Sandra Regina Georgetti

Scopus Publications

Resolvin D2 Reduces UVB Skin Pathology by Targeting Cytokines, Oxidative Stress, and NF-κB Activation
Ingrid C. Pinto, Priscila Saito, Camilla C. A. Rodrigues, Renata M. Martinez, Cristina P. B. Melo, Maiara Piva, Clovis M. Kumagai, David L. Vale, Telma Saraiva-Santos, Allan J. C. Bussmann, Marcela M. Baracat, Sandra R. Georgetti, Fabiana T. M. C. Vicentini, Waldiceu A. Verri, Rubia Casagrande
Antioxidants, 2025
UVB skin pathology is initiated by reactive oxygen species (ROS), differentiating this condition from other inflammatory diseases involving first the immune cell activation by danger or pathogen molecular patterns followed by oxidative stress. Resolvin D2 (RvD2) has been found to reduce inflammation in preclinical models. However, whether or not RvD2 reduces skin pathology caused by UVB irradiation is not yet known. Therefore, the efficacy of RvD2 on skin pathology triggered by UVB irradiation in female hairless mice was assessed. RvD2 (0.3, 1 or 3 ng/mouse, i.p.) was found to protect the skin against UVB inflammation, as observed in the reduction in edema (46%), myeloperoxidase activity (77%), metalloproteinase-9 activity (39%), recruitment of neutrophils/macrophages (lysozyme+ cells, 76%) and mast cells (106%), epidermal thickening (93%), sunburn cell formation (68%), collagen fiber breakdown (55%), and production of cytokines such as TNF-α (100%). Considering the relevance of oxidative stress to UVB irradiation skin pathologies, an important observation was that the skin antioxidant capacity was recovered by RvD2 according to the results that show the ferric reducing antioxidant power (68%), cationic radical scavenges (93%), catalase activity (74%), and the levels of reduced glutathione (48%). Oxidative damage was also attenuated, as observed in the reduction in superoxide anion production (69%) and lipid hydroperoxides (71%). The RvD2 mechanism involved the inhibition of NF-κB activation, as observed in the diminished degradation of IκBα (48%) coupled with a reduction in its downstream targets that are involved in inflammation and oxidative stress, such as COX-2 (66%) and gp91phox (77%) mRNA expression. In conclusion, RvD2 mitigates the inflammatory and oxidative pathologic skin aggression that is triggered by UVB.
Patches containing quercetin microcapsules to ameliorate dermal herpes simplex virus injuries in mice
Jéssica Bassetto Carra, Maria Laura Goussain Darido, Camila Felix Vecchi, Mariana Carla de Oliveira, Ricardo Luís Nascimento de Matos, Pietra Mitiko Tateyama Pattini, Bianca Larissa Masquetti, Beatriz da Silva Tavares, Marcos Luciano Bruschi, Ana Paula Frederico Rodrigues Loureiro Bracarense, Renê Oliveira do Couto, Rubia Casagrande, Sandra Regina Georgetti, Waldiceu A. Verri, Ligia Carla Faccin Faccin-Galhardi, Marcela Maria Baracat
European Journal of Pharmaceutics and Biopharmaceutics, 2025
Bioadhesive Polymeric Films Containing Rhamnolipids, An Innovative Antimicrobial Topical Formulation
Jéssica B. Carra, Kamila B. B. Wessel, Giovana N. Pereira, Mariana C. Oliveira, Pietra M. T. Pattini, Bianca L. Masquetti, Ismael R. Amador, Marcos L. Bruschi, Rúbia Casagrande, Sandra R. Georgetti, Waldiceu A. Verri, Gerson Nakazato, Josiane A. Vignoli, Doumit Camilios-Neto, Marcela M. Baracat
AAPS Pharmscitech, 2024
Acne affects most of the world's population, causing an impact on the self-esteem of adolescents and young adults. One of the causes is the presence of the bacteria Cutibacterium acnes which are part of the natural microbiota of the skin. Topical treatments consist of anti-inflammatory and antibiotics, which could select resistant strains. Alternatives to the antibiotic are biocomposites that have antimicrobial activity like biosurfactants which are produced by bacteria. An innovative way of applying these compounds is bioadhesive polymeric films that adhere to the skin and release the active principle topically. Rhamnolipids have great potential to be used in the treatment of acne because they present antimicrobial activity against C. acnes in low and safe concentrations (MIC of 15.62 µg/mL, CBM of 31.25 µg/mL and CC50 of 181.93 µg/mL). Four films with different rhamnolipids concentrations (0.0; 0.1; 0.2; and 0.3%, w/w) were obtained as to visual appearance, mass variation, thickness, density, solubility, pH, water vapor transmission, mechanical properties (folding endurance, bioadhesion strength, tensile strength, elongation at break and Young's modulus), scanning electron microscopy and infrared. The results show that these formulations had a homogeneous appearance; elastic mechanical properties; pH similar to human skin and bioadhesive. The polymeric films containing rhamnolipids were effective against C. acnes, in the in vitro test, at the three concentrations tested, the film with the highest concentration (0.3%, w/w) being the most promising for presenting the highest antimicrobial activity. Thus, the polymeric film containing rhamnolipids has the potential to be used in the treatment of acne.
Resolvin D5 Protects Female Hairless Mouse Skin from Pathological Alterations Caused by UVB Irradiation
Priscila Saito, Ingrid C. Pinto, Camilla C. A. Rodrigues, Ricardo L. N. de Matos, David L. Vale, Cristina P. B. Melo, Victor Fattori, Telma Saraiva-Santos, Soraia Mendes-Pierotti, Mariana M. Bertozzi, Ana P. F. R. L. Bracarense, Josiane A. Vignoli, Marcela M. Baracat, Sandra R. Georgetti, Waldiceu A. Verri, Rubia Casagrande
Antioxidants, 2024
Resolvin D5 (RvD5) is a lipid mediator that has been reported to present anti-inflammatory and pro-resolution properties. Evidence also supports its capability to enhance reactive oxygen species (ROS) production during bacterial infections, which would be detrimental in diseases driven by ROS. The biological activity of RvD5 and mechanisms against UVB irradiation skin pathology have not been investigated so far. Female hairless mice were treated intraperitoneally with RvD5 before UVB stimulus. RvD5 reduced skin edema in a dose-dependent manner as well as oxidative stress by increasing antioxidants (endogenous tissue antioxidant scavenging of cationic radical, iron reduction, catalase activity and reduced glutathione levels) and decreasing pro-oxidants (superoxide anion and lipid peroxidation). RvD5 antioxidant activity was accompanied by enhancement of Nrf2, HO-1 and NQO1 mRNA expression. RvD5 reduced the production of IL-1β, TNF-α, TGF-β, and IL-10. RvD5 also reduced the inflammatory cell counts, including mast cells and neutrophils/macrophages. The reduction of oxidative stress and inflammation resulted in diminished matrix metalloproteinase 9 activity, collagen degradation, epidermal thickening and sunburn cell development. Therefore, this study demonstrates, to our knowledge, the first body of evidence that RvD5 can be used to treat UVB skin pathology and unveils, at least in part, its mechanisms of action.
Development of trans-Chalcone loaded pectin/casein biodegradable microcapsules: Efficacy improvement in the management of experimental colitis
Carla F.S. Guazelli, Victor Fattori, Barbara B. Colombo, Isabela S. Ludwig, Laisa G. Vicente, Renata M. Martinez, Sandra R. Georgetti, Alexandre Urbano, Rubia Casagrande, Marcela M. Baracat, Waldiceu A. Verri
International Journal of Pharmaceutics, 2023
Aspirin-Triggered Resolvin D1 (AT-RvD1) Protects Mouse Skin against UVB-Induced Inflammation and Oxidative Stress
Cristina P. B. Melo, Priscila Saito, Renata M. Martinez, Larissa Staurengo-Ferrari, Ingrid C. Pinto, Camilla C. A. Rodrigues, Stephanie Badaro-Garcia, Josiane A. Vignoli, Marcela M. Baracat, Allan J. C. Bussmann, Sandra R. Georgetti, Waldiceu A. Verri, Rubia Casagrande
Molecules, 2023
Intense exposure to UVB radiation incites excessive production of reactive oxygen species (ROS) and inflammation. The resolution of inflammation is an active process orchestrated by a family of lipid molecules that includes AT-RvD1, a specialized proresolving lipid mediator (SPM). AT-RvD1 is derived from omega-3, which presents anti-inflammatory activity and reduces oxidative stress markers. The present work aims to investigate the protective effect of AT-RvD1 on UVB-induced inflammation and oxidative stress in hairless mice. Animals were first treated with 30, 100, and 300 pg/animal AT-RvD1 (i.v.) and then exposed to UVB (4.14 J/cm2). The results showed that 300 pg/animal of AT-RvD1 could restrict skin edema, neutrophil and mast cell infiltration, COX-2 mRNA expression, cytokine release, and MMP-9 activity and restore skin antioxidant capacity as per FRAP and ABTS assays and control O2•− production, lipoperoxidation, epidermal thickening, and sunburn cells development. AT-RvD1 could reverse the UVB-induced downregulation of Nrf2 and its downstream targets GSH, catalase, and NOQ-1. Our results suggest that by upregulating the Nrf2 pathway, AT-RvD1 promotes the expression of ARE genes, restoring the skin’s natural antioxidant defense against UVB exposition to avoid oxidative stress, inflammation, and tissue damage.
Fermented (By Monascus purpureus or Aspergillus oryzae) and Non-Fermented Defatted Soybean Flour Extracts: Biological Insight and Mechanism Differences in Inflammatory Pain and Peritonitis
Marília F. Manchope, Mariana M. Bertozzi, Sergio M. Borghi, Cíntia L. Handa, Mariana A. Queiroz-Cancian, Camila R. Ferraz, Sandra S. Mizokami, Stephanie Badaró-Garcia, Ketlem C. Andrade, Tiago H. Zaninelli, Wilma A. Spinosa, Sandra R. Georgetti, Elza I. Ida, Waldiceu A. Verri, Rubia Casagrande
Fermentation, 2023
Background: Monascus purpureus and Aspergillus oryzae have been used to ferment defatted soybean flour (DSF: DSFF-Mp and DSSF-Ao, respectively) extract, improving antioxidant availability and conversion of the glycosylated isoflavones to aglycones. The aim of the present study was to evaluate the biological activity of fermented and non-fermented DSF extracts in pain and inflammation, which has not yet been explored. Methods: Phenolic compounds of extracts were determined. Non-fermented DSF (DSF-Non), DSFF-Mp, and DSFF-Ao (10–100 mg/kg) were administrated i.p., 30 min before i.pl. or i.p. carrageenan stimulus. Mechanical and thermal hyperalgesia, edema, histopathology, leukocyte recruitment, and oxidative stress in the paw tissue, and inflammatory cell recruitment, NFκB activation, and cytokine production were assessed in the peritoneum. Stomach and kidney toxicity were evaluated. Results: DSF-Non, DSFF-Mp, and DSFF-Ao extracts inhibited mechanical and thermal hyperalgesia, paw edema, histopathology, neutrophil recruitment, and oxidative stress, as well as inhibited peritoneal leukocyte recruitment. DSF-Non increased IL-10, and DSFF-Ao reduced IL-33 levels. DSFF-Mp increased IL-10 and reduced IL-33 production, and NFκB activation in CD45+ cells, without inducing toxicity. Conclusions: The present data reveal for the first time that fermented/non-fermented DSF extracts are analgesic and anti-inflammatory, showing differences in the mechanism of action depending on fungi applied for fermentation.
Therapeutic Potential of Controlled Delivery Systems in Asthma: Preclinical Development of Flavonoid-Based Treatments
Sergio M. Borghi, Tiago H. Zaninelli, Jéssica B. Carra, Olivia K. Heintz, Marcela M. Baracat, Sandra R. Georgetti, Fabiana T. M. C. Vicentini, Waldiceu A. Verri, Rubia Casagrande
Pharmaceutics, 2023
Asthma is a chronic disease with increasing prevalence and incidence, manifested by allergic inflammatory reactions, and is life-threatening for patients with severe disease. Repetitive challenges with the allergens and limitation of treatment efficacy greatly dampens successful management of asthma. The adverse events related to several drugs currently used, such as corticosteroids and β-agonists, and the low rigorous adherence to preconized protocols likely compromises a more assertive therapy. Flavonoids represent a class of natural compounds with extraordinary antioxidant and anti-inflammatory properties, with their potential benefits already demonstrated for several diseases, including asthma. Advanced technology has been used in the pharmaceutical field to improve the efficacy and safety of drugs. Notably, there is also an increasing interest for the application of these techniques using natural products as active molecules. Flavones, flavonols, flavanones, and chalcones are examples of flavonoid compounds that were tested in controlled delivery systems for asthma treatment, and which achieved better treatment results in comparison to their free forms. This review aims to provide a comprehensive understanding of the development of novel controlled delivery systems to enhance the therapeutic potential of flavonoids as active molecules for asthma treatment.
Spray-drying of casein/pectin bioconjugate microcapsules containing grape (Vitis labrusca) by-product extract
Jéssica Bassetto Carra, Ricardo Luís Nascimento de Matos, Ana Paula Novelli, Renê Oliveira do Couto, Fabio Yamashita, Marcos Alessandro dos Santos Ribeiro, Eduardo César Meurer, Waldiceu Aparecido Verri, Rubia Casagrande, Sandra Regina Georgetti, Nilton Syogo Arakawa, Marcela Maria Baracat
Food Chemistry, 2022
Novel microcapsules containing grape peel by-product extract were obtained. In this pursuit, complex coacervation of casein/pectin bioconjugate and spray-drying were combined. We have investigated the role of the dispersion feed rate (FR), drying air inlet temperature (IT) and drying air flow rate (AR) in the drying yield, microencapsulation efficiency, total polyphenols and anthocyanins contents, antioxidant activity, and morphology of the products. Also, the first-order degradation kinetics of the phytochemicals for both the extract and dried microcapsules was assessed and compared. The loss on the phytochemicals during spray-drying was attenuated in up to 88%, and the IT was the main factor affecting the particle properties. The polyphenols on the extract interacted with the polymers, influencing the assemble of the bioconjugate and the particle's features. Such microencapsulation strategy enhanced the thermal stability of the phytochemicals and rendered biocompatible and biodegradable products of which the nutraceutical and cosmeceutical application may have potential.
Pimenta pseudocaryophyllus (Gomes) Landrum extract inhibits inflammatory pain in mice: targeting neutrophil recruitment, oxidative stress, and cytokine production
Marília F. Manchope, Sandra S. Mizokami, Camila R. Ferraz, Sergio M. Borghi, Josiane A. Vignoli, Doumit Camilios-Neto, Nilton S. Arakawa, Sandra R. Georgetti, Waldiceu A. Verri, Rubia Casagrande
Natural Product Research, 2022
Pimenta pseudocaryophyllus (Gomes) Landrum is a Brazilian native plant. The mechanisms by which it promotes analgesia are unknown. We demonstrated the analgesic effect of P. pseudocaryophyllus dried extract (3 mg/kg; i.p.) in the following models of inflammatory pain (maximal inhibition): phenyl-p-benzoquinone (89%), formalin (72% - 1st phase and 96% - 2nd phase for flinches, and 50% - 1st phase and 71% - 2nd phase for licking behavior), complete Freund's adjuvant (95% - flinches and 33% - licking behavior), and carrageenin (56% - mechanical and 85% - thermal hyperalgesia) without motor impairment. Its analgesic effect depends on inhibiting neutrophil recruitment (95% - histopathology, 83% - myeloperoxidase activity, and 80% - LysM-eGFP mice), oxidative stress (86% - GSH and 98% - superoxide anion), and cytokine production (35% - IL-33, 80% - TNF-α, and 95% - IL-1β). The present study advances in understanding the analgesic mechanisms of P. pseudocaryophyllus.
Hydroethanolic Extract of Grape Peel from Vitis labrusca Winemaking Waste: Antinociceptive and Anti-Inflammatory Activities
Cristiana F. G. Silva, Victor Fattori, Caroline R. Tonetti, Marcos A. S. Ribeiro, Ricardo L. N. Matos, Jéssica B. Carra, Eduardo C. Meurer, Elisa Y. Hirooka, Janice A. Rafael, Sandra R. Georgetti, Marcela M. Baracat, Waldiceu A. Verri Jr, Nilton S. Arakawa
Food Technology and Biotechnology, 2022
Rosmarinus officinalis extract-loaded emulgel prevents UVB irradiation damage to the skin
KÁTIA S. TAKAYAMA, MARIANA C. MONTEIRO, PRISCILA SAITO, INGRID C. PINTO, CLAUDIA T. NAKANO, RENATA M. MARTINEZ, DOUGLAS V. THOMAZ, WALDICEU A. VERRI JR, MARCELA M. BARACAT, NILTON S. ARAKAWA, HELENA M. RUSSO, MARIA L. ZERAIK, RUBIA CASAGRANDE, RENÊ O. DO COUTO, SANDRA R. GEORGETTI
Anais Da Academia Brasileira De Ciencias, 2022
Protection against UVB deleterious skin effects in a mouse model: effect of a topical emulsion containing Cordia verbenacea extract
Cristina P. B. Melo, Priscila Saito, David L. Vale, Camilla C. A. Rodrigues, Ingrid C. Pinto, Renata M. Martinez, Julia R. Bezerra, Marcela M. Baracat, Waldiceu A. Verri, Yris Maria Fonseca-Bazzo, Sandra R. Georgetti, Rubia Casagrande
Photochemical and Photobiological Sciences, 2021
Protective effect of oral treatment with Cordia verbenacea extract against UVB irradiation deleterious effects in the skin of hairless mouse
Cristina P.B. Melo, Priscila Saito, David L. Vale, Camilla C.A. Rodrigues, Ingrid C. Pinto, Renata M. Martinez, Julia Rojo Bezerra, Marcela M. Baracat, Waldiceu A. Verri, Yris Maria Fonseca-Bazzo, Sandra R. Georgetti, Rubia Casagrande
Journal of Photochemistry and Photobiology B Biology, 2021
A topical formulation containing quercetin-loaded microcapsules protects against oxidative and inflammatory skin alterations triggered by UVB irradiation: enhancement of activity by microencapsulation
David L. Vale, Renata M. Martinez, Daniela C. Medeiros, Camila da Rocha, Natália Sfeir, Renata F. V. Lopez, Fabiana T. M. C. Vicentini, Waldiceu A. Verri, Sandra R. Georgetti, Marcela M. Baracat, Rúbia Casagrande
Journal of Drug Targeting, 2021
Topical Administration of 15-Deoxy-Δ12,14-Prostaglandin J2 Using a Nonionic Cream: Effect on UVB-Induced Skin Oxidative, Inflammatory, and Histopathological Modifications in Mice
Clovis M. Kumagai, Renata M. Martinez, Barbara B. Colombo, Priscila Saito, Ingrid C. Pinto, Camilla C. A. Rodrigues, David L. Vale, Ricardo L. N. Matos, Ana P. F. R. L. Bracarense, Marcela M. Baracat, Sandra R. Georgetti, Juliana T. Clemente-Napimoga, Marcelo H. Napimoga, Victor Fattori, Waldiceu A. Verri, Rúbia Casagrande
Mediators of Inflammation, 2021
Analgesic activity and mechanism of action of a Beta vulgaris dye enriched in betalains in inflammatory models in mice
Renata M. Martinez, Miriam S. Hohmann, Daniela T. Longhi-Balbinot, Ana C. Zarpelon, Marcela M. Baracat, Sandra R. Georgetti, Fabiana T. M. C. Vicentini, Rogério Côrte Sassonia, Waldiceu A. Verri, Rubia Casagrande
Inflammopharmacology, 2020
The lipoxin receptor/FPR2 agonist BML-111 protects mouse skin against ultraviolet B radiation
Renata M. Martinez, Victor Fattori, Priscila Saito, Ingrid C. Pinto, Camilla C. A. Rodrigues, Cristina P. B. Melo, Allan J. C. Bussmann, Larissa Staurengo-Ferrari, Julia Rojo Bezerra, Josiane A. Vignoli, Marcela M. Baracat, Sandra R. Georgetti, Waldiceu A Verri Jr., Rubia Casagrande
Molecules, 2020
Prevention of uvb radiation-induced oxidative stress in mice by topical administration of azadirachta indica (Neem) extract
Renata Micheli Martinez, Clara Ruiza de Souza, Cristina de Paula Barros de Melo, Marcela Maria Baracat, Nilton Syogo Arakawa, José Carlos Duarte, Waldiceu Aparecido Verri, Rúbia Casagrande, Sandra Regina Georgetti
Revista De Ciencias Farmaceuticas Basica E Aplicada, 2020
Treatment with maresin 1, a docosahexaenoic acid-derived pro-resolution lipid, protects skin from inflammation and oxidative stress caused by UVB irradiation
Talita L. C. Cezar, Renata M. Martinez, Camila da Rocha, Cristina P. B. Melo, David L. Vale, Sergio M. Borghi, Victor Fattori, Josiane A. Vignoli, Doumit Camilios-Neto, Marcela M. Baracat, Sandra R. Georgetti, Waldiceu A. Verri, Rubia Casagrande
Scientific Reports, 2019
Parameters of the fermentation of soybean flour by Monascus purpureus or Aspergillus oryzae on the production of bioactive compounds and antioxidant activity
Cíntia Ladeira Handa, Fernando Sanches de Lima, Marcela Fernanda Geton Guelfi, Meg da Silva Fernandes, Sandra Regina Georgetti, Elza Iouko Ida
Food Chemistry, 2019
Preclinical Evaluation of Rutin-Loaded Microparticles with an Enhanced Analgesic Effect
Daniela Cristina de Medeiros, Sandra Satie Mizokami, Natalia Sfeir, Sandra Regina Georgetti, Alexandre Urbano, Rubia Casagrande, Waldiceu A. Verri, Marcela Maria Baracat
ACS Omega, 2019
Production of hydrolysate of okara protein concentrate with high antioxidant capacity and aglycone isoflavone content
Vitória Ribeiro Garcia de Figueiredo, Ariana Justus, Dafne Garcia Pereira, Sandra Regina Georgetti, Elza Iouko Ida, Louise Emy Kurozawa
Brazilian Archives of Biology and Technology, 2019
Validation of methodology for assay, pharmaceutical equivalence, and comparative dissolution profile for tablets containing amlodipine besylate
R. M. Martinez, Jenifer Freitas da Silva, L. R. Jorge, Rhye Lessa Ishikawa, Ana Paula Novelli, Tálita, Laiane Cardoso Cezar, S. R. Georgetti, M. Baracat, R. Casagrande
Journal of Applied Pharmaceutical Science, 2019
Topical emulsion containing pyrrolidine dithiocarbamate: effectiveness against ultraviolet B irradiation-induced injury of hairless mouse skin
Renata M. Martinez, Ana L. M. Ivan, David L. Vale, Marcela Z. Campanini, Vitor S. Ferreira, Vinicius S. Steffen, Fabiana T. M. C. Vicentini, Fernanda M. P. Vilela, Maria J. V. Fonseca, Marcela M. Baracat, Sandra R. Georgetti, Waldiceu A. Verri, Rúbia Casagrande
Journal of Pharmacy and Pharmacology, 2018
The Lipid Mediator Resolvin D1 Reduces the Skin Inflammation and Oxidative Stress Induced by UV Irradiation in Hairless Mice
Priscila Saito, Cristina P. B. Melo, Renata M. Martinez, Victor Fattori, Talita L. C. Cezar, Ingrid C. Pinto, Allan J. C. Bussmann, Josiane A. Vignoli, Sandra R. Georgetti, Marcela M. Baracat, Waldiceu A. Verri, Rubia Casagrande
Frontiers in Pharmacology, 2018
Optimization of ultrasound-assisted extraction of grape-seed oil to enhance process yield and minimize free radical formation
Bruna R Böger, Aroldo Salviato, Daniel F Valezi, Eduardo Di Mauro, Sandra R Georgetti, Louise E Kurozawa
Journal of the Science of Food and Agriculture, 2018
Lipoxin A4 inhibits UV radiation-induced skin inflammation and oxidative stress in mice
R.M. Martinez, V. Fattori, P. Saito, C.B.P. Melo, S.M. Borghi, I.C. Pinto, A.J.C. Bussmann, M.M. Baracat, S.R. Georgetti, W.A. Verri, R. Casagrande
Journal of Dermatological Science, 2018
Quercetin attenuates zymosan-induced arthritis in mice
Carla F.S. Guazelli, Larissa Staurengo-Ferrari, Ana C. Zarpelon, Felipe A. Pinho-Ribeiro, Kenji W. Ruiz-Miyazawa, Fabiana T.M.C. Vicentini, Josiane A. Vignoli, Doumit Camilios-Neto, Sandra R. Georgetti, Marcela M. Baracat, Rubia Casagrande, Waldiceu A. Verri
Biomedicine and Pharmacotherapy, 2018
Microencapsulation of grape seed oil by spray drying
Bruna Raquel BÖGER, Sandra Regina GEORGETTI, Louise Emy KUROZAWA
Food Science and Technology Brazil, 2018
Trans-chalcone added in topical formulation inhibits skin inflammation and oxidative stress in a model of ultraviolet B radiation skin damage in hairless mice
Renata M. Martinez, Felipe A. Pinho-Ribeiro, David L. Vale, Vinicius S. Steffen, Fabiana T.M.C. Vicentini, Josiane A. Vignoli, Marcela M. Baracat, Sandra R. Georgetti, Waldiceu A. Verri, Rubia Casagrande
Journal of Photochemistry and Photobiology B Biology, 2017
Trans -Chalcone, a flavonoid precursor, inhibits UV-induced skin inflammation and oxidative stress in mice by targeting NADPH oxidase and cytokine production
Renata M. Martinez, Felipe A. Pinho-Ribeiro, Vinicius S. Steffen, Carla V. Caviglione, Victor Fattori, Allan J. C. Bussmann, Carolina Bottura, Maria J. V. Fonseca, Josiane A. Vignoli, Marcela M. Baracat, Sandra R. Georgetti, Waldiceu A. Verri, Rubia Casagrande
Photochemical and Photobiological Sciences, 2017
Resveratrol-Loaded Liquid-Crystalline System Inhibits UVB-Induced Skin Inflammation and Oxidative Stress in Mice
Andressa T. Fujimura, Renata M. Martinez, Felipe A. Pinho-Ribeiro, Amélia M. Lopes Dias da Silva, Marcela M. Baracat, Sandra R. Georgetti, Waldiceu A. Verri, Marlus Chorilli, Rubia Casagrande
Journal of Natural Products, 2016
Multi-response optimisation of the extraction solvent system for phenolics and antioxidant activities from fermented soy flour using a simplex-centroid design
Cíntia Ladeira Handa, Fernando Sanches de Lima, Marcela Fernanda Geton Guelfi, Sandra Regina Georgetti, Elza Iouko Ida
Food Chemistry, 2016
Influence of the degree of hydrolysis and type of enzyme on antioxidant activity of okara protein hydrolysates
Melissa Ferreira SBROGGIO, Marina Silveira MONTILHA, Vitória Ribeiro Garcia de FIGUEIREDO, Sandra Regina GEORGETTI, Louise Emy KUROZAWA
Food Science and Technology Brazil, 2016
Naringenin inhibits superoxide anion-induced inflammatory pain: Role of oxidative stress, cytokines, Nrf-2 and the no-cGMP-PKG-KATP channel signaling pathway
Marília F. Manchope, Cássia Calixto-Campos, Letícia Coelho-Silva, Ana C. Zarpelon, Felipe A. Pinho-Ribeiro, Sandra R. Georgetti, Marcela M. Baracat, Rúbia Casagrande, Waldiceu A. Verri
Plos One, 2016
Topical formulation containing naringenin: Efficacy against ultraviolet B irradiation-induced skin inflammation and oxidative stress in mice
Renata M. Martinez, Felipe A. Pinho-Ribeiro, Vinicius S. Steffen, Thais C. C. Silva, Carla V. Caviglione, Carolina Bottura, Maria J. V. Fonseca, Fabiana T. M. C. Vicentini, Josiane A. Vignoli, Marcela M. Baracat, Sandra R. Georgetti, Waldiceu A. Verri, Rubia Casagrande
Plos One, 2016
Antinociceptive Effect of Tephrosia sinapou Extract in the Acetic Acid, Phenyl-p-benzoquinone, Formalin, and Complete Freund's Adjuvant Models of Overt Pain-Like Behavior in Mice
Renata M. Martinez, Ana C. Zarpelon, Talita P. Domiciano, Sandra R. Georgetti, Marcela M. Baracat, Isabel C. Moreira, Cesar C. Andrei, Waldiceu A. Verri, Rubia Casagrande
Scientifica, 2016
Topical formulation containing hesperidin methyl chalcone inhibits skin oxidative stress and inflammation induced by ultraviolet B irradiation
Renata M. Martinez, Felipe A. Pinho-Ribeiro, Vinicius S. Steffen, Carla V. Caviglione, Danilo Pala, Marcela M. Baracat, Sandra R. Georgetti, Waldiceu A. Verri, Rubia Casagrande
Photochemical and Photobiological Sciences, 2016
Vanillic Acid Inhibits Inflammatory Pain by Inhibiting Neutrophil Recruitment, Oxidative Stress, Cytokine Production, and NFκB Activation in Mice
Cássia Calixto-Campos, Thacyana T. Carvalho, Miriam S. N. Hohmann, Felipe A. Pinho-Ribeiro, Victor Fattori, Marília F. Manchope, Ana C. Zarpelon, Marcela M. Baracat, Sandra R. Georgetti, Rubia Casagrande, Waldiceu A. Verri
Journal of Natural Products, 2015
Naringenin Inhibits UVB Irradiation-Induced Inflammation and Oxidative Stress in the Skin of Hairless Mice
Renata M. Martinez, Felipe A. Pinho-Ribeiro, Vinicius S. Steffen, Carla V. Caviglione, Josiane A. Vignoli, Décio S. Barbosa, Marcela M. Baracat, Sandra R. Georgetti, Waldiceu A. Verri, Rubia Casagrande
Journal of Natural Products, 2015
Hesperidin methyl chalcone inhibits oxidative stress and inflammation in a mouse model of ultraviolet B irradiation-induced skin damage
Renata M. Martinez, Felipe A. Pinho-Ribeiro, Vinicius S. Steffen, Carla V. Caviglione, Josiane A. Vignoli, Marcela M. Baracat, Sandra R. Georgetti, Waldiceu A. Verri, Rubia Casagrande
Journal of Photochemistry and Photobiology B Biology, 2015
Anti-inflammatory activity of betalain-rich dye of Beta vulgaris: Effect on edema, leukocyte recruitment, superoxide anion and cytokine production
Renata M. Martinez, Daniela T. Longhi-Balbinot, Ana C. Zarpelon, Larissa Staurengo-Ferrari, Marcela M. Baracat, Sandra R. Georgetti, Rogério C. Sassonia, Waldiceu A. Verri, Rubia Casagrande
Archives of Pharmacal Research, 2015
Pyrrolidine dithiocarbamate inhibits UVB-induced skin inflammation and oxidative stress in hairless mice and exhibits antioxidant activity in vitro
Ana L.M. Ivan, Marcela Z. Campanini, Renata M. Martinez, Vitor S. Ferreira, Vinicius S. Steffen, Fabiana T.M.C. Vicentini, Fernanda M.P. Vilela, Frederico S. Martins, Ana C. Zarpelon, Thiago M. Cunha, Maria J.V. Fonseca, Marcela M. Baracat, Sandra R. Georgetti, Waldiceu A. Verri, Rúbia Casagrande
Journal of Photochemistry and Photobiology B Biology, 2014
Optimisation of soy flour fermentation parameters to produce β-glucosidase for bioconversion into aglycones
C.L. Handa, U.R. Couto, A.H. Vicensoti, S.R. Georgetti, E.I. Ida
Food Chemistry, 2014
The ruthenium nitric oxide donor, [Ru(HEDTA)NO], inhibits acute nociception in mice by modulating oxidative stress, cytokine production and activating the cGMP/PKG/ATP-sensitive potassium channel signaling pathway
Larissa Staurengo-Ferrari, Sandra S. Mizokami, Victor Fattori, Jean J. Silva, Patrícia G. Zanichelli, Sandra R. Georgetti, Marcela M. Baracat, Luiz G. da França, Wander R. Pavanelli, Rubia Casagrande, Waldiceu A. Verri
Naunyn Schmiedeberg S Archives of Pharmacology, 2014
Topical formulations containing pimenta pseudocaryophyllus extract: In vitro antioxidant activity and in vivo efficacy against UV-B-induced oxidative stress
Marcela Z. Campanini, Dayana L. Custódio, Ana L. M. Ivan, Sarah M. Martins, Maria J. R. Paranzini, Renata M. Martinez, Waldiceu A. Verri, Fabiana T. M. C. Vicentini, Nilton S. Arakawa, Terezinha de J. Faria, Marcela M. Baracat, Rúbia Casagrande, Sandra R. Georgetti
AAPS Pharmscitech, 2014
Tephrosia sinapou ethyl acetate extract inhibits inflammatory pain in mice: Opioid receptor dependent inhibition of TNFα and IL-1β production
Renata M. Martinez, Ana C. Zarpelon, Renato D. R. Cardoso, Fabiana T. M. C. Vicentini, Sandra R. Georgetti, Marcela M. Baracat, Cesar C. Andrei, Isabel C. Moreira, Waldiceu A. Verri, Rubia Casagrande
Pharmaceutical Biology, 2013
Protective effect of fermented soybean dried extracts against tpa-induced oxidative stress in hairless mice skin
Sandra R. Georgetti, Rúbia Casagrande, Fabiana T. M. C. Vicentini, Marcela M. Baracat, Waldiceu A. Verri, Maria J. V. Fonseca
Biomed Research International, 2013
Quercetin-loaded microcapsules ameliorate experimental colitis in mice by anti-inflammatory and antioxidant mechanisms
Carla F. S. Guazelli, Victor Fattori, Barbara B. Colombo, Sandra R. Georgetti, Fabiana T. M. C. Vicentini, Rubia Casagrande, Marcela M. Baracat, Waldiceu A. Verri
Journal of Natural Products, 2013
The ruthenium NO donor, [Ru(bpy)2(NO)SO3](PF 6), inhibits inflammatory pain: Involvement of TRPV1 and cGMP/PKG/ATP-sensitive potassium channel signaling pathway
Larissa Staurengo-Ferrari, Sandra S. Mizokami, Jean J. Silva, Francisco O.N. da Silva, Eduardo H.S. Sousa, Luiz G. da França, Mariana L. Matuoka, Sandra R. Georgetti, Marcela M. Baracat, Rubia Casagrande, Wander R. Pavanelli, Waldiceu A. Verri
Pharmacology Biochemistry and Behavior, 2013
Efficacy of topical formulations containing Pimenta pseudocaryophyllus extract against UVB-induced oxidative stress and inflammation in hairless mice
Marcela Z. Campanini, Felipe A. Pinho-Ribeiro, Ana L.M. Ivan, Vitor S. Ferreira, Fernanda M.P. Vilela, Fabiana T.M.C. Vicentini, Renata M. Martinez, Ana C. Zarpelon, Maria J.V. Fonseca, Terezinha J. Faria, Marcela M. Baracat, Waldiceu A. Verri, Sandra R. Georgetti, Rúbia Casagrande
Journal of Photochemistry and Photobiology B Biology, 2013
Preparation and characterization of microcapsules based on biodegradable polymers: Pectin/casein complex for controlled drug release systems
Marcela M. Baracat, Adriana M. Nakagawa, Rúbia Casagrande, Sandra R. Georgetti, Waldiceu A. Verri, Osvaldo de Freitas
AAPS Pharmscitech, 2012
Flavonoids as anti-inflammatory and analgesic drugs: Mechanisms of action and perspectives in the development of pharmaceutical forms
Waldiceu A. Verri, Fabiana T. M. C. Vicentini, Marcela M. Baracat, Sandra R. Georgetti, Renato D. R. Cardoso, et al.
Studies in Natural Products Chemistry, 2012
Tephrosia sinapou extract reduces inflammatory leukocyte recruitment in mice: Effect on oxidative stress, nitric oxide and cytokine production
Renata M. Martinez, Ana C. Zarpelon, Vanessa V. M. Zimermann, Sandra R. Georgetti, Marcela M. Baracat, Maria J. V. Fonseca, Fabiana T. M. C. Vicentini, Isabel C. Moreira, Cesar C. Andrei, Waldiceu A. Verri Jr, Rubia Casagrande
Revista Brasileira De Farmacognosia, 2012
Quercetin reduces inflammatory pain: Inhibition of oxidative stress and cytokine production
Daniel A. Valério, Sandra R. Georgetti, Danilo A. Magro, Rubia Casagrande, Thiago M. Cunha, Fabiana T. M. C. Vicentini, Silvio M. Vieira, Maria J. V. Fonseca, Sergio H. Ferreira, Fernando Q. Cunha, Waldiceu A. Verri
Journal of Natural Products, 2009
Quality evaluation of manipulated and industrialized simvastatin formulations
Latin American Journal of Pharmacy, 2009
Assessment of in vitro methodologies to determine topical and transdermal delivery of the flavonoid quercetin
Fabiana Testa Moura de Carvalho Vicentini, Sandra Regina Georgetti, Maria Vitória Lopes Badra Bentley, Maria José Vieira Fonseca
Brazilian Journal of Pharmaceutical Sciences, 2009
Antioxidant activity and physical-chemical properties of spray and spouted bed dried extracts of Bauhinia forficata
Claudia Regina Fernandes Souza, Sandra Regina Georgetti, Marcos José Salvador, Maria José Vieira Fonseca, Wanderley Pereira Oliveira
Brazilian Journal of Pharmaceutical Sciences, 2009
Enhanced in vitro and in vivo antioxidant activity and mobilization of free phenolic compounds of soybean flour fermented with different β-glucosidase-producing fungi
S.R. Georgetti, F.T.M.C. Vicentini, C.Y. Yokoyama, M.F. Borin, A.C.C. Spadaro, M.J.V. Fonseca
Journal of Applied Microbiology, 2009
Method validation and stability study of quercetin in topical emulsions
Rúbia Casagrande, Marcela M. Baracat, Sandra R. Georgetti, Waldiceu A. Verri Jr, Fabiana T. M. C. Vicentini, Janice A. Rafael, José R. Jabor, Maria J. V. Fonseca
Quimica Nova, 2009
Quercetin in lyotropic liquid crystalline formulations: Physical, chemical and functional stability
Fabiana T. M. C. Vicentini, Rúbia Casagrande, Waldiceu A. Verri, Sandra R. Georgetti, M. Vitória L. B. Bentley, Maria J. V. Fonseca
AAPS Pharmscitech, 2008
Evaluation of the antioxidant activity as an additional parameter to attain the functional quality of natural extracts
Latin American Journal of Pharmacy, 2008
Evaluation of in vivo efficacy of topical formulations containing soybean extract
Sandra. R. Georgetti, Rúbia Casagrande, Waldiceu. A. Verri, Renata F.V. Lopez, Maria J.V. Fonseca
International Journal of Pharmaceutics, 2008
Spray drying of the soybean extract: Effects on chemical properties and antioxidant activity
Sandra Regina Georgetti, Rúbia Casagrande, Cláudia Regina Fernandes Souza, Wanderley Pereira Oliveira, Maria José Vieira Fonseca
Lwt, 2008
Influence of vehicle on antioxidant activity of quercetin: A liquid crystalline formulation
Latin American Journal of Pharmacy, 2007
Assessment of the antioxidant activity of two plant extracts containing isoflavonoids by different in vitro methods
Latin American Journal of Pharmacy, 2007
In vitro evaluation of quercetin cutaneous absorption from topical formulations and its functional stability by antioxidant activity
Rúbia Casagrande, Sandra R. Georgetti, Waldiceu A. Verri, Maria F. Borin, Renata F.V. Lopez, Maria J.V. Fonseca
International Journal of Pharmaceutics, 2007
Validation of HPLC, DPPH• and nitrosation methods for mesalamine determination in pharmaceutical dosage forms
Janice Aparecida Rafael, José Roberto Jabor, Rúbia Casagrande, Sandra Regina Georgetti, Maria de Fátima Borin, Maria José Vieira Fonseca
Revista Brasileira De Ciencias Farmaceuticas Brazilian Journal of Pharmaceutical Sciences, 2007
Photostability of quercetin under exposure to UV irradiation
Latin American Journal of Pharmacy, 2007
Evaluation of the antioxidant activity of soybean extract by different in vitro methods and investigation of this activity after its incorporation in topical formulations
S GEORGETTI, R CASAGRANDE, F MOURADECARVALHOVICENTINI, W VERRIJR, M FONSECA
European Journal of Pharmaceutics and Biopharmaceutics, 2006
Protective effect of topical formulations containing quercetin against UVB-induced oxidative stress in hairless mice
Rúbia Casagrande, Sandra R. Georgetti, Waldiceu A. Verri, Daniel J. Dorta, Antônio C. dos Santos, Maria J.V. Fonseca
Journal of Photochemistry and Photobiology B Biology, 2006
Evaluation of functional stability of quercetin as a raw material and in different topical formulations by its antilipoperoxidative activity
Rúbia Casagrande, Sandra R. Georgetti, Waldiceu A. Verri, José R. Jabor, Antonio C. Santos, Maria J. V. Fonseca
AAPS Pharmscitech, 2006
Assessment of the antioxidant activities of Brazilian extracts of propolis alone and in topical pharmaceutical formulations
Franciane D. Marquele, Valéria M. Di Mambro, Sandra R. Georgetti, Rúbia Casagrande, Yara M.L. Valim, Maria José V. Fonseca
Journal of Pharmaceutical and Biomedical Analysis, 2005
Evaluation of the antioxidant activity of different flavonoids by the chemiluminescence method
AAPS Journal, 2003
Evaluation of the antioxidant activity of different flavonoids by the chemiluminescence method
Sandra R. Georgetti, Rúbia Casagrande, Valéria M. Di Mambro, Ana ECS Azzolini, Maria JV. Fonseca
AAPS Pharmsci, 2003

Sandra Regina Georgetti

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