I am Dr. AVULA BALAKRISHNA from India, an experienced researcher in Synthetic organic and Medicinal , Iam HOD of Chemistry@RGMCET, Nandyal. India. I pursued my postdoctoral research in Department of Chemistry, University of Delaware, USA from February 2015 till February February 2016 and University of Coimbra, Portugal since September 2011 to September 2014. My thesis is entitled “Synthesis, Spectral Characterization and Bioactivity of Some Novel Organophosphorus Compounds” JULY 2010, Sri Venkateswara University, Tirupati, India. I have expertize in Organic Synthesis, in particular those aspects related to Heterocyclic Chemistry Synthesis of Porphyrins and Metalloporphyrins which may be used in Medicinal Chemistry for photodynamic therapy, Biomedicine and Environmental Technologies. Synthesis of Phosphorus bio-active heterocycles as Potential Pharmaceuticals in Medicine.
EDUCATION
M.., Ph.D
RESEARCH, TEACHING, or OTHER INTERESTS
Organic Chemistry, Chemistry, Analytical Chemistry, General Chemistry
Method development and validation of a reversed phase HPLC method for determination of Anastrazole and Temozolomide in pharmaceutical dosage form N. M. D. Akram, N. Madana Gopal, A. Balakrishna, N. Bakthavatchala Reddy Aip Conference Proceedings, 2020 . A new simple assay method has been developed and validated for the determination of Anastrazole and Temozolomide using reverse-phase high performance liquid chromatography in their pharmaceutical dosage form. The chromatographic separation was performed on an Inertsil ODS (4.6 x 150mm, 5µm) using mobile phase phosphate buffer pH 3.0 and methanol of 30:70% v/v at a flow rate of 0.8 mL/min. Analytes were detected at 260 nm. The method was found to be linear in the concentration range of 1-5 μg/mL for both medicaments with the coefficient value (R2) of >0.999. The accuracy was measured via recovery studies and found to be acceptable and the percentage recoveries were found in the range of 98.81-100.72 and 99.29-100.70%. The proposed method was successfully validated and applied for the quantitative estimation of these drugs in both bulk and tablet dosage forms.
A new validated RP-HPLC method for the determination of Tinidazole and Roxithromycin in its bulk and pharmaceutical dosage forms N. M. D. Akram, N. Madana Gopal, A. Balakrishna, N. Bakthavatchala Reddy, Grigory V. Zyryanov Aip Conference Proceedings, 2020 . To develop and validate a novel reverse phase high performance liquid chromatography determination of Tinidazole and Roxithromycin in its Bulk and Pharmaceutical Dosage Forms. Examination of simultaneous determination is centered around the advancement of novel RPHPLC systematic technique for the assurance of medication substance in strong oral dose shapes and their approval. Optimized chromatographic condition was established for the estimation of Tinidazole and Roxithromycin by using Agilent C 18 (4.6 X 250mm, 5 µm) column, sodium acetate buffer (P H 3) and Methanol (30:70% v/v) as mobile phase at a flow rate of 1.0 ml/min sustain an ambient temperature. The total analysis time was 10 minutes and retention of Tinidazole and Roxithromycin was found to be 2.352 and 5.941 min with an injection volume of 20 µl. The system suitability parameters proved for optimized chromatographic conditions for Tinidazole and Roxithromycin
Synthesis of α-aminophosphonates by the Kabachnik-Fields reaction G. Sravya, A. Balakrishna, Grigory V. Zyryanov, G. Mohan, C. Suresh Reddy, et al. Phosphorus Sulfur and Silicon and the Related Elements, 2020 The review discusses recent achievements in the development of more ecofriendly and economically viable processes for the synthesis of biologically potent α-aminophosphonates via Kabachnik-Fields reaction by three-component coupling of carbonyl, amine and hydrophosphoryl compounds. These α-aminophosphonates exhibited promising antioxidant, antimicrobial and anticancer activity. Some recent developments on the synthesis of biologically active α-aminophosphonates in the presence of various catalysts, in catalytic solvent medium, in catalyst-free solvent medium, under solvent-free conditions, and reactions in solution are discussed. Miscellaneous reactions are also included. Graphical Abstract
A meglumine catalyst–based synthesis, molecular docking, and antioxidant studies of dihydropyrano[3, 2-b]chromenedione derivatives G. Sravya, G. Suresh, Grigory V. Zyryanov, A. Balakrishna, K. Madhu Kumar Reddy, et al. Journal of Heterocyclic Chemistry, 2020 A simple method was employed for the synthesis of dihydropyrano[3, 2‐b]chromenedione derivatives (4a‐o) in high yields by condensation of 5, 5‐dimethylcyclohexane‐1, 3‐dione(1), different aromatic aldehydes (2a‐o), and 5‐hydroxy‐2‐(hydroxymethyl)‐4H‐pyran‐4‐one(3), using meglumine as a stable and reusable catalyst. Meglumine, an amino sugar, was employed as an environmentally benign catalyst, due to its splendid properties such as being inexpensive, recyclable, and biodegradable. The accomplished protocol employs low catalyst loading and easy work‐up for the synthesis of 5‐hydroxy‐2‐(hydroxymethyl)‐4H‐pyran‐4‐one derivatives. A great asset is that without any significant loss, the catalyst could be recovered and reused for extended synthetic steps. This offer huge advantage to overcome recyclability issues. Our synthesized compounds were analyzed by IR, 1H, 13C NMR, mass spectra and evaluated for their antioxidant properties by 1, 1‐diphenyl‐2‐picryl hydrazyl radical (DPPH), hydrogen peroxide(H2O2), and nitric oxide (NO) scavenging methods. The correlation in exhibition of antioxidant activity was effective at all doses. The binding interactions and molecular docking studies for entitled compounds were studied against 3MNG protein; 4k exhibited marked binding affinity with excellent docking score of −7.6 Kcal/mol and emerged as a lead compound.
Synthesis and bioassay of styryl sulfonylmethyl oxazolyl tethered morpholines and thiomorpholines G. Sravya, N. Bakthavatchala Reddy, A. Balakrishna, Grigory V. Zyryanov Aip Conference Proceedings, 2019 A new class of mono and bis heterocycles-4-(chloromethyl)((styrylsulfonyl)methyl) oxazoles and 4-(chloromethyl)((styrylsulfonyl)methyl)oxazolyl morpholines/thiomorpholines were prepared from the synthetic intermediate Z-styrylsulfonylaceticacid adopting simple and well versed synthetic methodologies and were studied for their respective antimicrobial activity. All the entitled compounds were characterized by IR, 1 H, 13 C NMR, mass spectra.
Synthesis and antimicrobial activity of 2,10-dichloro-6-substituted amino acid ester- 12H-dibenzo [d,g] [1,3,2] dioxaphosphocin-6-oxides Bulgarian Chemical Communications, 2009