mina ebrahimi
@sums.ac.ir
Faculty of Medical Science
Shiraz university of medical sciences
RESEARCH, TEACHING, or OTHER INTERESTS
Parasitology
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Soraya Mohammadi Esfanjani, Leili Aghebati Maleki, Sanam Nami, Mina Ebrahimi, Amir Baghbanzadeh, Gregorio Perez-Cordon, Sonia M Rodrigues Oliveira, Maria De Lourdes Pereira, Aleksandra Barać, Ehsan Ahmadpour,et al.
Journal of Infection in Developing Countries
Introduction: Trichomoniasis is the most common non-viral sexually transmitted infection that increases the risk of cervical cancer. Trichomonas vaginalis (T. vaginalis) can regulate the pro-inflammatory cytokine production in the host cells. Toll-like receptors (TLRs) are a family of the pattern recognition receptors (PRRs) of mammalian cells, expressed in various host cells and have an important role in recognizing pathogens, and pro-inflammatory responses. The aim of the present study is to investigate the role of TLR5 in cervical cancer cells (HeLa) and human vaginal epithelial cells (HVECs) exposed to T. vaginalis. Methodology: First, the cells and parasites were cultured in RPMI and trypticase yeast extract maltose (TYM), respectively. After adaption of parasite and epithelial cells by RPMI-TYM medium co-culture (9:1 vol/vol), HVECs and HeLa cells were stimulated with T. vaginalis trophozoites (24-hour incubation at 37 °C, 5% CO2). Following RNA extraction and cDNA synthesis, the gene expression levels of TLR5, IRAK1, and NF-κB were assessed using real-time PCR. Besides, the protein levels were measured using western blotting. All tests and controls were normalized using β-actin as a housekeeping control. Results: Real-time PCR results showed an increased gene expression of TLR5, IRAK1, and NF-κB in T. vaginalis exposed HVECs and HeLa cells compared to the control group (p < 0.05). Additionally, western blot analysis showed a statistically significant increase in TLR5, and NF-κB proteins in both groups after exposure to the parasite (p < 0.05). Conclusions: These findings provide insight into the host-parasite interaction, and the results indicated that T. vaginalis could stimulate TLR5 and activate related pathways.
Ali Asghari, Mina Ebrahimi, Laya Shamsi, Alireza Sadrebazzaz, and Morteza Shams
Elsevier BV
Mina Ebrahimi, Nayer Mehdizad, Fatemeh Yeganeh-Sefidan, Hanie Safarpour, Abdol S. Pagheh, Amir Pouremamali, Somayeh Shiralizadeh, Ali Ghodrati, Sana Jafari, Firooz Shahrivar,et al.
Publicidad Permanyer, SLU
Nayer Mehdizad Bakhtiar, Abolfazl Akbarzadeh, Ehsan Ahmadpour, Mahmoud Mahami-Oskouei, Adriano Casulli, Roghayeh Norouzi, Milad Asadi, Mina Ebrahimi, Nahideh Asadi, Sonia M. Rodrigues Oliveira,et al.
Elsevier BV
Mina Ebrahimi, Mahbobeh Montazeri, Amirhosien Ahmadi, Sanam Nami, Hamed Hamishehkar, Firooz Shahrivar, Nayer Mehdizad Bakhtiar, Veeranoot Nissapatorn, Adel Spotin, and Ehsan Ahmadpour
Elsevier BV
Hanie Safarpour, Muge Cevik, Mehdi Zarean, Aleksandra Barac, Kareem Hatam-Nahavandi, Mohammad T. Rahimi, Hossein Bannazadeh Baghi, Tohid J. Koshki, Abdol S. Pagheh, Firooz Shahrivar,et al.
Ovid Technologies (Wolters Kluwer Health)
Objective: Toxoplasma infection remains as the most common cause of focal brain lesions among people living with HIV (PLHIV) despite the decline in opportunistic infections with the introduction of antiretroviral treatment. This study was conducted to provide a summary of evidence about the seroprevalence of Toxoplasma gondii and prevalence of active T. gondii infection and associated risk factors among PLHIV. Design: Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. Scopus, PubMed, Science Direct and EMBASE were searched from 1997 to July 2018. All peer-reviewed original research articles describing T. gondii infection among PLHIV with different diagnostic methods were included. Methods: Incoherence and heterogeneity between studies were quantified by I 2 index and Cochran's Q test. Publication and population bias were assessed with funnel plots and Egger's regression asymmetry test. All statistical analyses were performed using StatsDirect. Results: In total, 111 studies from 37 countries assessing 66 139 blood samples were included in this study. The pooled prevalence of T. gondii infection among PLHIV was 3.24% by IgM and 26.22% by molecular methods using the random-effects model. Pooled seroprevalence of T. gondii by IgG was 44.22%. There was a relationship between Toxoplasma prevalence and sex, raw meat consumption, contact with cat and knowledge about toxoplasmosis. Conclusion: High Toxoplasma seroprevalence among PLHIV observed in this study emphasizes the need for implementing screening and prophylaxis tailored to the local context. Owing to the serious and significant clinical manifestations of the parasite in case of reactivation, early identification of seropositivity for initiating prophylaxis among those with a CD4+ cell count of less than 200 cells/ml is recommended.
Ehsan Ahmadpour, Mohammad Ali Ghanizadegan, Atefeh Razavi, Mahsa Kangari, Rouhollah Seyfi, Maryam Shahdust, Ali Yazdanian, Hanie Safarpour, Hossein Bannazadeh Baghi, Mehdi Zarean,et al.
Hindawi Limited
Strongyloidiasis is caused by nematode infections of the genus Strongyloides, mainly Strongyloides stercoralis, and affects tens of millions of people around the world. S. stercoralis hyperinfection and disseminated strongyloidiasis are unusual but potentially fatal conditions mostly due to Gram-negative bacteremia and sepsis, primarily affecting immunocompromised patients. Infections with immunosuppressive viruses such as human immunodeficiency virus (HIV) and Human T-cell leukemia virus type 1 (HTLV-1) have been reported as risk factors for strongyloidiasis. Hyperinfection syndrome has been described in HIV-positive patients following the use of corticosteroids or during immune reconstitution inflammatory syndrome (IRIS). In this research, we conducted a global systematic review and meta-analysis to assess the seroprevalence and odds ratios (ORs) of S. stercoralis infections in HIV infected patients. A total of 3,649 records were screened, 164 studies were selected and evaluated in more detail, and 94 studies were included in the meta-analysis. The overall pooled prevalence of S. stercoralis infection in HIV positive patients was 5.1 % (CI95%: 4 % - 6.3 %), and a meta-analysis on six studies showed that with a pooled OR of 1.79 (CI95%: 1.18 - 2.69 %) HIV positive men are at a higher risk of S. stercoralis infections (P<0.0052) compared to HIV positive women.