Kubra SOLAK

@atauni.edu.tr



                 

https://researchid.co/arbukkalos
6

Scopus Publications

Scopus Publications

  • Metal Nanoparticles for Simultaneous Use in AC Magnetic Field Hyperthermia and Magnetic Resonance Imaging
    Kübra Solak, Mustafa Atiş, Ahmet Emre Kasapoğlu, Adem Karaman, and Ahmet Mavi
    Wiley
    ABSTRACTMagnetic nanoparticles (MNPs) are produced for both diagnosis and treatment due to their simultaneous availability in magnetic resonance imaging (MRI) and magnetic hyperthermia (MHT). Extensive investigations focus on developing MNPs for individual MHT or MRI applications, but the development of MNPs for theragnostic applications has received very little attention. In this study, through efficient examination of synthesis conditions such as metal precursors, reaction parameters, and solvent choices, we aimed to optimize MNP production for effective utilization for MHT and MRI simultaneously. MNPs were synthesized by thermal decomposition under 17 different conditions and deeply characterized by transmission electron microscopy (TEM), x‐ray diffraction (XRD), and x‐ray photoelectron spectroscopy (XPS). The heating efficiency of MNPs under an alternating current (AC) magnetic field was quantified, while MRI performance was evaluated through agar phantom experiments. Our findings highlight the crucial role of benzyl ether in metal ion reduction and size control. Metal‐doped iron oxide MNPs displayed promise for MHT, whereas Mn‐doped iron oxide MNPs exhibited enhanced MRI capabilities. Consequently, five engineered MNPs were considered potential candidates for further studies, demonstrating their dual ability in MRI and MHT.

  • Heterologous Expression of Codon-Optimized Azurin Transferred by Magnetofection Method in MCF-10A Cells
    Saadet Kalakenger, Seyda Yildiz Arslan, Fatma Turhan, Melek Acar, Kubra Solak, Ahmet Mavi, and Yagmur Unver
    Springer Science and Business Media LLC

  • Design, physicochemical confirmation, single crystal structures as well as exploration of antibacterial and anticancer potential of organotin(IV) carboxylates
    Roshni Gul, Niaz Muhammad, Muhammad Sirajuddin, Awal Noor, Nikolay Tumanov, Johan Wouters, Abdelbasset Chafik, Kübra Solak, Ahmet Mavi, Shaukat Shujah,et al.
    Elsevier BV

  • Machine Learning-Assisted SERS Reveals the Biochemical Signature of Enhanced Protein Secretion from Surface-Modified Magnetic Nanoparticles
    Ibrahim Dagci, Kubra Solak, Nazli Oncer, Seyda Yildiz Arslan, Yagmur Unver, Mehmet Yilmaz, and Ahmet Mavi
    American Chemical Society (ACS)
    This study introduces a novel investigation of the interaction between Komagataella phaffii cells and iron oxide-based magnetic nanoparticles (Fe3O4 MNPs) via protein secretion and machine learning (ML)-assisted surface-enhanced Raman scattering (SERS). For the first time, we produced Fe3O4, Fe3O4@PEG, Fe3O4@PEI10kDa, and Fe3O4@PEI25kDa MNPs by a one-pot coprecipitation reaction. The addition of polymers to the reaction conditions significantly affected the shape, surface charge, size, and size distribution of the MNPs. The surface modification of MNPs is effectively accomplished using polyethylenimine (PEI), and the ζ-potential values of the MNPs exceed +25 mV under the NH4OH control. The homogeneity of MNPs synthesized with NH4OH is more pronounced according to transmission electron microscopy (TEM) pictures. All MNPs exhibited excellent immobilization efficiency (>92%) when we used 250 ppm Fe-containing MNP solutions. Smaller MNPs uniformly encapsulated the surface of K. phaffii cells, whereas larger MNPs exhibited irregular accumulation. K. phaffii cells exhibited excellent viability in all MNP solutions at up to 1000 ppm of Fe concentrations. Finally, the highest recombinant azurin protein secretion rate was obtained in Fe3O4@PEI10kDa MNP-immobilized cells (about 1.3 times). The ML-assisted SERS analysis revealed that MNP interactions with K. phaffii cells were mediated by proteins such as mannoproteins and membrane transporter proteins as well as N-acetylglucosamine (i.e., chitin). These findings revealed the effect of the size and surface properties of MNPs on the immobilization of K. phaffii cells and the enormous potential of magnetic immobilization for protein secretion.

  • Combination of magnetic hyperthermia and gene therapy for breast cancer
    Kubra Solak, Seyda Yildiz Arslan, Melek Acar, Fatma Turhan, Yagmur Unver, and Ahmet Mavi
    Springer Science and Business Media LLC

  • Sulfanilamide Modified Magnetic Nanoparticles for Purification of Carbonic Anhydrase from Bovine Blood
    Safinur Yıldırım Çelik, Kübra Solak, and Ahmet Mavi
    Springer Science and Business Media LLC

  • Comparative heating efficiency and cytotoxicity of magnetic silica nanoparticles for magnetic hyperthermia treatment on human breast cancer cells
    Melek Acar, Kubra Solak, Seyda Yildiz, Yagmur Unver, and Ahmet Mavi
    Springer Science and Business Media LLC

  • Electrically controlled mRNA delivery using a polypyrrole-graphene oxide hybrid film to promote osteogenic differentiation of human mesenchymal stem cells
    Huijung Kim, Kübra Solak, Yoojoong Han, Yeon-Woo Cho, Kyeong-Mo Koo, Chang-Dae Kim, Zhengtang Luo, Hyungbin Son, Hyung-Ryong Kim, Ahmet Mavi,et al.
    Springer Science and Business Media LLC

  • Synthesis, Characterization, Biological Activity and Molecular Docking Studies of Novel Organotin(IV) Carboxylates
    Niaz Muhammad, Mukhtar Ahmad, Muhammad Sirajuddin, Zafar Ali, Nikolay Tumanov, Johan Wouters, Abdelbasset Chafik, Kübra Solak, Ahmet Mavi, Shabbir Muhammad,et al.
    Frontiers Media SA
    Four new carboxylates complexes with general formula R2SnL2 and R3SnL, where R = n-butyl (1, 3), methyl (2, 4) and L = 4-Chlorophenoxyacetate, were synthesized in significant yields. FT-IR analysis revealed a chelating (1 and 2) and a bridging bidentate (3 and 4) coordination modes for the carboxylate ligand in solid state which was further confirmed by the single crystal X-ray analysis of complex 4. The NMR data (1H, 13C and 119Sn) revealed a higher coordination number around the tin center in R2SnL2 (1 and 2) compared to R3SnL (3 and 4). A close matching was observed between the experimental and calculated structures (obtained at B3LYP/6-31G* + LANL2DZ basis set). Quantum chemical analysis indicates that the carboxylate moiety has the major contribution in the formation of filled and unfilled orbitals as well as in ligand to ligand intramolecular charge transfer during the electronic transitions. The cytotoxicity data of the screened compounds evaluated against lung cancer cell line (A549) and normal lung fibroblast cell line (MRC-5) revealed that 1, 3 and 4 have shown dose dependent cytotoxic effects while HL and 2 have shown steady and low cytotoxic activities. The antibacterial activity of complexes 1–4 is higher than that of HL. Molecular docking study showed an intercalation binding mode for complex 3 with DNA (docking score = −3.6005) involving four polar interactions. Complex 3 docking with tubulin (PDB ID 1SA0) with colchicine as a target protein resulted in three polar interactions (docking score −5.2957). Further, the docking analysis of the HL and 1–4 has shown an adequate interactions with the coronavirus SARS-CoV-2 spike protein, nucleocapsid protein and human angiotensin converting enzyme (ACE2).

  • Magnetic nanoparticle mediated-gene delivery for simpler and more effective transformation ofPichia pastoris
    Seyda Yildiz, Kubra Solak, Melek Acar, Ahmet Mavi, and Yagmur Unver
    Royal Society of Chemistry (RSC)
    We describe a novel gene delivery method for Pichia pastoris by using magnetic nanoparticles under magnetic forces. This method that uses smaller amounts of DNA is very simple, effective and advanced equipment-free compared to traditional methods.



  • Plasma polymerized linalool (ppLin): An antimicrobial and biocompatible coating
    Kenan ÇAKMAK, Özkan BAYRAM, Kübra SOLAK, Güzin KABAN, Önder ŞİMŞEK, and Ahmet MAVİ
    The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS
    Bacterial infections in medical devices and drug resistance of bacteria can cause chaos in the world due to loss of lives in addition to the cost of device revisions, quarantine, disinfection of infected areas, and patient treatment. Antibacterial coatings of essential oils on medical devices can prevent bacterial attachment and reduce costs. Linalool is an antibacterial constituent of essential oils. Herein, we examine for the first time the fabrication and characterization of radio frequency (RF) plasma polymerized hydrophilic thin films from linalool (ppLin) by varying deposition parameters (RF power and deposition time) and the behavior of ppLin with two bacteria (Escherichia coli and Staphylococcus aureus) commonly related to microbial contamination of medical devices. While a dramatic reduction in E. coli and S. aureus attachment was observed on ppLin films, their hydrophilic surface was also bactericidal to S. aureus. Additionally, ppLin films were shown to be adherent and noncytotoxic to human fibroblast cells. ppLin can be potentially integrated into medical and other clinical devices as a promising low-cost biocompatible antimicrobial coating.

  • Plasma polymerized linalool (ppLin): An antimicrobial and biocompatible coating
    Kenan ÇAKMAK, Özkan BAYRAM, Kübra SOLAK, Güzin KABAN, Önder ŞİMŞEK, and Ahmet MAVİ
    The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS
    Bacterial infections in medical devices and drug resistance of bacteria can cause chaos in the world due to loss of lives in addition to the cost of device revisions, quarantine, disinfection of infected areas, and patient treatment. Antibacterial coatings of essential oils on medical devices can prevent bacterial attachment and reduce costs. Linalool is an antibacterial constituent of essential oils. Herein, we examine for the first time the fabrication and characterization of radio frequency (RF) plasma polymerized hydrophilic thin films from linalool (ppLin) by varying deposition parameters (RF power and deposition time) and the behavior of ppLin with two bacteria (Escherichia coli and Staphylococcus aureus) commonly related to microbial contamination of medical devices. While a dramatic reduction in E. coli and S. aureus attachment was observed on ppLin films, their hydrophilic surface was also bactericidal to S. aureus. Additionally, ppLin films were shown to be adherent and noncytotoxic to human fibroblast cells. ppLin can be potentially integrated into medical and other clinical devices as a promising low-cost biocompatible antimicrobial coating.

  • Curcumin on the “flying carpets” to modulate different signal transduction cascades in cancers: Next-generation approach to bridge translational gaps
    Hulya Celik, Tuba Aydin, Kubra Solak, Sumbul Khalid, and Ammad A. Farooqi
    Wiley
    ABSTRACTCurcumin, a bioactive and pharmacologically efficient component isolated from Curcuma longa has attracted considerable attention because of its ability to modulate diverse cellular and physiological pathways. WNT, TGF/SMAD, NOTCH, and SHH are fundamentally different signaling cascades, but their choreographed activation is strongly associated with cancer development and progression. In this review we have attempted to set spotlight on regulation of different cell signaling pathways by curcumin in different cancers. We partition this multi‐component review into in‐depth biological understanding of various signal transduction cascades and how curcumin targets intracellular signal transducers of deregulated pathways to inhibit cancer development and progression. Rapidly broadening landscape of both established and candidate oncogenic driver mutations identified in different cancers is a major stumbling block in the standardization of drugs having significant clinical outcome. Intra and inter‐tumor heterogeneity had leveraged the complexity of therapeutic challenges to another level. Multi‐pronged approach and molecularly guided treatments will be helpful in improving the clinical outcome.

  • Partial Purification and Some Interesting Properties of Glutathione Peroxidase from Liver of Camel (Camelus dromedarius)
    Abdelbasset Chafik, Abdelkhalid Essamadi, Safinur Yildirim Çelik, Kübra Solak, and Ahmet Mavi
    Pleiades Publishing Ltd

  • Nanomaterials and the microbial sphere
    Kübra Solak, Ahmet Mavi, Tülay Ergon, Alev Sezen, and Ömer Faruk Algur
    American Scientific Publishers