SREENIVASA CHARAN ARCHAKAM

@spsp.ac.in

Head-Department of Pharmaceutical Analysis
SRI PADMAVATHI SCHOOL OF PHARMACY

https://researchid.co/charan4ma

EDUCATION

Ph.D In Pharmaceutical Sciences

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmaceutical Science, Analytical Chemistry, Spectroscopy, Drug Discovery

Scopus Publications

111

Scholar Citations

Scholar h-index

Scholar i10-index

Scopus Publications

Simultaneous Determination of Amitriptyline Hydrochloride and Propranolol Hydrochloride in Commercial Formulation by Multitudinal UV and Multivariate FT-IR Spectroscopic Methods
Sreenivasa Charan Archakam, Keerthisikha Palur, Rajitha Galla, Sai Sucharitha Padiri, Praveen Kumar Tulasi, and Ranganayakulu Diviti
EManuscript Technologies

SIMULTANEOUS DETERMINATION OF CHLORPHENIRAMINE MALEATE AND PHENYLEPHRINE HYDROCHLORIDE IN LIQUIDDOSAGE FORMS BY UV SPECTROSCOPIC METHODS

Development and Validation of Chemometric Assisted UV Spectroscopic Methods for the Simultaneous Determination of Amitriptyline Hydrochloride and Propranolol Hydrochloride in Marketed Formulation
KEERTHISIKHA PALUR, SREENIVASA CHARAN ARCHAKAM, PRIYANKA PATAKAM, KAVYA ORUPALLI, PADMAJA YADAVALI, YOGESWAR POTHAPALA, and RANGANAYAKULU DIVITI
Asian Journal of Chemistry
The present work discusses the development and validation of chemometric assisted UV spectroscopic methods for analyzing two drugs amitriptyline hydrochloride and propranolol hydrochloride in their marketed formulation. The developed methods are two prominent chemometric models namely, principal component regression (PCR) and partial least squares regression (PLS) on which several research articles have been published for their immense contribution in the quantification of multi-component formulations. Linearity of the UV spectroscopic method was in the concentration ranges of 3-15 μg/mL of amitriptyline hydrochloride and 5-45 μg/mL of propranolol hydrochloride. The PCR and PLS chemometric models were established by employing fourteen mixtures as a calibration set and five mixtures as a validation set and were executed in the wavelength range of 240-320 nm with data interval of 5 nm. The statistical parameters obtained from both the methods revealed their validity and hence allows their suitability for analysis in regular quality control laboratories.

Development and Validation of Chemometric Assisted UV Methods for the Simultaneous Determination of Ambroxol Hydrochloride, Terbutaline Sulphate and Guaiphenesin in Pharmaceutical Dosage Form
Keerthisikha Palur, Sreenivasa Charan Archakam, and Bharathi Koganti
EManuscript Technologies

Chemometric assisted UV spectrophotometric and RP-HPLC methods for simultaneous determination of paracetamol, diphenhydramine, caffeine and phenylephrine in tablet dosage form
Keerthisikha Palur, Sreenivasa Charan Archakam, and Bharathi Koganti
Elsevier BV

Chemometric-assisted RP-HPLC method for the simultaneous determination of ambroxol hydrochloride, terbutaline sulfate,and guaiphenesin in combined dosage form
Keerthisikha Palur, Bharathi Koganti and S. C. Archakam
Journal of Applied Pharmaceutical Science
An isocratic reverse phase HPLC method using chemometric model was developed and validated for the simultaneous determination of Ambroxol hydrochloride, Terbutaline sulfate and Guaiphenesin in their combined dosage form. Central composite design which is a subset of Response surface Methodology was used as the chemometric model. The separation of three drugs was carried out by using Phenomenex C18 column and detection at 220 nm using UV detector. Based on initial trials, the three factors selected for the design were Methanol (MN) concentration, Mobile phase pH and flow rate in the range of 55-65% (v/v), 4-5 units and 0.6-1 ml/min respectively. The impact of the selected factors on the responses like retention time of first peak (tR1), resolution of 2nd and 3rd peak (Rs2,3) and theoretical plates of first peak (TP1) were evaluated. Derringers’ desirability function was used to optimize the responses. The conditions which were optimized for the assay of drugs were MN, ACN, 50 mM KH2PO4 (pH 5) in the ratio of 55:10:35 at a flow rate of 0.8 ml/min. The developed and optimized method was validated as per the ICH guidelines and can be used for routine analysis in quality control laboratories.

Development and validation of chemometric assisted analytical methods for simultaneous estimation of atorvastatin calcium and Aspirin in capsule dosage form
Keerthisikha Palur, BharathiKoganti, and Sreenivasa Charan Archakam
GP Innovations Pvt. Ltd.
To develop two Chemometric-assisted analytical methods like UV spectrophotometry and RP-HPLC methods for the quantification of Atorvastatin calcium (ASC) and Aspirin (APN) in the capsule dosage form. Chemometric models used in UV spectrophotometry were Principal component regression model (PCRM) and Partial least-square regression (PLSR). Both the models were applied for the drugs in the calibration ranges of 4-20 and 30-150 μg/mL for ASC and APN respectively. Total of nineteen laboratory prepared mixtures were used for calibration and prediction set of the models. In addition, RP-HPLC method by using chemometric approach for was developed using C18 column at room temperature with a mobile phase of acetonitrile: methanol: triethylamine (53.1:11.9:35 v/v/v), pH- 3.0, with detection at 275 nm. PCRM and PLSR models were evaluated by statistical parameters and RP-HPLC method was optimized by using Response surface methodology. The developed methods like UV and RP-HPLC by using chemometrics showed almost similar results and both the methods can be used for their analysis.

New stability indicating RP-HPLC method for the simultaneous estimation of terbutaline sulphate and bromhexine hydrochloride in tablet dosage form

Development and validation of a new stability indicating reversed-phase high-performance liquid chromatography method for the simultaneous estimation of tegafur and uracil in capsule dosage form

Simultaneous estimation of atorvastatin and aspirin in bulk and capsule dosage form by chemometric assisted spectrophotometric methods
Keerthisikha Palur, Bharathi Koganti, Sreenivasa Charan Archakam, Sridhar Chenchugari, Bhavana Nagireddy, Mahesh Babu Devabhaktuni, and Meenakshi Sankranthi
EManuscript Technologies
Objective: To develop the UV-spectrophotometric method and to apply the Chemometric designs to the developed method for the simultaneous estimation of Atorvastatin calcium (ATR) and Aspirin (ASP) in intact capsule dosage form without further extraction. Methods: The UV-Spectrophotometric method was developed by using methanol as solvent for both the drugs and the data generated from the absorption spectra was mined by two Chemometric designs which were based on the principles of linear regression analysis method (LRC) and Crammer’s matrix method (CRM). The wavelengths selected for linear regression analysis and crammers’matrix methods were 245 nm (wavelength of maximum absorption; λ max of ATR) and 275 nm (wavelength of maximum absorption; λ max of ASP). Results: Both the methods hold good linearity for ATR from 4-20 μg/ml and for ASP from 20-120 μg/ml with regression coefficient values of 0.9999 and 0.9991 respectively. The intraday and inter-day precision was found to be less than 2% RSD. The percentage recovery was in the range of 100.1-102.65 for Atorvastatin calcium and 99.95-101.15 for Aspirin by both the methods. The percentage assay was found to be 102.52 for ATR and 98.9 for ASP by LRC method and 101.62 for ATR and 98.84 for ASP by CRM method. Conclusion: The developed methods neither require any cumbersome separation procedure nor complex derivatization procedures for the analysis of the two drugs and moreover they are effective in minimizing the errors in analysis, simple and economical. Key words: Chemometrics, Regression analysis, Cramer’s Matrix method, Atorvastatin, Aspirin.

RECENT SCHOLAR PUBLICATIONS

Multivariate Ultraviolet Spectrophotometric Methods for the Simultaneous Analysis of Phenazone and Lidocaine in Ear Drops
SC Archakam, K Palur, H Neelofar, SS Devarala
Indian Journal of Pharmaceutical Sciences 86 (5), 1642-1651 2024

Simultaneous Determination of Amitriptyline Hydrochloride and Propranolol Hydrochloride in Commercial Formulation by Multitudinal UV and Multivariate FT-IR Spectroscopic Methods
SC Archakam, K Palur, R Galla, SS Padiri, PK Tulasi, R Diviti
Indian Journal of Pharmaceutical Education and Research 58 (2s), s552-s557 2024

SIMULTANEOUS DETERMINATION OF CHLORPHENIRAMINE MALEATE AND PHENYLEPHRINE HYDROCHLORIDE IN LIQUID DOSAGE FORMS BY UV SPECTROSCOPIC METHODS
N H, K Palur, SC Archakam, S Reddy C, M K, J Reddy K, H Priya K, ...
African Journal of Biological Sciences 6 (8), 633-649 2024

Development and validation of chemometric assisted UV methods for the simultaneous determination of ambroxol hydrochloride, terbutaline sulphate and guaiphenesin in
K Palur, SC Archakam, B Koganti
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH 57 (1), 242-249 2023

Estimation of eugenol in different tulsi ayurvedic formulations by RP-HPLC method
SC Archakam, K Palur, MK Yerragunta, B Kuruba Pujari
IP International Journal of Comprehensive and Advanced Pharmacology 7 (1), 51-53 2022

Multivariate analytical methods for simultaneous estimation of Atenolol and Hydrochlorothiazide in bulk and tablet dosage form
SC Archakam, K Palur, PK Arava
IP International Journal of Comprehensive and Advanced Pharmacology 6 (4 2021

Chemometric assisted UV spectrophotometric and RP-HPLC methods for simultaneous determination of paracetamol, diphenhydramine, caffeine and phenylephrine in tablet dosage form
K Palur, SC Archakam, B Koganti
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 243, 118801 2020

Chemometric-assisted RP-HPLC method for the simultaneous determination of ambroxol hydrochloride, terbutaline sulfate, and guaiphenesin in combined dosage form
K Palur, B Koganti, SC Archakam
Journal of Applied Pharmaceutical Science 9 (9), 092-097 2019

Development and Validation of a New Stability Indicating Reversed-phase High‑Performance Liquid Chromatography Method for the Simultaneous Estimation of Tegafur and Uracil in
SC Archakam
Asian Journal of Pharmaceutics (AJP) 12 (03), 221-227 2018

New stability indicating RP-HPLC method for the simultaneous estimation of terbutaline sulphate and bromhexine hydrochloride in tablet dosage form
CKB Sreenivasa Charan Archakam, Sridhar Chenchugari
International Journal of Research in Pharmaceutical Sciences 9 (3), 776-781 2018

Quantitative determination of N-Acetyl cysteine by RP-HPLC method in bulk and parenteral injection
CKB Sreenivasa Charan Archakam, Sridhar Chenchugari
Asian Journal of Pharmacy ad Pharmacology 4 (5), 702-705 2018

SIMULTANEOUS ESTIMATION OF ZOLPIDEM TARTRATE AND MELATONIN IN TABLET DOSAGE FORM BY UV SPECTROPHOTOMETRY AND RP-HPLC
SCRD Keerthisikha Palur, Sreenivasa Charan Archakam, Hemavathi Bodagala
European Journal of Biomedical AND Pharmaceutical sciences 4 (9), 462-470 2017

ESTIMATION OF NEFOPAM HYDROCHLORIDE IN BULK AND PARENTERAL DOSAGE FORM BY ZERO ORDER AND AREA UNDER THE CURVE UV SPECTROPHOTOMETRIC METHODS
SC Archakam, S Chenchugari, CSK Banoth
Journal of Global Trends in Pharmaceutical Sciences 8 (3), 4088-4095 2017

RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF PHENYLEPHRINE HYDROCHLORIDE AND CHLORPHENIRAMINE MALEATE IN PHARMACEUTICAL DOSAGE FORM
RD Sreenivasa Charan Archakam, Keerthisikha Palur, Naveen Kumar Reddy ...
Journal of Global Trends in Pharmaceutical Sciences 8 (3), 4122-4129 2017

Simultaneous Estimation of Atorvastatin and Aspirin in Bulk and Capsule Dosage Form by Chemometric Assisted Spectrophotometric Methods
K Palur, B Koganti, SC Archakam, S Chenchugari, B Nagireddy, ...
Journal of Young Pharmacists 8 (4), 424-429 2016

ANALYTICAL METHODS FOR THE RECENTLY APPROVED FDA NEW MOLECULAR ENTITIES – A REVIEW
SC Archakam, S Chenchugari, CSK Banoth
Journal of Comprehensive Pharmacy 3 (3), 70-82 2016

Bioanalytical method development and validation of rizatriptan in human plasma using LC–MS/MS method
S Velusamy, VM Masimukku, S Chereddy, JK Jadapalli, K Palur, ...
International journal of chemical and analytical science 4 (2), 108-114 2013

Quantitative estimation of Ceftibuten by RP-HPLC method in bulk and capsule dosage form
SC Archakam, K Palur, SN Sarabu, RK Kumarachari, R Diviti, S Velusamy
journal of pharmacy research 6 (4), 395-400 2013

RP-HPLC method for the estimation of ceftiofur hydrochloride in bulk form
K Palur, SC Archakam, N Lingasani, R Diviti, RK Kumarachari, ...
journal of pharmacy research 7 (3), 246-251 2013

MOST CITED SCHOLAR PUBLICATIONS

Chemometric assisted UV spectrophotometric and RP-HPLC methods for simultaneous determination of paracetamol, diphenhydramine, caffeine and phenylephrine in tablet dosage form
K Palur, SC Archakam, B Koganti
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 243, 118801 2020
Citations: 55

RP-HPLC method for the estimation of ceftiofur hydrochloride in bulk form
K Palur, SC Archakam, N Lingasani, R Diviti, RK Kumarachari, ...
journal of pharmacy research 7 (3), 246-251 2013
Citations: 16

ANALYTICAL METHODS FOR THE RECENTLY APPROVED FDA NEW MOLECULAR ENTITIES – A REVIEW
SC Archakam, S Chenchugari, CSK Banoth
Journal of Comprehensive Pharmacy 3 (3), 70-82 2016
Citations: 4

Kinetic Spectrophotometric estimation of Tramadol hydrochloride in bulk, tablet and capsule dosage forms
KK RajaSekhar, V Shankarananth, A Sreenivasa Charan, L NagaMallika, ...
Journal of Pharmacy Research 4 (10), 3842-3844 2011
Citations: 2

Spectrophotometric method for the estimation of zidovudine in bulk, tablet and capsule dosage forms
U Rajath, PK Sikha, AS Charan, M Padmavathamma, Y Kalyani, ...
Journal of Pharmacy Research 5 (7), 3834-3836 2012
Citations: 1