Gabriele Laudadio received his PhD in chemistry from Eindhoven University of Technology in 2020. He conducted his doctoral research in the Micro Flow Chemistry & Synthetic Methodology group under the supervision of Prof. Timothy Noël. Following his PhD, he briefly served as a postdoctoral fellow and group leader in Prof. Noël’s group at the University of Amsterdam. In 2021, he joined the research group of Prof. Phil S. Baran at the Scripps Research Institute (La Jolla, USA) as a Hewitt Foundation Fellow. Currently, Gabriele Laudadio is University assistant at the University of Graz and Key Researcher at the Research Center Pharmaceutical Engineering GmbH (RCPE). His research is primarily focused on the application of technology in the field of organic chemistry, with a specific emphasis on the use of flow chemistry and electrochemistry in organic synthesis.
RESEARCH, TEACHING, or OTHER INTERESTS
Organic Chemistry, Electrochemistry, Chemical Engineering
42
Scopus Publications
3806
Scholar Citations
24
Scholar h-index
28
Scholar i10-index
Scopus Publications
Electrolysis-Assisted Reduction of Dimethylformamide for Unactivated Alkene Functionalizations Yifan Xi, Sulekha Sharma, C. Oliver Kappe, Gabriele Laudadio Journal of the American Chemical Society, 2026 High Resolution Image Download MS PowerPoint Slide N,N -Dimethylformamide is a widely used solvent, which can be employed as a reagent under certain conditions. Among the different ionic and radical activation approaches, the direct single-electron reduction of this amide appears elusive, owing to its prohibitively low reductive potential. In this work, electrolysis-assisted generation of the N,N -dimethylformamide distonic radical anion is presented. Its synthetic applicability was established by the functionalization of unactivated alkenes. The transformation was validated across several mono- and disubstituted olefins, generating the corresponding hydroformylated and hydroaminomethylated products. Mechanistic experiments confirmed the generation of the distonic radical, demonstrating that this intermediate was generated at the surface of the magnesium anode. This work provides a new perspective on the activation of this commonly used solvent, paving the way to other radical transformations.
Automating Synthetic Organic Electrochemistry: Concepts and Advancements Eduardo Rial‐Rodríguez, C. Oliver Kappe, Gabriele Laudadio Chemistry Methods, 2025 Automated electrochemical platforms are attracting attention for their potential in streamlining reaction preparation, electrolysis, and analysis to generate large datasets in a fast and efficient manner. Moreover, the recent implementation of on‐line analytics together with closed‐loop workflows has enabled the emergence of electrochemical self‐driving laboratories. In this review, the common guidelines for the development of these platforms are presented, covering the main modules to assemble these systems. Furthermore, a comprehensive survey of all the platforms applied in synthetic organic electrochemistry is reported, where each example is described in terms of elements and applications and classified by category. Finally, an outlook including a perspective on the topic is presented, proposing potential future directions of the field.
Electrochemical telescoped synthesis of alkyl pinacol boranes David M. Köpfler, Andreas Baumgartner, Leo Ribic, Simon Wagschal, Clara Bovino, Dominique M. Roberge, C. Oliver Kappe, Gabriele Laudadio Journal of Flow Chemistry, 2025 Boron-containing compounds are essential building blocks in organic synthesis. A significant advancement in the preparation of alkyl boranes relied on the use of B 2 Cat 2 with competent radical precursors under chemical, photochemical, and electrochemical conditions. However, these molecules are unstable and require one-pot formation of corresponding pinacol boranes to be isolated. In this work, we present a continuous flow electrochemical decarboxylative borylation approach telescoped with the exchange from unstable catechol boranes intermediates to isolable pinacol boranes. The study encompassed the optimization of a single-pass protocol employing an electrochemical microreactor, followed by the telescoped pinacol addition. No supporting electrolyte was necessary to successfully execute the process. The continuous-flow approach was validated across 11 examples comprising primary, secondary, and tertiary alkyl carboxylic acids. Graphical Abstract
Reimagining Advanced Chemistry Education: A Community-based Approach to Course Design for Modern Learners Matthew A. Horwitz, Reem Al-Ahmad, Xingfeng Bai, Matteo Balletti, Peter Bellotti, Yael Ben-Tal, Mark W. Campbell, Kathleen Cheasty, Steven W. M. Crossley, Craig S. Day, Patrick J. Deneny, Katherine C. Forbes, Emma S. Gogarnoiu, Phillip S. Grant, Riya Halder, Georgia R. Harris, Pol Hernández-Lladó, Morgan Jouanneau, Vera Jost, Dennis A. Kutateladze, Gabriele Laudadio, Chun Liu, Aidan P. Looby, Aitor Maestro, Terry McCallum, Maximilian D. Palkowitz, Joshua M. Paolillo, Matthew W. D. Perry, Julia C. Reisenbauer, Cesar Reyes, Hayden A. Sharma, Fu Kit Sheong, Benjamin Thoma, Andrew V. Tran, Duc N. Tran, Francisco José Aguilar Troyano, Thomas Verheyen, Mark P. Walsh, Alicia Wagner, Emily R. Wearing, Georg Wuitschik Journal of Chemical Education, 2025 High Resolution Image Download MS PowerPoint Slide Chemistry education at the graduate level and beyond faces the formidable challenge of a boundless and constantly expanding frontier of knowledge on many fronts. While modern learners have an increasingly broad range of resources available at their disposal (including open access text-based references, online videos, training problems, and other digital learning materials), there are comparatively fewer such materials aimed at the highest levels of study. With the goal of producing widely accessible graduate-level learning content, we created a community-based approach to online course design that is easily digestible to meet the expectations of modern learners. Herein, we report the development of an open access Advanced Organic Chemistry video-based online course and several other specialized minicourses using the Synthesis Workshop YouTube channel.
Intensifying Electrochemical Hydrocarboxylation of Activated Alkenes Andreas Baumgartner, Nikola Petrović, C. Oliver Kappe, Gabriele Laudadio Chemelectrochem, 2025 There is an increasing attention in developing reactions that can incorporate CO2 into organic molecules. In this context, electrochemistry offers a sustainable and mild approach to utilize this valuable yet elusive C1 building block in a scalable fashion. Herein, the intensification of the electrochemical hydrocarboxylation of activated alkenes is presented. The study covers the evaluation of critical chemical and electrochemical parameters to maximize the efficiency of the process in standardized small‐scale batch cells, followed by the transfer to a spinning cylinder electrochemical reactor. Leveraging the enhanced mass transfer of this reactor design, the reaction can be further optimized, leading to a more efficient process. After validating the transformation across different substrates, the regioselective addition of CO2 is further improved by tuning the current density of the process. Finally, a scale‐up in recirculation mode is performed, achieving a productivity of 55 g day−1 and demonstrating its potential for the efficient and scalable utilization of the electrochemical hydrocarboxylation reaction.
The Role of Synthetic Organic Electrochemistry in the Technological Revolution of Pharmaceutical Industry Gabriele Laudadio Chimia, 2025 Electrochemistry is significantly contributing to the technological revolution of organic synthesis, where the implementation of different techniques has garnered innovative and scalable synthetic methodologies. This article explores the impact of synthetic organic electrochemistry in the pharmaceutical and agrochemical industry. Key examples in high throughput experimentation, medicinal chemistry, discovery process chemistry, and process chemistry are presented, highlighting the relevance of electrochemistry in the advancement of organic synthesis, and driving innovation in the fine chemical industry.
Scalable Electrochemical Dehalogenative Carboxylation without a Sacrificial Metal Anode Nikola Petrovic, Gabriele Laudadio, Chase A. Salazar, Caleb J. Kong, Jenson Verghese, Alexander Hesketh, Giselle P. Reyes, Jean‐Nicolas Desrosiers, C. Oliver Kappe, David Cantillo Advanced Synthesis and Catalysis, 2025 A scalable electrochemical procedure for the synthesis of carboxylic acids from organic halides has been developed using a spinning cylinder electrode electrochemical reactor. The electrochemical process is based on the reductive dehalogenation of the starting material followed by trapping of the resulting carbanion with CO2. The protocol is compatible both with organic chlorides and bromides and uses inexpensive graphite and stainless steel as electrode materials. As sacrificial metal anodes are avoided, the method can be readily scaled up in flow mode. The procedure is compatible with a wide range of substrates (24 examples), including aryl and alkyl halides as well as heterocyclic compounds. Multigram scale preparations in flow mode have been demonstrated by processing 600 mL of reaction mixture in an electrolyte recirculation setup.
Electrochemical Fluorination of Organic Compounds Using a Hexafluorosilicate Salt as an Inexpensive and Widely Available Fluorine Source David M. Köpfler, Gabriele Laudadio, Clara Bovino, Michael Bersier, Ryan Littich, Dominique M. Roberge, Simon Wagschal, C. Oliver Kappe, David Cantillo Organic Letters, 2025 The introduction of fluorine into organic molecules is of the utmost importance in the preparation of active pharmaceutical ingredients (APIs). While a wide range of fluorine sources for organic synthesis have been used over the past decades, the associated safety risks, cost, or environmental impact are still serious limitations. Hexafluorosilicate salts are one of the most inexpensive and readily available sources of nucleophilic fluorine, but they have so far not been used in organic synthesis. Herein we report the first example of the use of a hexafluorosilicate salt as a reagent for the formation of C-F bonds. We have selected as the model reaction an electrochemical decarboxylative fluorination procedure. The synthesis of bis(5-ethyl-2-methylpyridin-1-ium) hexafluorosilicate(IV) was key to obtaining a soluble and reactive hexafluorosilicate salt. This protocol enabled the synthesis of a wide range of primary, secondary, and tertiary aliphatic fluorides (22 examples) in up to 85% yield. The electrochemical method was also successfully transferred to a flow electrolysis cell, demonstrating its robustness and scalability. Finally, we extended the scope of the fluorine source by demonstrating its applicability to electrochemical benzylic C-H fluorination.
Synthesis of Unnatural Amino Acids via Ni/Ag Electrocatalytic Cross-Coupling Gabriele Laudadio, Philipp Neigenfind, Rajesh Chebolu, Vanna D. Blasczak, Shambabu Joseph Maddirala, Maximilian D. Palkowitz, Philippe N. Bolduc, Michael C. Nicastri, Ravi Kumar Puthukanoori, Bheema Rao Paraselli, Phil S. Baran Organic Letters, 2024
Prioritizing Mentorship as Scientific Leaders Jacky M. Deng, Salma Elgaili Ahmed, Ernest Awoonor-Williams, Progna Banerjee, Magda H. Barecka, Laura E. Bickerton, Silvina A. Di Pietro, Stanna K. Dorn, Kevin Maik Jablonka, Gabriele Laudadio, Elisabeth Kreidt, Helena Mannochio-Russo, Júlio Terra, Olivia Harper Wilkins, Saigopalakrishna S. Yerneni, Maha Yusuf ACS Central Science, 2024
Nickel-Electrocatalytic Decarboxylative Arylation to Access Quaternary Centers** Gabriele Laudadio, Philipp Neigenfind, Áron Péter, Camille Z. Rubel, Megan A. Emmanuel, Martins S. Oderinde, Tamara El‐Hayek Ewing, Maximilian D. Palkowitz, Jack L. Sloane, Kevin W. Gillman, Daniel Ridge, Michael D. Mandler, Philippe N. Bolduc, Michael C. Nicastri, Benxiang Zhang, Sebastian Clementson, Nadia Nasser Petersen, Pablo Martín‐Gago, Pavel Mykhailiuk, Keary M. Engle, Phil S. Baran Angewandte Chemie International Edition, 2024
Electroreductive Synthesis of Nickel(0) Complexes** Camille Z. Rubel, Yilin Cao, Tamara El‐Hayek Ewing, Gabriele Laudadio, Gregory L. Beutner, Steven R. Wisniewski, Xiangyu Wu, Phil S. Baran, Julien C. Vantourout, Keary M. Engle Angewandte Chemie International Edition, 2024
Complex molecule synthesis by electrocatalytic decarboxylative cross-coupling Benxiang Zhang, Jiayan He, Yang Gao, Laura Levy, Martins S. Oderinde, Maximilian D. Palkowitz, T. G. Murali Dhar, Michael D. Mandler, Michael R. Collins, Daniel C. Schmitt, Philippe N. Bolduc, TeYu Chen, Sebastian Clementson, Nadia Nasser Petersen, Gabriele Laudadio, Cheng Bi, Yu Kawamata, Phil S. Baran Nature, 2023
Overcoming Limitations in Decarboxylative Arylation via Ag-Ni Electrocatalysis Maximilian D. Palkowitz, Gabriele Laudadio, Simon Kolb, Jin Choi, Martins S. Oderinde, Tamara El-Hayek Ewing, Philippe N. Bolduc, TeYu Chen, Hao Zhang, Peter T. W. Cheng, Benxiang Zhang, Michael D. Mandler, Vanna D. Blasczak, Jeremy M. Richter, Michael R. Collins, Ryan L. Schioldager, Martin Bravo, T. G. Murali Dhar, Benjamin Vokits, Yeheng Zhu, Pierre-Georges Echeverria, Michael A. Poss, Scott A. Shaw, Sebastian Clementson, Nadia Nasser Petersen, Pavel K. Mykhailiuk, Phil S. Baran Journal of the American Chemical Society, 2022
The Role of Electrochemically Reduced Tungsten in Deoxygenative Reactions N Petrović, A Bonino, S Sharma, C Bottecchia, D Lehnherr, CO Kappe, ... 2026
Electrochemical generation of NHC-boryl radicals for carbon-centered radical formation V Morlacci, E Venturi, G Gallorini, S Scaringi, D Merli, A Cerveri, ... 2026
Electrolysis-Assisted Reduction of Dimethylformamide for Unactivated Alkene Functionalizations Y Xi, S Sharma, CO Kappe, G Laudadio Journal of the American Chemical Society 148 (9), 9367-9374 , 2026 2026 Citations: 2
Combining Water and Biorenewable Solvents for Sustainable Anodic Reactions N Petrović, A Bonino, A Baumgartner, SHA Rajendran, CO Kappe, ... 2026
INNOVAZIONE NELL’ELETTROSINTESI ORGANICA G Laudadio 2026
Automating Synthetic Organic Electrochemistry: Concepts and Advancements E Rial‐Rodríguez, CO Kappe, G Laudadio Chemistry‐Methods 5 (12), e202500104 , 2025 2025 Citations: 1
Electrochemical telescoped synthesis of alkyl pinacol boranes DM Köpfler, A Baumgartner, L Ribic, S Wagschal, C Bovino, DM Roberge, ... Journal of Flow Chemistry, 1-5 , 2025 2025 Citations: 1
Intensifying Electrochemical Hydrocarboxylation of Activated Alkenes A Baumgartner, N Petrović, CO Kappe, G Laudadio ChemElectroChem 12 (17), e202500210 , 2025 2025 Citations: 2
Reimagining Advanced Chemistry Education: A Community-based Approach to Course Design for Modern Learners MA Horwitz, R Al-Ahmad, X Bai, M Balletti, P Bellotti, Y Ben-Tal, ... Journal of Chemical Education 102 (9), 3777-3783 , 2025 2025 Citations: 1
Versatile Flow Electrochemical Methodology for the Manufacturing of Pharmaceutically Relevant Sulfoxides and Sulfones from Thioethers K Simon, R Bandichhor, M Beesu, IS Manisha, G Laudadio, CO Kappe, ... ACS Electrochemistry 1 (9), 1803-1811 , 2025 2025 Citations: 5
The role of synthetic organic electrochemistry in the technological revolution of pharmaceutical industry G Laudadio Chimia 79 (6), 417-423 , 2025 2025 Citations: 10
Electrochemical self-optimization for the synthesis of densely functionalized molecules E Rial-Rodríguez, FL Wagner, T Fuchß, A Sommer, J Krieger, ... ChemRxiv 2025 (0430) , 2025 2025 Citations: 5
Reflections in search of faculty (and other) positions in Europe G Laudadio, G Lavarda, H Park, S Cranford Matter 8 (2) , 2025 2025
Electrochemical fluorination of organic compounds using a hexafluorosilicate salt as an inexpensive and widely available fluorine source DM Köpfler, G Laudadio, C Bovino, M Bersier, R Littich, DM Roberge, ... Organic Letters 27 (4), 1084-1088 , 2025 2025 Citations: 5
Scalable Electrochemical Dehalogenative Carboxylation without a Sacrificial Metal Anode N Petrovic, G Laudadio, CA Salazar, CJ Kong, J Verghese, A Hesketh, ... Advanced Synthesis & Catalysis , 2025 2025 Citations: 1
Scalable electrocatalyzed formation of C–O bonds using flow reactor technology M Prieschl, D Cantillo, CO Kappe, G Laudadio Reaction Chemistry & Engineering 10 (1), 130-134 , 2025 2025 Citations: 4
Introducing... G Laudadio Angewandte Chemie International Edition 63, e202419110 , 2024 2024
An automated electrochemical flow platform to accelerate library synthesis and reaction optimization E Rial-Rodríguez, JD Williams, D Cantillo, T Fuchß, A Sommer, ... Angewandte Chemie International Edition, e202412045 , 2024 2024 Citations: 38
Synthesis of Unnatural Amino Acids via Ni/Ag Electrocatalytic Cross-Coupling G Laudadio, P Neigenfind, R Chebolu, VD Blasczak, SJ Maddirala, ... Organic Letters 26 (11), 2276–2281 , 2024 2024 Citations: 18
Prioritizing mentorship as scientific leaders JM Deng, SE Ahmed, E Awoonor-Williams, P Banerjee, MH Barecka, ... ACS Central Science 10 (2), 209-213 , 2024 2024 Citations: 6
MOST CITED SCHOLAR PUBLICATIONS
The Fundamentals Behind the Use of Flow Reactors in Electrochemistry T Noël, Y Cao, G Laudadio Accounts of Chemical Research , 2019 2019 Citations: 631
C(sp3)–H functionalizations of light hydrocarbons using decatungstate photocatalysis in flow G Laudadio, Y Deng, K van der Wal, D Ravelli, M Nuño, M Fagnoni, ... Science 369 (6499), 92-96 , 2020 2020 Citations: 455
Selective sp3 C‐H Aerobic Oxidation enabled by Decatungstate Photocatalysis in Flow G Laudadio, S Govaerts, Y Wang, D Ravelli, H Koolman, M Fagnoni, ... Angewandte Chemie International Edition 57 (15), 4078-4082 , 2018 2018 Citations: 308
Safety assessment in development and operation of modular continuous-flow processes N Kockmann, P Thenée, C Fleischer-Trebes, G Laudadio, T Noël Reaction Chemistry & Engineering 2 (3), 258-280 , 2017 2017 Citations: 252
Sulfonamide synthesis through electrochemical oxidative coupling of amines and thiols G Laudadio, E Barmpoutsis, C Schotten, L Struik, S Govaerts, DL Browne, ... Journal of the American Chemical Society 141 (14), 5664-5668 , 2019 2019 Citations: 241
Sulfonyl Fluoride Synthesis through Electrochemical Oxidative Coupling of Thiols and Potassium Fluoride G Laudadio, A de A. Bartolomeu, LMHM Verwijlen, Y Cao, KT de Oliveira, ... Journal of American Chemical Society 141 (30), 11832-11836 , 2019 2019 Citations: 216
An environmentally benign and selective electrochemical oxidation of sulfides and thiols in a continuous-flow microreactor G Laudadio, NJW Straathof, MD Lanting, B Knoops, V Hessel, T Noël Green Chemistry 19 (17), 4061-4066 , 2017 2017 Citations: 201
Decarboxylative cross-coupling: a radical tool in medicinal chemistry G Laudadio, MD Palkowitz, T El-Hayek Ewing, PS Baran ACS Medicinal Chemistry Letters 13 (9), 1413-1420 , 2022 2022 Citations: 141
Silyl radical-mediated activation of sulfamoyl chlorides enables direct access to aliphatic sulfonamides from alkenes SM Hell, CF Meyer, G Laudadio, A Misale, MC Willis, T Noel, ... Journal of the American Chemical Society 142 (2), 720-725 , 2019 2019 Citations: 134
Overcoming limitations in decarboxylative arylation via Ag–Ni electrocatalysis MD Palkowitz, G Laudadio, S Kolb, J Choi, MS Oderinde, TEH Ewing, ... Journal of the American Chemical Society 144 (38), 17709-17720 , 2022 2022 Citations: 120
Design and application of a modular and scalable electrochemical flow microreactor G Laudadio, W de Smet, L Struik, Y Cao, T Noël Journal of Flow Chemistry 8, 157-165 , 2018 2018 Citations: 119
Practical and Regioselective Synthesis of C-4-Alkylated Pyridines J Choi, G Laudadio, E Godineau, PS Baran Journal of American Chemical Society 143 (31), 11927–11933 , 2021 2021 Citations: 111
Decatungstate‐mediated C (sp3)‒H Heteroarylation via Radical‐Polar Crossover in Batch and Flow T Wan, L Capaldo, G Laudadio, A Nyuchev, J Rincon, P Garcia-Losada, ... Angewandte Chemie International Edition , 2021 2021 Citations: 107
Electrochemical Aziridination of Internal Alkenes with Primary Amines M Ošeka, G Laudadio, NP van Leest, M Dyga, A de A. Bartolomeu, ... Chem 7 (1), 255-266 , 2020 2020 Citations: 98
A Modular Flow Design for the meta ‐Selective C−H Arylation of Anilines HPL Gemoets, G Laudadio, K Verstraete, V Hessel, T Noël Angewandte Chemie 129 (25), 7267-7271 , 2017 2017 Citations: 87
Complex molecule synthesis by electrocatalytic decarboxylative cross-coupling B Zhang, J He, Y Gao, L Levy, MS Oderinde, MD Palkowitz, TGM Dhar, ... Nature, 1-3 , 2023 2023 Citations: 80
Accelerated and Scalable C(sp 3 )–H Amination via Decatungstate Photocatalysis Using a Flow Photoreactor Equipped with High-Intensity LEDs T Wan, Z Wen, G Laudadio, L Capaldo, R Lammers, JA Rincón, ... ACS Central Science 8 (1), 51-56 , 2021 2021 Citations: 78
Flow Synthesis of Diaryliodonium Triflates G Laudadio, HPL Gemoets, V Hessel, T Noël The Journal of Organic Chemistry , 2017 2017 Citations: 64
Optimization of a decatungstate-catalyzed C(sp3)-H alkylation using a continuous oscillatory milli-structured photoreactor Z Wen, A Maheshwari, C Sambiagio, Y Deng, G Laudadio, K van Aken, ... Organic Process Research & Development , 2020 2020 Citations: 56
β-Zeolite-Assisted Lignin-First Fractionation in a Flow-Through Reactor A Kramarenko, D Etit, G Laudadio, FN D’Angelo ChemSusChem 14, 3838-3849 , 2021 2021 Citations: 49
