Mr. Arvind Kumar currently works at the Department of Pharmaceutical Chemistry, Maharaja Agrasen school of Pharmacy, Maharaja Agrasen University, Atal Shiksha Kunj, Village kalujhanda, near Barotiwala, Baddi, Himachal Pradesh Mr. Kumar does research in Synthetic Chemistry, Green chemistry and Pharma
Design, Synthesis and Molecular Docking Studies of Pyrazoline Derivatives as PI3K Inhibitors Rohit Kumar, Arvind Kumar, Adarsh Kumar, Ankit Kumar Singh, Pradeep Kumar Combinatorial Chemistry and High Throughput Screening, 2024 Aim: Design, synthesis and molecular docking studies of quinoline/naphthalene containing pyrazoline derivatives as PI3K inhibitors. Background: Phosphatidylinositol 3-kinases (PI3Ks) belong to the family of enzymes, which are associated with various cellular functions such as cell growth, proliferation, differentiation etc. Overexpression or any changes in these functions may result in various abnormalities, which in turn cause cancer. Objectives: To perform synthesis and molecular docking studies of quinoline/naphthalene containing pyrazoline derivatives as PI3K inhibitors. Methods: 2-Chloroquinoline-3-carbaldehyde was synthesized by a reaction of acetanilide and POCl3. The latter was reacted with substituted acetophenones to synthesize chalcones, which were reacted with substituted phenyl hydrazines to yield pyrazoline derivatives (Series I). Similarly, pchloro benzaldehyde was reacted with 2-acetonapthone to yield chalcone with substituted phenyl hydrazines to yield pyrazoline derivatives (Series II). Results: The synthetic compounds were subjected to molecular modelling experiments using Schrodinger 2016 software and evaluated in silico for their PI3K binding affinities. All the compounds had better docking scores than AMG-319 (-4.36 Kcal/mol) and comparable docking scores with PI-103 (-6.83 Kcal/mol). Conclusion: Compounds 5 and 3 had the best docking scores (-7.85 and -7.17 Kcal/mol, respectively). The synthesized compounds have better docking scores than the reference drug AMG-319. As a result, they might be used as lead molecules in investigating PI3K inhibitors.
Derivatization, an Applicable Asset for Conventional HPLC Systems without MS Detection in Food and Miscellaneous Analysis Raghav Dogra, Mohit Kumar, Arvind Kumar, Marco Roverso, Sara Bogialli, Paolo Pastore, Uttam Kumar Mandal Critical Reviews in Analytical Chemistry, 2023 One of the most valuable practices for analyzing not-so-analytical-friendly analytes in complex, heterogenous matrices is derivatization. Availability of numerous derivatizing reagents (DRs) makes the modification of analyte more exploitable in terms of an analytical perspective. A wide array of derivatization techniques like pre or post-column, in-situ, enzymatic, ultrasound-assisted, microwave-assisted, photochemical derivatization has added much-needed methodological strength in analyzing intricate analytical matrices (food, water, and soil). In recent years, analytical chemistry has achieved greater heights through the development of new sensitive methods with simple conventional instruments like High-Performance Liquid Chromatography (HPLC) devoid of Mass detectors. The prompt availability of these straightforward instruments also makes it a favorable option for routine analysis in food, environmental, bioanalytical chemistry. Analyzing food, environmental or bioanalytical specimen has some of the most problematic aspects, like the low concentration of the analytes accompanied by not too suitable analytical properties. Even though conventional HPLC lacks the required sensitivity but merger with derivatization can lead to a remarkable increase in sensitivity. In recent years there has been a lot of application of diverse derivatizations to increase the sensitivity and selectivity of the analyte for available instruments, resulting in notable findings. Therefore, this review describes the application of derivatization principles in the analysis of analytes in food and additional matrices using conventional HPLC instruments such as HPLC-UV, HPLC-DAD, and HPLC-FD. In this article, we will briefly review the different modes and multiple types of derivatizing reagents with their mechanisms and importance for encouraging the use of established HPLC instruments.
Acetylation of histone and modification of gene expression via HDAC inhibitors affects the obesity Deepika Sharma, Swati Sharma, Preeti Chauhan Biomedical and Pharmacology Journal, 2021 Obesity is due to imbalance between energy intake and energy expenditure. Adipose tissues are the main site for the fat storage as well as for dissipation. There are two types of adipose tissues: white adipose tissue, which store fat as triglyceride, brown adipose tissue, which burns the fat into energy through the thermogenesis due to uncoupling protein1 present in inner mitochondrial membrane. Histone acylation causes changes in the chromatin structure without causing any change in the deoxyribonucleic acidsequence and thus regulate gene expression.Histonedeacetylase causes the deacylation of histone and interfere with function of histone. Thus histonedeacetylase inhibitors alter the expression of thermogenic gene encoding uncoupling protein 1, peroxisome proliferator activated receptor γ and also causes browning or beiging of white adipose tissue and increases the energy expenditure.
RECENT SCHOLAR PUBLICATIONS
Calcium Supplementation for the Prevention of Pre-Eclampsia A Kumar, SG Devi, S Batra, C Singh, DK Shukla INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS 168 (2), 854-854 , 2025 2025
A study on antimicrobial effect of sugars at low concentration BR Singh, M Chandra, M Bhardwaj, V Jayakumar, A Kumar Infect Dis Res 6 (1), 1 , 2025 2025 Citations: 3
A Z-scheme defect-rich and dimensionally confined double functionalized g-C3N4 homojunction pectin hydrogels for the photocatalysis-self-Fenton-peroxymonosulfate system … A Balakrishnan, M Chinthala, A Kumar, D Barceló, S Rtimi Chemical Engineering Journal 503, 158378 , 2025 2025 Citations: 31
Valorization of raw papaya (Carica papaya) and citrus peels for development of antimicrobial and biodegradable edible film P Pawle, S Pandey, A Kumar, A Agarwal, AD Tripathi, M Saeed, SO Rab, ... Food Chemistry: X 25, 102129 , 2025 2025 Citations: 14
Role of Patents in Economic Development and Integration R Sharma, R Malviya, S Verma, A Kumar, DU Meenakshi Pharma Marketing and Pharmacoeconomics, 151-174 , 2024 2024
The Implications of Pharma Marketing to Improve Return on Investment (ROI) D Yadav, R Malviya, A Kumar, N Fuloria Pharma Marketing and Pharmacoeconomics, 225-245 , 2024 2024
Effect of Brinkman and Maiga's correlations of viscosity on forced convection turbulent flow PJ Sanga, P Datta, A Kumar International Communications in Heat and Mass Transfer 159, 108367 , 2024 2024 Citations: 4
AYURVEDIC MANAGEMENT OF MUTRASHMARI-A REVIEW A Kumar, I Sharma, KK Sharma, Y Singh, T Kapadia 2024
Analytical Approach to Predict Water Breakthrough Time Using Time-Lapse Pressure Transient Analysis: Application to Single Gas Well Reservoirs S Bhat, A Choudhary, A Kumar, D Fife Abu Dhabi International Petroleum Exhibition and Conference, D041S126R006 , 2024 2024
Degradation of tetracycline via peroxymonosulfate activation by highly reusable Titanium dioxide/impregnated Zirconium-chitosan beads A Balakrishnan, R Marskole, M Chinthala, A Kumar Journal of Environmental Management 370, 122514 , 2024 2024 Citations: 12
12560 RIMOC1, A Novel Regulator Of Mitochondrial Function, And Its Role In Pancreatic Beta-cell Survival, Mitophagy, And Diabetogenesis D Filingeri, R Liu, V Negi, J Lee, A Kumar, V Mandi, M Moulik, V Yechoor Journal of the Endocrine Society 8 (Supplement_1), bvae163. 916 , 2024 2024
Effect of Different Powder Bed Thermal Conductivity Models on the Melt Pool Characteristics and Solidification Parameters during Laser Powder Bed Fusion of Ti6Al4V AK Mishra, A Kumar Transactions of the Indian Institute of Metals 77 (10), 2971-2975 , 2024 2024 Citations: 2
Reduced LC3 expression without Beclin 1 alteration in diabetic patients' right atrial appendage during coronary artery bypass surgery R Jha, A Kumar, PK Jha DIABETOLOGIA 67, S479-S479 , 2024 2024
Neuroprotective Action of Betulin in Parkinson's disease (PD): Alleviating Mitochondrial Dysfunction and Oxidative Stress-Induced Apoptosis in Rat Model A Kumar MOVEMENT DISORDERS 39, S355-S355 , 2024 2024
The study to assess the shifts of target volume in relation to bladder & rectal filling in patients undergoing pelvic image guided radiotherapy in carcinoma cervix and … A Prakash, A Upadhyay, A Kumar Clinical Oncology 36 (9), e360 , 2024 2024 Citations: 1
Seaweed based hydrogels: extraction, gelling characteristics, and applications in the agriculture sector A Kumar, P Hart, VK Thakur ACS Sustainable Resource Management 1 (9), 1876-1905 , 2024 2024 Citations: 22
Identification of fatty acids, amides and cinnamic acid derivatives in supercritical-CO2 extracts of Cinnamomum tamala leaves using UPLC-Q-TOF-MSE combined with chemometrics H Lohani, A Kumar, V Bidarakundi, L Agrawal, SZ Haider, NK Chauhan Molecules 29 (16), 3760 , 2024 2024 Citations: 10
Diversified Synthesis of N -Benzoyl Piperidine Tetraoxane Analogues Using Molybdenum Trioxide as a Newer Catalyst and Its Antiplasmodial Activity A Kumar, D Agarwal, B Sharma, RD Gupta, SK Awasthi ACS omega 9 (29), 31611-31619 , 2024 2024 Citations: 5
340 Investigating the Effectiveness of Folic Acid-Fortified Iodized Salt on Serum Folate Concentration-a Primary Prevention Strategy for Spina Bifida in India J Pattisapu, V Manda, MN Rao, PM Kajana, V Kancherla, VR Veerappan, ... British Journal of Surgery 111 (Supplement_6), znae163. 150 , 2024 2024
Hepatitis A and Leptospirosis Dual Infection-Induced Fulminant Hepatic Failure Successfully Treated with Standard Volume Therapeutic Plasma Exchange. UB Davood, P Kaur, A Gupta, A Tripathi, A Kumar Chatterjee, A Kumar, ... Transfusion Clinique et Biologique: Journal de la Societe Francaise de … , 2024 2024
MOST CITED SCHOLAR PUBLICATIONS
Genetic variability, heritability and genetic advance for yield and its components in bottle gourd ( Lagenaria siceraria M.). AK Arvind Kumar, B Singh, MK Mukesh Kumar, RK Naresh 2011.0 Citations: 41
A Z-scheme defect-rich and dimensionally confined double functionalized g-C3N4 homojunction pectin hydrogels for the photocatalysis-self-Fenton-peroxymonosulfate system … A Balakrishnan, M Chinthala, A Kumar, D Barceló, S Rtimi Chemical Engineering Journal 503, 158378 , 2025 2025.0 Citations: 31
Seaweed based hydrogels: extraction, gelling characteristics, and applications in the agriculture sector A Kumar, P Hart, VK Thakur ACS Sustainable Resource Management 1 (9), 1876-1905 , 2024 2024.0 Citations: 22
Unified training of universal time series forecasting transformers. arXiv 2024 G Woo, C Liu, A Kumar, C Xiong, S Savarese, D Sahoo arXiv preprint arXiv:2402.02592 , 2024 2024.0 Citations: 17
Isothermal vapour-liquid equilibrium of isomeric butanols with n-heptane A Kumar, SS Katti Indian J. Technol 18, 60-63 , 1980 1980.0 Citations: 15
Valorization of raw papaya (Carica papaya) and citrus peels for development of antimicrobial and biodegradable edible film P Pawle, S Pandey, A Kumar, A Agarwal, AD Tripathi, M Saeed, SO Rab, ... Food Chemistry: X 25, 102129 , 2025 2025.0 Citations: 14
A poly-δ-decalactone (PDL) based nanoemulgel for topical delivery of ketoconazole and eugenol against Candida albicans P Dubey, A Kumar, KK Vaiphei, S Basrani, A Jadhav, CE Wilen, ... Nanoscale Advances 6 (21), 5322-5336 , 2024 2024.0 Citations: 14
Groundwater arsenic poisoning in Buxar District, Bihar, India: health hazards A Kumar, R Kumar, M Ali, V Gahlot, A Ghosh Arsenic Research and Global Sustainability: Proceedings of the Sixth … , 2016 2016.0 Citations: 14
Springer Nature: Singapore, 2023 A Kumar, A Pal, SS Kachhwaha, PK Jain Google Scholar, 223-233 , 0 Citations: 14
Effect of carrot on quality characteristics of chicken sausages M Kaur, A Kumar, S Kumar, HR Hakeem, S Gupta Journal of Indian veterinary science 92, 44-47 , 2015 2015.0 Citations: 13
SOME THEOREMS OF AFFINE MOTION IN A RECURRENT FINSLER SPACE IV. A Kumar 1977.0 Citations: 13
CoST: Contrastive learning of disentangled seasonal-trend representations for time series forecasting. arXiv 2022 G Woo, C Liu, D Sahoo, A Kumar, S Hoi arXiv preprint arXiv:2202.01575 , 0 Citations: 13
Degradation of tetracycline via peroxymonosulfate activation by highly reusable Titanium dioxide/impregnated Zirconium-chitosan beads A Balakrishnan, R Marskole, M Chinthala, A Kumar Journal of Environmental Management 370, 122514 , 2024 2024.0 Citations: 12
Interrater reliability of National Institutes of Health traumatic brain injury imaging common data elements for brain magnetic resonance imaging in mild traumatic brain injury SP Rincon, P Mukherjee, HS Levin, NR Temkin, CL Mac Donald, ... Journal of Neurotrauma 38 (20), 2831-2840 , 2021 2021.0 Citations: 12
Identification of fatty acids, amides and cinnamic acid derivatives in supercritical-CO2 extracts of Cinnamomum tamala leaves using UPLC-Q-TOF-MSE combined with chemometrics H Lohani, A Kumar, V Bidarakundi, L Agrawal, SZ Haider, NK Chauhan Molecules 29 (16), 3760 , 2024 2024.0 Citations: 10
Multi-organ segmentation of organ-at-risk (OAR's) of head and neck site using ensemble learning technique S Singh, BK Singh, A Kumar Radiography 30 (2), 673-680 , 2024 2024.0 Citations: 10
Evaluation of quantitative characters of okra (Abelmoschus esculentus L. Moench) genotypes V Pandey, A Kumar, DK Singh Current Journal of Applied Science and Technology 24 (5), 1-6 , 2017 2017.0 Citations: 9
Effective control measure of tobacco caterpillar (Spodoptera litura) on soybean through various insecticides AK Sharma, A Kumar, BL Kumhar Chemical Science Review and Letters 6 (21), 533-537 , 2017 2017.0 Citations: 9
Evaluation of promising varieties of Ethiopian mustard (Brassica carinata) and Indian mustard (Brassica juncea) at different fertility levels under rainfed conditions D Singh, A Kumar, RP Singh Indian Journal of Agronomy 47 (2), 47_2-47_2 , 2002 2002.0 Citations: 9
