@rgmcet.edu.in
Head of the Department and Asst Professor
Rajeev Gandhi Memorial College of Engineering and Technology
I am Dr. AVULA BALAKRISHNA from India, an experienced researcher in Synthetic organic and Medicinal , Iam HOD of Chemistry@RGMCET, Nandyal. India. I pursued my postdoctoral research in Department of Chemistry, University of Delaware, USA from February 2015 till February February 2016 and University of Coimbra, Portugal since September 2011 to September 2014. My thesis is entitled “Synthesis, Spectral Characterization and Bioactivity of Some Novel Organophosphorus Compounds” JULY 2010, Sri Venkateswara University, Tirupati, India. I have expertize in Organic Synthesis, in particular those aspects related to Heterocyclic Chemistry Synthesis of Porphyrins and Metalloporphyrins which may be used in Medicinal Chemistry for photodynamic therapy, Biomedicine and Environmental Technologies. Synthesis of Phosphorus bio-active heterocycles as Potential Pharmaceuticals in Medicine.
M.., Ph.D
Organic Chemistry, Chemistry, Analytical Chemistry, General Chemistry
Scopus Publications
K. Srishailam, A. Balakrishna, B. Venkatram Reddy, and G. Ramana Rao
Elsevier BV
N. MD. Akram, N. Madana Gopal, A. Balakrishna, N. Bakthavatchala Reddy, G. Sravya, and Grigory V. Zyryanov
AIP Publishing
Synthesis of macrocyclic ligands based on monosubstituted pillar[5]arenes containing amidopyridine fragments and study of their complexing properties with d-metal cations
N. M. D. Akram, N. Madana Gopal, A. Balakrishna, N. Bakthavatchala Reddy, and Grigory V. Zyryanov
AIP Publishing
. To develop and validate a novel reverse phase high performance liquid chromatography determination of Tinidazole and Roxithromycin in its Bulk and Pharmaceutical Dosage Forms. Examination of simultaneous determination is centered around the advancement of novel RPHPLC systematic technique for the assurance of medication substance in strong oral dose shapes and their approval. Optimized chromatographic condition was established for the estimation of Tinidazole and Roxithromycin by using Agilent C 18 (4.6 X 250mm, 5 µm) column, sodium acetate buffer (P H 3) and Methanol (30:70% v/v) as mobile phase at a flow rate of 1.0 ml/min sustain an ambient temperature. The total analysis time was 10 minutes and retention of Tinidazole and Roxithromycin was found to be 2.352 and 5.941 min with an injection volume of 20 µl. The system suitability parameters proved for optimized chromatographic conditions for Tinidazole and Roxithromycin
N. M. D. Akram, N. Madana Gopal, A. Balakrishna, and N. Bakthavatchala Reddy
AIP Publishing
. A new simple assay method has been developed and validated for the determination of Anastrazole and Temozolomide using reverse-phase high performance liquid chromatography in their pharmaceutical dosage form. The chromatographic separation was performed on an Inertsil ODS (4.6 x 150mm, 5µm) using mobile phase phosphate buffer pH 3.0 and methanol of 30:70% v/v at a flow rate of 0.8 mL/min. Analytes were detected at 260 nm. The method was found to be linear in the concentration range of 1-5 μg/mL for both medicaments with the coefficient value (R2) of >0.999. The accuracy was measured via recovery studies and found to be acceptable and the percentage recoveries were found in the range of 98.81-100.72 and 99.29-100.70%. The proposed method was successfully validated and applied for the quantitative estimation of these drugs in both bulk and tablet dosage forms.
G. Sravya, A. Balakrishna, Grigory V. Zyryanov, G. Mohan, C. Suresh Reddy, and N. Bakthavatchala Reddy
Informa UK Limited
Abstract The review discusses recent achievements in the development of more ecofriendly and economically viable processes for the synthesis of biologically potent α-aminophosphonates via Kabachnik-Fields reaction by three-component coupling of carbonyl, amine and hydrophosphoryl compounds. These α-aminophosphonates exhibited promising antioxidant, antimicrobial and anticancer activity. Some recent developments on the synthesis of biologically active α-aminophosphonates in the presence of various catalysts, in catalytic solvent medium, in catalyst-free solvent medium, under solvent-free conditions, and reactions in solution are discussed. Miscellaneous reactions are also included. Graphical Abstract
A. Balakrishna, G. Sravya, T.V. Surendra, C. Suresh Reddy, Grigory V. Zyryanov, and N. Bakthavatchala Reddy
Elsevier
G. Sravya, G. Suresh, Grigory V. Zyryanov, A. Balakrishna, K. Madhu Kumar Reddy, C. Suresh Reddy, C. Venkataramaiah, W. Rajendra, and N. Bakthavatchala Reddy
Wiley
AbstractA simple method was employed for the synthesis of dihydropyrano[3, 2‐b]chromenedione derivatives (4a‐o) in high yields by condensation of 5, 5‐dimethylcyclohexane‐1, 3‐dione(1), different aromatic aldehydes (2a‐o), and 5‐hydroxy‐2‐(hydroxymethyl)‐4H‐pyran‐4‐one(3), using meglumine as a stable and reusable catalyst. Meglumine, an amino sugar, was employed as an environmentally benign catalyst, due to its splendid properties such as being inexpensive, recyclable, and biodegradable. The accomplished protocol employs low catalyst loading and easy work‐up for the synthesis of 5‐hydroxy‐2‐(hydroxymethyl)‐4H‐pyran‐4‐one derivatives. A great asset is that without any significant loss, the catalyst could be recovered and reused for extended synthetic steps. This offer huge advantage to overcome recyclability issues. Our synthesized compounds were analyzed by IR, 1H, 13C NMR, mass spectra and evaluated for their antioxidant properties by 1, 1‐diphenyl‐2‐picryl hydrazyl radical (DPPH), hydrogen peroxide(H2O2), and nitric oxide (NO) scavenging methods. The correlation in exhibition of antioxidant activity was effective at all doses. The binding interactions and molecular docking studies for entitled compounds were studied against 3MNG protein; 4k exhibited marked binding affinity with excellent docking score of −7.6 Kcal/mol and emerged as a lead compound.
Nemallapudi Bakthavatchala Reddy, Grigory V. Zyryanov, Guda Mallikarjuna Reddy, Avula Balakrishna, Adivireddy Padmaja, Venkatapuram Padmavathi, Cirandur Suresh Reddy, Jarem Raul Garcia, and Gundala Sravya
Wiley
G. Sravya, N. Bakthavatchala Reddy, A. Balakrishna, and Grigory V. Zyryanov
Author(s)
A new class of mono and bis heterocycles-4-(chloromethyl)((styrylsulfonyl)methyl) oxazoles and 4-(chloromethyl)((styrylsulfonyl)methyl)oxazolyl morpholines/thiomorpholines were prepared from the synthetic intermediate Z-styrylsulfonylaceticacid adopting simple and well versed synthetic methodologies and were studied for their respective antimicrobial activity. All the entitled compounds were characterized by IR, 1 H, 13 C NMR, mass spectra.
Avula Balakrishna, António Aguiar, Pedro J. M. Sobral, Mohmmad Younus Wani, Joana Almeida e Silva, and Abilio J. F. N. Sobral
Informa UK Limited
ABSTRACT The pyrrole molecular framework is found in a large number of natural and synthetic compounds of great importance. Since functionalized pyrroles are essential for the progress of many branches of science, its synthesis by simple, efficient and eco-friendly routes are particularly attractive in modern organic and bio-organic chemistry. To this end, a number of synthetic methods have been developed, in which the Paal–Knorr pyrrole synthesis stands out to be the easiest route to synthesize pyrroles. In spite of the efficiency, Paal–Knorr synthesis of pyrroles is considered limited by harsh reaction conditions, such as prolonged heating in acid, which may degrade sensitive functionalities in many potential precursors. Through this route almost all dicarbonyls can be converted to their corresponding heterocycles and therefore it is a synthetically valued process. To address the adverse issues this reaction route has undergone numerous modifications recently and today it can be said that this reaction route is a prominent green route for the synthesis of pyrroles. This review is a tour from the evolution and application of this harsh synthetic route to the eco-friendly greener route developed for the synthesis of pyrroles.
A simple and efficient method has been employed for synthesis of a novel series of biologically active α-aminophosphonates (4a-j) by reacting 1H-benzo[d]imidazole-2-carbaldehyde (1) and various aromatic amines (2a-j) and diethyl/dimethyl phosphite (3) by Kabachnik-Field's reaction in the presence of efficient heterogeneous K2CO3/Al2O3 catalyst under solvent-free conditions at 140 ºC. Structures of all the compounds were confirmed by 1H, 13C and 31P NMR and LC-MS. In addition to this antioxidant activity were also evaluated.
G. Sravya, Zyryanov Grigory V., A. Balakrishna, K. Madhu Kumar Reddy, C. Suresh Reddy, G. Mallikarjuna Reddy, A. Camilo, J. R. Garcia, and N. Bakthavatchala Reddy
Informa UK Limited
GRAPHICAL ABSTRACT ABSTRACT A simple and highly efficient method has been employed for the synthesis of a novel series of diverse biologically active α-aminophosphonates (4a-m) by reacting 7-nitro-2,3-dihydrobenzo[b][1,4]dioxine-6-carbaldehyde (1) with various aromatic/hetero aromatic amines (2a-m) and dimethyl phosphite (3) by the Kabachnik-Fields reaction in the presence of an efficient heterogeneous Nano-TiO2/SiO2 (5 mol%) catalyst, which represents an effective Lewis acid and reusable catalyst under reflux conditions. A systematic structure activity relationships (SAR) analysis was performed on all the title compounds to define a relationship between their chemical structures and their antimicrobial activities. In addition, theoretical calculations such as density functional theory (DFT) and minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC) were also evaluated.
N. Bakthavatchala Reddy, Grigory V. Zyryanov, G. Mallikarjuna Reddy, A. Balakrishna, J. R. Garcia, A. Camilo, and G. Sravya
Springer Science and Business Media LLC
For comprehensive studies on drugs primarily in the form of biomimetic systems, electronic parameters are becoming essential tools in elucidating the structures of the investigated compounds. In this study we present the synthesis, characterization, and evaluation of biological potency of 4(a–g), 5(a–g), and 7(a–g) by conducting structure–activity relationship (SAR) studies. Further conducting density functional theory (DFT) simulation studies for entitled compounds 4(a–g), 5(a–g), and 7(a–g) allowed us to fully study the effect of the changes of electronic and molecular structures on their biological activity by demonstrating the role of frontier molecular orbitals, in particular LUMO. The electron withdrawing nitro group substituted compounds 5d and 7d have higher activity than all other active compounds. Thus, the results strongly suggest that the SARs are in good agreement with simulation studies.
Balu Krishnakumar, Avula Balakrishna, Shaik Abdullah Nawabjan, V. Pandiyan, António Aguiar, and Abilio J.F.N. Sobral
Elsevier BV
Balu Krishnakumar, Avula Balakrishna, Cláudia T. Arranja, Carlos M.F. Dias, and Abilio J.F.N. Sobral
Elsevier BV
Jarupat Kanjanarong, Balendu S. Giri, Deb P. Jaisi, Fernanda R. Oliveira, Piyarat Boonsawang, Sumate Chaiprapat, R.S. Singh, Avula Balakrishna, and Samir Kumar Khanal
Elsevier BV
Deb P. Jaisi, Hui Li, Adam F. Wallace, Prajwal Paudel, Mingjing Sun, Avula Balakrishna, and Robert N. Lerch
American Chemical Society (ACS)
Degradation of glyphosate in the presence of manganese oxide and UV light was analyzed using phosphate oxygen isotope ratios and density function theory (DFT). The preference of C-P or C-N bond cleavage was found to vary with changing glyphosate/manganese oxide ratios, indicating the potential role of sorption-induced conformational changes on the composition of intermediate degradation products. Isotope data confirmed that one oxygen atom derived solely from water was incorporated into the released phosphate during glyphosate degradation, and this might suggest similar nucleophilic substitution at P centers and C-P bond cleavage both in manganese oxide- and UV light-mediated degradation. The DFT results reveal that the C-P bond could be cleaved by water, OH- or •OH, with the energy barrier opposing bond dissociation being lowest in the presence of the radical species, and that C-N bond cleavage is favored by the formation of both nitrogen- and carbon-centered radicals. Overall, these results highlight the factors controlling the dominance of C-P or C-N bond cleavage that determines the composition of intermediate/final products and ultimately the degradation pathway.
Mohmmad Younus Wani, Avula Balakrishna, Santosh Kumar, and Abilio J.F.N Sobral
Bentham Science Publishers Ltd.
Consuelo Yuste, Claudia C. Arranja, Mariana Marcos, Avula Balakrishna, Abilio J. F. N. Sobral, and Manuela Ramos Silva
Walter de Gruyter GmbH
Abstract C44H28ClMnN4, monoclinic, P21/c (no. 14), a = 12.3044(6) Å, b = 21.688(1) Å, c = 17.0016(8) Å, β = 123.536(3)°, V = 3781.9 Å3, Z = 4, Rgt(F) = 0.0645, wRref(F2) = 0.0939, T = 293 K
Micael D. Miranda, Manuela Ramos Silva, Teresa M. R. Maria, Avula Balakrishna, and Abilio J. F. N. Sobral
International Union of Crystallography (IUCr)
Molecules of the title compound, C52H38N4O8, are located on an inversion center so that the asymmetric cell contains one half of the molecule. The macrocycle exhibits a ruffled conformation with a maximum deviation of 0.16 Å for the 24 macrocycle atoms: the dihedral angle between adjacent five-membered rings is 5.13 (19)°. The benzene rings are rotated by 70.25 (19)° with respect to their adjacent protonated five-membered rings, and by 65.56 (19)° with respect to the unprotonated rings. The porphyrin conformation is supported by bifurcated N—H⋯(N,N) hydrogen bonds. The structure contained poorly resolved solvent molecules in voids of volume 217 Å3 per unit cell. The latter were treated using the SQUEEZE routine in PLATON [Spek (2009 ▶). Acta Cryst. D65, 148–155]. As the solvent could not be identified exactly, it was not included in the calculation of the overall formula weight, density and absorption coefficient.
A. Balakrishna, M. Veera Narayana Reddy, P. Visweswara Rao, M. Anil Kumar, B. Siva Kumar, S.K. Nayak, and C. Suresh Reddy
Elsevier BV
M. Veera Narayana Reddy, A. Bala krishna, and C. Suresh Reddy
Elsevier BV
Avula Balakrishna, Kishore Chiruvella, Mudumala Reddy, Rajesh Reddy, Sandip Nayak, Sathees Raghavan, and Cirandur Reddy
Bentham Science Publishers Ltd.
A series of novel fluoroaminophosphates 4a-4j were synthesized by one-pot method in presence of tetramethylguanidine (TMG) as a catalyst and were characterized by elemental analysis, FTIR, H-1, C-13, P-31, F-19 NMR, and mass spectra. All the title compounds were evaluated forin vitro cytotoxicity against leukemic cell line derived from T-cells of leukemia patient (CEM cells) by Trypan blue exclusion and MTT assays, and these were found to exert concentration dependent cytotoxic effects. Among them 4f, 4g & 4j possessed marked cytotoxicity. 4g
(with IC50 value of 6 mu M) had emerged as lead compound.