Taha Nazir

Taha Nazir was awarded the Ph.D Microbiology in 2010; M.Phil Pharmacology 2000 and graduation in pharmacy in 1997. Dr. Nazir has ≤25 year’s research, academic and professional experience along with exceptional knowledge epidemiology, cell pathology, molecular biology and biotechnology. He has sufficient teaching experience to the graduate and post-graduate students in different universities. That assumed to lead the responsibility of developing curriculum, designing programs and deploying the projects in defined budgetary order. The institutional needs of those that are a part of the organization often dictate him regarding the scope and magnitude the projects. Thus, Dr. Nazir has played multitudinous roles in a variety of academic, scientific and professional capacities/ positions. Additionally, he has strong experience of writing, reviewing, and publishing the research manuscripts. Because he compiled seven books and published ≤80 research articles published in accredited scientific

EDUCATION

B.Pharm., M.Phil., Ph.D.

RESEARCH, TEACHING, or OTHER INTERESTS

Microbiology (medical), Pharmacology, Toxicology and Pharmaceutics, Pharmacology (medical), Applied Microbiology and Biotechnology

Scopus Publications

History and Clinical Development of Nanomedicines, Nanostructure, and Nanoscale Sciences




The Role of Pro-Inflammatory Mediator Interleukin-32 in Osteoclast Differentiation
Taha NAZIR, Nida TAHA, Azharul ISLAM, Ishtiaq RABBI, and Pervaiz Akhter SHAH
Galenos Yayinevi
The recently explained cytokine, which is produced after the stimulation of interferon (IFN)-c, interleukin (IL)-2, and IL-18 is IL-32, has pro-inflammatory IFN-c, IL-2 and IL-18 are IL-32 mediator's properties that are generally entailed in many diseases, including infections, cancer, and chronic inflammation. After the initial statement in 2005, it promoted the osteoclast precursor's differentiation into TRAcP plus VNR plus multinucleated cells that express explicit osteoclast indicators. Furthermore, the loss of bone resorption might be accredited because of the collapse of the multinucleated cells, which are produced of the reaction to IL-32 to direct factoring that is ultimately essential for attaching the cells for bone resorption. Thus, in conclusion, IL-32, the pro-inflammatory mediator, has an important and indirect role in regulating osteoclast differentiation. In bone disorder's pathophysiology, critical role of IL-32 needs more scientific evidence to develop a rational treatment protocol. IL-32 can become a potent mediator of active osteoclast generation in the presence of receptor activator of NF-κB ligand (RANKL). This novel cytokine can introduce more favorable conditions for osteoclastogenesis in the rheumatic arthritis by increasing the RANKL and osteoprotegerin ratio in fibroblast-like synoviocytes.


Formulation Development and In vitro Characterization of Omperazole Floating Tablets by Using Eudragit and HPMC




Esomeprazole Floating Tablets by Using HUSK/HPMC Polymers: Formulation Development and In-vitro Characterization




Medicinal Plants and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in Treatment of Arthritis: A Literature Review




The Potentially Recommended Pharmacotherapy for COVID-19




Biochemical dynamics and clinical features of novel corona virus (2019-NCOV)




Developing methods for the evaluation of isotonicity of parenteral products




Formulation, evaluation and in vitro characterization of gastroretentive floating tablet of diclofenac sodium
Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi



Role of chitosan, carboxy methyl cellulos, polyvinyl pyrrolidone, kyron T134 and primogel to design the mouth disintegrating telmisartan tablet with extended release profile
Muhammad Abdullah Akram, Nida Taha, and Taha Nazir
Universitas Gadjah Mada
The Mouth Disintegrating Extended Release Telmisartan (MDERT) tablets are designed for adequate pharmacokinetic profile to avoid the unusual peaks and troughs. Although, there are extensive advance techniques used to deliver drugs. But oral route is still remains effective in most of the therapeutical situations. Thus we aimed this study to formulate a dosage form with dual character of orodispersion as well as extended effectiveness. MDERTS dosage form was prepared by direct compression method. The major components of this preparation were Telmisartan (TLM), Carboxy methyl cellulose polyvinyl Pyrrolidone, Chitosan, Talc, Mg-stearate, Lactose. The MDERTS dosage form was characterized with different determinants. While, the drug release curves of all 6 formulations upto 12h, DSC spectra of TLM, Kyron T 134 , Primogel, TLM+Kyron T 134 +Primogel, Chitosan, CMC and different excepients are presented as comprehensive scientific figures. DSC and FTIR spectroscopic studies indicate the compatibility of drugs with each other and with excipients. Moreover, the formulation F2 containing more than 10% of Kyron T had shown best results. Whereas, the overall results had shown that Kyron T containing tablets had best, in vitro dispersion time, wetting time and wetting volume, water absorption ratio. The order in which superdisintegrants and polymers had produced desirable effect is Kyron T134 > Kyron  T134134 + primogel > primogel and for polymers chitosan> chitosan+CMC> chitosan +PVP> CMC> CMC+PVP> PVP. Thus, Kyron T is the best superdisintegrant of others which were used in present study and direct compression method is the best used to prepare extended release mouth disintegrating tablets.


Monocytopenia; induction by vinorelbine, cisplatin and doxorubicin in breast, non-small cell lung and cervix cancer patients




Review of pharmacy professionals and drug jurisprudence to achieve the millennium development goals in Punjab province of Pakistan
Taha Nazir, Azharul Islam, Nida Taha, Saeed Urasheed Nazir, Muhammad Ather Chaudhary, and Muhammad Iqbal
EManuscript Technologies
The current health practice of Punjab Province of Pakistan needs a serious attention to control the unnecessary drug usage, improve pharmaceutical care and establish excellent public health system. Hence, the health officials of Govt. of Pakistan have established “Drug Regulatory Authority”, and Punjab Health Department has chalked out Punjab Drug Rule, 2007 to deployed a revised health structure in Punjab. But, unluckily, the medical physicians, drug store owners and bureaucracy have not put it into actual practice. Punjab Health Department has made amendments in the Drug Rules, 2007; substituted the word “three” by the “ten” and suspended it until 2017 via notification printed in the official weekly gazette dated February 10, 2010. This potential confliction of interest can also be noticed in hospital settings, community clinical practice and other allied health institutions. The most awful part the current scenario is the insufficient aspirations to share the clinical burden to provide the health facilities for patients presented in hospital/ clinical setting. The consultant physicians and medical practitioners are very much reluctant to involve the pharmacy professionals to perform their primary professional role. They want them to stay away from their actual scientific job and keep doing the administrative and clerical work. Therefore, the current health system and drug jurisprudence needs a serious attention to address the health problem. That will help to minimize avoidable mortalities, wrong medication, irrational prescription and development of drug resistance. Moreover, a conclusive prescribing guidelines and appropriate drug jurisprudence will expedite the achievement of MDG of WHO.


Lymphocytopenia; Induced by vinorelbine, doxorubicin and cisplatin in human cancer patients
Taha Nazir, Azharul Islam, Muhammad Ovais Omer, and Mazhar Mustafa
IOS Press
Cancer chemotherapy exerts deleterious effects in patients, causing structural and physiological changes to their vital organs. These drugs are capable of destroying bone marrow cells and may reduce lymphocyte count. This study was aimed to investigate the frequency of lymphocytopenia in cancer patients taking vinorelbine and its combination as part of cancer chemotherapy. A total 60 adult cancer patients were selected and divided into two groups; Group-1 patients were either on Vinorelbine alone treatment protocol, while group 2 patients were on either Vinorelbine/Cisplatin or Vinorelbine/Doxorubicin treatment protocol. The mean ± SEM lymphocyte counts (× 10^{3}) per uL, pre and post chemotherapy were noted. The outcomes demonstrated no statistically important difference in the patients who were either on vinorelbine alone, vinorelbine plus cisplatin or vinorelbine plus doxorubicin combinations. On comparison of the lymphocytopenia over time for Group-I & II (P-values 0.064, 0.23), and at every week (P-value -0.063, 0.427), we observed the non significant statistical differences. However, comparison of mean values before with that of at week-1,2 and 3 showed significant (P-value^{3} 0.003, 0.003 and 0.055), and at week-4 no significant difference (P-value^{3} 0.727). Thus, the overall lymphocytopenic syndrome in both of the chemotherapy protocols allows the clinical oncologists and consultant physicians to select either of the chemotherapy protocol. Vinorelbine may be a choice of cancer chemotherapy, as they do not compromise immunity in cancer patients. Hence; therapeutic efficacy should constitute the intervening consideration in treating a particular neoplasm.


Neutropenia induction by vinorelbine alone and in combination with doxorubicin and cisplatin in cancer patients




Avoidable childhood death: A case of mismanagement and inappropriate medication use
Taha Nazir
Academic Journals
Rational drug usage, clinical regulations and pharmaceutical care are important features of health practice. Thus; we have aimed case report to elaborate the clinical pharmaceutical services. A 3 year old girl, was presented in a hospital with minor burn that happened by spilt hot water on her wrist. She was in severe pain. The emergency ward staff applied an ointment. The doctor instructed injection Dormicum two times with short gape and then 3rd injection of Pavulon (Pancuronium). Patient went silent and started losing consciousness and eventually passed away. In view of the above facts and circumstances the inquiry board and judiciary took action against the negligence, mishandling. While; going through the investigation the inquiry board did not bothered the channel through which this injection came without proper check that is therapeutical drug monitoring, prescription reviewing, bio-safety and pharmaceutical evaluation. Furthermore, it is not a single death but representation of so many casualties because of the wrong medications. The medial practice needs some more legal, professional and principled restrictions to make sure the safe and correct therapy plans. The clinical legislation, drug rules and medical practice seriously need the attention of judiciary, society and leadership to assure the safety of precious live.   Key words: Wrong medication, medical malpractice, professional negligence, pharmaceutical services, Suo-moto notice of chief justice of high court.


Eosinopenia induction by vinorelbine alone and in combination with doxorubicin and cisplatin in cancer patients




Ethambutol resistance of indigenous Mycobacterium tuberculosis isolated from human patients
Taha Nazir, Muhammad Hidayat Rasool, Abdul Hameed, Bashir Ahmad, and Javed Anver Qureshi
FapUNIFESP (SciELO)
The present study was conducted to find out the ethambutol resistance pattern of indigenous isolates of Mycobacterium tuberculosis from Tuberculosis diagnosed human patients. A total of 172 specimens were collected from six different sources and comprised of 84.9% sputum, 10.5% pus and 4.7% bronchial washings. There were 70.9% males and 29.1% females with 84.30% pulmonary and 15.69% extra-pulmonary tuberculosis. The Mycobacterium tuberculosis isolates collected from primary culture were further studied to determine their pattern and level of resistance. The inoculums were prepared using 0.5 Mac Farland turbidity standards. Five different concentration of ethambutol were used in Lowenstein Jensen (LJ) medium i.e. 2μg/ml, 4μg/ml, 6μg/ml, 8μg/ml and 10μg/ml for sensitivity testing. Data showed 10 (5.8%) resistant and 162 (94.2%) sensitive Mycobacterium tuberculosis out of total 172 clinical isolates. The growth was not inhibited at 1st (2μg/ml) and 2nd (4μg/ml) drug levels, while growth of 50% isolates inhibited at 3rd level (6μg/ml), 30% inhibited at 4th level (8μg/ml) and 20% at 5th level (10μg/ml). The last three levels are above the therapeutic index and not recommended in actual clinical practice. It is thus conceivable to explore some other more effective chemotherapeutic agents, modify combinations or find more effective procedures to stop morbidity and mortality due to ethambutol resistant Mycobacterium tuberculosis.


Rifampicin resistance profile of Mycobacterium tuberculosis isolated from human patients




Study of anemic syndrome induced by vinorelbine, doxorubicin and cisplatin in human cancer patients

RECENT SCHOLAR PUBLICATIONS

MOLECULAR CHARACTERIZATION, CLINICAL MANAGEMENT AND DEVELOPMENT OF THE VACCINES AGAINST THE TARGETED VIRAL COMPONENTS OF COVID-19
T Nazir, M Ahmed, HA Mirza, N Taha
MMSL 2024



CRISPR-Cas Associated Cells and Animal Mediated Biomedical Modelling
T Nazir, HA Mirza, N Rao
2024



Crispr-cas System: Classification, Benefits, Applications And Function
T Nazir, HA Mirza, N Taha
2024



Gene Editing, Indiscriminate Degradation And Recyclic Catalytic Events In Crispr Cas Technology
DT Nazir, S Radwan, N Taha
2024



CRISPR/CAS Genome Editing Technology: Implications And Challenges
T Nazir, A Islam, HA Mirza, S Radwan, N Taha
2024



History, Development and Characteristics of CRISPR-Cas System
T Nazir, H Mirza, N Taha
2024



History and Clinical Development of Nanomedicines, Nanostructure, and Nanoscale Sciences
T Nazir, M Ahmed, H Mirza, N Taha
Alternative therapies in health and medicine 29 (6), 25-29 2023



The Role of Pro-Inflammatory Mediator Interleukin-32 in Osteoclast Differentiation
T Nazir, T Nida, A Islam, I Rabbi, PA Shah
Turkish Journal of Pharmaceutical Sciences 20 (2), 121 2023



Formulation Development and In vitro Characterization of Omperazole Floating Tablets by Using Eudragit and HPMC
PA Shah, Y Kamal, FA Razzaq, HM Ramzan, A Shoukat, A Pervaiz, ...
LATIN AMERICAN JOURNAL OF PHARMACY 42 (6), 1148-1154 2023



Esomeprazole Floating Tablets by Using HUSK/HPMC Polymers: Formulation Development and In-vitro Characterization
PA Shah, Y Kamal, FA Razzaq, HM Ramzan, A Shoukat, A Pervaiz, ...
Lat. Am. J. Pharm 42 (6), 1133-9 2023



CONCEALMENT OF FACTS AND HIDING INFORMATION REGARDING THE ILLEGAL APPOINTMENT OF PROFESSOR OF PHARMACY IN PUBLIC SECTOR UNIVERSITY OF PAKISTAN.
T Nazir
2023



Assessment of knowledge and health related quality of life among chronic obstructive pulmonary disease patients: an observational study
M Iqbal, M Sultana, H Riaz, R Shamim, SS Munir, T Nazir, SUR Nazir, ...
Journal of Peoples University of Medical & Health Sciences Nawabshah.(JPUMHS 2022



Prevalence and Clinical Evaluation of Rotavirus Influences
PA Shah, EAK Saad-Bin-Haroon, T Nazir, S Ur, R Nazir, M Muneeb, ...
2022



SAUSSUREA COSTUS AS HERBAL MEDICINES HAVE IM-MUNOMODULATORY AND POTENTIAL NUTRACEUTICAL COMPONENTS THAT MAY HELP IN COVID-19 REMEDY
MM Elmaghrabi, NM Majrashi, DS Alharbi, NA Marraiki, T Nazir, U Farooq, ...
2022



ANOTHER PIECE OF BEAUTIFUL CORRUPTION MOCKING THE ADMINISTRATION OF THE HONORABLE CHANCELLOR/GOVERNOR PUNJAB, HEC’S QUALITY ASSURANCE AND ACCOUNTABILITY SYSTEM OF NATIONAL
T Nazir
2022



POTENTIAL THREATS OF ORDINARY INVESTIGATION AND LITIGATION MODEL OF THE NATIONAL ACCOUNTABILITY BUREAU ON THE PHARMACEUTICAL AND HEALTH SYSTEM IN PAKISTAN.
T Nazir
2022



Pharmacy Council of Pakistan, Pharmacy discipline and pharmacist community.
T Nazir
Phamraceutical Review 12 2021



Prospective Study of the HCV-RNA Genotype 3a Diagnosed Patients Treated with Sofosbuvir and Peg Interferon Alpha-3
T Nazir, N Taha, H Sadia, A Rehman, M Farooq, M Sultana, SS Munir
RADS Journal of Pharmacy and Pharmaceutical Sciences 9 (2), 124-129 2021



Medicinal Plants and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in Treatment of Arthritis: A Literature Review.
R Shamim, M Sultana, SUR Nazir, H Riaz, T Nazir, A Islam
Alternative Therapies in Health and Medicine 2021



An amazing character revealing the fundamental factors hurting the health standards, pharmaceutical patient's care and teaching quality in developing countries.
T Nazir
Phamraceutical Review 12 2021

MOST CITED SCHOLAR PUBLICATIONS

An evaluation of two aerosol delivery systems for rhDNase
PL Shah, SF Scott, DM Geddes, S Conway, A Watson, T Nazir, SB Carr, ...
European Respiratory Journal 10 (6), 1261-1266 1997
Citations: 35



Monocytopenia; induction by vinorelbine, cisplatin and doxorubicin in breast, non-small cell lung and cervix cancer patients
T Nazir, N Taha, A Islam, S Abraham, A Mahmood, M Mustafa
International journal of health sciences 10 (4), 542 2016
Citations: 26



Emergence of potential superbug Mycobacterium tuberculosis, lessons from New Delhi mutant-1 bacterial strains
T Nazir, S Abraham, A Islam
International journal of health sciences 6 (1), 87 2012
Citations: 22



Antibacterial activity of black tea against streptococcus mutans and its synergism with antibiotics
T Mughal, A Tahir, S Qureshi, T Nazir, M Rasheed
J App Pharm 2 (2), 60-67 2010
Citations: 19



Lymphocytopenia; induced by vinorelbine, doxorubicin and cisplatin in human cancer patients
T Nazir, A Islam, MO Omer, M Mustafa
Breast disease 35 (1), 1-4 2015
Citations: 18



Designing, development and formulation of mouth disintegrating telmisartan tablet with extended release profile using response surface methodology
MA Akram, T Nazir, N Taha, A Adil, M Sarfraz, SR Nazir
J. Bioequiv. Availab 7, 262-266 2015
Citations: 16



High performance liquid chromatography of a cyclosporin A formulation on a porous graphitic carbon column
T Nazir, LA Gould, C Marriott, GP Martin, MB Brown
Chromatographia 46, 628-636 1997
Citations: 15



Medicinal Plants and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in Treatment of Arthritis: A Literature Review.
R Shamim, M Sultana, SUR Nazir, H Riaz, T Nazir, A Islam
Alternative Therapies in Health and Medicine 2021
Citations: 9



Studies of ketoprofen toxicity in avian species
AF Awan, T Nazir
Journal of Basic & Applied Sciences 7 (2) 2011
Citations: 9



Rifampicin resistance profile of Mycobacterium tuberculosis isolated from human patients
T Nazir, A Hameed, JA Qureshi, B Ahmad, S Abraham
Proc. Pakistan Acad. Sci 46 (3), 131-136 2009
Citations: 8



Review of the basic components of clinical pharmaceutical care in Pakistan
T Nazir, SMM Zaidi
Can J App Sci 1 (3), 168-173 2011
Citations: 7



Pyrazinamide resistance of Mycobacterium tuberculosis strains isolated from human patients
T Nazir, A Hameed, MS Akhtar, E Shabbir, JA Qureshi, A Malik, ...
Pharmacol. Online 3, 948-957 2008
Citations: 7



Review of pharmacy professionals and drug jurisprudence to achieve the millennium development goals in punjab province of Pakistan
T Nazir, A Islam, N Taha, SU Nazir, MA Chaudhary, M Iqbal
Indian J Pharm Educ Res 50 (1), 24-33 2016
Citations: 6



Toxicity study of piroxicam in broilers
AF Awan, M Ashraf, A Malik, A Akram, G Murtaza
Latin American Journal of Pharmacy 31 2012
Citations: 6



The potentially recommended pharmacotherapy for COVID-19
M Sultana, R Shamim, H Riaz, SS Munir, RR Kayani, S Manzoor, A Islam
Health Med 27 (S1), 24-28 2021
Citations: 5



Studies of dipyrone (metamizole sodium) toxicity in avian species
AF Awan, M Ashraf, O Umer, T Nazir, MS Akhtar, HU Rehman
J. App. Pharm 1 (1), 1-6 2009
Citations: 4



Extended Release Orally Disintegrating Dosage Forms are Potential Techniques to Deliver and Maintain the Therapeutic Ranges of Plasma Drug Concentrations
T Nazir
J App Pharm 7, 001 2015
Citations: 3



Neutropenia induction by vinorelbine alone and in combination with doxorubicin and cisplatin in cancer patients
T Nazir, Habib-Ur-Rehman, O Omar, TA Mughal
HEALTHMED 5 (3), 486-490 2011
Citations: 3



Study of phenylbutazone toxicity in avian species
AF Awan, T Nazir, M Ashraf, O Umer, HU Rehman
Pak J Pharm 16, 25-28 2003
Citations: 3



Formulation, evaluation and in vitro characterization of gastroretentive floating tablet of diclofenac sodium
N Taha, T Jamil, MA Akram
Pak. J. Pharm. Sci 32 (6), 2573-2578 2019
Citations: 2