Systemic Sclerosis-Associated ILD: Insights and Limitations of ScleroID Cristina Niță, Laura Groșeanu Diagnostics, 2026 Background/Objective: Pulmonary involvement in systemic sclerosis (SSc) is typically assessed using pulmonary function tests (PFTs), high-resolution CT (HRCT), and composite indices. Patient-reported outcomes (PRO), including ScleroID, provide insight into quality of life, but their relationship with clinical measures and role in overall disease assessment remain unclear. To assess the correlation between ScleroID scores and both lung involvement and disease activity/damage in a cohort of SSc-ILD patients from a large tertiary care center. Methods: Disease activity [European Scleroderma Study Group Activity Index (EScSG-AI), Scleroderma Clinical Trials Consortium Activity Index (SCTC-AI)], disease severity [Medsger severity scale (MSS)], and PRO measure ScleroID were assessed for associations with the extent and severity of SSc-ILD. Results: In 82 patients with SSc-ILD (mean age 56.0 ± 10.8 years; median disease duration 4.2 ± 4.7 years), higher fibrosis extent (>20%) was associated with worse lung function, greater exercise limitation, and higher ScleroID scores, particularly in fatigue, social life, and body mobility domains (all p ≤ 0.03). Patients with >20% fibrosis also had worse NYHA class and Borg scores during 6-MWD (p < 0.001). Cross-sectional correlations showed that ScleroID total and individual domains were negatively associated with FVC% and 6-MWD, and positively with ILD extent on HRCT. Fatigue, social impact, and mobility domains correlated most strongly with disease activity and severity scores, especially in patients with > 20% fibrosis (r = 0.384–0.635, all p ≤ 0.016), whereas breathlessness showed minimal associations (r < 0.2). Conclusions: In SSc-ILD, greater lung fibrosis and functional impairment are associated with worse patient-reported quality of life, particularly in fatigue, mobility, and social domains. ScleroID scores reflect both physiological severity and disease burden highlighting its value as a multidimensional outcome measure in patients with more advanced disease.
Link between alkali metals in salt templates and in electrolytes for improved carbon-based electrochemical capacitors Anetta Platek-Mielczarek, Cristina Nita, Camélia Matei Ghimbeu, Elzbieta Frackowiak, Krzysztof Fic ACS Applied Materials and Interfaces, 2021 Various alkali metal (Li+, Na+, K+, Rb+, and Cs+) chlorides with Pluronic F127 were used as a soft-salt template for tuning the textural and structural properties of carbon. Highly conductive metal hydroxide solutions, where the cations are the same as those in the salt template, have been used as electrolytes. By increasing the size of the cation in the template, the textural properties of carbon, such as the specific surface area, micropore volume, and pore size, were remarkably enhanced. It directly translates to an increase in the specific capacitance of the electrode material. For a constant current charge/discharge at 0.1 A g–1, the electrode composed of LiCl-T and operating with 1 mol L–1 LiOH demonstrates the capacitance of 124 F g–1, whereas CsCl-T with the same electrolyte has a capacitance of 216 F g–1. Moreover, the materials show the highest capacitance retention (up to 75%) vs. the current regime applied when the cation used during synthesis matches the cation present in the electrolyte (i.e., LiCl-T with LiOH). Interestingly, capacitance normalized by specific surface area has been found to be the highest when LiOH solution is applied as an electrolyte. Thus, for this metric, the size of ions seems to be a crucial parameter. The importance of mesoporosity is highlighted as well by using materials with a similar fraction of micropores and with or without mesopores. Briefly, the presence of mesopore fraction proved to be essential for improved capacity retention (69% vs. 30%). Besides textural properties, the graphitization degree impacts the electrochemical performance as well. It increases among the samples, in accordance with cation-π binding energy, e.g., LiCl-T is the most “graphitic-like” material and CsCl-T is the most disordered. Thus, the more graphitic-like materials demonstrate higher rate capability and cycle stability.
Understanding the Sn Loading Impact on the Performance of Mesoporous Carbon/Sn-Based Nanocomposites in Li-Ion Batteries Cristina Nita, Julien Fullenwarth, Laure Monconduit, Jean‐Marc Le Meins, Julien Parmentier, et al. Chemelectrochem, 2018 Herein, we report a systematic study to understand the influence of the amount of tin metal precursor salt on the formation of carbon/tin hybrid materials and their performances as anodes in Li‐ion batteries. Small Sn metallic particles (ca. 5 nm) covered by a SnO2 layer were uniformly dispersed in a mesoporous carbon for a low loading of tin; whereas, for higher Sn loadings, the formation of Sn‐based particles aggregates (ca. 200 nm) is promoted as well. By increasing the Sn loading from 20 to 80 %, the irreversible capacity was successfully reduced and the reversible capacity improved. This could be related to the decrease of the C/Sn hybrids specific surface area and the increase of the Sn active species. For long‐term cycling, capacity fading was observed, particularly for high Sn loadings assigned to the Sn nanoparticles placed outside the carbon network, which upon lithiation witness large volume expansion, leading to severe particle growth and agglomeration. Therefore, similar reversible capacities at long cycling are reached, no matter the Sn loading. For optimal electrochemical performances, it appears that a balance between the amount of Sn and uniform small Sn‐based particles dispersion within carbon matrix must be assured to design high‐performance anodes for Li‐ion batteries.