ARUN ARUN

@psgpharma.edu.in

ASSISTANT PROFESSOR & DEPARTMENT OF PHARMACEUTICAL ANALYSIS
PSG COLLEGE OF PHARMACY

ARUN ARUN


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https://researchid.co/arunyuvant

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmaceutical Science
2

Scopus Publications

16

Scholar Citations

2

Scholar h-index

1

Scholar i10-index

Scopus Publications

  • RP-HPLC and Ms Methods for Simultaneous Estimation of Arbutin and Quercetin from Origanum majorana
    N. T. Arun, A. Suganthi
    Journal of Natural Remedies, 2025
    Background: Arbutin (ARB) and quercetin (QUER) are two important phytoconstituents with proven anti-cancer effects. In vitro cytotoxic actions against a variety of tumor cell lines or antitumor-promoting properties have also been associated with extracts from Origanum majorana. Aim: To develop an easy, rapid, accurate, precise and reliable novel analytical method for the simultaneous estimation of quercetin and arbutin from Origanum majorana extracts and its marketed formulation. Method: The ideal chromatographic conditions for estimating arbutin and quercetin simultaneously using the RP-HPLC method are a stationary phase LichroCART C18 column (250mm × 4.0mm, 5μm), a mobile phase that contains 1% orthophosphoric acid and methanol in a 50:50% v/v ratio, a flow rate of 1 ml/min, ambient temperature operation, and a detection wavelength of 287 nm. The presence of arbutin and quercetin were qualitatively analyzed using mass spectroscopy. Results: The new RP-HPLC technique yielded a correlation value of 0.9999 and was demonstrated to be linear in the 0.5-2.5μg/ml range. Arbutin and quercetin were shown to have retention periods of 2.24 and 13.5 minutes, respectively. The amount of arbutin and quercetin in formulation were found to be 0.6484 μg and 0.1420 μg, respectively. The technique was validated using criteria such as specificity, accuracy, LOD, LOQ, precision, repeatability, stability, and system adaptability. Arbutin and quercetin were also confirmed to be present in the extract and formulation using mass spectroscopy (273 and 303 m/z values). Conclusion: Simple, fast, accurate, reliable, and economical, the suggested RP-HPLC and mass spectroscopy techniques are useful for consistently identifying arbutin and quercetin in both their prescription dose form and bulk. Major Findings: For arbutin and quercetin, the linearity was found to be between 0.5 and 2.5μg/ml, respectively. Among the extracts chloroform extract was found with separation of many components. The amount of arbutin and quercetin was determined to be 0.6484 μg and 0.1420 μg in the formulation.
  • Validated UV spectroscopic method for the quantitative determination of ubidecarenone
    K. Anandakumar, V. P. Sangeetha, V. Sindhuja, S. Sree Iswarya, J. Ramesh, N T. Arun, M. Raja
    Research Journal of Pharmacy and Technology, 2020
    A new, simple, precise, accurate, sensitive and reproducible UV spectroscopic method for the estimation of Ubidecarenone in bulk and in capsule formulation was developed and validated. Shimadzu AUX-220 Digital balance was used for weighing purpose, Perkin Elmer Double beam UV Visible Spectrophotometer with pair of 10mm matched quartz cells, pre-aligned Deuterium and halogen lamp as a light source and photodiode detector was used for the analysis. Ethanol was used as a solvent. The λmax was found to be 275nm. The drug obeyed Beer's law in the concentration range of 10–80μg/ml with correlation coefficient (r2) of 0.9996. The LOD and LOQ for the developed UV Spectroscopic method were found to be 0.0371μg/ml and 0.1125μg/ml, respectively. The amount of Ubidecarenone in the capsule formulation was found to be 98.78±1.3682. The percentage recovery was found to be in the range of 98.95–100.10 for Ubidecarenone. The % RSD was found to be 0.5190 ± 0.1722. The % RSD value for the intraday and inter day analysis of Ubidecarenone was found to be 0.3921 and 0.5268, respectively. The % RSD was found to be less than 2. The developed method was validated as per ICH guidelines. The percentage recovery obtained indicated that there is no interference due to the excipients used in the formulation. Hence the developed method was found to be accurate. The proposed method can be successfully applied for the routine quality control analysis of Ubidecarenone in bulk and in capsule formulation.

RECENT SCHOLAR PUBLICATIONS

  • RP-HPLC and Ms Methods for Simultaneous Estimation of Arbutin and Quercetin from Origanum majorana
    SA Arun NT
    Journal of Natural Remedies JNR 25 (Jan), 177-185 , 2025
    2025.0
    Citations: 1
  • DEVELOPMENT AND VALIDATION OF NOVEL GREEN ANALYTICAL SPECTROSCOPIC METHODS FOR SIMULTANEOUS ESTIMATION OF ARBUTIN AND QUERCETIN FROM ORIGANUM MAJORANA
    AS ARUN NT, M KARTHIKEYAN
    YMER 22 (12), 1366-1380 , 2022
    2022.0
  • Study of Various Factors impacting the Quality of Terminalia Chebula Fruit Rind Raw Material and Phytochemical Evaluation of Fruit, Fruit Rind and Nut Part of Terminalia Chebula
    SKDR Anandakumar Karunakaran1 , Sangeetha Premkumar1 , Ramesh Jayaprakash1 ...
    Phyto Chem & Bio Sub Journal 14 (2), 122-136 , 2020
    2020.0
  • Validated UV spectroscopic method for the quantitative determination of Ubidecarenone
    K Anandakumar, VP Sangeetha, V Sindhuja, SS Iswarya, J Ramesh, ...
    Research Journal of Pharmacy and Technology 13 (5), 2233-2237 , 2020
    2020.0
    Citations: 4
  • SIMULTANEOUS STANDARDIZATION OF ARBUTIN AND QUERCETIN FROM ORIGANUM MAJORANA BY NOVEL HPTLC TECHNIQUE
    TKR A SUGANTHI, ARUN NT
    American Journal of PharmTech Research 6 (6), 552-560 , 2016
    2016.0
  • SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL SCHIFF BASES OF CEPHALEXIN.
    NT Arun, B Gowramma
    International Journal of Pharmacy & Life Sciences , 2014
    2014.0
    Citations: 10
  • DEVELOPMENT AND VALIDATION OF NOVEL GREEN ANALYTICAL SPECTROSCOPIC METHODS FOR SIMULTANEOUS ESTIMATION OF ARBUTIN AND QUERCETIN FROM ORIGANUM MAJORANA
    NT Arun, M Karthikeyan, A Suganthi
    Citations: 1

MOST CITED SCHOLAR PUBLICATIONS

  • SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL SCHIFF BASES OF CEPHALEXIN.
    NT Arun, B Gowramma
    International Journal of Pharmacy & Life Sciences , 2014
    2014.0
    Citations: 10
  • Validated UV spectroscopic method for the quantitative determination of Ubidecarenone
    K Anandakumar, VP Sangeetha, V Sindhuja, SS Iswarya, J Ramesh, ...
    Research Journal of Pharmacy and Technology 13 (5), 2233-2237 , 2020
    2020.0
    Citations: 4
  • RP-HPLC and Ms Methods for Simultaneous Estimation of Arbutin and Quercetin from Origanum majorana
    SA Arun NT
    Journal of Natural Remedies JNR 25 (Jan), 177-185 , 2025
    2025.0
    Citations: 1
  • DEVELOPMENT AND VALIDATION OF NOVEL GREEN ANALYTICAL SPECTROSCOPIC METHODS FOR SIMULTANEOUS ESTIMATION OF ARBUTIN AND QUERCETIN FROM ORIGANUM MAJORANA
    NT Arun, M Karthikeyan, A Suganthi
    Citations: 1
  • DEVELOPMENT AND VALIDATION OF NOVEL GREEN ANALYTICAL SPECTROSCOPIC METHODS FOR SIMULTANEOUS ESTIMATION OF ARBUTIN AND QUERCETIN FROM ORIGANUM MAJORANA
    AS ARUN NT, M KARTHIKEYAN
    YMER 22 (12), 1366-1380 , 2022
    2022.0
  • Study of Various Factors impacting the Quality of Terminalia Chebula Fruit Rind Raw Material and Phytochemical Evaluation of Fruit, Fruit Rind and Nut Part of Terminalia Chebula
    SKDR Anandakumar Karunakaran1 , Sangeetha Premkumar1 , Ramesh Jayaprakash1 ...
    Phyto Chem & Bio Sub Journal 14 (2), 122-136 , 2020
    2020.0
  • SIMULTANEOUS STANDARDIZATION OF ARBUTIN AND QUERCETIN FROM ORIGANUM MAJORANA BY NOVEL HPTLC TECHNIQUE
    TKR A SUGANTHI, ARUN NT
    American Journal of PharmTech Research 6 (6), 552-560 , 2016
    2016.0