Pediatrics, Perinatology and Child Health, Nephrology
21
Scopus Publications
118
Scholar Citations
5
Scholar h-index
3
Scholar i10-index
Scopus Publications
A challenging diagnosis of hereditary microspherocytosis (Minkowski-Chauffard disease) in a child (a case report) Л.І. Вакуленко, A.V. Riznyk Modern Pediatrics Ukraine, 2025 Hereditary microspherocytosis (HM) is an inherited hemolytic anemia associated with erythrocyte membrane abnormalities which should be suspected in patients with a triad of symptoms: anemia, jaundice, and splenomegaly. The distinct clinical manifestations may not appear until a certain age, resulting in many undiagnosed mild-to-moderate forms of HM. Although modern technology allows to detect genetic mutations for HM confirmation, many issues remain largely unresolved and need to be addressed. The aim: to analyze a complex clinical case of HM in a child with a long-term diagnostic stage to raise awareness among physicians about this pathology. The clinical case of a 17-year-old boy with a clinical diagnosis of “Hereditary microspherocytosis, crisis course, complicated by secondary chronic calculous cholecystitis” was discussed. Clinical and paraclinical findings were analyzed. The medical case describes HM in the boy who presented with the first symptoms of anemia at the age of 3 years, and manifestations of jaundice syndrome with hyperbilirubinemia, hepatomegaly debuted only at the age of 12 years. Such features of the disease course have translated to diagnostic delay of HM and the development of calculous cholecystitis as a complication. Conclusions. Currently, mild forms of hereditary microspherocytosis are underdiagnosed. Mild and moderately severe course of hereditary microspherocytosis, apart from jaundice and moderate splenomegaly, can be manifested by cutoff hemoglobin values, making it difficult to timely diagnose primary disease and its complications. Since the most common complication of hereditary microspherocytosis is gallstone disease, regular ultrasound examinations of the gallbladder and monitoring of the hepatobiliary system are the best imaging modalities for patients even in the absence of overt hemolysis. In case of conservative therapy ineffectiveness, it is necessary to consider the issue of performing a complete or partial splenectomy, and in the presence of a complication in the form of calculous cholecystitis, it should be combined with cholecystectomy. The analyzed clinical case is a demonstrative example of underdiagnosed mild hereditary microspherocytosis complicated by secondary chronic calculous cholecystitis. The research was carried out in accordance with the principles of the Declaration of Helsinki. The informed consent of the patients was obtained for the study. The authors have no conflicts of interest to declare.
Analysis of the dependence of the levels of markers of early kidney damage — cytokines KIM-1 and TGF-β1 in children with juvenile idiopathic arthritis L.I. Vakulenko, S.V. Samsonenko Kidneys, 2025 Background. Juvenile idiopathic arthritis (JIA) is a heterogeneous group of diseases characterized by chronic joint inflammation in children under the age of 16 years. Kidney damage in JIA ranges from asymptomatic proteinuria to severe glomerulonephritis that can lead to chronic kidney disease. Given the above data, the assumption of an increased risk of early development of kidney damage in children with JIA is reasonable. The purpose was to analyze the risk factors for structural tubular lesions by studying the level of kidney injury molecule-1 (KIM-1) and transforming growth factor β1 (TGF-β1) in children with JIA, depending on the characteristics of the clinical course of the disease and the treatment received. Materials and methods. Eighty children with JIA who were undergoing inpatient treatment at the Regional Medical Center for Family Health of the State Regional Health Department were examined. A retrospective analysis of medical documentation was conducted to assess the child’s age at the onset of JIA, the duration of its course, clinical features, and treatment. Further, during the work, a clinical examination, assessment of the health of children, general clinical, biochemical, immunoenzymatic and immunological studies, ultrasound examination of joints and kidneys were performed. Structural tubular markers KIM-1 and TGF-β1 were measured in urine samples. Results. The average KIM-1 level was 0.9970 ± 0.1662 (0.98; 0.90–1.12) ng/ml, TGF-β1 — 20.26 ± 16.34 (14.02; 12.5–17.98) pg/ml. The average KIM-1 values varied depending on the form of JIA and the degree of disease activity. At the same time, with high JIA activity, the KIM-1 level was statistically significantly higher (1.1510 ± 0.0806 ng/ml, p < 0.05 compared to remission). A similar trend was observed when analyzing TGF-β1 levels. Elevated KIM-1 was associated with high JIA activity, involvement of ≥ 6 joints at the time of examination, and lesions of small joints of the hands and wrist joints. Elevated TGF-β1 was statistically significantly associated with polyarthritis, JIA duration of ≥ 6 years, and active disease stage of ≥ 4 years. Conclusions. Our study revealed a statistically significant relationship between the levels of KIM-1 and TGF-β1 biomarkers and the degree of JIA activity. The antinuclear antibodies status in patients with JIA did not affect the levels of KIM-1 and TGF-β1. Elevated content of KIM-1 and TGF-β1 in urine indicate the risk of structural kidney damage in patients with JIA. Risk factors are high JIA activity, significant joint involvement, prolonged active stage, the presence of hypertension, and NSAIDs treatment. The combination of NSAIDs with methotrexate increased the levels of KIM-1 and TGF-β1, which indicated a nephrotoxic effect, while the combination of methotrexate with immunobiological drugs decreased the levels of biomarkers.
STATISTICAL DATA AND ANALYSIS OF LITERATURE SOURCES ON PATHOPHYSIOLOGICAL MECHANISMS OF THE CROSSTALK BETWEEN ACUTE KIDNEY AND LIVER INJURY IN PRETERM NEWBORNS DURING THE EARLY NEONATAL PERIOD O. Obolonska, L. Vakulenko Neonatology Surgery and Perinatal Medicine, 2025 Acute kidney injury (AKI) and acute liver failure (ALF) are common and potentially dangerous complications in neonates admitted to the NICU. This article reviews data on the adverse effects of AKI on liver function and the development of ALF in preterm neonates. Infants with hemodynamically significant patent ductus arteriosus (hsPDA) are highlighted.Aim. To analyze risk factors and the incidence of liver damage in preterm newborns who experienced AKI during the early neonatal period.Materials and methods. The study retrospectively analyzed the medical history of 74 preterm infants admitted to the anesthesiology and neonatal intensive care unit. Patients were examined using a complex of general clinical, biochemical, immunoenzymatic, and instrumental methods, as well as measuring the urinary neutrophil gelatinase-associated lipocalin (NGAL) biomarker and performing statistical analysis. Scientific research was conducted in accordance with the provisions of GCP (1996), the Convention of the Council of Europe on Human Rights and Biomedicine (April 4, 1997), the Declaration of Helsinki of the World Medical Association on the Ethical Principles for Conducting Scientific Research with Human Participation (1964-2008), and the Order of the Ministry of Health of Ukraine No. 690 dated September 23, 2009 (as amended by the Order of the Ministry of Health of Ukraine No. 523 dated July 12, 2012).The distribution of patients was carried out depending on the AKI development, that was diagnosed and stratified by the severity based on the neonatal modification of the 2012 KDIGO criteria. AKI was diagnosed according to the Pediatric Acute Liver Failure Study Group recommendations: prothrombin time ≥20 seconds after vitamin K administration or International Normalized Ratio values ≥2 units).Results. AKI was diagnosed in 36.5% of all preterm infants studied and 77.8% of them had hsPDA. ALF manifestations were mostly detected on day 5 and accounted for 79.3% of infants with AKI, 3 times more frequent in its severe course (p<0.05) and 4.2 times more frequent than in those without AKI signs (p<0.05). Correlation analysis of blood creatinine levels on days 3 and 10 showed a direct association with the development of AKI (ρ=0.496, p˂0.05 and ρ=0.456, p˂0.05, respectively). At the same time, AKI was 3.4 times (p<0.05) more severe when combined with ALF. An increase in bilirubin levels to levels indicating the need for phototherapy was directly correlated with the development of AKI (ρ=0.544, p˂0.05). Episodes of hypoglycemia and the need for its additional correction were directly correlated with the severity and duration of AKI (ρ=0.349, p˂0.05 and ρ=0.556, p˂0.05, respectively). In addition, 78% of the children were predisposed to lactic acidosis.The diagnostic value of urinary NGAL for AKI in preterm infants was 229.7±94.82 (208.5; 176-297.3). An NGAL concentration of 249.0±113.27 (210; 185.5-302) tripled the odds of developing AKI (p˂0.05). Elevated urine NGAL was an independent prognostic factor for 28-day mortality. Unfortunately, all 6 infants with urine NGAL levels above 250 μg/L developed severe AKI with ALF manifestations and died in the neonatal period. Analysis of the perinatal history of the studied preterm infants showed a statistically significant association between AKI and ALF in those infants whose mothers had a history of renal disease, chronic infection, or chorioamnionitis.Conclusions. Understanding the impact of acute kidney injury on liver function in preterm infants can help address the issues of early diagnosis, management and prevention of acute liver failure and improve outcomes of care for these infants. Identification of early pathological manifestations using biomarkers and analysis of patient history are needed to prevent complications caused by the complex and potentially dangerous vicious circle related to kidney-liver crosstalk.
Rituximab Administration to Treat Nephrotic Syndrome in Children: 2-Year Follow-Up Dmytro Ivanov, Lutz T. Weber, Elena Levtchenko, Liudmyla Vakulenko, Mariia Ivanova, Iryna Zavalna, Yelizaveta Lagodych, Ninel Boiko Biomedicines, 2024 Background: Steroid-sensitive nephrotic syndrome (SSNS) and steroid-resistant nephrotic syndrome (SRNS) significantly affect children’s quality of life. There are frequent relapses in SSNS and progression in SRNS. IPNA guidelines suggest that monoclonal antibodies like rituximab (RTX) are promising treatments. Objective: This study aims to evaluate the long-term efficacy and safety of rituximab administration in children with SSNS, encompassing FRNS and SDNS, and SRNS over a two-year follow-up period, facilitating individualized management. Methods: We conducted an open-label, multicenter, randomized, and patient-oriented study (RICHNESS), involving children aged 3–18 with SRNS (18) and SSNS (11) undergoing 2 years continuous RTX therapy. The primary outcome was complete/partial remission (CR/PR), as defined by IPNA/KDIGO guidelines, at 6, 12, 18, and 24 months on RTX; secondary outcomes included adverse events. Key endpoints included the estimated glomerular filtration rate (eGFR), the albumin-to-creatinine ratio (ACR), CD20 levels, IgG levels, and the incidence of infections. Kidney biopsies were performed in 94% of SRNS patients. RTX was administered every 6–9 months, depending on CD20 levels, IgG levels, and the presence of infections. The eGFR and ACR were assessed every 6 months. Results: Some 31 children were selected for RTX treatment. Overall, 2 experienced severe allergic reactions, leading to their exclusion from the final analysis of 29 children. In the SSNS group, all children achieved and maintained complete remission within 2 years. Remission rates in the SRNS group ranged from 39% (RR 0.78; 95% CI: 16.4–61.4%, NNT 9) at the 6th month to 72% (RR 1.44; 95% CI: 51.5–92.9%) over the 2-year follow-up period due to continuous RTX therapy. The median duration of RTX use was 26.1 months, with a median cumulative dose of 1820 mg/m2. Adverse reactions and complications were presented by mild infusion-related reactions in 3 children (10.3%), severe allergic reactions in 2 children (6.2%), hypogammaglobulinemia in 7 children (24%), infections in 3 children (10.3%), severe destructive pneumonia in 1 child, recurrent respiratory infections in 2 children, and neutropenia in 1 child (3.44%). Conclusions: RTX was tolerated well, and proved highly effective as a steroid-sparing agent, offering potential in terms of stopping relapses and minimizing steroid-related side effects. It also demonstrated efficacy in slowing progression in SRNS, indicating potential for use in ACR reduction and renal function restoration, but requires careful use given potential severe allergic reactions and infectious complications. Further studies should focus on long-term cost-effectiveness and deferred side effects.
Consideration of a family case of X-linked hypophosphatemia through the prism of modern diagnostic and treatment methods L.I. Vakulenko Kidneys, 2024 Background. X-linked hypophosphatemia is the most common form of hereditary vitamin D-resistant rickets. Today, there is a late diagnosis, later treatment start and a significant deterioration in the quality of life of patients with X-linked hypophosphatemia. The aim of the study is to use a clinical case as an example in order to draw attention to the problem of X-linked hypophosphatemia and consider traditional and novel approaches to the diagnosis and therapy. Materials and methods. We analyzed a family case of X-linked hypophosphatemia in a 4-year-old boy. Results. Based on the analysis of a family case, modern approaches to clinical, laboratory and instrumental diagnosis recommended by international clinical guidelines for the diagnosis and treatment of X-linked hypophosphatemia are considered. The causes for late diagnosis, advantages and disadvantages of traditional therapy are analyzed. Treatment was adjusted including phosphate and active vitamin D preparations, taking into account international clinical guidelines. The latest data are presented on the treatment of X-linked hypophosphatemia with biological therapy using burosumab. The results of short-term studies on the efficacy and safety of burosumab in children and adults are described. Conclusions. X-linked hypophosphatemia is a complex hereditary tubulopathy requiring timely diagnosis, treatment and thorough patient management by a multidisciplinary team of doctors. Once X-linked hypophosphatemia is suspected, a clinical, laboratory and instrumental examination of a patient should be carried out in accordance with international recommendations. Although traditional therapy has limited therapeutic efficacy and side effects, its early initiation is associated with better outcomes. A significant progress in the treatment of hypophosphatemic vitamin D-resistant rickets was achieved due to the biological therapy with burosumab aimed at its pathophysiological mechanisms. The profile of burosumab effects allows this therapy to be considered life-saving.
INNOVATIVE METHODS IN TEACHING PEDIATRICS TO STUDENTS OF HIGHER MEDICAL EDUCATION IN V AND VI YEARS: DIALOGUE TEACHING L. Vakulenko, L. Badogina, O. Obolonska, A. Riznyk, S. Samsonenko Neonatology Surgery and Perinatal Medicine, 2024 The article substantiates the need to fi nd and implement the latest learning technologies for students of higher medical education in the context of modern circumstances in Ukraine, which have caused the situation that a certain part of teaching is conducted remotely. This reduces the possibility for students to acquire the competencies defi ned by the discipline program. The principles of teaching with the use of dialogue technology were analyzed according to the literature. The positive eff ects of dialogue training on the development of communicative skills, the ability to express one’s thoughts and ideas, and to listento others have been identifi ed. Meaningful dialogue contributes to a deeper understanding of the educational material and can be used as a basis for solving problem situations, working in groups, using the case method, in project technology. In addition, a dialogic approach to learning is an opportunity to support the development of critical thinking. Certain problems in the introduction of dialogic technology in higher medical education are also pointed out: the presence of diagnostic and treatment protocols in medicine somewhat limits discussions in the educational process. The implementation of the principles of dialogical learning in pediatrics teaching at the fi nal stages of higher medical education and in students’ research work is demonstrated.Conclusions. The search for alternative methods of education in higher medical education institutions is an urgent problem today. The dialogical method of learning, as a progressive method, should be included in the teaching process, as a method that promotes self-criticism, the development of students’ communicative skills, and has a positive infl uence on cognitive activity. Eff ective dialog among students and between students and teachers is possible in any variant of the educational process: in the classroom, at a distance and in a mixed format. The successful implementation of the dialogical teaching method in clinical teaching requires its thorough methodical development. Scientifi c activity of students can be considered as one of the options ofdialogical education.
Raynaud’s phenomenon: a modern view of the problem , S.V. Samsonenko, L.I. Vakulenko, and Modern Pediatrics Ukraine, 2024 Raynaud's phenomenon (RP) is present in almost all patients with systemic connective tissue diseases and is often the first clinical manifestation of the disease, preceding skin and organ involvement several years later. Aim - to study and analyze available data regarding the prevalence, risk factors for development, clinical features and diagnosis of RF based on an analysis of modern literature data. Raynaud's phenomenon is quite common in the general population (about 5%), and is usually caused by cold exposure or significant changes in temperature (primary RF). There are primary and secondary RF. In both primary and secondary RF, the typical episode is characterized by the sudden appearance of cold fingers (or toes) coupled with sharply limited changes in skin color (white) due to restricted blood flow, followed by cyanotic skin color (blue), indicating on tissue hypoxia. During rewarming, the ischemic phase (white or blue attack) usually lasts 15-20 minutes. After recovery, the skin turns red, which leads to reperfusion erythema. To establish a diagnosis, blue-white changes are usually necessary. In patients with highly pigmented skin, skin changes may be more visible on the palmar surface of the fingers. Conclusions. Despite the significant prevalence of RF, it is extremely difficult to establish its exact prevalence, especially in the pediatric population. If RF is suspected, the doctors should pay attention not only to changes in the color of the extremities, but also to swelling and telangiectasia in the patient during examination and medical history. Despite the absence of a “gold standard” for diagnosing RF, nail fold capillaroscopy is recognized as the main method for diagnosing RF today. The authors declare that there is no conflict of interest.
Is chronic urticaria or urticarial vasculitis a diagnostic dilemma? , L.I. Vakulenko, S.V. Samsonenko, , K.V. Skriabina, and Modern Pediatrics Ukraine, 2024 Introduction. Urticarial vasculitis (UV) is a rare disease that has two components: clinical manifestations of urticaria and histopathological signs of cutaneous leukocytoclastic vasculitis of small vessels, predominantly involving postcapillary venules. This condition is characterized by chronic or recurrent episodes of urticaria, each element of which lasts more than 24 hours and is accompanied by a feeling of pain and burning. The aim is to reveal the key points of pathogenetic mechanisms, differential diagnosis and therapeutic tactics of UV based on a clinical case. Clinical case. A clinical case of a 17-year-old boy with normocomplementemic UV is described. The patient's main complaint was a long-lasting rash (more than three weeks) with itching. From the anamnesis it is known that the provoking factors for the onset of the disease were an insect bite and the start of taking a new drug, namely vitamin K (two days before the onset of the disease). Throughout this time, the child was examined by various specialists and received treatment. Alternative diagnoses: bacterial folliculitis, viral exanthem, unspecified urticaria. There was no positive effect from the received treatment. The diagnosis of UV was made in the sixth week of the disease using a punch biopsy. Regression of the skin syndrome was achieved using a combination of antihistamine and antileukotriene drugs. Conclusions. Performing a punch biopsy, which is currently the gold standard for diagnosis, allows us to solve the diagnostic dilemma: “UV or chronic urticaria”. Timely diagnosis helps to avoid false diagnoses and, as a result, incorrect treatment of UV. The description of this clinical case is a contribution to the disclosure of this globally complex problem. The research was carried out in accordance with the principles of the Declaration of Helsinki. The informed consent of the child and child's parents was obtained for conducting the research. No conflict of interest was declared by the authors.
RISK FACTORS AND CLINICAL CORRELATIONS OF URINARY TGF-Β1 IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS AND EARLY KIDNEY FIBROSIS T. Borysova, S. Samsonenko, L. Vakulenko Neonatology Surgery and Perinatal Medicine, 2024 The course of juvenile idiopathic arthritis (JIA) is associated with a long-term infl ammatory process and the use of nonsteroidal anti-infl ammatory drugs (NSAIDs), which can cause nephrotoxicity with fi brotic kidney damage in patients with JIA. Regardless of the etiology of joint damage, prolonged infl ammation promotes the progression of fi brosis, and renal fi brosis is the fi nal common stage of chronic kidney disease (CKD). Kidney biopsy, which is invasive, risky and underutilized, is generally considered the only clinical method to detect fi brosis. Over the past decade, some progress has been made in the search for minimally invasive biomarkers of early kidney fi brosis, with transforming growth factor-β1 (TGF-β1) playing a key role in the progression of kidney fi brosis, but the signifi cance of TGF-β1 in children with JIA is unknown.Material and Methods: 80 children with JIA were examined. Urinary TGF-β1 levels were determined using a TGF-β1 ELISA kit(DRG International, Inc., Germany, EIA-1864) according to the manufacturer’s instructions. Methods of variation statistics were used. Informed consent was obtained from all patients. The study has a positive conclusion of the Commission on Biomedical Ethics of Dnipro State Medical University (Minutes of the meeting of the Commission No. 12 dated December 19, 2002), which decided that the scientifi c research can be considered in accordance with generally accepted moral standards, the requirements of respecting the rights, interests and personal dignity of study participants, bioethical standards for work with pediatric patients. There is no risk to the research subjects in the performance of the work. The legal representatives of the children involved in the research are informed about all aspects related to the purpose, objectives, methods and expected benefi ts of the research. Laboratory and instrumental research methods are generally accepted; the drugs to be used are approved for use. No human experiments were performed.Methods of variation statistics were used. Statistical analysis was performed using the STATISTICA 6.1 software package(StatSoft Inc., serial no. AGAR909E415822FA). The work was carried out as part of the research work of the Department of Propaedeutic of Childhood Diseases and Pediatrics 2 of the Dnipro State Medical University «Development of criteria for early diagnosis and prediction of comorbid kidney damage in children with somatic and infectious diseases» (state registration No. 0119U100932, implementation period 01.2019-12.2023).Results. The mean TGF-β1 level in our study was 20.26±16.34 (14.02, 12.5-17.98) pg/ml. Polyarthritis almost quadrupledthe probability of pathological changes in TGF-β1. The overwhelming majority of children with elevated TGF-β1 suff ered from polyarthritis (80.0 %) – one and a half times more often than those with relatively normal TGF-β1 concentration, p<0.04.If the active stage of the disease lasted at least 4 years, the probability of elevated TGF-β1 increased more than sixfold. Thetendency of signifi cant nephrotoxic eff ect of prolonged active JIA was confi rmed by the results of correlation analysis, according to which, in general, the duration of active JIA was directly related to the increase of TGF-β1 (ρ=0.38, p<0.001), and the duration of remission and the total duration of JIA had no signifi cant correlation with it (ρ= –0.19 and ρ=0.18, respectively, p>0.05). The direct dependence of elevated urinary TGF-β1 levels on clinical features such as polyarthritis and the duration of the active phase of JIA has been demonstrated. These clinical features in children with JIA can be considered as risk factors for the development of early renal fi brosis. Against the background of elevated TGF-β1, a reduced GFR according to the Hoek formula (<90 ml/min/1.73 m2) was found in 95 % of cases, i. e. the estimates of the functional state of the kidneys obtained by two diff erent methods were quite clearly the same. In the sample with TGF-β1<17.98 pg/ml, 22.76 % of children received immunobiologic therapy, while in the sample to increase TGF-β1 – only 14.76 %. Immunobiological therapy reduced the risk of increasing this urinary marker by 5.5 times.Conclusions. Elevated levels of the TGF-β1 biomarker were found in 25 % of children with JIA. An association of early renalfi brosis with duration of active phase of JIA ≥ 4 years, increased ESR, polyarthritis, arterial hypertension, and dental carieswas observed. Elevated urinary TGF-β1 levels are associated with reduced eGFR and are observed in almost all children witheGFR<90 ml/min/1.73 m2, confi rming the importance of early renal fi brosis in the development of renal dysfunction.
Peculiarities of Kawasaki disease in pre-COVID-19 period , L.I. Vakulenko, A.V. Riznyk, , S.V. Samsonenko, , Yu.S. Stepanovsky, and Modern Pediatrics Ukraine, 2024 Kawasaki disease (KD) is one of the most common causes of fevers of unknown origin and acquired heart defects in children under five years of age. Currently, there are no specific laboratory tests for the diagnosis of KD, so it is established on the basis of clinical data. Aim - to determine the clinical, laboratory and instrumental features of KD in the pre-modern period in order to optimize treatment. Materials and methods. Retrospective review of medical histories of 8 children with KD aged 6 months to 5 years (boys - 4, girls - 4). The diagnosis was verified according to the criteria of the American Heart Association, which were approved by the EULAR/PreS Consensus in 2017. Objective and laboratory parameters were examined. Results. According to the results of the main clinical criteria of KD, febrile fever for more than 5 days, bilateral conjunctival injection without exudation and oropharyngeal changes were observed in all the examined (100%). According to the results of laboratory tests, 100% of the examined had thrombocytosis, 87.5% - anemia, 75.0% - neutrophilic leukocytosis and increased in the erythrocyte sedimentation rate. According to the echocardiological examination of the heart, 100% of the children had signs of dilatation of the heart cavities. Aneurysm of coronary arteries was diagnosed in 37.5% of the examined. Conclusions. The time of diagnosis of KD determines the therapy and prognosis of the disease. The peculiarities of the course of KD are the cyclic nature and symptoms inherent in many other diseases, which complicates timely diagnosis, leads to the delay of therapy, prolonged hospitalization of patients and worsening of the prognosis. The study was carried out according to the principles of the Declaration of Helsinki. The study protocol was accepted by the Local Ethical Committee of these institutions. The informed consent of the children's parents was obtained for the research. The authors declare no conflict of interest.
THE IMPACT OF THE SARS-COV-2 (COVID-19) PANDEMIC ON THE NOSOMORPHOSIS OF PAEDIATRIC NEUROPATHOLOGY Л Вакуленко, О Власов, А Різник, К Венгер, К Петулько, В Маврутенков, ... Неонатологія, хірургія та перинатальна медицина 15 (4 (58)), 46-55 , 2025 2025
STATISTICAL DATA AND ANALYSIS OF LITERATURE SOURCES ON PATHOPHYSIOLOGICAL MECHANISMS OF THE CROSSTALK BETWEEN ACUTE KIDNEY AND LIVER INJURY IN PRETERM NEWBORNS DURING THE EARLY … О Оболонська, Л Вакуленко Неонатологія, хірургія та перинатальна медицина 15 (1 (55)), 31-36 , 2025 2025
Клінічний випадок неповної форми хвороби Кавасакі у дитини ЛІ Вакуленко, АВ Різник, АА Голікова, ОГ Забудська, АВ Залізняк Матеріали XХV наукової конференції студентів та молодих вчених «Новини і … , 2025 2025
INNOVATIVE METHODS IN TEACHING PEDIATRICS TO STUDENTS OF HIGHER MEDICAL EDUCATION IN V AND VI YEARS: DIALOGUE TEACHING Л Вакуленко, Л Бадогіна, О Оболонська, А Різник, С Самсоненко Неонатологія, хірургія та перинатальна медицина 14 (2 (52)), 23-27 , 2024 2024
Розгляд сімейного випадку Х-зчепленої гіпофосфатемії через призму сучасних методів діагностики й лікування. В ЛІ Kidneys: Ukrainian Journal of Renal Medicine 13 (3) , 2024 2024
RISK FACTORS AND CLINICAL CORRELATIONS OF URINARY TGF-Β1 IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS AND EARLY KIDNEY FIBROSIS Т Борисова, С Самсоненко, Л Вакуленко Неонатологія, хірургія та перинатальна медицина 14 (1 (51)), 54-60 , 2024 2024
Розгляд сімейного випадку Х-зчепленої гіпофосфатемії через призму сучасних методів діагностики й лікування ЛІ Вакуленко Нирки, 220-227 , 2024 2024
Особливості перебігу хвороби Кавасакі в доковідний час ЛІ Вакуленко, АВ Різник, СВ Самсоненко, ЮС Степановський Сучасна педіатрія. Україна, 34-42 , 2024 2024
Фактори ризику та клінічні кореляції TGF-β1 в сечі у дітей з ювенільним ідіопатичним артритом та раннім фіброзом нирок Т Борисова, С Самсоненко, Л Вакуленко ІВАН СЕМЕНОВИЧ СМІЯН–95!!!, 59 , 2024 2024
Складний пацієнт в педіатрії. Клінічні спостереження ГВ Бекетова, ОП Волосовець, ОМ Охотнікова, ЛІ Вакуленко, ... Харків: ХНМУ , 2024 2024
Diagnostic value of additional markers for acute kidney injury in preterm neonates with patent ductus arteriosus О Оболонська, Т Мавропуло, Л Вакуленко, Т Борисова, О Оболонський Неонатологія, хірургія та перинатальна медицина 13 (3 (49)), 26-35 , 2023 2023 Citations: 2
Клінічний випадок стероїдзалежного нефротичного синдрому в дитини Є Лагодич, Д Іванов, Л Вакуленко, О Литвинова 2023
Аналіз сімейного випадку синдрому Гурлера, тяжкого прояву мукополісахаридозу I типу у дітей ЛІ Вакуленко, ОС Бабінська, ЮД Михайлова Дніпровський державний медичний університет , 2022 2022
Застосування ритуксимабу в лікуванні дітей з нефротичним синдромом ЛІ Вакуленко, ОМ Литвинова, ІВ Посмітюха Нирки= Почки= Kidneys 11 (2), 86-91 , 2022 2022
Фактори ризику розвитку ретинопатії у недоношених дітей ОЮ Оболонська, ЛІ Вакуленко, ЛП Бадогіна, ОІ Оболонський, ... Здоров’я дитини= Zdorov’e Rebenka 17 (3), 138-143 , 2022 2022
ОСОБЛИВОСТІ ПЕРИНАТАЛЬНОГО АНАМНЕЗУ В ДІТЕЙ З ХРОНІЧНОЮ ХВОРОБОЮ НИРОК ЛІ Вакуленко, ЛП Бадогіна The 6th International scientific and practical conference “Modern directions … , 2021 2021
Ситуаційні задачі в навчанні студентів медичного вузу в період пандемії COVID-19 ТП Борисова, ЛІ Вакуленко, АВ Різник, НГ Порохня Reviewed and recommended for publication The decision of the Organizing … , 2021 2021
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