Dr. Melinda Boussoussou

Verified email at gmail.com

Cardiovascular Imaging Research Group
Semmelweis University




cardiovascular imaging, fractional flow reserve, acute cardiovascular disease, plaque progression


Scopus Publications

Scopus Publications

  • Atmospheric fronts as minor cardiovascular risk factors, a new approach to preventive cardiology
    Melinda Boussoussou, Nora Boussoussou, Gergő Merész, Márton Rakovics, László Entz, and Attila Nemes

    Journal of Cardiology, ISSN: 09145087, eISSN: 18764738, Pages: 196-202, Published: February 2020 Elsevier BV
    BACKGROUND Cardiovascular diseases are the number one cause of death globally and represent 31% of all global deaths. The aim of our study was to determine the influence of front effects on acute cardiovascular diseases (ACVDs). METHODS We obtained all ACVD admissions in a Central-European region, Hungary, Budapest. A time-series analysis was applied to 6499 morbidity cases during a five-year period (2009-2013). Poisson-regression model was used and adjusted for air temperature, pressure, humidity, wind velocity, their interactions and seasonality to assess the association of fronts and ACVDs. RESULTS There is a positive significant association between ACVDs and a cold front effect lagged by one day (p=0.018) with a relative risk (RR) of 1.095 [95% CI (1.021,1.181)]. Our findings show that among patient subgroups with major cardiovascular risk factors (hypertension, diabetes, hyperlipidemia, history of CVDs) the patterns are similar, but occluded fronts also have a significant effect. CONCLUSION Atmospheric fronts could play an important role in the pathogenesis of ACVDs. Our findings might help to provide a better understanding about fronts as minor cardiovascular risk factors and to organize medical prevention more effectively. Our research project may become a basis of a new field of preventive cardiovascular medicine in the future.

  • Complex effects of atmospheric parameters on acute cardiovascular diseases and major cardiovascular risk factors: data from the Cardiometeorology SM study
    Nora Boussoussou, Melinda Boussoussou, Gergő Merész, Márton Rakovics, László Entz, and Attila Nemes

    Scientific Reports, eISSN: 20452322, Published: 1 December 2019 Springer Science and Business Media LLC
    Several studies have examined the cardiovascular effects of atmospheric parameters as separate factors; however, few have investigated atmospheric parameters’ joint effects. We aim to explore the joint effects of atmospheric parameters on acute cardiovascular diseases (ACVDs) and on major cardiovascular risk factors (CRFs). We correlated all ACVD admissions with major CRFs and local atmospheric conditions during a 5-year study period. A seasonal variation was detected in a higher incidence rate during cold atmospheric conditions. There were significant incidence relative ratios, including: 1.140 (95% CI [1.020, 1.283]) for daily temperature change (≥5 °C); 0.991 (95% CI [0.988, 0.994]) for average daily temperature; and 1.290 (95% CI [1.090, 1.599]) for the interaction of daily temperature change (≥5 °C) with humidity change (≥40%). We observed a significant association between the atmospheric parameters’ joint effects and hyperlipidaemia, diabetes, and previous ACVDs. Patients with diabetes had the highest significant incidence relative ratio at 2.429 (95% CI [1.088, 5.424]) for humidity-temperature interactions. Thus, the atmospheric parameters’ joint effects play an important role as minor CRFs. These unfavourable atmospheric situations are predicted to increase the number of ACVDs mainly. Our study may help to organize prevention strategies more effectively and to reduce cardiovascular risks.

  • P-060: Hypertension induced acut cardiovascular risk and atmospherical parameters: 2670 population based meteoro sensitivity study
    N. Boussoussou, M. Boussoussou, L. Entz, and A. Nemes

    Annales de Cardiologie et d'Angeiologie, ISSN: 00033928, eISSN: 17683181, Pages: S43-S44, Published: December 2015 Elsevier BV
    BACKGROUND Climate change is a significant threat to public health. Research on medical effects of climate may help to increase the success of the cardiovascular prevention. We aimed to understand and to provide evidence on relationship of several atmospherical parameters and hypertension. METHODS We conducted a 2670 population-based retrospective study of acut cardiovascular (ACV) diseases at Semmelweis University Heart and Vascular Center in 2012-2013, using daily atmospherical parameters data provided by the National Meteorology Service. Our research examined atmospherical parameters effects on hypertensive and non-hypertensive ACV patients. RESULTS Our study supports the hypothesis of a robust association between hypertension and several atmospherical parameters. Hypertensive ACV patients showed a strong seasonal variation with the highest incidence rate in winter months. A significant association was found between the temperature, the atmospherical pressure and the incidence of hypertensive patients. We also observed a significant association of hypertension with front movements. Our results prove that ACV risk is higher in patients with hypertension during days with negative atmospherical condition. CONCLUSION In light of our study the magnitude of atmospherical parameters cardiovascular risk effects depend on hypertension factor. These results may help in the understanding of the hypertensive population's sensitivity to different atmospherical factors. The consequences of our study should be taken into account in future cardiovascular preventive medicine planning.

  • Occurrence of acute cardiovascular diseases under different atmospheric parameters
    Nora Boussoussou, Melinda Boussoussou, László Entz, and Attila Nemes

    Orvosi Hetilap, ISSN: 00306002, eISSN: 17886120, Volume: 155, Pages: 1078-1082, Published: 1 July 2014 Akademiai Kiado Zrt.
    Introduction: Research on the effects of meteorological parameters on cardiovascular diseases may allow the development of novel prevention strategies. Aim: The aim of the authors was to examine the correlation between meteorological parameters and the occurrence of acute cardiovascular diseases. Method: A retrospective analysis was performed in 343 patients diagnosed with acute cardiovascular disease and treated at the Department of Vascular Surgery, Semmelweis University in 2010. Results: Acute cardiovascular diseases showed a seasonal variation with the highest occurrence in winter months (p = 0.0001). The daily increase of the events (n≥3) were associated with front movements days (in 62.5% of cases). A significant correlation was found between the intraday temperature difference (p<0.0001), the intraday atmospheric pressure difference (p = 0.0034), the lowest maximum daily temperature (p<0.0001) and the occurrence of acute cardiovascular diseases. During the days with front movements 64% of the patients were older than 66 years of age. Among risk factors, hypertension showed front sensitivity. Conclusions: Meteorological parameters are minor risk factors in the occurrence of acute cardiovascular diseases. Orv. Hetil., 2014, 155(27), 1078–1082.