Polymer research department, Advanced Technology and New Materials Research Institute, City of Scientific Research and Technological Applications (SRTA-City)
My research interests are largely directed toward utilized of natural or semi-natural polymer in different fields including biomedical, pharmaceutical and environmental applications. This droves me to get a lot of experience in the functionalization and formulation of polymers in different forms like sponges, membranes, hydrogels, and nano-particles. Currently, I am working in the generation of new antimicrobial polymers based on natural source (i.e., polysaccharide and proteins) via functionalized it with biocidal groups. In the same direction but different application, I am working in protection the RO membrane from biofouling by immobilized the surface
EDUCATION
I got my Ph.D. from Ain Shams University in Egypt. My thesis focused on the modification of chitosan for wound dressing application. That included the chemical functionalization of chitosan with various promising groups. Several techniques of preparation, characterization, and evaluation were studied and employed during that period
RESEARCH, TEACHING, or OTHER INTERESTS
Organic Chemistry, Polymers and Plastics, Materials Chemistry, Biomaterials
127
Scopus Publications
6260
Scholar Citations
43
Scholar h-index
93
Scholar i10-index
Scopus Publications
Smart Release of the Antioxidant from Chitosan-Hyaluronan Reservoir in Skin Wound Healing † Ladislav Šoltés, Tamer M. Tamer, Mohamed E. Hassan, Mojmír Mach, Katarína Valachová Pharmaceutics, 2026 Reactive oxygen species (ROS) play a dual role in biological systems as indispensable signaling molecules and as key mediators of oxidative damage. Chronic wounds are often associated with excessive ROS formation, which impedes the healing process. Locally applied antioxidants may mitigate such imbalance and support tissue regeneration. The chitosan–hyaluronan (Ch/HA) composite membranes’ biocompatibility, moisture retention, and ability to maintain local redox balance rank these materials among the most promising next-generation wound dressings. The aim of this review is to summarize the Ch/HA composite membranes serving as reservoirs for locally applied antioxidants to accelerate the healing of full-thickness skin wounds in experimental animals. Composite Ch/HA membranes fortified with the selected antioxidants such as phosphatidylcholine dihydroquercetin and glutathione were evaluated in rats. A mitochondria-targeted derivative such as mitoquinone mesylate was evaluated in rats and rabbits, while l-(+)-ergothioneine has been examined in rabbits so far. This review demonstrates that smartly designed Ch/HA composite membranes represent a novel-generation wound dressing platform capable of smart antioxidant release and efficient stimulation of skin regeneration.
Progress in Hyaluronan-Based Nanoencapsulation Systems for Smart Drug Release and Medical Applications Katarína Valachová, Mohamed E. Hassan, Tamer M. Tamer, Ladislav Šoltés Molecules, 2025 Hyaluronan (HA), a high-molecular-weight polysaccharide naturally found in vertebrate tissues such as skin, joints, and the vitreous body, plays a critical role in various biological processes. Its functionality is highly dependent on molecular weight, with high-molecular-weight HA exhibiting anti-inflammatory and immunosuppressive effects, while low-molecular-weight HA promotes inflammation, immunostimulation, and angiogenesis. Due to its biocompatibility, biodegradability, and tunable properties, HA has gained increasing attention in biomedical applications. This review summarizes recent advances in the encapsulation of HA with other polymers and therapeutic agents in nanosystems, particularly hydrogels and nanoparticles. HA-based formulations demonstrate improved therapeutic outcomes, including drug release sustained up to 7 days, wound closure rates exceeding 90% in animal models, particle size in the range of 50–300 nm, and enhanced bioavailability of encapsulated drugs by 2–3 fold compared with free drugs. Such properties have shown promise in enhancing therapeutic efficacy and targeted drug delivery in the treatment of skin wound healing, diabetes, osteoarthritis, rheumatoid arthritis, and ophthalmic diseases. The review emphasizes how HA’s modifications and composite systems optimize drug release profiles and biological interactions, thereby contributing to the development of next-generation biomedical therapies.
Development of biodegradable poly (vinyl alcohol) /chitosan cross linked membranes for antibacterial wound dressing applications Jordan Journal of Biological Sciences, 2021
Development of superabsorbent graft copolymer hydrogel based on carboxymethyl cellulose for water retention in sandy soil Carboxymethyl Cellulose Volume II Pharmaceutical and Industrial Applications, 2019
Novel smart pH sensitive chitosan grafted alginate hydrogel microcapsules for oral protein delivery: I. preparation and characterization International Journal of Pharmacy and Pharmaceutical Sciences, 2015
Novel smart pH sensitive chitosan grafted alginate hydrogel microcapsules for oral protein delivery: II. evaluation of the swelling behavior International Journal of Pharmacy and Pharmaceutical Sciences, 2015
Antifungal Activity of Aminated Chitosan against Three Different Fungi Species News in Chemistry Biochemistry and Biotechnology State of the Art and Prospects of Development, 2010
Chitosan modified membranes for wound dressing applications: Preparations, characterization and Bio-evaluation Trends in Biomaterials and Artificial Organs, 2008
Antibacterial activity of chitosan chemically modified with new technique Trends in Biomaterials and Artificial Organs, 2008
RECENT SCHOLAR PUBLICATIONS
Smart Release of the Antioxidant from Chitosan-Hyaluronan Reservoir in Skin Wound Healing L Šoltés, TM Tamer, ME Hassan, M Mach, K Valachová Pharmaceutics , 2026 2026
Development of antioxidant-enhanced hyaluronan derivatives functionalized with cinnamaldehyde and pyrogallol-4-carboxaldehyde: Integrated experimental and in silico evaluation ME Hassan, TM Tamer, K Valachova, MA Hassan, A Ragab, L Soltes International Journal of Biological Macromolecules, 151423 , 2026 2026
Water soluble polyacrylamide-grafted carboxymethyl cellulose flocculant: Synthesis, characterization, and flocculation activity evaluation A Elkassas, MH Abd-El-Magied, SA Nosier, TM Tamer, MSM Eldin, ... Arabian Journal of Chemistry 19 , 2026 2026
Fabrication of bioactive gelatin boosted by vanillylideneacetone with enhanced antioxidant performance: in vitro, molecular docking, and pharmacokinetic studies TM Tamer, MA Hassan, A Ragab, R Yao, MS Mohy-Eldin, N Hassan, ... Materials Chemistry and Physics, 132202 , 2026 2026
Evaluation of novel multifunctional polymeric Schiff bases as anticorrosive agents for the medical grade 316L stainless steel A Hendy, J El-Nady, A Nour, SM Ali, TM Tamer, ASI Ahmed, ... RSC advances 16 (8), 6768-6785 , 2026 2026
Microencapsulation process: methods, properties, and applications ME Hassan, TM Tamer, K Valachová, L Šoltés Polymer Bulletin 82 (17), 11593-11624 , 2025 2025 Citations: 1
Enhancing antioxidant and antibacterial properties of gelatin: Modification with phloretin and 2-acetylphloroglucinol for advanced biomaterial applications MM Sabet, TM Tamer, RE Khalifa, M Shaalan, MA Hassan, ... Materials Chemistry and Physics, 131725 , 2025 2025 Citations: 1
Progress in hyaluronan-based nanoencapsulation systems for smart drug release and medical applications K Valachová, ME Hassan, TM Tamer, L Šoltés Molecules 30 (19), 3883 , 2025 2025 Citations: 6
Synthesis and characterization of functionalized chitosan coupled with phenolic aldehyde to thwart antibiotics-resistant bacteria with antioxidant and anti-inflammatory … TM Tamer, MA Hassan, MM Eltantawy, A Brussevich, A Nebalueva, ... International Journal of Biological Macromolecules, 146697 , 2025 2025 Citations: 5
Unveiling the antioxidant potential of new modified hyaluronan derivatives: Design, synthesis, characterization, antioxidant evaluation, and in-silico studies with molecular … ME Hassan, TM Tamer, K Valachová, A Ragab, L Šoltés International Journal of Biological Macromolecules 318, 145054 , 2025 2025 Citations: 6
Taro leaf inspired micro/nanocellulose-based hierarchical structural coating and its application on O/W separation and food preservation MM Rahman, L Zhu, R Yao, C Wang, TM Tamer, MA Habib, M Wu Carbohydrate Polymers 358, 123493 , 2025 2025 Citations: 9
Application of nanocellulose in solar photo/thermal energy conversion and electrochemical energy storage devices C Wang, L Zhu, X Wang, TM Tamer, R Yao, MM Rahman, L Zhang, M Wu Green Carbon , 2025 2025 Citations: 10
Enhancement of biological properties in casein protein through functionalization with cinnamaldehyde via Schiff base bonding: antibacterial and antioxidant effects A Hendy, N Hassan, J El-Nady, ASI Ahmed, RM Abou Shahba, TM Tamer RSC advances 15 (33), 27300-27310 , 2025 2025 Citations: 5
Dichromate Contaminated Water Treatment using Novel Crystal Violet Azo Dye-Sulphonated Poly (Glycidyl methacrylate) Nano-Composite Adsorbent TM Tamer, RE Khalifa, MM Abou-Krisha, AM Omer, AG Alhamzani, ... Water, Air, & Soil Pollution 236 (1), 35 , 2025 2025 Citations: 2
Crystal violet removal from waste water by sulfonated poly (glycidyl methacrylate) nano-adsorbent: optimization by response surface methodology, isotherms, kinetics, and … RE Khalifa, MM Abou-Krisha, AM Omer, AG Alhamzani, ME Youssef, ... Polymer Bulletin 82 (1), 165-196 , 2025 2025 Citations: 7
Advances in stimuli-responsive polymeric hydrogels for anticancer drug delivery: A review AM Omer, EM Abd El-Monaem, AS Eltaweil, TM Tamer, MSM Eldin, ... Journal of Drug Delivery Science and Technology 102, 106394 , 2024 2024 Citations: 23
Nano-Sulphonated Poly (glycidyl methacrylate)-Hexamethyl Pararosaniline chloride novel composite adsorbent development for treatment of dichromate and permanganate contaminated … T Tamer, M Abou-Krisha, A Omer, A Alhamzani, M Youssef, T Yousef, ... Adsorption 30 (6), 877-890 , 2024 2024 Citations: 4
Novel amino-ethyl carboxymethyl cellulose crosslinked ampholyte hydrogel development for Methyl orange removal from waste water AM Omer, WA Sadik, R Abbas, TM Tamer, MM Abd-Ellatif, MS Mohy-Eldin Scientific Reports 14 (1), 14701 , 2024 2024 Citations: 29
Development of novel vanillylidene acetonyl chitosan Schiff base using click chemistry: antibacterial and antioxidant characters TM Tamer, G Zhang, MS Mohy-Eldin, Z Su Polymer Bulletin 81 (9), 8489-8509 , 2024 2024 Citations: 7
Formulation of novel bioactive gelatin inspired by cinnamaldehyde for combating multi-drug resistant bacteria: Characterization, molecular docking, pharmacokinetic analyses … MA Hassan, S Abd El-Aziz, A Nabil-Adam, TM Tamer International Journal of Pharmaceutics 652, 123827 , 2024 2024 Citations: 23
MOST CITED SCHOLAR PUBLICATIONS
Hyaluronan and synovial joint: function, distribution and healing TM Tamer Interdiscip Toxicol 6 (3), 111–125 , 2013 2013 Citations: 464
Poly (vinyl alcohol)-alginate physically crosslinked hydrogel membranes for wound dressing applications: characterization and bio-evaluation EA Kamoun, ERS Kenawy, TM Tamer, MA El-Meligy, MSM Eldin Arabian Journal of Chemistry 8 (1), 38-47 , 2015 2015 Citations: 413
Preparation, physicochemical characterization and antimicrobial activities of novel two phenolic chitosan Schiff base derivatives MA Hassan, AM Omer, E Abbas, WMA Baset, TM Tamer Scientific reports 8 (1), 11416 , 2018 2018 Citations: 269
Fabrication of biodegradable gelatin/chitosan/cinnamaldehyde crosslinked membranes for antibacterial wound dressing applications E Kenawy, AM Omer, TM Tamer, MA Elmeligy, MSM Eldin International Journal of Biological Macromolecules 139, 440-448 , 2019 2019 Citations: 196
Co-encapsulation of Vitamin C and β-Carotene in liposomes: Storage stability, antioxidant activity, and in vitro gastrointestinal digestion X Liu, P Wang, YX Zou, ZG Luo, TM Tamer Food Research International 136, 109587 , 2020 2020 Citations: 184
Synthesis, characterization and antimicrobial evaluation of two aromatic chitosan Schiff base derivatives TM Tamer, MA Hassan, AM Omer, WMA Baset, ME Hassan, ... Process Biochemistry 51 (10), 1721-1730 , 2016 2016 Citations: 182
Green synthesis of platinum nanoparticles using Atriplex halimus leaves for potential antimicrobial, antioxidant, and catalytic applications AS Eltaweil, M Fawzy, M Hosny, EM Abd El-Monaem, TM Tamer, ... Arabian Journal of Chemistry 15 (1), 103517 , 2022 2022 Citations: 162
Hemostatic and antibacterial PVA/Kaolin composite sponges loaded with penicillin–streptomycin for wound dressing applications TM Tamer, MM Sabet, AM Omer, E Abbas, AI Eid, MS Mohy-Eldin, ... Scientific Reports 11 (1), 3428 , 2021 2021 Citations: 156
Antibacterial and antioxidative activity of O-amine functionalized chitosan TM Tamer, MA Hassan, AM Omer, K Valachová, MSM Eldin, MN Collins, ... Carbohydrate polymers 169, 441-450 , 2017 2017 Citations: 153
Antioxidant and antibacterial polyelectrolyte wound dressing based on chitosan/hyaluronan/phosphatidylcholine dihydroquercetin MA Hassan, TM Tamer, K Valachová, AM Omer, M El-Shafeey, MSM Eldin, ... International journal of biological macromolecules 166, 18-31 , 2021 2021 Citations: 150
Chitosan/hyaluronan/edaravone membranes for anti-inflammatory wound dressing: In vitro and in vivo evaluation studies TM Tamer, K Valachová, MA Hassan, AM Omer, M El-Shafeey, MSM Eldin, ... Materials Science and Engineering: C 90, 227-235 , 2018 2018 Citations: 142
Comprehensive insights into microbial keratinases and their implication in various biotechnological and industrial sectors: A review MA Hassan, D Abol-Fotouh, AM Omer, TM Tamer, E Abbas International journal of biological macromolecules 154, 567-583 , 2020 2020 Citations: 134
Evaluation of antimicrobial and antioxidant activities for cellulose acetate films incorporated with Rosemary and Aloe Vera essential oils GF El Fawal, AM Omer, TM Tamer Journal of food science and technology 56 (3), 1510-1518 , 2019 2019 Citations: 112
MitoQ loaded chitosan-hyaluronan composite membranes for wound healing TM Tamer, MN Collins, K Valachová, MA Hassan, AM Omer, ... Materials 11 (4), 569 , 2018 2018 Citations: 107
Development of amphoteric alginate/aminated chitosan coated microbeads for oral protein delivery AM Omer, TM Tamer, MA Hassan, P Rychter, MSM Eldin, N Koseva International journal of biological macromolecules 92, 362-370 , 2016 2016 Citations: 104
Insight into multidrug-resistant microorganisms from microbial infected diabetic foot ulcers MA Hassan, TM Tamer, AA Rageh, AM Abou-Zeid, EHF Abd El-Zaher, ... Diabetes & Metabolic Syndrome: Clinical Research & Reviews 13 (2), 1261-1270 , 2019 2019 Citations: 98
Antibacterial activity of chitosan chemically modified with new technique MSM Eldin, EA Soliman, AI Hashem, TM Tamer Trends Biomater Artif Organs 22 (3), 125-137 , 2008 2008 Citations: 97
Carboxymethyl cellulose/sericin-based hydrogels with intrinsic antibacterial, antioxidant, and anti-inflammatory properties promote re-epithelization of diabetic wounds in rats LM El-Samad, MA Hassan, AA Basha, S El-Ashram, EH Radwan, ... International journal of pharmaceutics 629, 122328 , 2022 2022 Citations: 95
Effects of octenyl succinic anhydride groups distribution on the storage and shear stability of Pickering emulsions formulated by modified rice starch PP Wang, ZG Luo, TM Tamer Carbohydrate Polymers 228, 115389 , 2020 2020 Citations: 93
Formulation of quaternized aminated chitosan nanoparticles for efficient encapsulation and slow release of curcumin AM Omer, ZM Ziora, TM Tamer, RE Khalifa, MA Hassan, MS Mohy-Eldin, ... Molecules 26 (2), 449 , 2021 2021 Citations: 89