Dr Rizwan Ahmad
@vivekcollege.ac.in
Professor,Department of Pharmacognosy, Vivek College of Technical Education
Vivek College of Technical Education
Dr. Rizwan Ahmad is graduate in pharmacy from Kumun University Nainital, post graduate in Pharmacy from Al Ameen College of Pharmacy, Bangalore and Doctorate from Uttarakhand Technical University, Dehradun.
Dr. Rizwan Ahmad has been into teaching right after his M. Pharm. with more than 17 years of teaching experience. He authored more than 30 papers in national and international journals and has widely delivered lectures on various topics in Pharmacy. He has successfully supervised 3 Ph.D. scholars and is also presently guiding one PhD research scholars in the areas of Phytomedicine.
Dr. Rizwan Ahmad is also working as Member Secretary in IAEC, Centre Superintendent in AKTU Semester examination and Nodal Officer in Smartphone Distribution scheme of UP Govt. and Scholarship Distribution System of UPG and Training and Placement officer in AKTU placement Cell. He has been associated with several Universities, as Evaluator and Paper setter and also at PCI, New Delhi
EDUCATION
M.Pharm ,Ph.D
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmaceutical Science, Pharmacy, Pharmaceutical Science, Pharmacy
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Nadeem Rais, Akash Ved, Rizwan Ahmad, and Aashna Parveen
Bentham Science Publishers Ltd.
Background: The degenerative tendency of diabetes leads to micro- and macrovascular complications due to abnormal levels of biochemicals, particularly in patients with poor diabetic control. Diabetes is supposed to be treated by reducing blood glucose levels, scavenging free radicals, and maintaining other relevant parameters close to normal ranges. In preclinical studies, numerous in vivo trials on animals as well as in vitro tests are used to assess the antidiabetic and antioxidant effects of the test substances. Since a substance that performs poorly in vitro won't perform better in vivo, the outcomes of in vitro studies can be utilized as a direct indicator of in vivo activities. Objective: The objective of the present study is to provide research scholars with a comprehensive overview of laboratory methods and procedures for a few selected diabetic biomarkers and related parameters. Method: The search was conducted on scientific database portals such as ScienceDirect, PubMed, Google Scholar, BASE, DOAJ, etc. Conclusion: The development of new biomarkers is greatly facilitated by modern technology such as cell culture research, lipidomics study, microRNA biomarkers, machine learning techniques, and improved electron microscopies. These biomarkers do, however, have some usage restrictions. There is a critical need to find more accurate and sensitive biomarkers. With a few modifications, these biomarkers can be used with or even replace conventional markers of diabetes.
Nadeem Rais, Akash Ved, Rizwan Ahmad, Manoj Kumar, Mrunal Deepak Barbhai, Radha, Deepak Chandran, Abhijit Dey, Sangram Dhumal, Marisennayya Senapathy,et al.
Elsevier BV
Nadeem Rais, Akash Ved, Mohd. Shadab, Rizwan Ahmad, and Mohammad Shahid
Emerald
PurposeTaurine (2-aminoethane sulfonic acid; C2H7NO3S) is a nonprotein sulfur-containing β-amino acid present in nearly all mammalian tissues and the most ubiquitous free endogenous biomolecule in human cells. Taurine is commonly known as a conditionally essential amino acid because taurine is one of the few amino acids that are not incorporated in protein synthesis. The purpose of this study is to review the existing articles related to taurine and to give an account how useful is taurine to the different body systems. In this thorough overview, taurine is covered in terms of its essentiality, sources, advantages for neonates and the elderly, the effects of taurine deficiency, and the safety and toxicity of taurine supplements.Design/methodology/approachThis is a narrative review into the subject matter. Published articles were searched on different portals like PubMed, EMBASE, Scopus, Google Scholar, PubChem etc. The authors also evaluated the availability of taurine in commercially available energy drinks.FindingsThis comprehensive review, presents the potential clinical benefits and functional properties of taurine as a conditionally essential amino acid. Energy drinks containing taurine (and their concentration) are also reported in this review.Originality/valueThis is the first data that the authors are aware of that shows taurine content in a variety of energy drinks on the market.
Nadeem Rais, Akash Ved, Rizwan Ahmad, Kehkashan Parveen, and Mohd. Shadab
Emerald
PurposeRenal failure is an end-stage consequence after persistent hyperglycemia during diabetic nephropathy (DN), and the etiology of DN has been linked to oxidative stress. The purpose of this research was to determine the beneficial synergistic effects of S-Allyl Cysteine (SAC) and Taurine (TAU) on oxidative damage in the kidneys of type 2 diabetic rats induced by hyperglycemia.Design/methodology/approachExperimental diabetes was developed by administering intraperitoneal single dose of streptozotocin (STZ; 65 mg/kg) with nicotinamide (NA; 230 mg/kg) in adult rats. Diabetic and control rats were treated with SAC (150 mg/kg), TAU (200 mg/kg) or SAC and TAU combination (75 + 100 mg/kg) for four weeks. The estimation of body weight, fasting blood glucose (FBG), oral glucose tolerance test (OGTT), oxidative stress markers along with kidney histopathology was done to investigate the antidiabetic potential of SAC/TAU in the NA/STZ diabetic group.FindingsThe following results were obtained for the therapeutic efficacy of SAC/TAU: decrease in blood glucose level, decreased level of thiobarbituric acid reactive substances (TBARS) and increased levels of GSH, glutathione-s-transferase (GST) and catalase (CAT). SAC/TAU significantly modulated diabetes-induced histological changes in the kidney of rats.Originality/valueSAC/TAU combination therapy modulated the oxidative stress markers in the kidney in diabetic rat model and also prevented oxidative damage as observed through histopathological findings.
Nadeem Rais, Rizwan Ahmad, Akash Ved, Kehkashan Parveen, Darakhshan Gazala Bari, and Om Prakash
Bentham Science Publishers Ltd.
Introduction: Diabetes mellitus (DM) and steroid medication, coincided with coronavirus disease 2019 (COVID-19), results in a weakened immune system, allowing some commonly found pathogens to become more harmful. Mucormycosis (black fungus) is a type of opportunistic infection caused by fungi belonging to the Mucorales family. DM is the most prominent risk factor for mucormycosis. Excessive blood sugar and decreased insulin levels lead to diabetic ketoacidosis (DKA), a devastating complication of DM that can be fatal if left untreated. Methods: Diabetic ketoacidosis is more common in type 1 diabetic patients, although it can also be fall in type 2 diabetic patients. DKA occurs when the body lacks enough insulin to allow blood sugar to enter the cells and is used for energy. Instead, the liver breaks down fat for fuel-producing chemicals known as ketones. Results: When too many ketones are created too quickly, they can reach dangerously high levels in the body. Mucormycosis is a rare but serious infectious disease that requires medication or surgical removal. Conclusion: The confluence of diabetes and COVID-19 makes managing mucormycosis a serious and dead issue. Although the effectiveness of prophylactic antifungal therapy has yet to be demonstrated, hyperglycemia control appears to be the most important step in managing mucormycosis in DKA patients.
Akash Ved, Nadeem Rais, Rizwan Ahmad, Kehkashan Parveen, Girendra Kumar Gautam, Darakhshan Gazala Bari, Karuna S. Shukla, Ravi Gaur, and Akhand Pratap Singh
Bentham Science Publishers Ltd.
: The aim of the present study was to review the streptozotocin-nicotinamide (STZ-NA) diabetes model. Type 2 diabetes is more prevalent (90-95%) in adults than type 1. Experimentally- induced diabetes models may be established by chemicals, viral agents, insulin antibodies, surgery, etc. The most advisable and prompt method to induce diabetes is using chemicals, and STZ and alloxan are widely used chemicals. STZ has proven to be a better diabetogenic agent than alloxan because alloxan has many drawbacks, as it induces only type 1 diabetes, has a high mortality rate in rats, and causes ketosis in animals. Moreover, it has lesser selectivity towards β-cells, and the diabetes-induced is reversible. STZ can be used to induce both type 1 and type 2 diabetes. It is noted that the genotoxic behavior of STZ in animals is accomplished through a reduction of nicotinamide adenine dinucleotide (NAD+) in pancreatic β-cells via the GLUT2 (Glucose transporter 2), which can cause cellular damage by DNA (Deoxyribonucleic acid) strand breaks that lead to cell death. NA is a biochemical precursor of NAD+, and it is a poly-ADP-ribose-polymerase-1 (PARP- 1) inhibitor. NAD+ is an important redox reaction co-enzyme for the production of adenosine triphosphate (ATP) and many other metabolic pathways. Extreme DNA damage contributes to the over-activation of PARP-1, loss of cellular resources, and necrotic cells death. Some studies have expressed that NA can protect pancreatic β-cells against the severe cytotoxicity of STZ. The review concluded that the STZ-NA model is dependent on the competency of NA to attain partial protection against the β-cytotoxic essence of STZ to induce type-2 diabetes.
Nadeem Rais, Akash Ved, Rizwan Ahmad, Kehkashan Parveen, Om Prakash, Darakhshan Gazala Bari, Khursheed Ahmad, Muhammad Farman, and Naze Alam
Bentham Science Publishers Ltd.
Background: Coronavirus disease 2019 (Covid-19) is caused by a novel coronavirus (SARS-CoV-2) infection, while influenza viruses cause the flu. SARS-CoV-2 and influenza virus co-infection seems to be a real and serious concern. Objective: This study aims to evaluate the clinical features, laboratory investigations, computed tomography scans, and interventions of Covid-19 patients during seasonal influenza. Methods: This was a multi-center prospective cohort study that collected data from hospitals, clinics, and laboratories on measurements, treatments, and outcomes from Covid-19 patients admitted to temporary Covid-19 care centers. Results: A total of 480 individuals (female, 231 [48.12%]; male, 249 [51.88%]) were recruited from March 31st to May 14th, 2021 at five hospitals/clinics in Uttar Pradesh, North India. The patients were divided into six groups based on their age (65+ years [25.41% of cases] being the most affected age) and five groups based on their conditions (asymptomatic 65 [13.54%], mild 94 [19.58%], moderate 206 [42.91%], severe 84 [17.50%] and critical 31 [6.45%]). Patients’ outcomes were documented as death (19 [3.95%]), recovery (421 [87.71%]) and undertreatment (40 [8.34%]). Conclusions: The most common clinical symptoms reported were fever, sore throat, and dyspnea. The severity was linked to hypoxemia, lymphocytopenia, thrombocytopenia, elevated erythrocyte sedimentation rate (ESR), and high blood urea nitrogen (BUN). The vast majority of patients were given symptomatic treatment. Any onset of fever should be suspected and examined for the viral strain to distinguish between Covid-19 and the seasonal flu.
Akash Ved, Nadeem Rais, Rizwan Ahmad, Kehkashan Parveen, Tauheed Ishrat, Om Prakash, Mohd Shadab, Darakhshan Gazala Bari, and Nasir Ali Siddiqui
Bentham Science Publishers Ltd.
Background: Diabetes mellitus (DM) is among the most frequently reported comorbidities in patients tainted with the pandemic coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With a high pervasiveness of diabetes mellitus, there is an urgency to understand the special aspects of COVID-19 in hyperglycemic patients. Diabetic patients are at higher risk than the general population of viral or bacterial infections, thus require special attention since diabetes is linked with severe, critical, and lethal modes of COVID-19. Objective: The objective of this study was to focus on epidemiology, pathophysiology, mechanism, and management of DM with COVID-19. Method: The search was carried out on databases portals such as Pubmed, EMBASE, Google Scholar, and CINAHL with the keywords, i.e., COVID-19, coronavirus, SARS-CoV-2, diabetes, covid-19, etc. Result: DM and COVID-19 disease conditions can impact each other in terms of clinical progression and outcome. Available laboratory/clinical observations suggest that hyperglycemia-induced immune dysfunction, inflated lactate grades, and cytokines storm may play critical roles in the seriousness of COVID-19 in patients with diabetes; however, the exact mechanisms linking diabetes and COVID-19 remain to be further clarified. Conclusion: Standards to constrain the disease spread at the individual and community level are the key to extenuate the speedily rising pandemic, while definitive treatment, like plasma therapy, chemoprophylaxis, or vaccine for COVID-19, has yet to be discovered.
Nadeem Rais, Kehkashan Parveen, Rizwan Ahmad, Waseem Ahmad Siddiqui, Ayasha Nadeem, and Akash Ved
FapUNIFESP (SciELO)
Nadeem Rais, Akash Ved, Rizwan Ahmad, Kehkashan Parveen, and Om Prakash
Radiance Research Academy
Rizwan Ahmad, Mohd. Mujeeb, Aftab Ahmad, and Firoz Anwar
Bangladesh Journals Online (JOL)
<p class="Abstract">The methanolic extract of <em>Aegle marmelos</em> leaves was evaluated against cisplatin-induced renal toxicity in rats. Rats were divided into 5 groups: Group 1 received normal saline (1 mL, p.o.) for 15 days; Group II received single dose of cisplatin (5 mg/kg, i.p.) on day 15 and normal saline (1 mL, p.o.) for 15 days; Group III, IV and V were pretreated with extract at doses of 100, 300, 600 mg/kg, p.o., respectively for 15 days followed by single dose of cisplatin on day 15. The blood was collected on the day 16. The urea, creatinine, uric acid, sodium, potassium levels in the serum/blood and TBARS, reduced glutathione (GSH), sueroxide dismutase, catalase in tissue homogenate of kidneys were analyzed. The extract at all doses significantly ameliorated the changes in the serum parameters and decreased the elevated level of TBARS and increased the reduced level of GSH, sueroxide dismutase, catalase. The <em>A. marmelos</em> extract was found to possess nephroprotective and anti-oxidant activities.</p><p> </p>