Chun Yin Chan

@carellgroup.de

Ph.D. candidate, Department of Chemistry and Pharmacy
Ludwig Maximilian University of Munich



           

https://researchid.co/chanjamie43

Research interest:
Prebiotic chemistry
Modified RNA
Directed evolution
SELEX
G-quadruplex
Nucleic acids

EDUCATION

2020-
Ph.D. candidate, Prof. Dr. Thomas Carell
Graduate School of Life Science Munich
Ludwig Maximilian University of Munich

2014-2018
Bachelor of Science in Applied Chemistry (1st class hon.)
City University of Hong Kong

RESEARCH, TEACHING, or OTHER INTERESTS

Biochemistry, Genetics and Molecular Biology, Chemistry

400

Scholar Citations

9

Scholar h-index

9

Scholar i10-index

RECENT SCHOLAR PUBLICATIONS

  • Lockd promotes myoblast proliferation and muscle regeneration via binding with DHX36 to facilitate 5′ UTR rG4 unwinding and Anp32e translation
    X Chen, G Xue, J Zhao, Y Zhang, S Zhang, W Wang, Y Li, J Yuan, L He, ...
    Cell Reports 39 (10) 2022

  • Development of RNA G-quadruplex (rG4)-targeting l-RNA aptamers by rG4-SELEX
    MI Umar, CY Chan, CK Kwok
    Nature Protocols 17 (6), 1385-1414 2022

  • A prebiotically plausible scenario of an RNA–peptide world
    F Mller, L Escobar, F Xu, E Węgrzyn, M Nainytė, T Amatov, CY Chan, ...
    Nature 605 (7909), 279-284 2022

  • Proteomic and Transcriptome Profiling of G-Quadruplex Aptamers Developed for Cell Internalization
    Y Zhang, Y Wu, H Zheng, H Xi, T Ye, CY Chan, CK Kwok
    Analytical Chemistry 93 (14), 5744-5753 2021

  • Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA‐Peptide World
    M Nainytė, F Mller, G Ganazzoli, CY Chan, A Crisp, D Globisch, T Carell
    Chemistry–A European Journal 26 (65), 14856-14860 2020

  • Specific Binding of a d‐RNA G‐Quadruplex Structure with an l‐RNA Aptamer
    CY Chan, CK Kwok
    Angewandte Chemie International Edition 59 (13), 5293-5297 2020

  • G-quadruplex-based fluorescent turn-on ligands and aptamers: from development to applications
    MI Umar, D Ji, CY Chan, CK Kwok
    Molecules 24 (13), 2416 2019

  • Spectroscopic analysis reveals the effect of a single nucleotide bulge on G-quadruplex structures
    CY Chan, MI Umar, CK Kwok
    Chemical communications 55 (18), 2616-2619 2019

  • Structural analysis and cellular visualization of APP RNA G-quadruplex
    K Lyu, SB Chen, CY Chan, JH Tan, CK Kwok
    Chemical Science 10 (48), 11095-11102 2019

  • Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs
    KL Chan, B Peng, MI Umar, CY Chan, AB Sahakyan, MTN Le, CK Kwok
    Chemical communications 54 (77), 10878-10881 2018

  • A cancer cell-selective and low-toxic bifunctional heterodinuclear Pt (IV)–Ru (II) anticancer prodrug
    L Ma, X Lin, C Li, Z Xu, CY Chan, MK Tse, P Shi, G Zhu
    Inorganic Chemistry 57 (5), 2917-2924 2018

MOST CITED SCHOLAR PUBLICATIONS

  • A prebiotically plausible scenario of an RNA–peptide world
    F Mller, L Escobar, F Xu, E Węgrzyn, M Nainytė, T Amatov, CY Chan, ...
    Nature 605 (7909), 279-284 2022
    Citations: 94

  • G-quadruplex-based fluorescent turn-on ligands and aptamers: from development to applications
    MI Umar, D Ji, CY Chan, CK Kwok
    Molecules 24 (13), 2416 2019
    Citations: 78

  • A cancer cell-selective and low-toxic bifunctional heterodinuclear Pt (IV)–Ru (II) anticancer prodrug
    L Ma, X Lin, C Li, Z Xu, CY Chan, MK Tse, P Shi, G Zhu
    Inorganic Chemistry 57 (5), 2917-2924 2018
    Citations: 61

  • Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs
    KL Chan, B Peng, MI Umar, CY Chan, AB Sahakyan, MTN Le, CK Kwok
    Chemical communications 54 (77), 10878-10881 2018
    Citations: 45

  • Specific Binding of a d‐RNA G‐Quadruplex Structure with an l‐RNA Aptamer
    CY Chan, CK Kwok
    Angewandte Chemie International Edition 59 (13), 5293-5297 2020
    Citations: 30

  • Structural analysis and cellular visualization of APP RNA G-quadruplex
    K Lyu, SB Chen, CY Chan, JH Tan, CK Kwok
    Chemical Science 10 (48), 11095-11102 2019
    Citations: 26

  • Spectroscopic analysis reveals the effect of a single nucleotide bulge on G-quadruplex structures
    CY Chan, MI Umar, CK Kwok
    Chemical communications 55 (18), 2616-2619 2019
    Citations: 22

  • Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA‐Peptide World
    M Nainytė, F Mller, G Ganazzoli, CY Chan, A Crisp, D Globisch, T Carell
    Chemistry–A European Journal 26 (65), 14856-14860 2020
    Citations: 17

  • Proteomic and Transcriptome Profiling of G-Quadruplex Aptamers Developed for Cell Internalization
    Y Zhang, Y Wu, H Zheng, H Xi, T Ye, CY Chan, CK Kwok
    Analytical Chemistry 93 (14), 5744-5753 2021
    Citations: 11

  • Lockd promotes myoblast proliferation and muscle regeneration via binding with DHX36 to facilitate 5′ UTR rG4 unwinding and Anp32e translation
    X Chen, G Xue, J Zhao, Y Zhang, S Zhang, W Wang, Y Li, J Yuan, L He, ...
    Cell Reports 39 (10) 2022
    Citations: 9

  • Development of RNA G-quadruplex (rG4)-targeting l-RNA aptamers by rG4-SELEX
    MI Umar, CY Chan, CK Kwok
    Nature Protocols 17 (6), 1385-1414 2022
    Citations: 7