SANGARAJU RAJENDRA

EDUCATION

B. Pharm, M. Pharm ( Pharmacology), Ph.D. Biological Sciences/ Pharmaceutical Sciences/ Pharmacology//Inflammo Pharmacology

RESEARCH, TEACHING, or OTHER INTERESTS

General Pharmacology, Toxicology and Pharmaceutics, Pharmacy, General Biochemistry, Genetics and Molecular Biology, Food Science

Scopus Publications

Stevioside alleviates high-fat diet-induced MASLD in Apo-E‑/‑ mice by modulating the TGF-β signaling
Sateesh Alavala, Nidhi Sharma, Rajendra Sangaraju, Suresh Challa, Ramakrishna Sistla, et al.
Journal of Nutritional Biochemistry, 2026
Inhibiting Neuropilin-1 as a novel therapeutic approach to mitigate pulmonary fibrosis: Highlighting the potential anti-fibrotic effects of ATWLPPR peptide
Gauthami Pulivendala, Swarna Bale, Sai Kiran Yanala, Rajendra Sangaraju, Chandraiah Godugu
International Immunopharmacology, 2025
Effect of ethyl acetate extract of the whole plant Clerodendrum phlomidis on improving bleomycin (BLM)-induced idiopathic pulmonary fibrosis (IPF) in Rats: In vitro and in vivo research
Rajendra Sangaraju, Sukesh Narayan Sinha, Sathish Kumar Mungamuri, Balaji Gouda, Sapna Kumari, et al.
International Immunopharmacology, 2025
Extraction, Phytochemical profile, and neuroprotective activity of Phyllanthus emblica fruit extract against sodium valproate-induced postnatal autism in BALB/c mice
Balaji Gouda, Sukesh Narayan Sinha, Rajendra Sangaraju, Tien Huynh, Shashikala Patangay, et al.
Heliyon, 2024
Effect of ethyl gallate and propyl gallate on dextran sulfate sodium (DSS)-induced ulcerative colitis in C57BL/6 J mice: preventive and protective
Priyanka Raju Chougule, Rajendra Sangaraju, Pradeep B. Patil, S. S. Y. H. Qadri, Virendra V. Panpatil, et al.
Inflammopharmacology, 2023
A novel RP-HPLC method for quantification of cholinesterase activity in human blood: An application for assessing organophosphate and carbamate insecticide exposure
Sukesh Narayan Sinha, Ramakrishna Ungarala, Dileshwar Kumar, Rajendra Sangaraju, Sarita Kumar
Plos One, 2022
Several methods have been reported to estimate Acetylcholinesterase (AChE) enzyme activity in blood samples. The Ellman assay is the most important among all but with several shortcomings, and there is a need to develop a method which is accurate, sensitive and quick for analyzing AChE. Therefore, we have developed an assay utilizing RP-HPLC with UV detection for the determination of AChE activity. This method measured the conversion of 1-naphthol acetate to 1-naphthol to estimate AChE activity in blood samples. Performance was judged on the basis of reproducibility, sensitivity, accuracy, and the ability to screen enzyme activity within 20minutes. A series of experiments were performed, varying the concentration of blood and substrate, with optimal sensitivity using 50 μM substrate and 10μL blood. The validation parameters such as linearity (R2 of ≥ 0.9842 for 1-naphthol and ≥ 0.9897 for 1-naphthol acetate), precision (94.21–96.41%), accuracy (85.2%–99.6% and 82.6%–99.3% for 1-naphthol and 1-naphthol acetate respectively), and robustness were validated according to International Conference on Harmonization (ICH) guidelines. Blood samples were collected from healthy people, farmers exposed to spraying of pesticides, and suicidal patients who ingested pesticides and were hospitalized and were analyzed by the developed method. The AChE level was approximately 21 units/mL compared to 24units/mL in controls, whereas suicidal patients showed the least AChE levels of 1 unit/mL. The employment of this method is recommended for estimating AChE level on various matrices.
Investigation of acute organophosphate poisoning in humans based on sociodemographic and role of neurotransmitters with survival study in South India
Sukesh Narayan Sinha, Rajesh Kumar Kumpati, Pandu Naik Ramavath, Rajendra Sangaraju, Balaji Gouda, et al.
Scientific Reports, 2022
The aim of this study was to investigate the sociodemographic characteristics of patients based on the poison chosen and different types of organophosphorus compounds. The data were collected to explore the sociodemographic characteristics of organophosphate (OP)-poisoned patients based on the source, site, and route of poisoning, education level, occupational status, and the purpose of poisoning. Furthermore, we estimated the serotonin and dopamine levels in the plasma samples of patients, and survival plots were also described. During the study of OP pesticide poisoning in 116 human subjects and 5 healthy volunteers, we observed, based on the survival plot, that75.9% of the patients were discharged, and the remaining patients died (24.1% of the patients) due to respiratory failure followed by cardiac arrest. Our findings suggest that the serotonin levels significantly (p < 0.01 and p < 0.001) decreased from 12 to 36 h, whereas the dopamine levels slightly increased from 12 to 36 h in the group with OP poisoning compared to the control group. Based on these findings, this study may aid in deciphering the precise mechanism by which pesticides cause behavioural changes that influence serotonin and dopamine levels in OP-poisoned patients. The purpose of this work was to serve as a small reminder of the risk to public health associated with organophosphate pesticides.
Galangin ameliorates Imiquimod-Induced psoriasis-like skin inflammation in BALB/c mice via down regulating NF-κB and activation of Nrf2 signaling pathways
Rajendra Sangaraju, Sateesh Alavala, Nasiruddin Nalban, Mahesh Kumar Jerald, Ramakrishna Sistla
International Immunopharmacology, 2021
Anti-inflammatory effect of stevioside abates Freund’s complete adjuvant (FCA)-induced adjuvant arthritis in rats
Sateesh Alavala, Nasiruddin Nalban, Rajendra Sangaraju, Madhusudana Kuncha, Mahesh Kumar Jerald, et al.
Inflammopharmacology, 2020
Arbutin Attenuates Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting TLR-4/NF-κB Pathway in Mice
Nasiruddin Nalban, Rajendra Sangaraju, Sateesh Alavala, Salma Mukhtar Mir, Mahesh Kumar Jerald, et al.
Cardiovascular Toxicology, 2020
Synthesis and biological evaluation of some novel 1,2,3-triazole hybrids of myrrhanone B isolated from Commiphora mukul gum resin: Identification of potent antiproliferative leads active against prostate cancer cells (PC-3)
Chandrashekhar Madasu, Shailaja Karri, Rajendra Sangaraju, Ramakrishna Sistla, Mallavadhani Venkata Uppuluri
European Journal of Medicinal Chemistry, 2020
Protective effect of galangin against dextran sulfate sodium (DSS)-induced ulcerative colitis in Balb/c mice
Rajendra Sangaraju, Nasiruddin Nalban, Sateesh Alavala, Vinoth Rajendran, Mahesh Kumar Jerald, et al.
Inflammation Research, 2019
Stevioside, a diterpenoid glycoside, shows anti-inflammatory property against Dextran Sulphate Sodium-induced ulcerative colitis in mice
Sateesh Alavala, Rajendra Sangaraju, Nasiruddin Nalban, Bidya Dhar Sahu, Mahesh Kumar Jerald, et al.
European Journal of Pharmacology, 2019
Therapeutic Targeting of Oxidative Stress and Inflammation in Asthma and COPD and Pharmacological Interventions with Phytochemicals
Nasiruddin Nalban, Sateesh Alavala, Rajendra Sangaraju, Salma Mukhtar Mir, Ramakrishna Sistla
Oxidative Stress in Lung Diseases Volume 1, 2019

RECENT SCHOLAR PUBLICATIONS

Modulation of inflammatory and cuproptotic crosstalk by Ethyl and propyl gallate: a multi-targeted strategy against experimental colitis
PR Chougule, SN Sinha, S Ghosh, S Rajendra, S Varma, S Challa, ...
Molecular Biology Reports 52 (1), 1030 , 2025
2025
Citations: 1
Stevioside alleviates high-fat diet-induced MASLD/MASH in Apo-E‑/‑mice by modulating the TGF-β signaling
S Alavala, N Sharma, R Sangaraju, S Challa, R Sistla, SB Andugulapati
The Journal of Nutritional Biochemistry, 110125 , 2025
2025
Citations: 4
Inhibiting Neuropilin-1 as a novel therapeutic approach to mitigate pulmonary fibrosis: Highlighting the potential anti-fibrotic effects of ATWLPPR peptide
G Pulivendala, S Bale, SK Yanala, R Sangaraju, C Godugu
International Immunopharmacology 158, 114757 , 2025
2025
Citations: 2
Effect of ethyl acetate extract of the whole plant Clerodendrum phlomidis on improving bleomycin (BLM)-induced idiopathic pulmonary fibrosis (IPF) in Rats: In vitro and in vivo …
R Sangaraju, SN Sinha, SK Mungamuri, B Gouda, S Kumari, PB Patil, ...
International Immunopharmacology 145, 113688 , 2025
2025
Citations: 3
Pesticide effects on human health and pest management
R Sangaraju, R Kumar, T Huynh, SN Sinha
Insecticides in Pest Control-Impact, Challenges and Strategies , 2024
2024
Citations: 9
Extraction, Phytochemical profile, and neuroprotective activity of Phyllanthus emblica fruit extract against sodium valproate-induced postnatal autism in BALB/c mice
B Gouda, SN Sinha, R Sangaraju, T Huynh, S Patangay, SV Mullapudi, ...
Heliyon 10 (15) , 2024
2024
Citations: 12
Extraction, Phytochemical profile and Neuroprotective Activity of Phyllanthus emblica Fruit Extract Against Sodium Valproate-Induced Postnatal Autism in BALB/c Mice via …
B Gouda, SN Sinha, R Sangaraju, P Shashikala, VM Surekha, ...
2023
Assessing farmer's exposure to pesticides and the risk for non-communicable diseases: A biomonitoring study
D Kumar, SN Sinha, S Rajendra, K Sharma
Science of the Total Environment 891, 164429 , 2023
2023
Citations: 36
Effect of ethyl gallate and propyl gallate on dextran sulfate sodium (DSS)-induced ulcerative colitis in C57BL/6 J mice: preventive and protective: PR Chougule et al.
PR Chougule, R Sangaraju, PB Patil, S Qadri, VV Panpatil, S Ghosh, ...
Inflammopharmacology 31 (4), 2103-2120 , 2023
2023
Citations: 24
Evaluation of Pro-and Anti-Inflammatory Cytokines in Glioma Patients: Correlation with Tumor Grading
NK Jadhav, R Sangaraju, V Mudumba, D Ara, S Dheeravath, R Alugolu, ...
2023
A novel RP-HPLC method for quantification of cholinesterase activity in human blood: An application for assessing organophosphate and carbamate insecticide exposure
SN Sinha, R Ungarala, D Kumar, R Sangaraju, S Kumar
Plos one 17 (12), e0279287 , 2022
2022
Citations: 17
Investigation of acute organophosphate poisoning in humans based on sociodemographic and role of neurotransmitters with survival study in South India
SN Sinha, RK Kumpati, PN Ramavath, R Sangaraju, B Gouda, ...
Scientific Reports 12 (1), 16513 , 2022
2022
Citations: 32
Nature, risk factors, prevalence, neurotransmitter role, and survival investigation of acute organophosphate (OP) pesticide cases in humans in a tertiary hospital in Telangana …
SN Sinha, KR Kumar, S Rajendra, B Gouda, P Chougule, RP Naik
2022
Citations: 1
Sukesh Narayan Sinha1Ε, Rajesh Kumar Kumpati1, Pandu Naik Ramavath2
R Sangaraju, B Gouda, P Chougule
Scientific Reports 12, 16513 , 2022
2022
Identification and characterization of Ethyl gallate from Ethyl acetate fraction of Phyllanthus emblica fruit, and invitro free radical scavenging activity
G Balaji, R Sangaraju, SN Sinha, P Shashikala
International Journal of Health Sciences 6 (S8), 2390-2400 , 2022
2022
Citations: 4
Galangin ameliorates Imiquimod-Induced psoriasis-like skin inflammation in BALB/c mice via down regulating NF-κB and activation of Nrf2 signaling pathways
R Sangaraju, S Alavala, N Nalban, MK Jerald, R Sistla
International Immunopharmacology 96, 107754 , 2021
2021
Citations: 64
Anti-inflammatory compounds for use in the treatment of dermal disorders
S Kotamraju, SR Bathula, R Sistla, A ADDLAGATTA, R Thennati, ...
WO Patent WO2021100027A1 , 2021
2021
Anti-inflammatory effect of stevioside abates Freund’s complete adjuvant (FCA)-induced adjuvant arthritis in rats
S Alavala, N Nalban, R Sangaraju, M Kuncha, MK Jerald, EK Kilari, ...
Inflammopharmacology 28 (6), 1579-1597 , 2020
2020
Citations: 67
Arbutin attenuates isoproterenol-induced cardiac hypertrophy by inhibiting TLR-4/NF-κB pathway in mice
N Nalban, R Sangaraju, S Alavala, SM Mir, MK Jerald, R Sistla
Cardiovascular Toxicology 20 (3), 235-248 , 2020
2020
Citations: 49
Synthesis and biological evaluation of some novel 1, 2, 3-triazole hybrids of myrrhanone B isolated from Commiphora mukul gum resin: Identification of potent antiproliferative …
C Madasu, S Karri, R Sangaraju, R Sistla, MV Uppuluri
European Journal of Medicinal Chemistry 188, 111974 , 2020
2020
Citations: 66

MOST CITED SCHOLAR PUBLICATIONS

Protective effect of galangin against dextran sulfate sodium (DSS)-induced ulcerative colitis in Balb/c mice
R Sangaraju, N Nalban, S Alavala, V Rajendran, MK Jerald, R Sistla
Inflammation Research 68 (8), 691-704 , 2019
2019
Citations: 75
Anti-inflammatory effect of stevioside abates Freund’s complete adjuvant (FCA)-induced adjuvant arthritis in rats
S Alavala, N Nalban, R Sangaraju, M Kuncha, MK Jerald, EK Kilari, ...
Inflammopharmacology 28 (6), 1579-1597 , 2020
2020
Citations: 67
Synthesis and biological evaluation of some novel 1, 2, 3-triazole hybrids of myrrhanone B isolated from Commiphora mukul gum resin: Identification of potent antiproliferative …
C Madasu, S Karri, R Sangaraju, R Sistla, MV Uppuluri
European Journal of Medicinal Chemistry 188, 111974 , 2020
2020
Citations: 66
Galangin ameliorates Imiquimod-Induced psoriasis-like skin inflammation in BALB/c mice via down regulating NF-κB and activation of Nrf2 signaling pathways
R Sangaraju, S Alavala, N Nalban, MK Jerald, R Sistla
International Immunopharmacology 96, 107754 , 2021
2021
Citations: 64
Stevioside, a diterpenoid glycoside, shows anti-inflammatory property against Dextran Sulphate Sodium-induced ulcerative colitis in mice
S Alavala, R Sangaraju, N Nalban, BD Sahu, MK Jerald, EK Kilari, ...
European Journal of Pharmacology 855, 192-201 , 2019
2019
Citations: 64
Arbutin attenuates isoproterenol-induced cardiac hypertrophy by inhibiting TLR-4/NF-κB pathway in mice
N Nalban, R Sangaraju, S Alavala, SM Mir, MK Jerald, R Sistla
Cardiovascular Toxicology 20 (3), 235-248 , 2020
2020
Citations: 49
Assessing farmer's exposure to pesticides and the risk for non-communicable diseases: A biomonitoring study
D Kumar, SN Sinha, S Rajendra, K Sharma
Science of the Total Environment 891, 164429 , 2023
2023
Citations: 36
Investigation of acute organophosphate poisoning in humans based on sociodemographic and role of neurotransmitters with survival study in South India
SN Sinha, RK Kumpati, PN Ramavath, R Sangaraju, B Gouda, ...
Scientific Reports 12 (1), 16513 , 2022
2022
Citations: 32
Effect of ethyl gallate and propyl gallate on dextran sulfate sodium (DSS)-induced ulcerative colitis in C57BL/6 J mice: preventive and protective: PR Chougule et al.
PR Chougule, R Sangaraju, PB Patil, S Qadri, VV Panpatil, S Ghosh, ...
Inflammopharmacology 31 (4), 2103-2120 , 2023
2023
Citations: 24
Oxidative stress in lung diseases
S Chakraborti, T Chakraborti, SK Das, D Chattopadhyay
Springer 1, p331 , 2019
2019
Citations: 22
A novel RP-HPLC method for quantification of cholinesterase activity in human blood: An application for assessing organophosphate and carbamate insecticide exposure
SN Sinha, R Ungarala, D Kumar, R Sangaraju, S Kumar
Plos one 17 (12), e0279287 , 2022
2022
Citations: 17
Extraction, Phytochemical profile, and neuroprotective activity of Phyllanthus emblica fruit extract against sodium valproate-induced postnatal autism in BALB/c mice
B Gouda, SN Sinha, R Sangaraju, T Huynh, S Patangay, SV Mullapudi, ...
Heliyon 10 (15) , 2024
2024
Citations: 12
Synthesis of some novel orsellinates and lecanoric acid related depsides as α -glucosidase inhibitors
B Rama Krishna, S Ramakrishna, S Rajendra, K Madhusudana, ...
Journal of Asian natural products research 21 (10), 1013-1027 , 2019
2019
Citations: 12
Therapeutic targeting of oxidative stress and inflammation in asthma and COPD and pharmacological interventions with phytochemicals
N Nalban, S Alavala, R Sangaraju, SM Mir, R Sistla
Oxidative Stress in Lung Diseases: Volume 1, 429-449 , 2019
2019
Citations: 11
Pesticide effects on human health and pest management
R Sangaraju, R Kumar, T Huynh, SN Sinha
Insecticides in Pest Control-Impact, Challenges and Strategies , 2024
2024
Citations: 9
Stevioside alleviates high-fat diet-induced MASLD/MASH in Apo-E‑/‑mice by modulating the TGF-β signaling
S Alavala, N Sharma, R Sangaraju, S Challa, R Sistla, SB Andugulapati
The Journal of Nutritional Biochemistry, 110125 , 2025
2025
Citations: 4
Identification and characterization of Ethyl gallate from Ethyl acetate fraction of Phyllanthus emblica fruit, and invitro free radical scavenging activity
G Balaji, R Sangaraju, SN Sinha, P Shashikala
International Journal of Health Sciences 6 (S8), 2390-2400 , 2022
2022
Citations: 4
Effect of ethyl acetate extract of the whole plant Clerodendrum phlomidis on improving bleomycin (BLM)-induced idiopathic pulmonary fibrosis (IPF) in Rats: In vitro and in vivo …
R Sangaraju, SN Sinha, SK Mungamuri, B Gouda, S Kumari, PB Patil, ...
International Immunopharmacology 145, 113688 , 2025
2025
Citations: 3
Inhibiting Neuropilin-1 as a novel therapeutic approach to mitigate pulmonary fibrosis: Highlighting the potential anti-fibrotic effects of ATWLPPR peptide
G Pulivendala, S Bale, SK Yanala, R Sangaraju, C Godugu
International Immunopharmacology 158, 114757 , 2025
2025
Citations: 2
Modulation of inflammatory and cuproptotic crosstalk by Ethyl and propyl gallate: a multi-targeted strategy against experimental colitis
PR Chougule, SN Sinha, S Ghosh, S Rajendra, S Varma, S Challa, ...
Molecular Biology Reports 52 (1), 1030 , 2025
2025
Citations: 1

Publications

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Industry, Institute, or Organisation Collaboration

CSIR INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY

INDIAN COUNCIL OF MEDICAL RESEARCH

NATIONAL INSTITUTE OF NUTRITION

JNTU ANANTAPUR

RMIT UNIVERSITY MELBOURNE

INDUSTRY EXPERIENCE

Prof. Brien Holden Eye Research Foundation

LVPEI HOSPITAL

DRUG TESTING LABORATORY at CSIR IICT