Beatriz P. Nobre, PhD in chemical Engineering, (Instituto Superior Técnico, Universidade de Lisboa, Portugal). Post-Doc at Bioenergy Unit of LNEG (Lisbon, Portugal) 2008-2014. Post-Doct at CQE (IST, Lisbon Portugal), IBB (IST, Universidade de Lisboa) and UCIBIO (NOVA School of Science and Technology) 2015-2018. Auxiliary Researcher at CQE (IST, Universidade de Lisboa), from 2018.
Her research interest concerned the use of green solvents, i.e. supercritical fluids, pressurized liquids in chemical engineering processes: extraction and fractionation processes of bioactive compounds from non-edible biomass and industrial waste residues; particle engineering for the production of micro and nanoparticles of bioactives, APIs, catalysts and encapsulates; catalytic heterogeneous reactions using green routes.
EDUCATION
PhD, Chemical Engineering, Lsbon University (Insituto Superior Técnico), Lisbon, Portugal
RESEARCH, TEACHING, or OTHER INTERESTS
Chemical Engineering, Process Chemistry and Technology, Chemistry, Biomaterials
The Treatment of Natural Calcium Materials Using the Supercritical Antisolvent Method for CO2 Capture Applications Luís C. S. Nobre, Paula Teixeira, Carla I. C. Pinheiro, António M. F. Palavra, Mário J. F. Calvete, et al. Processes, 2024 The potential of the supercritical antisolvent micronization (SAS) technique was evaluated for the production of CaO-based particles with a size and a physical structure that could enable high performance for CO2 capture through the calcium looping process. Two sources of calcium derivative compounds were tested, waste marble powder (WMP) and dolomite. The SAS micronization of the derivate calcium acetate was carried out at 60 °C, 200 bar, a 0.5 mL min−1 flow rate of liquid solution, and 20 mg mL−1 concentration of solute, producing, with a yield of more than 70%, needle-like particles. Moreover, since dolomite presents with a mixture of calcium and magnesium carbonates, the influence of the magnesium fraction in the SAS micronization was also assessed. The micronized mixtures with lower magnesium content (higher calcium fraction) presented needle-like particles similar to WMP. On the other hand, for the higher magnesium fractions, the micronized material was similar to magnesium acetate micronization, presenting sphere-like particles. The use of the micronized material in the Ca-looping processes, considering 10 carbonation-calcination cycles under mild and realistic conditions, showed that under mild conditions, the micronized WMP improved CaO conversion. After 10 cycles the micronization, WMP presented a conversion 1.8 times greater than the unprocessed material. The micronized dolomite, under both mild and real conditions, maintained more stable conversion after 10 cycles.
Peroxidative Oxidation of Cyclohexane Using 3d Metal Complexes with Hydrazone-Derived Ligands as Catalysts: Exploring (Un)Conventional Conditions Nuno Reis Conceição, Beatriz P. Nobre, Atash V. Gurbanov, António M. F. Palavra, M. Fátima C. Guedes da Silva, et al. Inorganics, 2023 Two tetranuclear and two mononuclear Cu(II) complexes with arylhydrazones of malononitrile derived ligands (compounds 1–2 and 3–4, respectively), one trinuclear Co(II/III) complex with an arylhydrazone of acetoacetanilide (5) and one tetranuclear Zn(II) complex of 3-(2-carboxyphenyl-hydrazone)pentane-2,4-dione (6) were screened as potential catalysts in the peroxidative oxidation of cyclohexane by aqueous H2O2 in acetonitrile. The best results were attained in the presence of pyrazine-2-carboxylic acid (PCA) with 1 (26% yield, TON = 52.0) and with 2 (24%, TON = 48.0) after 4 h at 40 °C. In the presence of complexes 5 and 6, no oxygenated products were detected in the studied conditions. The employment of non-conventional conditions like supercritical carbon dioxide (scCO2) as reaction medium or microwave (MW) irradiation was assessed for complexes 1 and 2. After 6 h in acetonitrile–scCO2, at 50 °C and with HNO3 as promoter, only 17% yield was achieved using 1 as catalyst, and 21% using 2. Total yields of oxygenates up to 14 (with 1) and 13% (2) and TOFs of 56.0 and 52.0 h−1, respectively, were obtained working under MW irradiation at 70 °C and for the much shorter time of 0.5 h.
Extraction and bioprocessing with supercritical fluids José Coelho, Paolo Trucillo, Beatriz Nobre, António Figueiredo Palavra, Roberta Campardelli, et al. Physical Sciences Reviews, 2020 Supercritical fluid (SCF) technologies have emerged as a real alternative to various natural product extraction processes and pharmaceutical production to obtain micronized particles, coprecipitates, nanocomposite polymer structures and liposomes, in addition to other increasingly larger applications described in literature. In the present work, a brief literature review of the application of supercritical fluid extraction (SFE) is presented. This is evidenced by several publications and patents, contributions from several countries and the increase of industries around the world dedicated to this technique. Next, we aim to focus the analysis of SFE on a review of the literature applied to microalgae as a substitute primitive feedstock due to its high growth rate, valuable biologically active lipophilic substances, and photosynthetic efficiency without competition with food sources or needs of arable lands. We finally discussing an SCF bioprocess with a very new perspective for liposome production focalized on its potential at industrial scale.
Extraction of value-added compounds from microalgae S.P.M Ventura, B.P. Nobre, F. Ertekin, M. Hayes, M. Garciá-Vaquero, et al. Microalgae Based Biofuels and Bioproducts from Feedstock Cultivation to End Products, 2017
