Eleni Giannopoulou

@uniklinik-ulm.de

Department of Pediatric Endocrinology and Diabetology
University Hospital Ulm

Eleni Giannopoulou


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EDUCATION

Subspecialty in Pediatric Endocrinology and Diabetology (University Hospital Ulm, Germany)
Doctoral studies in Pediatric Diabetology (Technische Universität München)

RESEARCH, TEACHING, or OTHER INTERESTS

Pediatrics, Perinatology and Child Health, Endocrinology, Diabetes and Metabolism
28

Scopus Publications

1877

Scholar Citations

17

Scholar h-index

18

Scholar i10-index

Scopus Publications

  • The conundrum in diagnosing Maturity-Onset Diabetes of the Young (MODY) in a large German pedigree with early-onset diabetes and a novel HNF1A variant
    Eleni Z. Giannopoulou, Abubakar Moawia, Josef Högel, Joanna Lerner, Stefanie Zorn, et al.
    Molecular and Cellular Pediatrics, 2026
  • Monogenic obesity due to MC4R deficiency: lessons from a multigenerational case
    Eleni Z. Giannopoulou, Stefanie Zorn, Melanie Schirmer, Stephanie Brandt-Heunemann, Julia von Schnurbein, et al.
    Molecular and Cellular Pediatrics, 2026
    Background Melanocortin 4 receptor (MC4R) deficiency is the most common monogenic cause of obesity, yet remains underdiagnosed. Patients with monogenic obesity often undergo a frustrating diagnostic and therapeutic odyssey of years of ineffective lifestyle interventions before a causal diagnosis is made. We report a four-generation family where genetic testing in a child identified a likely pathogenic MC4R variant also carried by three ancestors. Methods The studied family included a 7-year-old index patient, her mother, grandmother, and great-grandmother with a history of early-onset obesity. Panel sequencing of monogenic obesity genes was performed in the index patient whereas in the relatives targeted analysis of the familial MC4R variant was performed by Sanger sequencing. Results The index patient developed severe obesity by age 2 years, with hyperphagia, tall stature, and dyslipidemia. Despite lifestyle interventions, her body mass index (BMI) continued to increase. At the age of 7 years, genetic panel testing identified a rare monoallelic variant in the MC4R gene c.913C > T; p.Arg305Trp, previously shown to impair receptor function. Treatment with liraglutide (3.0 mg/day) was initiated at age 8 years, resulting in marked reduction in BMI during the first year of treatment. Subsequent genetic testing of family members identified the same variant in her mother, grandmother, and great-grandmother, all of whom had a history of early-onset obesity and related comorbidities, consistent with segregation of the variant within the family. Conclusions This case underscores the importance of early genetic testing in severe childhood obesity to avoid ineffective treatments and enable targeted therapies (e.g., GLP-1 analogues). Diagnosing (likely) pathogenic MC4R variants can also identify at-risk relatives, providing psychological and clinical benefits across generations.
  • Two-year outcomes after early postnatal high-dose fat-soluble enteral vitamin A supplementation in extremely low birth weight infants: follow-up of the NeoVitaA randomized controlled trial
    Martin Poryo, Ludwig Gortner, Johannes Bay, Axel R. Franz, Harald Ehrhardt, et al.
    Eclinicalmedicine, 2025
  • Corrigendum to “Two-year outcomes after early postnatal high-dose fat-soluble enteral vitamin A supplementation in extremely low birth weight infants: follow-up of the NeoVitaA randomized controlled trial”
    Martin Poryo, Ludwig Gortner, Johannes Bay, Axel R. Franz, Harald Ehrhardt, et al.
    Eclinicalmedicine, 2025
  • Exploring Metabolic Signatures: Unraveling the Association with Obesity in Children and Adolescents
    Diamanto Koutaki, Garyfallia Stefanou, Sofia-Maria Genitsaridi, Eleni Ramouzi, Athanasia Kyrkili, et al.
    Nutrients, 2025
    Background: Childhood obesity is a growing global health concern. Metabolomics, the comprehensive study of metabolites within biological systems, offers a powerful approach to better define the phenotype and understand the complex biochemical alterations associated with obesity. The aim of this systematic review was to summarize current knowledge in the field of metabolomics in childhood obesity and to identify metabolic signatures or biomarkers associated with overweight/obesity (Ov/Ob) and Metabolically Unhealthy Obesity (MUO) in children and adolescents. Methods: We performed a systematic search of Medline and Scopus databases according to PRISMA guidelines. We included only longitudinal prospective studies or randomized controlled trials with ≥12 months of follow-up, as well as meta-analyses of the above that assessed the relation between metabolic signatures related to obesity and Body Mass Index (BMI) or other measures of adiposity in children and adolescents aged 2–19 years with overweight or obesity. Initially, 595 records were identified from PubMed and 1565 from Scopus. After removing duplicates and screening for relevance, 157 reports were assessed for eligibility. From the additional search, 75 new records were retrieved, of which none were eligible for our study. Finally, 7 reports were included in the present systematic review (4 reporting on Ov/Ob and 4 on MUO). Results: The presented studies suggest that the metabolism of amino acids and lipids is primarily affected by childhood obesity. Metabolites like glycoprotein acetyls, the Apolipoprotein B/Apolipoprotein A-1 ratio, and lactate have emerged as potential biomarkers for insulin resistance and metabolic syndrome, highlighting their potential value in clinical applications. Conclusions: There is a need for future longitudinal studies to assess metabolic changes over time, interventional studies to evaluate the efficacy of therapeutic strategies, and large-scale population studies to explore metabolic diversity across different demographics. Our findings reveal specific biomarkers in the amino acid and lipid pathway that may serve as early indicators of childhood obesity and its associated cardiometabolic complications.
  • Early postnatal high-dose fat-soluble enteral vitamin A supplementation for moderate or severe bronchopulmonary dysplasia or death in extremely low birthweight infants (NeoVitaA): a multicentre, randomised, parallel-group, double-blind, placebo-controlled, investigator-initiated phase 3 trial
    Sascha Meyer, Johannes Bay, Axel R Franz, Harald Erhardt, Lars Klein, et al.
    Lancet Respiratory Medicine, 2024
  • Long term effects of aromatase inhibitor treatment in patients with aromatase excess syndrome
    Eleni Z. Giannopoulou, Stephanie Brandt, Stefanie Zorn, Christian Denzer, Julia von Schnurbein, et al.
    Frontiers in Endocrinology, 2024
    IntroductionAromatase excess syndrome (AEXS) is a rare, autosomal dominant disorder, characterized by enhanced aromatization of androgens and estrogen excess. In males it is characterized by pre-/peripubertal gynecomastia, hypogonadotropic hypogonadism, advanced bone age and short adult height. Only a few female patients have been described so far.MethodsWe report on a family with four members with AEXS and present the long-term effects of aromatase inhibitor use in three of them. Genetic analysis showed a monoallelic 0.3-Mb deletion in 15q21, involving parts of CYP19A1, GLDN and DMXL2 in all four patients with AEXS.ResultsThe index patient (male, 8 years old) presented with gynecomastia and accelerated growth and bone age. With start of puberty, estradiol levels increased, while testosterone levels remained low. Gynecomastia progressed and a mastectomy was performed twice. Presuming AEXS, a therapy with letrozole was initiated at the age of 19 years. Low-dose letrozole treatment was associated with an increase in testicular volume, increase in virilization and improvement in physical strength and libido. His brother (age 3 years) presented with accelerated growth and bone age. Treatment with letrozole, which was started at the age of 7 years, resulted in achieving an adult height of 179 cm and prevented the appearance of gynecomastia. His sister (age 6 years), who presented with premature thelarche and accelerated growth and bone age, was treated with an estrogen receptor modulator and a GnRH analog followed by letrozole treatment. Menarche occurred at age 13.5 years and adult height was 158 cm. Their father had an early, accelerated growth with an adult height of 171 cm, a delayed puberty and no gynecomastia. In vitro studies provided evidence for involvement of aromatase induction in atypical cells and an increased range of potential mechanisms regulating aromatase activity due to the presence of the mutated allele.DiscussionIn conclusion, we observed a phenotypic variability within family members with AEXS carrying the same CYP19A1 microdeletion. When started early, treatment with letrozole was found to prevent the development of gynecomastia and increase adult height in one patient. In adult life, low-dose letrozole treatment resulted in improved physical strength and libido in the index patient.
  • Genetic Obesity in Children: Overview of Possible Diagnoses with a Focus on SH2B1 Deletion
    Eleni Z. Giannopoulou, Stefanie Zorn, Melanie Schirmer, Gloria Herrmann, Sabine Heger, et al.
    Hormone Research in Paediatrics, 2022
    <b><i>Introduction:</i></b> Genetic obesity is rare and quite challenging for pediatricians in terms of early identification. Src-homology-2 (SH2) B adapter protein 1 (SH2B1) is an important component in the leptin-melanocortin pathway and is found to play an important role in leptin and insulin signaling and therefore in the pathogenesis of obesity and diabetes. Microdeletions in chromosome 16p11.2, encompassing the <i>SH2B1</i> gene, are known to be associated with obesity, insulin resistance, hyperphagia, and developmental delay. The aim of our study is to report on a case series of young individuals with 16p11.2 microdeletions, including the <i>SH2B1</i> gene, and provide detailed information on body mass index (BMI) development and obesity-associated comorbidities. In this way, we want to raise awareness of this syndromic form of obesity as a differential diagnosis of genetic obesity. <b><i>Methods:</i></b> We describe the phenotype of 7 children (3 male; age range: 2.8–18.0 years) with 16p11.2 microdeletions, encompassing the <i>SH2B1</i> gene, and present their BMI trajectories from birth onward. Screening for obesity-associated comorbidities was performed at the time of genetic diagnosis. <b><i>Results:</i></b> All children presented with severe, early-onset obesity already at the age of 5 years combined with variable developmental delay. Five patients presented with elevated fasting insulin levels, 1 patient developed diabetes mellitus type 2, 4 patients had dyslipidemia, and 4 developed nonalcoholic fatty-liver disease. <b><i>Discussion/Conclusion:</i></b> Chromosomal microdeletions in 16p11.2, including the <i>SH2B1</i> gene, in children are associated with severe, early-onset obesity and comorbidities associated with insulin resistance. Early genetic testing in suspicious patients and early screening for comorbidities are recommended.
  • Transient neonatal diabetes due to a disease causing novel variant in the ATP-binding cassette subfamily C member 8 (ABCC8) gene unmasks maturity-onset diabetes of the young (MODY) diabetes cases within a family
    Eleni Z Giannopoulou, Olga Ovcarov, Elisa De Franco, Fabian Kassberger, Susanne Nusser, et al.
    Journal of Pediatric Endocrinology and Metabolism, 2021
    Objectives Neonatal diabetes mellitus (NDM) is a rare monogenic diabetes form, occurring mainly from ATP-binding cassette subfamily C member 8 (ABCC8) and KCNJ11 mutations. ABCC8 mutations have also been found to cause adult-onset diabetes. What is new?: •Novel ABCC8 mutation in an NDM case •Heterogeneous clinical presentation of diabetes and response to sulfonylurea therapy among family members with the same ABCC8 mutation. Case presentation We report the case of a newborn with NDM and a heterozygous ABCC8 novel variant (c.3835G>A), successfully treated with sulfonylurea. The same ABCC8 variant was found in two other family members, already treated for type 2 diabetes. Conclusions This case demonstrates the variable phenotypic presentation of diabetes due to a novel ABCC8 mutation (c.3835G>A), ranging from transient NDM to adult-onset, insulin-demanding diabetes, among family members. Genetic testing in young individuals with a strong family history of diabetes, presenting with non-autoimmune diabetes is recommended as it can determine prognosis and treatment of affected family members.
  • Subclinical arterial damage in children and adolescents with type 1 diabetes: A systematic review and meta-analysis
    Eleni Z. Giannopoulou, Ioannis Doundoulakis, Christina Antza, Athanasios Christoforidis, Anna Bettina Haidich, et al.
    Pediatric Diabetes, 2019
    Type 1 diabetes is an important risk factor for the development of cardiovascular disease. Pulse wave velocity (PWV) and carotid intima‐media thickness (cIMT) measurements are well recognized as independent predictors for future cardiovascular disease. The aim of the present study was to systematically review the literature and conduct a meta‐analysis assessing measures of subclinical arterial damage in children and adolescents with type 1 diabetes in comparison to healthy controls.
  • Efficacy of vildagliptin for prevention of postpartum diabetes in women with a recent history of insulin-requiring gestational diabetes: A phase II, randomized, double-blind, placebo-controlled study
    Sandra Hummel, Andreas Beyerlein, Markus Pfirrmann, Anna Hofelich, Daniela Much, et al.
    Molecular Metabolism, 2018
  • Novel Mutation in an Infant with Niemann-Pick Disease Type A/B
    E. Giannopoulou, R. Furtwängler, F. Bürger, D. Schöndorf, L. Gortner, et al.
    Klinische Padiatrie, 2016
  • Islet autoantibody phenotypes and incidence in children at increased risk for type 1 diabetes
    Eleni Z. Giannopoulou, Christiane Winkler, Ruth Chmiel, Claudia Matzke, Marlon Scholz, et al.
    Diabetologia, 2015
  • Solitary Median Maxillary Central Incisor
    Eleni Z. Giannopoulou, Tilman Rohrer, Paul Hoffmann, Umut Yilmaz, Ludwig Gortner, et al.
    Journal of Pediatrics, 2015
  • Vasopressin in arterial hypotension in extremely low birth weight infants
    Sascha Meyer, Eleni Z. Giannopoulou
    Journal of Pediatrics, 2015
  • A dangerous ride: A case of traumatic splenic rupture
    Eleni Z. Giannopoulou, Ludwig Gortner, Clemens-Magnus Meier, Sascha Meyer
    Journal of Pediatrics, 2015
  • Progression from single to multiple islet autoantibodies often occurs soon after seroconversion: implications for early screening
    Ruth Chmiel, Eleni Z. Giannopoulou, Christiane Winkler, Peter Achenbach, Anette-Gabriele Ziegler, et al.
    Diabetologia, 2015
  • Erratum to: Feature ranking of type 1 diabetes susceptibility genes improves prediction of type 1 diabetes [Diabetologia, (2014), DOI 10.1007/s00125-014-3362-1]
    Christiane Winkler, Jan Krumsiek, Florian Buettner, Christof Angermüller, Eleni Z. Giannopoulou, et al.
    Diabetologia, 2015
  • Cellular and humoral coagulation profiles and occurrence of IVH in VLBW and ELWB infants
    Perrine Duppré, Harald Sauer, Eleni Z. Giannopoulou, Ludwig Gortner, Holger Nunold, et al.
    Early Human Development, 2015
  • Feature ranking of type 1 diabetes susceptibility genes improves prediction of type 1 diabetes
    Christiane Winkler, Jan Krumsiek, Florian Buettner, Christof Angermüller, Eleni Z. Giannopoulou, et al.
    Diabetologia, 2014
  • Prevalence of vitamin D deficiency in pre-type 1 diabetes and its association with disease progression
    Jennifer Raab, Eleni Z. Giannopoulou, Simone Schneider, Katharina Warncke, Miriam Krasmann, et al.
    Diabetologia, 2014
  • Effect of a single autologous cord blood infusion on beta-cell and immune function in children with new onset type 1 diabetes: A non-randomized, controlled trial
    Eleni Z Giannopoulou, Ramona Puff, Andreas Beyerlein, Irene von Luettichau, Heike Boerschmann, et al.
    Pediatric Diabetes, 2014
  • Reduced blood leukocyte and neutrophil numbers in the pathogenesis of type 1 diabetes
    M. Harsunen, R. Puff, O. D'Orlando, E. Giannopoulou, L. Lachmann, et al.
    Hormone and Metabolic Research, 2013
  • Gestational diabetes: The PINGUIN-Study of the diabetes research group TU Munich
    Medizinische Welt, 2012
  • A strategy for combining minor genetic susceptibility genes to improve prediction of disease in type 1 diabetes
    C Winkler, J Krumsiek, J Lempainen, P Achenbach, H Grallert, et al.
    Genes and Immunity, 2012
  • Two-year cyclic infusion of pamidronate improves bone mass density and eliminates risk of fractures in a girl with osteoporosis due to Hajdu-Cheney syndrome
    Minerva Endocrinologica, 2012
  • Insulin resistance is associated with at least threefold increased risk for prothrombotic state in severely obese youngsters
    Assimina Galli-Tsinopoulou, Ioannis Kyrgios, Ioanna Maggana, Eleni Z. Giannopoulou, Eleni P. Kotanidou, et al.
    European Journal of Pediatrics, 2011
  • Acquired toxoplasmosis accompanied by facial nerve palsy in an immunocompetent 5-year-old child
    Assimina Galli-Tsinopoulou, Ioannis Kyrgios, Eleni Z. Giannopoulou, Styliani Gourgoulia, Ioanna Maggana, et al.
    Journal of Child Neurology, 2010

RECENT SCHOLAR PUBLICATIONS

  • The conundrum in diagnosing Maturity-Onset Diabetes of the Young (MODY) in a large German pedigree with early-onset diabetes and a novel HNF1A variant
    EZ Giannopoulou, A Moawia, J Högel, J Lerner, S Zorn, C Denzer, ...
    Molecular and Cellular Pediatrics 13 (1), 16 , 2026
    2026
  • Monogenic obesity due to MC4R deficiency: lessons from a multigenerational case
    EZ Giannopoulou, S Zorn, M Schirmer, S Brandt-Heunemann, ...
    Molecular and Cellular Pediatrics 13 (1), 3 , 2026
    2026
    Citations: 5
  • Two-year outcomes after early postnatal high-dose fat-soluble enteral vitamin A supplementation in extremely low birth weight infants: follow-up of the NeoVitaA randomized …
    M Poryo, L Gortner, J Bay, AR Franz, H Ehrhardt, L Klein, J Behnke, ...
    EClinicalMedicine 89 , 2025
    2025
  • Exploring Metabolic Signatures: Unraveling the Association with Obesity in Children and Adolescents
    D Koutaki, G Stefanou, SM Genitsaridi, E Ramouzi, A Kyrkili, ...
    Nutrients 17 (11), 1833 , 2025
    2025
    Citations: 1
  • Exploration of metabolic signatures or biomarkers associated with obesity in children and adolescents
    D Koutaki, G Stefanou, SM Genitsaridi, E Ramouzi, A Kyrkili, E Kokkou, ...
    Endocrine Abstracts 110 , 2025
    2025
  • Long term effects of aromatase inhibitor treatment in patients with aromatase excess syndrome
    EZ Giannopoulou, S Brandt, S Zorn, C Denzer, J Von Schnurbein, ...
    Frontiers in endocrinology 15, 1487884 , 2024
    2024
    Citations: 4
  • MC4R Variant in A Four-Generation Family with Early-Onset Severe Obesity
    EZ Giannopoulou, M Schirmer, C Denzer, M Wabitsch
    Age (years) 9 (39), 64 , 2024
    2024
  • BIO-STREAMS: Multi-Pillar Framewor k for children’s Anti-Obesity Behavior building on an EU biobank, Micro Moments and Mobile Recommendation Systems
    P Kassari, SM Genitsaridi, E Ramouzi, E Giannopoulou, E Kokkou, ...
    HORMONE RESEARCH IN PAEDIATRICS 97, 173-173 , 2024
    2024
  • Early postnatal high-dose fat-soluble enteral vitamin A supplementation for moderate or severe bronchopulmonary dysplasia or death in extremely low birthweight infants …
    S Meyer, J Bay, AR Franz, H Ehrhardt, L Klein, J Petzinger, C Binder, ...
    The Lancet Respiratory Medicine 12 (7), 544-555 , 2024
    2024
    Citations: 30
  • Genetic Obesity in Children: Overview of Possible Diagnoses with a Focus on SH2B1 Deletion
    EZ Giannopoulou, S Zorn, M Schirmer, G Herrmann, S Heger, T Reinehr, ...
    Hormone Research in Paediatrics 95 (2), 137-148 , 2022
    2022
    Citations: 13
  • Long-term follow-up of aromatase-inhibitor use in 3 family members with aromatase excess syndrome
    E Giannopoulou, S Brandt, M Schmidt, M Fukami, M Wabitsch
    HORMONE RESEARCH IN PAEDIATRICS 95 (SUPPL 2), 279-279 , 2022
    2022
  • Monogenic obesity in children: focusing on SH2B1 deletion
    E GIANNOPOULOU, S Zorn, M Schirmer, G Herrmann, S Heger, ...
    HORMONE RESEARCH IN PAEDIATRICS 94 (SUPPL 1), 130-131 , 2021
    2021
  • Transient neonatal diabetes due to a disease causing novel variant in the ATP-binding cassette subfamily C member 8 ( ABCC8 ) gene unmasks maturity-onset …
    EZ Giannopoulou, O Ovcarov, E De Franco, F Kassberger, S Nusser, ...
    Journal of Pediatric Endocrinology and Metabolism 34 (2), 273-276 , 2021
    2021
    Citations: 4
  • 11. Obesity and Weight Regulation
    M Wabitsch, D Tews, J von Schnurbein, M Schirmer, E Giannopoulou, ...
    Yearbook of Paediatric Endocrinology 28 (7), 116 , 2020
    2020
  • Subclinical arterial damage in children and adolescents with type 1 diabetes: a systematic review and meta‐analysis
    EZ Giannopoulou, I Doundoulakis, C Antza, A Christoforidis, AB Haidich, ...
    Pediatric Diabetes 20 (6), 668-677 , 2019
    2019
    Citations: 65
  • SUBCLINICAL ARTERIAL DAMAGE IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES: A SYSTEMATIC REVIEW AND META-ANALYSIS
    I Doundoulakis, E Giannopoulou, C Antza, C Christoforidis, A Haidich, ...
    Journal of Hypertension 37, e138-e139 , 2019
    2019
  • Efficacy of vildagliptin for prevention of postpartum diabetes in women with a recent history of insulin-requiring gestational diabetes: A phase II, randomized, double-blind …
    S Hummel, A Beyerlein, M Pfirrmann, A Hofelich, D Much, S Hivner, ...
    Molecular metabolism 9, 168-175 , 2018
    2018
    Citations: 17
  • Interleukin‐1 antagonism moderates the inflammatory state associated with type 1 diabetes during clinical trials conducted at disease onset
    SM Cabrera, X Wang, YG Chen, S Jia, ML Kaldunski, CJ Greenbaum, ...
    European journal of immunology 46 (4), 1030-1046 , 2016
    2016
    Citations: 65
  • Neue Mutation bei einem Säugling mit Niemann-Pick-Krankheit Typ A/B
    EZ Giannopoulou, R Furtwängler, F Bürger, D Schöndorf, L Gortner, ...
    Klinische Padiatrie 228 (1), 47-48 , 2016
    2016
  • Novel Mutation in an Infant with Niemann-Pick Disease Type A/B
    EZ Giannopoulou, R Furtwängler, F Bürger, D Schöndorf, L Gortner, ...
    Klinische Pädiatrie 228 (01), 47-48 , 2016
    2016

MOST CITED SCHOLAR PUBLICATIONS

  • Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials
    A Moran, B Bundy, DJ Becker, LA DiMeglio, SE Gitelman, R Goland, ...
    The Lancet 381 (9881), 1905-1915 , 2013
    2013
    Citations: 437
  • Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes
    AG Ziegler, E Bonifacio, Babydiab-Babydiet Study Group
    Diabetologia 55 (7), 1937-1943 , 2012
    2012
    Citations: 374
  • Feature ranking of type 1 diabetes susceptibility genes improves prediction of type 1 diabetes
    C Winkler, J Krumsiek, F Buettner, C Angermüller, EZ Giannopoulou, ...
    Diabetologia 57 (12), 2521-2529 , 2014
    2014
    Citations: 197
  • Islet autoantibody phenotypes and incidence in children at increased risk for type 1 diabetes
    EZ Giannopoulou, C Winkler, R Chmiel, C Matzke, M Scholz, A Beyerlein, ...
    Diabetologia 58 (10), 2317-2323 , 2015
    2015
    Citations: 132
  • Prevalence of vitamin D deficiency in pre-type 1 diabetes and its association with disease progression
    J Raab, EZ Giannopoulou, S Schneider, K Warncke, M Krasmann, ...
    Diabetologia 57 (5), 902-908 , 2014
    2014
    Citations: 104
  • Reduced blood leukocyte and neutrophil numbers in the pathogenesis of type 1 diabetes
    MH Harsunen, R Puff, O D’Orlando, E Giannopoulou, L Lachmann, ...
    Hormone and metabolic research 45 (06), 467-470 , 2013
    2013
    Citations: 97
  • A strategy for combining minor genetic susceptibility genes to improve prediction of disease in type 1 diabetes
    C Winkler, J Krumsiek, J Lempainen, P Achenbach, H Grallert, ...
    Genes & Immunity 13 (7), 549-555 , 2012
    2012
    Citations: 90
  • Subclinical arterial damage in children and adolescents with type 1 diabetes: a systematic review and meta‐analysis
    EZ Giannopoulou, I Doundoulakis, C Antza, A Christoforidis, AB Haidich, ...
    Pediatric Diabetes 20 (6), 668-677 , 2019
    2019
    Citations: 65
  • Interleukin‐1 antagonism moderates the inflammatory state associated with type 1 diabetes during clinical trials conducted at disease onset
    SM Cabrera, X Wang, YG Chen, S Jia, ML Kaldunski, CJ Greenbaum, ...
    European journal of immunology 46 (4), 1030-1046 , 2016
    2016
    Citations: 65
  • Progression from single to multiple islet autoantibodies often occurs soon after seroconversion: implications for early screening
    R Chmiel, EZ Giannopoulou, C Winkler, P Achenbach, AG Ziegler, ...
    Diabetologia 58 (2), 411-413 , 2015
    2015
    Citations: 60
  • Cellular and humoral coagulation profiles and occurrence of IVH in VLBW and ELWB infants
    P Duppré, H Sauer, EZ Giannopoulou, L Gortner, H Nunold, S Wagenpfeil, ...
    Early Human Development 91 (12), 695-700 , 2015
    2015
    Citations: 51
  • Effect of a single autologous cord blood infusion on beta‐cell and immune function in children with new onset type 1 diabetes: A non‐randomized, controlled trial
    EZ Giannopoulou, R Puff, A Beyerlein, I von Luettichau, H Boerschmann, ...
    Pediatric Diabetes 15 (2), 100-109 , 2014
    2014
    Citations: 44
  • Early postnatal high-dose fat-soluble enteral vitamin A supplementation for moderate or severe bronchopulmonary dysplasia or death in extremely low birthweight infants …
    S Meyer, J Bay, AR Franz, H Ehrhardt, L Klein, J Petzinger, C Binder, ...
    The Lancet Respiratory Medicine 12 (7), 544-555 , 2024
    2024
    Citations: 30
  • Two-year cyclic infusion of pamidronate improves bone mass density and eliminates risk of fractures in a girl with osteoporosis due to Hajdu-Cheney syndrome.
    A Galli-Tsinopoulou, I Kyrgios, S Giza, EZ Giannopoulou, I Maggana, ...
    Minerva endocrinologica 37 (3), 283-289 , 2012
    2012
    Citations: 28
  • Insulin resistance is associated with at least threefold increased risk for prothrombotic state in severely obese youngsters
    A Galli-Tsinopoulou, I Kyrgios, I Maggana, EZ Giannopoulou, ...
    European journal of pediatrics 170 (7), 879-886 , 2011
    2011
    Citations: 18
  • Efficacy of vildagliptin for prevention of postpartum diabetes in women with a recent history of insulin-requiring gestational diabetes: A phase II, randomized, double-blind …
    S Hummel, A Beyerlein, M Pfirrmann, A Hofelich, D Much, S Hivner, ...
    Molecular metabolism 9, 168-175 , 2018
    2018
    Citations: 17
  • Acquired toxoplasmosis accompanied by facial nerve palsy in an immunocompetent 5-year-old child
    A Galli-Tsinopoulou, I Kyrgios, EZ Giannopoulou, S Gourgoulia, ...
    Journal of child neurology 25 (12), 1525-1528 , 2010
    2010
    Citations: 17
  • Genetic Obesity in Children: Overview of Possible Diagnoses with a Focus on SH2B1 Deletion
    EZ Giannopoulou, S Zorn, M Schirmer, G Herrmann, S Heger, T Reinehr, ...
    Hormone Research in Paediatrics 95 (2), 137-148 , 2022
    2022
    Citations: 13
  • Tongue fasciculations in an infant with spinal muscular atrophy type 1
    EZ Giannopoulou, T Martin, B Wirth, U Yilmaz, L Gortner, S Meyer
    Clinical Case Reports 3 (10), 832 , 2015
    2015
    Citations: 7
  • Solitary median maxillary central incisor
    EZ Giannopoulou, T Rohrer, P Hoffmann, U Yilmaz, L Gortner, S Meyer
    The Journal of Pediatrics 167 (3), 770-770. e1 , 2015
    2015
    Citations: 7