Mohamed Abdel-haleem Hafez Abdel-haleem

Scopus Publications

Eco-friendly synthesis of Balanites aegyptiaca-derived selenium nanoparticles: extract and assessment of their anticancer, antimicrobial, cytogenetic and molecular docking insights
Mohamed I. M. El-Zaidy, Heba G. Ayoub, Gehan El-Akabawy, Amira A. Ibrahim, Mohamed Abdel-Haleem
Scientific Reports, 2026
This study reports the eco-friendly synthesis of selenium nanoparticles (SeNPs) using the methanolic extract of Balanites aegyptiaca mesocarp and evaluates their biological activities. The synthesized spherical SeNPs (average size: 2.82 nm) were characterized by TEM, FESEM, and UV–Vis spectroscopy, confirming that phenolic compounds serve as both reducing and stabilizing agents. HPLC analysis revealed eight major phenolics, with gallic acid, chlorogenic acid, and daidzein being the predominant compounds. The SeNPs exhibited strong cytotoxicity against HCT-116 colorectal cancer cells (IC₅₀ = 30.03 µg/mL), potent antibacterial activity against Klebsiella pneumoniae , Escherichia coli , and Enterococcus faecalis , and induced concentration-dependent cytogenetic effects in Vicia faba root tips. Molecular docking studies suggested that phenolic compounds effectively interact with the CDK4 active site, supporting their potential anticancer properties. These findings highlight B. aegyptiaca -derived SeNPs as promising candidates for biomedical applications.
Transcriptional signatures of salinity tolerance in Egyptian wheat: unveiling WRKY-mediated defense mechanisms
Amira A. Ibrahim, Marwa A. Fakhr, Samah Ramadan, Mostafa M. Basuoni, Mohamed Abdel-Haleem
BMC Plant Biology, 2026
Phytochemical signatures and multifunctional bioactivities of two Ocimum basilicum varieties (Obb vs. Obg): antimicrobial, antioxidant, and anticancer potential
Akram B. Sultan, Khaled Haidar, Mohamed M. Sayedahmed, Mohammed Hanafy, Gehan El-Akabawy, et al.
Scientific Reports, 2026
Basal immunity of date palm under biotic stress: Redox signaling, immune suppression, and hidden vulnerabilities revealed by red palm weevil attack
Mohamed M. El-Mogy, Mostafa Ibrahim Abdelglil, Mohamed Abdel-Haleem, Amira A. Ibrahim, Fatmah Ahmed Safhi, et al.
Physiological and Molecular Plant Pathology, 2026
Decoding the multifunctional role of γ-aminobutyric acid in plant adaptation to drought stress
Hossam S. El-Beltagi, Mohamed Abdel-Haleem, Tarek A. Shalaby, Emad H. Khedr
Planta, 2026
Seed, leaf, or soil? rethinking agricultural application strategies for boosting crop growth, resilience, and yield
Mohamed Abdel-Haleem, Mostafa Ibrahim Abdelglil, Mohamed Gad, Nermeen Foda, Alzhraa Ali Mohamed, et al.
Plant and Soil, 2026
Background Global crop productivity is increasingly constrained by diverse environmental stresses, highlighting the urgent need for efficient, targeted, and sustainable agricultural input delivery strategies to enhance crop performance and resilience. Scope This review critically compares three widely used agricultural approaches: seed priming, foliar spraying, and soil application with emphasis on their practical impacts on crop growth, stress tolerance, and yield performance. Seed priming is shown to enhance early germination, seedling vigor, and uniform crop establishment. Foliar spraying provides rapid correction of nutrient deficiencies and effective mitigation of acute stress during critical growth stages. In contrast, soil application supports long-term root development, sustained nutrient uptake, and beneficial interactions with soil microbial communities. By synthesizing evidence across multiple crop species and stressconditions, this review highlights the advantages, limitations, and context-dependent effectiveness of each approach, while also discussing integrated application strategies to optimize crop responses under variable field conditions. Conclusions Overall, strategic selection and integration of seed priming, foliar spraying, and soil application can substantially improve crop resilience to environmental stresses and enhance yield stability. The insights presented in this review offer practical guidance for developing sustainable, resilient, and adaptive agricultural management practices suited to changing environmental and climatic conditions.
Molecular crosstalk between plant defense hormones and reactive oxygen species during fungal infection: Insights into integrated resistance mechanisms
Mohamed M. El-Mogy, Amira A. Ibrahim, Sameh A. Hussein, Hossam S. El-Beltagi, Ahmed M. Ismail, et al.
Physiological and Molecular Plant Pathology, 2026
Harnessing artificial intelligence and machine learning for fruit quality management: A comprehensive review
Hossam S. El-Beltagi, Mohamed Gad, Nagwa Khedr, Mohamed Abdel-Haleem, Mohamed S. Al Saikhan, et al.
Journal of Stored Products Research, 2026
SPECTROPHOTOMETRIC DETERMINATION OF ANTIOXIDANT CAPACITY AMONG DIVERSE JASMINUM SPECIES VIA ABTS+ AND Fe3+/Fe2+ REDUCING SYSTEMS
Nelly Michel George, Nermeen Foda, Mohamed Abdel-Haleem, Mohamed Ragab AbdelGawwad, Mohamed Taha Yassin
Bulletin of the Chemical Society of Ethiopia, 2026
The present study employed two complementary in vitro chemical assays, namely Ferric Reducing Antioxidant Power (FRAP) and ABTS⁺ radical scavenging, to evaluate and compare the antioxidant potential of methanolic extracts derived from five distinct Jasminum species. The electron-donating capacity of the extracts, mediated through redox-based mechanisms, as well as their ability to neutralize free radicals, was determined using spectrophotometric analysis. Results revealed significant interspecific variation in antioxidant activity. Based on absorbance values, FRAP measurements (µmol Fe²⁺/g), and antioxidant power indices, J. azoricum and J. nudiflorum exhibited the highest antioxidant potential, whereas J. sambac demonstrated the lowest activity across both assays. Specifically, the FRAP assay quantified the extracts’ capacity to reduce Fe³⁺ to Fe²⁺, while the ABTS assay measured their ability to scavenge ABTS⁺ radical cations. The observed variability is likely attributable to differences in phytochemical composition, particularly in phenolic and flavonoid content. Overall, this comparative evaluation underscores the promise of certain Jasminum species as potential natural sources of antioxidants for pharmaceutical and nutraceutical applications.KEY WORDS: Jasminum species, Spectrophotometric analysis, Antioxidant activity, ABTS assay, FRAP assayBull. Chem. Soc. Ethiop. 2026, 40(3), 679-689. DOI: https://dx.doi.org/10.4314/bcse.v40i3.14
The Sulfur Saga in Plants: From Uptake to Metabolism, Stress Response, and Microbe Interaction
Hossam S. El-Beltagi, Mohamed Abdel-Haleem, Mohammed Hanafy, Ahmed Mahmoud Ismail, Wael Elmenofy, et al.
Journal of Plant Growth Regulation, 2026
Strigolactones as Integrative Regulators of Plant Adaptation and Resilience to Abiotic Stress
Hossam S. El‐Beltagi, Mohamed Gad, Nagwa Khedr, Mohamed Abdel‐Haleem, Mohamed S. Al Saikhan, et al.
Plant Cell and Environment, 2026
Integrated study on kaempferol’s efficacy and mechanism of action: targeting Escherichia coli biofilms and colon cancer pathways alongside oxidative stress regulation
Akram B. Sultan, Mostafa Ibrahim Abdelglil, Alzhraa Ali Mohamed, Eman M. Haggag, Gehan El-Akabawy, et al.
Chemical Papers, 2026
Encapsulated GABA coatings as a postharvest strategy to enhance mango chilling tolerance
Emad H. Khedr, Mohamed M. El-Mogy, Mohamed Abdel-Haleem, Hossam S. El-Beltagi
Plant Physiology and Biochemistry, 2025
Mitigating drought stress and enhancing maize resistance through biopriming with Rhizopus arrhizus: insights into Morpho-Biochemical and molecular adjustments
Asmaa S. Taha, Hoda A. Fathey, Asmaa H. Mohamed, Amira A. Ibrahim, Mohamed Abdel-Haleem
BMC Plant Biology, 2025
Quercetin-mediated repression of adrA gene expression in Escherichia coli: dual roles in antibiofilm activity and oxidative stress regulation
Alzhraa Ali Mohamed, Eslam Abdelhakim Seyam, Sameh A. Hussein, Mohamed Abdel‐Haleem
Biologia, 2025
Millets as climate-resilient crops: Emerging technologies for sustainable postharvest management
Hossam S. El-Beltagi, Mohamed Abdel-Haleem, Nagwa Khedr, Tarek A. Shalaby, Mohamed M. El-Mogy, et al.
Journal of Food Composition and Analysis, 2025
Phytocytokines: Key regulators of plant immunity and emerging tools for sustainable agriculture
Bader Alsubaie, Mohamed Abdel-Haleem, Fatmah Ahmed Safhi, Alzhraa Ali Mohamed, Othman Al-Dossary, et al.
Physiological and Molecular Plant Pathology, 2025
Leveraging Endophytic Fungi for Enhancing Plant Resilience to Abiotic Stresses
Mariam Rabiae, Mostafa Ibrahim Abdelglil, Nermeen Foda, Mohamed M. Sayedahmed, Emad Hamdy Khedr, et al.
Journal of Crop Health, 2025
Harnessing biological control agents to mitigate red palm weevil infestations
Hossam S. El-Beltagi, Emad Hamdy Khedr, Ahmed Mahmoud Ismail, Basma A. Khalifa, Wael Elmenofy, et al.
Chilean Journal of Agricultural Research, 2025
Progesterone as a Plant Physiochemical Regulator: Mechanisms and Efficacy in Alleviating Abiotic Stress
Hossam S. El-Beltagi, Mohamed Abdel-Haleem, Adel A. Rezk, Emad Hamdy Khedr
Journal of Crop Health, 2025
Triacontanol: a Multifunctional Growth Regulator for Enhancing Stress Tolerance
Hossam S. El-Beltagi, Mohamed Gad, Mohamed Abdel-Haleem, Tarek A. Shalaby, Adel A. Rezk, et al.
Journal of Crop Health, 2025
Optimization of progesterone treatment via response surface methodology to maintain quality and mitigate chilling injury in Prunus persica L.
Hossam S. El-Beltagi, Mohamed Abdel-Haleem, Mohamed S. Al Saikhan, Emad Hamdy Khedr
New Zealand Journal of Crop and Horticultural Science, 2025
Resilience of forests in a changing climate: Responses, mechanisms, and adaptations
Hossam S. EL-BELTAGI, Mohamed ABDEL-HALEEM, Mohamed M. EL-MOGY, Emad H. KHEDR
Notulae Botanicae Horti Agrobotanici Cluj Napoca, 2025
Antibacterial coatings: pioneering solutions for maintaining fruit quality and prolonging storability
Hossam S. El-Beltagi, Mohamed Abdel-Haleem, Mohamed S. Al Saikhan, Tarek A. Shalaby, Amal A. Mohamed, et al.
Journal of Horticultural Science and Biotechnology, 2025
METABOLOMIC CHARACTERIZATION OF FRESH AND DRIED KOREAN RED GINSENG (Panax ginseng) BASED ON GC-MS ANALYSIS, ALONGSIDE AN EXPLORATION OF THE ANTIOXIDANT AND ANTICANCER PROPERTIES OF THEIR METHANOLIC EXTRACT
Hayfa Habes Almutairi, Mohamed Abdel-Haleem, Hossam S. El-Beltagi, Emad Hamdy Khedr, Ahlam Saleh Alhajri, et al.
Bulletin of the Chemical Society of Ethiopia, 2025
Harnessing GABA Pathways to Improve Plant Resilience Against Salt Stress
Jameel Mohammed Al-Khayri, Mohamed Abdel-Haleem, Emad Hamdy Khedr
Horticulturae, 2024
Offsetting pb induced oxidative stress in Vicia faba plants by foliar spray of chitosan through adjustment of morpho-biochemical and molecular indices
Reda E. Abdelhameed, Hanan Abdalla, Mohamed Abdel-Haleem
BMC Plant Biology, 2024
Alleviating the drought stress and improving the plant resistance properties of Triticum aestivum via biopriming with aspergillus fumigatus
Nelly Michel George, Gehad Hany-Ali, Ekram Abdelhaliem, Mohamed Abdel-Haleem
BMC Plant Biology, 2024
A combined therapy of meropenem-ZnO nanoparticles efficiently eliminates carbapenem-resistant Klebsiella pneumoniae biofilms, with reduced nephrotoxicity (in vitro)
Alzhraa Ali Mohamed, Safaa Saed, Sara Ramadan El-Sayed, Mohamed Taha Yassin, Mohamed Gad, et al.
Letters in Applied Microbiology, 2024
Harnessing the metabolic modulatory and antioxidant power of 1-(3-Phenyl-Propyl) cyclopropane and melatonin in maintaining mango fruit quality and prolongation storage life
Emad Hamdy Khedr, Nagwa Khedr, Mohamed Abdel-Haleem
BMC Plant Biology, 2023
PHYTOCHEMICAL PROFILING OF BIOACTIVE METABOLITES IN METHANOLIC EXTRACT OF TWO WILD SOLANUM SPECIES AND EVALUATION OF THEIR ANTIOXIDANT ACTIVITY.
Journal of Animal and Plant Sciences, 2022
Combination of Meropenem and Zinc Oxide Nanoparticles; Antimicrobial Synergism, Exaggerated Antibiofilm Activity, and Efficient Therapeutic Strategy against Bacterial Keratitis
Mohamed El-Telbany, Alzhraa Ali Mohamed, Galal Yahya, Aliaa Abdelghafar, Mahmoud Saad Abdel-Halim, et al.
Antibiotics, 2022
GC-MS Identification of Bioactive Compounds in Unripe Solanum nigrum Berries and Assessment of Antioxidant and Anticancer Activities
Latin American Journal of Pharmacy, 2021

Mohamed Abdel-haleem Hafez Abdel-haleem

RESEARCH, TEACHING, or OTHER INTERESTS

Scopus Publications