Amrita Das

Scopus Publications

α-C–H Functionalization of Benzylamines: A Crucial Yet Challenging Transformation
Sri Dinesh M, Ilene M. Varghese, Sinduja Mohanraj, Amrita Das
Chemistry A European Journal, 2026
The functionalization of benzylamines continues to be a long‐standing interest for organic chemists. This moiety can be found as core structural building block in many pharmaceutical and agrochemical compounds. The suitable application of this core structure not only lies with biological importance but also of great importance from strategic overview. In this review, various strategic implications of functionalizing the α‐C─H bond of benzylamines will be thoroughly discussed. Non‐directed functionalization mostly involves radical pathway in α‐C─H functionalization in benzylamines. The inherent inertness of this α‐C─H bond can be directly reasoned to the low acidity due to the presence of adjacent N atom. SET combined with HAT process was demonstrated to generate the desired benzylic radical, which leads to benzylic arylation in benzylamines. Radical carbonyl chemistry was involved in SET process to result in α‐C─H alkylation. Umpolung chemistry on benzylamines leads to diverse functionalization on α‐C─H bond. Stereoselective α‐C─H addition to aldehydes generates chiral amines catalyzed by organocatalysts and enzyme catalysts in separate reports following a nucleophilic addition pathway. Another important transformation of α‐C─H bonds is attributed to the C─H bond activation triggered by directed transition‐metal catalysis.
Catalytic hydrogenative dechlorination reaction for efficient synthesis of a key intermediate of SDHI fungicides under continuous-flow conditions
Haruro Ishitani, Tomoya Kawase, Amrita Das, Shū Kobayashi
Catalysis Science and Technology, 2023
Selective hydrodechlorination under continuous-flow conditions for a fungicide intermediate was investigated using heterogeneous Pd catalysts, and the desired difluoromethyl-substituted pyrazole obtained quantitatively at 1.5 h−1 of SVmol value.
Metal-Free Catalytic Hydroboration of Unsaturated Compounds: A Greener Strategy for the Synthesis of Organoboranes
Amrita Das, Tarun K. Panda
Chemcatchem, 2023
This review discusses the immense progress made over recent years in metal‐free catalytic hydroboration. Reactions with several unsaturated functional groups, such as alkynes, alkenes, carbonyl compounds, carbon dioxide, carbodiimides, imines, allenes, pyridines, carboxylic acid derivatives etc., have been explored. Although there are significant developments in hydroboration reactions using metal‐based catalysts, metal‐free catalytic strategies are more desirable from a sustainability perspective. Considerable effort has been made by various research groups on metal‐free catalysts in the hydroboration of unsaturated compounds. Lewis acid, Brønsted acid, Lewis acid‐base pairs, and frustrated Lewis pairs were involved as metal‐free sources to catalyze hydroboration reactions in a sustainable manner. Detailed mechanisms of the catalytic pathways of metal‐free hydroboration are also discussed in this review. This discussion will provide an overview of the extent of work carried out as well as indicate scope for future research.
Aluminium complexes: next-generation catalysts for selective hydroboration
Amrita Das, Supriya Rej, Tarun K. Panda
Dalton Transactions, 2022
Development of efficient Al-complexes and their crucial roles in catalytic selective hydroboration of several unsaturated compounds such as carbonyls, alkenes, alkynes, imines, nitriles and others were well documented in this review.
Rh(i)-catalysed imine-directed C-H functionalization: via the oxidative [3 + 2] cycloaddition of benzylamine derivatives with maleimides
Amrita Das, Naoto Chatani
Chemical Communications, 2022
The Rh(i)-catalysed imine-directed oxidative [3 + 2] cycloaddition of benzylamines with maleimides is reported. The reaction is proposed to proceed via a zwitterionic intermediate.
Overview of Regioselective and Stereoselective Catalytic Hydroboration of Alkynes
Supriya Rej, Amrita Das, Tarun K. Panda
Advanced Synthesis and Catalysis, 2021
Hydroboration of alkynes is of special interest to researchers since it is the most straightforward process for the synthesis of highly important vinylborane synthetic intermediate compounds. It is significant in terms of both regioselectivity and stereoselectivity, since several positional isomers are formed during the process of hydroboration. Given the importance of this class of compounds, an extensive study has been carried out regarding catalytic condition development and detailed mechanistic studies for selectively obtaining a single isomer. This review comprehensively summarizes both the regioselective and stereoselective catalytic hydroboration of alkynes. It is aimed at giving readers accurate knowledge of the catalytic systems available for the hydroboration of certain alkynes. We anticipate that this inclusive review will encourage researchers to explore more new types of catalytic systems to achieve the remarkable process of hydroboration of alkynes.magnified image
The Directing Group: A Tool for Efficient and Selective C-F Bond Activation
Amrita Das, Naoto Chatani
ACS Catalysis, 2021
Pyrimidine-directed metal-free C-H borylation of 2-pyrimidylanilines: a useful process for tetra-coordinated triarylborane synthesis
Supriya Rej, Amrita Das, Naoto Chatani
Chemical Science, 2021
We present the metal-free ortho-C–H borylation of 2-pyrimidylanilines to afford synthetically important boronic esters and tetra-coordinated triarylboranes, which could be useful in materials science as well as Lewis-acid catalysts.
Synthesis of α-amino acid derivatives through the iridium-catalyzed α-c-h amidation of 2-acylimidazoles with dioxazolones under continuous-flow
Nozomi Ohara, Amrita Das, Sanjit K. Mahato, Naoto Chatani
Chemistry Letters, 2021
A continuous-flow synthesis of α-amino acid derivatives via a nitrene transfer by the Ir(III)-catalyzed α-C-H amidation of 2-acylimidazoles with dioxazolones is reported.
Rh(II)-Catalyzed C-H Alkylation of Benzylamines with Unactivated Alkenes: The Influence of Acid on Linear and Branch Selectivity
Amrita Das, Naoto Chatani
Organic Letters, 2021
The Rh-catalyzed C-H alkylation of benzylamine derivatives with unactivated 1-alkenes that proceeds via a picolinamide directing group is reported. The crucial role of an acid additive in this transformation is confirmed. Aromatic acids showed high linear selectivity, and aliphatic acids provided branched alkylation products as the major product. The reaction has a broad scope for benzylamines and alkenes. Deuterium labeling experiments suggest that a Rh-carbene intermediate is involved in the case of linear product formation. A different reaction pathway, however, appears to be involved in the case of branched alkylation products, and this pathway also appeared to be a minor pathway in linear-selective reactions.
Strategic evolution in transition metal-catalyzed directed C–H bond activation and future directions
Supriya Rej, Amrita Das, Naoto Chatani
Coordination Chemistry Reviews, 2021
Rh(i)- And Rh(ii)-catalyzed C-H alkylation of benzylamines with alkenes and its application in flow chemistry
Amrita Das, Naoto Chatani
Chemical Science, 2021
Toward Continuous-Flow Synthesis of Biologically Interesting Pyrazole Derivatives
Amrita Das, Haruro Ishitani, Shū Kobayashi
Advanced Synthesis and Catalysis, 2019
Boronic Acid Accelerated Three-Component Reaction for the Synthesis of α-Sulfanyl-Substituted Indole-3-acetic Acids
Amrita Das, Kenji Watanabe, Hiroyuki Morimoto, Takashi Ohshima
Organic Letters, 2017
An efficient synthesis of highly substituted indanones and chalcones promoted by superacid
Amrita Das, Alavala Gopi Krishna Reddy, Jonnada Krishna, Gedu Satyanarayana
Rsc Advances, 2014

RECENT SCHOLAR PUBLICATIONS

α-C–H Functionalization of Benzylamines: A Crucial Yet Challenging Transformation
AD Sri Dinesh M, Ilene M. Varghese, Sinduja Mohanraj
Chemistry – A European Journal , 2026
2026
Metal‐Free Catalytic Hydroboration of Unsaturated Compounds: A Greener Strategy for the Synthesis of Organoboranes
A Das, TK Panda
ChemCatChem 15 (2), e202201011 , 2023
2023
Citations: 40
Eliminations to Form Alkenes, Allenes, Alkynes and Related Reactions
A Das, JF Teichert
Elsevier , 2023
2023
Catalytic hydrogenative dechlorination reaction for efficient synthesis of a key intermediate of SDHI fungicides under continuous-flow conditions
H Ishitani, T Kawase, A Das, S Kobayashi
Catalysis Science & Technology 13 (11), 3282-3291 , 2023
2023
Citations: 5
Aluminium Complexes: Next-Generation Catalysts in Selective Hydroboration
A Das, S Rej, TK Panda
Dalton Trans. , 2022
2022
Citations: 48
Rh(i)-catalysed imine-directed C–H functionalization via the oxidative [3 + 2] cycloaddition of benzylamine derivatives with maleimides
A Das, N Chatani
Chem. Commun. , 2021
2021
Citations: 12
The Directing Group: A Tool for Efficient and Selective C–F Bond Activation
A Das, N Chatani
ACS Catalysis 11, 12915-12930 , 2021
2021
Citations: 75
Overview of Regioselective and Stereoselective Catalytic Hydroboration of Alkynes
S Rej, A Das, TK Panda
Advanced Synthesis & Catalysis , 2021
2021
Citations: 130
Synthesis of α-Amino Acid Derivatives through the Iridium-catalyzed α-CH Amidation of 2-Acylimidazoles with Dioxazolones under Continuous-flow
N Ohara, A Das, SK Mahato, N Chatani
Chemistry Letters 50 (9), 1722-1724 , 2021
2021
Citations: 4
Rh (II)-catalyzed C–H alkylation of benzylamines with unactivated alkenes: the influence of acid on linear and branch selectivity
A Das, N Chatani
Organic letters 23 (11), 4273-4278 , 2021
2021
Citations: 15
Strategic evolution in transition metal-catalyzed directed C–H bond activation and future directions
S Rej, A Das, N Chatani
Coordination Chemistry Reviews 431, 213683 , 2021
2021
Citations: 298
Pyrimidine-directed metal-free C–H borylation of 2-pyrimidylanilines: a useful process for tetra-coordinated triarylborane synthesis
S Rej, A Das, N Chatani
Chemical Science 12 (34), 11447-11454 , 2021
2021
Citations: 36
Rh (I)-and Rh (II)-catalyzed C–H alkylation of benzylamines with alkenes and its application in flow chemistry
A Das, N Chatani
Chemical Science 12 (9), 3202-3209 , 2021
2021
Citations: 16
Toward continuous‐flow synthesis of biologically interesting pyrazole derivatives
A Das, H Ishitani, S Kobayashi
Advanced Synthesis & Catalysis 361 (22), 5127-5132 , 2019
2019
Citations: 19
Boronic acid accelerated three-component reaction for the synthesis of α-sulfanyl-substituted indole-3-acetic acids
A Das, K Watanabe, H Morimoto, T Ohshima
Organic letters 19 (21), 5794-5797 , 2017
2017
Citations: 23
An efficient synthesis of highly substituted indanones and chalcones promoted by superacid
A Das, AGK Reddy, J Krishna, G Satyanarayana
RSC advances 4 (51), 26662-26666 , 2014
2014
Citations: 32

MOST CITED SCHOLAR PUBLICATIONS

Strategic evolution in transition metal-catalyzed directed C–H bond activation and future directions
S Rej, A Das, N Chatani
Coordination Chemistry Reviews 431, 213683 , 2021
2021
Citations: 298
Overview of Regioselective and Stereoselective Catalytic Hydroboration of Alkynes
S Rej, A Das, TK Panda
Advanced Synthesis & Catalysis , 2021
2021
Citations: 130
The Directing Group: A Tool for Efficient and Selective C–F Bond Activation
A Das, N Chatani
ACS Catalysis 11, 12915-12930 , 2021
2021
Citations: 75
Aluminium Complexes: Next-Generation Catalysts in Selective Hydroboration
A Das, S Rej, TK Panda
Dalton Trans. , 2022
2022
Citations: 48
Metal‐Free Catalytic Hydroboration of Unsaturated Compounds: A Greener Strategy for the Synthesis of Organoboranes
A Das, TK Panda
ChemCatChem 15 (2), e202201011 , 2023
2023
Citations: 40
Pyrimidine-directed metal-free C–H borylation of 2-pyrimidylanilines: a useful process for tetra-coordinated triarylborane synthesis
S Rej, A Das, N Chatani
Chemical Science 12 (34), 11447-11454 , 2021
2021
Citations: 36
An efficient synthesis of highly substituted indanones and chalcones promoted by superacid
A Das, AGK Reddy, J Krishna, G Satyanarayana
RSC advances 4 (51), 26662-26666 , 2014
2014
Citations: 32
Boronic acid accelerated three-component reaction for the synthesis of α-sulfanyl-substituted indole-3-acetic acids
A Das, K Watanabe, H Morimoto, T Ohshima
Organic letters 19 (21), 5794-5797 , 2017
2017
Citations: 23
Toward continuous‐flow synthesis of biologically interesting pyrazole derivatives
A Das, H Ishitani, S Kobayashi
Advanced Synthesis & Catalysis 361 (22), 5127-5132 , 2019
2019
Citations: 19
Rh (I)-and Rh (II)-catalyzed C–H alkylation of benzylamines with alkenes and its application in flow chemistry
A Das, N Chatani
Chemical Science 12 (9), 3202-3209 , 2021
2021
Citations: 16
Rh (II)-catalyzed C–H alkylation of benzylamines with unactivated alkenes: the influence of acid on linear and branch selectivity
A Das, N Chatani
Organic letters 23 (11), 4273-4278 , 2021
2021
Citations: 15
Rh(i)-catalysed imine-directed C–H functionalization via the oxidative [3 + 2] cycloaddition of benzylamine derivatives with maleimides
A Das, N Chatani
Chem. Commun. , 2021
2021
Citations: 12
Catalytic hydrogenative dechlorination reaction for efficient synthesis of a key intermediate of SDHI fungicides under continuous-flow conditions
H Ishitani, T Kawase, A Das, S Kobayashi
Catalysis Science & Technology 13 (11), 3282-3291 , 2023
2023
Citations: 5
Synthesis of α-Amino Acid Derivatives through the Iridium-catalyzed α-CH Amidation of 2-Acylimidazoles with Dioxazolones under Continuous-flow
N Ohara, A Das, SK Mahato, N Chatani
Chemistry Letters 50 (9), 1722-1724 , 2021
2021
Citations: 4
α-C–H Functionalization of Benzylamines: A Crucial Yet Challenging Transformation
AD Sri Dinesh M, Ilene M. Varghese, Sinduja Mohanraj
Chemistry – A European Journal , 2026
2026
Eliminations to Form Alkenes, Allenes, Alkynes and Related Reactions
A Das, JF Teichert
Elsevier , 2023
2023

Amrita Das

RESEARCH, TEACHING, or OTHER INTERESTS

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS