine at the fifth base position. Here, we present crystal structures of M.BceJIV/DNA/sinefungin ternary complex and allied biochemical, computational, and thermodynamic analyses. Remarkably, the structures show not one, but two DNA substrates bound to the M.BceJIV dimer, with each monomer contributing to the recognition of two recognition sequences. We also show that methylation at the two recognition sequences occurs independently, and that the GTWWAC motifs are enriched in intergenic regions in the genomes of B. cenocepacia strains. We further computationally assess the interactions underlying the affinities of different ligands (SAM, SAH, and sinefungin) for M.BceJIV, as a step towards developing selective inhibitors for limiting B. cenocepacia infection. Crystal structures of DNA methyltransferase M.BceJIV in complex with DNA and sinefungin reveal an unusual mode of DNA binding and methylation, wherein each M.BceJIV monomer contributes to the recognition of two DNA sequences.
  • H19 influenza A virus exhibits species-specific MHC class II receptor usage
    Umut Karakus, Ignacio Mena, Jithesh Kottur, Sara S. El Zahed, Rocío Seoane, Soner Yildiz, Leanne Chen, Magdalena Plancarte, LeAnn Lindsay, Rebecca Halpin, Timothy B. Stockwell, David E. Wentworth, Geert-Jan Boons, Florian Krammer, Silke Stertz, Walter Boyce, Robert P. de Vries, Aneel K. Aggarwal, Adolfo García-Sastre
    Cell Host and Microbe, 2024
  • Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides
    Olga Rechkoblit, Daniela Sciaky, Dale F. Kreitler, Angeliki Buku, Jithesh Kottur, et al.
    Nature Structural and Molecular Biology, 2024
  • Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer
    Xufen Yu, Dongxu Li, Jithesh Kottur, Huen Suk Kim, Laura E. Herring, Yao Yu, Ling Xie, Xiaoping Hu, Xian Chen, Ling Cai, Jing Liu, Aneel K. Aggarwal, Gang Greg Wang, Jian Jin
    Journal of Medicinal Chemistry, 2023
    As a core chromatin-regulatory scaffolding protein, WDR5 mediates numerous protein-protein interactions (PPIs) with other partner oncoproteins. However, small-molecule inhibitors that block these PPIs exert limited cell-killing effects. Here, we report structure-activity relationship studies in pancreatic ductal adenocarcinoma (PDAC) cells that led to the discovery of several WDR5 proteolysis-targeting chimer (PROTAC) degraders, including 11 (MS132), a highly potent and selective von Hippel-Lindau (VHL)-recruiting WDR5 degrader, which displayed positive binding cooperativity between WDR5 and VHL, effectively inhibited proliferation in PDAC cells, and was bioavailable in mice and 25, a cereblon (CRBN)-recruiting WDR5 degrader, which selectively degraded WDR5 over the CRBN neo-substrate IKZF1. Furthermore, by conducting site-directed mutagenesis studies, we determined that WDR5 K296, but not K32, was involved in the PROTAC-induced WDR5 degradation. Collectively, these studies resulted in a highly effective WDR5 degrader, which could be a potential therapeutic for pancreatic cancer and several potentially useful tool compounds.
  • Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals
    Jithesh Kottur, Kris M. White, M. Luis Rodriguez, Olga Rechkoblit, Richard Quintana-Feliciano, Ahana Nayar, Adolfo García-Sastre, Aneel K. Aggarwal
    Plos Pathogens, 2023
    The RNA N7-methyltransferase (MTase) activity of SARS-CoV-2’s nsp14 protein is essential for viral replication and is a target for the development of new antivirals. Nsp14 uses S-adenosyl methionine (SAM) as the methyl donor to cap the 5’ end of the SARS-CoV-2 mRNA and generates S-adenosyl homocysteine (SAH) as the reaction byproduct. Due to the central role of histone MTases in cancer, many SAM/SAH analogs with properties of cell permeability have recently been developed for the inhibition of these MTases. We have succeeded in identifying two such compounds (SGC0946 and SGC8158) that display significant antiviral activity and bind to the SARS-CoV-2 nsp14 N7-MTase core. Unexpectedly, crystal structures of SGC0946 and SGC8158 with the SARS-CoV-2 nsp14 N7-MTase core identify them as bi-substrate inhibitors of the viral MTase, co-occupying both the SAM and RNA binding sites; positing novel features that can be derivatized for increased potency and selectivity for SARS-CoV-2 nsp14. Taken together, the high-resolution structures and the accompanying biophysical and viral replication data provide a new avenue for developing analogs of SGC0946 and SGC8158 as antivirals.
  • High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development
    Jithesh Kottur, Olga Rechkoblit, Richard Quintana-Feliciano, Daniela Sciaky, Aneel K. Aggarwal
    Nature Structural and Molecular Biology, 2022
  • Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
    Dongxu Li, Xufen Yu, Jithesh Kottur, Weida Gong, Zhao Zhang, Aaron J. Storey, Yi-Hsuan Tsai, Hidetaka Uryu, Yudao Shen, Stephanie D. Byrum, Rick D. Edmondson, Samuel G. Mackintosh, Ling Cai, Zhijie Liu, Aneel K. Aggarwal, Alan J. Tackett, Jing Liu, Jian Jin, Gang Greg Wang
    Oncogene, 2022
  • A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models
    Xufen Yu, Dongxu Li, Jithesh Kottur, Yudao Shen, Huen Suk Kim, Kwang-Su Park, Yi-Hsuan Tsai, Weida Gong, Jun Wang, Kyogo Suzuki, Joel Parker, Laura Herring, H. Ümit Kaniskan, Ling Cai, Rinku Jain, Jing Liu, Aneel K Aggarwal, Gang Greg Wang, Jian Jin
    Science Translational Medicine, 2021
  • A polar filter in DNA polymerases prevents ribonucleotide incorporation
    Mary K Johnson, Jithesh Kottur, Deepak T Nair
    Nucleic Acids Research, 2019
  • Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction
    Jithesh Kottur, Deepak T Nair
    Nucleic Acids Research, 2018
  • Reactive oxygen species play an important role in the bactericidal activity of quinolone antibiotics
    Jithesh Kottur, Deepak T. Nair
    Angewandte Chemie International Edition, 2016
  • The N2-Furfuryl-deoxyguanosine Adduct Does Not Alter the Structure of B-DNA
    Pratibha P. Ghodke, Kiran R. Gore, S. Harikrishna, Biswajit Samanta, Jithesh Kottur, Deepak T. Nair, P. I. Pradeepkumar
    Journal of Organic Chemistry, 2016
  • A rescue act: Translesion DNA synthesis past N2-deoxyguanosine adducts
    Deepak T. Nair, Jithesh Kottur, Rahul Sharma
    IUBMB Life, 2015
  • Erratum: Fast native-SAD phasing for routine macromolecular structure determination (Nature Methods (2015) 12 (131-133))
    Tobias Weinert, Vincent Olieric, Sandro Waltersperger, Ezequiel Panepucci, Lirong Chen, Hua Zhang, Dayong Zhou, John Rose, Akio Ebihara, Seiki Kuramitsu, Dianfan Li, Nicole Howe, Gisela Schnapp, Alexander Pautsch, Katja Bargsten, Andrea E Prota, Parag Surana, Jithesh Kottur, Deepak T Nair, Federica Basilico, Valentina Cecatiello, Sebastiano Pasqualato, Andreas Boland, Oliver Weichenrieder, Bi-Cheng Wang, Michel O Steinmetz, Martin Caffrey, Meitian Wang
    Nature Methods, 2015
  • Unique structural features in DNA polymerase IV enable efficient bypass of the N2 adduct induced by the nitrofurazone antibiotic
    Jithesh Kottur, Amit Sharma, Kiran R. Gore, Naveen Narayanan, Biswajit Samanta, Pushpangadan I. Pradeepkumar, Deepak T. Nair
    Structure, 2015
  • Fast native-SAD phasing for routine macromolecular structure determination
    Tobias Weinert, Vincent Olieric, Sandro Waltersperger, Ezequiel Panepucci, Lirong Chen, Hua Zhang, Dayong Zhou, John Rose, Akio Ebihara, Seiki Kuramitsu, Dianfan Li, Nicole Howe, Gisela Schnapp, Alexander Pautsch, Katja Bargsten, Andrea E Prota, Parag Surana, Jithesh Kottur, Deepak T Nair, Federica Basilico, Valentina Cecatiello, Sebastiano Pasqualato, Andreas Boland, Oliver Weichenrieder, Bi-Cheng Wang, Michel O Steinmetz, Martin Caffrey, Meitian Wang
    Nature Methods, 2015
  • A strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coli
    Amit Sharma, Jithesh Kottur, Naveen Narayanan, Deepak T. Nair
    Nucleic Acids Research, 2013

RECENT SCHOLAR PUBLICATIONS

  • Discovery of a Potent, Selective, and In Vivo Efficacious Covalent Inhibitor for Lysine Methyltransferase SETD8
    H Chen, RP Dutta, Z Li, Y Zhong, A Ma, KS Park, J Kottur, A Park, ...
    Journal of medicinal chemistry 69 (4), 4255-4269 , 2026
    2026
  • Mechanism of DNA degradation by CBASS Cap5 endonuclease immune effector
    O Rechkoblit, D Sciaky, M Ni, Y Li, J Kottur, G Fang, AK Aggarwal
    Nature Communications 16 (1), 5243 , 2025
    2025
    Citations: 4
  • Burkholderia cenocepacia epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation
    R Quintana-Feliciano, J Kottur, M Ni, R Ghosh, L Salas-Estrada, G Ahlsen, ...
    Nature Communications 15 (1), 7839 , 2024
    2024
    Citations: 4
  • H19 influenza A virus exhibits species-specific MHC class II receptor usage
    U Karakus, I Mena, J Kottur, SS El Zahed, R Seoane, S Yildiz, L Chen, ...
    Cell host & microbe 32 (7), 1089-1102. e10 , 2024
    2024
    Citations: 100
  • Nucleic acid mediated activation of a short prokaryotic Argonaute immune system
    J Kottur, R Malik, AK Aggarwal
    Nature Communications 15 (1), 4852 , 2024
    2024
    Citations: 14
  • Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides
    O Rechkoblit, D Sciaky, DF Kreitler, A Buku, J Kottur, AK Aggarwal
    Nature structural & molecular biology 31 (5), 767-776 , 2024
    2024
    Citations: 24
  • Natural Product-Based Anti-Viral Agents Against RNA Viruses: An Important Strategy for Pandemic Preparedness
    TG Nandu, K Jithesh
    Drugs from Nature: Targets, Assay Systems and Leads, 411-440 , 2024
    2024
    Citations: 6
  • Discovery of potent and selective WDR5 proteolysis targeting chimeras as potential therapeutics for pancreatic cancer
    X Yu, D Li, J Kottur, HS Kim, LE Herring, Y Yu, L Xie, X Hu, X Chen, L Cai, ...
    Journal of medicinal chemistry 66 (23), 16168-16186 , 2023
    2023
    Citations: 27
  • Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals
    J Kottur, KM White, ML Rodriguez, O Rechkoblit, R Quintana-Feliciano, ...
    PLoS Pathogens 19 (7), e1011546 , 2023
    2023
    Citations: 12
  • High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development
    J Kottur, O Rechkoblit, R Quintana-Feliciano, D Sciaky, AK Aggarwal
    Nature structural & molecular biology 29 (9), 850-853 , 2022
    2022
    Citations: 41
  • Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
    D Li, X Yu, J Kottur, W Gong, Z Zhang, AJ Storey, YH Tsai, H Uryu, Y Shen, ...
    Oncogene 41 (24), 3328-3340 , 2022
    2022
    Citations: 59
  • A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models
    X Yu, D Li, J Kottur, Y Shen, HS Kim, KS Park, YH Tsai, W Gong, J Wang, ...
    Science translational medicine 13 (613), eabj1578 , 2021
    2021
    Citations: 145
  • A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med, 13 (613), eabj1578
    X Yu, D Li, J Kottur, Y Shen, HS Kim, KS Park, YH Tsai, W Gong, J Wang, ...
    2021
    Citations: 6
  • A polar filter in DNA polymerases prevents ribonucleotide incorporation
    MK Johnson, J Kottur, DT Nair
    Nucleic acids research 47 (20), 10693-10705 , 2019
    2019
    Citations: 21
  • Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction
    J Kottur, DT Nair
    Nucleic Acids Research 46 (12), 5875-5885 , 2018
    2018
    Citations: 89
  • Reactive oxygen species play an important role in the bactericidal activity of quinolone antibiotics
    J Kottur, DT Nair
    Angewandte Chemie International Edition 55 (7), 2397-2400 , 2016
    2016
    Citations: 50
  • The N 2 -Furfuryl-deoxyguanosine Adduct Does Not Alter the Structure of B-DNA
    PP Ghodke, KR Gore, S Harikrishna, B Samanta, J Kottur, DT Nair, ...
    The Journal of Organic Chemistry 81 (2), 502-511 , 2016
    2016
    Citations: 18
  • A rescue act: Translesion DNA synthesis past N 2 ‐deoxyguanosine adducts
    DT Nair, J Kottur, R Sharma
    IUBMB life 67 (7), 564-574 , 2015
    2015
    Citations: 11
  • Fast native-SAD phasing for routine macromolecular structure determination
    T Weinert, V Olieric, S Waltersperger, E Panepucci, L Chen, H Zhang, ...
    Nature methods 12 (2), 131-133 , 2015
    2015
    Citations: 154
  • Unique structural features in DNA polymerase IV enable efficient bypass of the N2 adduct induced by the nitrofurazone antibiotic
    J Kottur, A Sharma, KR Gore, N Narayanan, B Samanta, PI Pradeepkumar, ...
    Structure 23 (1), 56-67 , 2015
    2015
    Citations: 31

MOST CITED SCHOLAR PUBLICATIONS

  • Fast native-SAD phasing for routine macromolecular structure determination
    T Weinert, V Olieric, S Waltersperger, E Panepucci, L Chen, H Zhang, ...
    Nature methods 12 (2), 131-133 , 2015
    2015
    Citations: 154
  • A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models
    X Yu, D Li, J Kottur, Y Shen, HS Kim, KS Park, YH Tsai, W Gong, J Wang, ...
    Science translational medicine 13 (613), eabj1578 , 2021
    2021
    Citations: 145
  • H19 influenza A virus exhibits species-specific MHC class II receptor usage
    U Karakus, I Mena, J Kottur, SS El Zahed, R Seoane, S Yildiz, L Chen, ...
    Cell host & microbe 32 (7), 1089-1102. e10 , 2024
    2024
    Citations: 100
  • Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction
    J Kottur, DT Nair
    Nucleic Acids Research 46 (12), 5875-5885 , 2018
    2018
    Citations: 89
  • Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
    D Li, X Yu, J Kottur, W Gong, Z Zhang, AJ Storey, YH Tsai, H Uryu, Y Shen, ...
    Oncogene 41 (24), 3328-3340 , 2022
    2022
    Citations: 59
  • Reactive oxygen species play an important role in the bactericidal activity of quinolone antibiotics
    J Kottur, DT Nair
    Angewandte Chemie International Edition 55 (7), 2397-2400 , 2016
    2016
    Citations: 50
  • A strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coli
    A Sharma, J Kottur, N Narayanan, DT Nair
    Nucleic acids research 41 (9), 5104-5114 , 2013
    2013
    Citations: 46
  • High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development
    J Kottur, O Rechkoblit, R Quintana-Feliciano, D Sciaky, AK Aggarwal
    Nature structural & molecular biology 29 (9), 850-853 , 2022
    2022
    Citations: 41
  • Unique structural features in DNA polymerase IV enable efficient bypass of the N2 adduct induced by the nitrofurazone antibiotic
    J Kottur, A Sharma, KR Gore, N Narayanan, B Samanta, PI Pradeepkumar, ...
    Structure 23 (1), 56-67 , 2015
    2015
    Citations: 31
  • Expression and purification of organic solvent stable lipase from soil metagenomic library
    M Khan, K Jithesh
    World Journal of Microbiology and Biotechnology 28 (6), 2417-2424 , 2012
    2012
    Citations: 28
  • Discovery of potent and selective WDR5 proteolysis targeting chimeras as potential therapeutics for pancreatic cancer
    X Yu, D Li, J Kottur, HS Kim, LE Herring, Y Yu, L Xie, X Hu, X Chen, L Cai, ...
    Journal of medicinal chemistry 66 (23), 16168-16186 , 2023
    2023
    Citations: 27
  • Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides
    O Rechkoblit, D Sciaky, DF Kreitler, A Buku, J Kottur, AK Aggarwal
    Nature structural & molecular biology 31 (5), 767-776 , 2024
    2024
    Citations: 24
  • A polar filter in DNA polymerases prevents ribonucleotide incorporation
    MK Johnson, J Kottur, DT Nair
    Nucleic acids research 47 (20), 10693-10705 , 2019
    2019
    Citations: 21
  • The N 2 -Furfuryl-deoxyguanosine Adduct Does Not Alter the Structure of B-DNA
    PP Ghodke, KR Gore, S Harikrishna, B Samanta, J Kottur, DT Nair, ...
    The Journal of Organic Chemistry 81 (2), 502-511 , 2016
    2016
    Citations: 18
  • Nucleic acid mediated activation of a short prokaryotic Argonaute immune system
    J Kottur, R Malik, AK Aggarwal
    Nature Communications 15 (1), 4852 , 2024
    2024
    Citations: 14
  • Cloning and characterization of two functionally diverse lipases from soil metagenome
    M Khan, K Jithesh, R Mookambikay
    The Journal of General and Applied Microbiology 59 (1), 21-31 , 2013
    2013
    Citations: 13
  • Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals
    J Kottur, KM White, ML Rodriguez, O Rechkoblit, R Quintana-Feliciano, ...
    PLoS Pathogens 19 (7), e1011546 , 2023
    2023
    Citations: 12
  • A rescue act: Translesion DNA synthesis past N 2 ‐deoxyguanosine adducts
    DT Nair, J Kottur, R Sharma
    IUBMB life 67 (7), 564-574 , 2015
    2015
    Citations: 11
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