Non-Invasive Prenatal Testing (NIPT): A Paradigm Shift in Prenatal Care Ram K. Garg, Yogesh Kumar, Ram Niwas, Jitendra Singh International Journal of Preventive Medicine, 2025 Prenatal screening has undergone a profound transformation with the emergence of Non-Invasive Prenatal Testing (NIPT), a technology that analyzes cell-free fetal DNA (cffDNA) in maternal blood to detect common chromosomal abnormalities. Compared to traditional biochemical and ultrasound-based screening, NIPT offers markedly higher accuracy, earlier detection, and reduced procedural risk, representing a true paradigm shift in prenatal care. This narrative review synthesizes current evidence on the clinical performance, technological evolution, and ethical implications of NIPT within modern obstetric practice. Findings indicate that NIPT demonstrates exceptional sensitivity and specificity for trisomy 21, with strong performance for trisomy’s 18 and 13 and promising application to sex chromosome aneuploidies. Its adoption has led to a significant reduction in invasive diagnostic procedures such as amniocentesis, thereby enhancing maternal safety and psychological comfort. Recent advancements—including SNP-based and fragmentomics-enhanced sequencing, artificial intelligence integration, and combined screening approaches—have further expanded NIPT’s precision and potential scope. However, challenges persist regarding test accessibility, cost-effectiveness, and the interpretation of complex results from expanded panels. Beyond its clinical and technological merits, the review underscores the importance of addressing ethical, legal, and social concerns such as informed consent, privacy protection, and equitable access, particularly as direct-to-consumer models emerge. Ultimately, NIPT stands as a transformative innovation in reproductive medicine, offering a safer and more individualized approach to prenatal screening. Its continued success will depend on the establishment of robust ethical frameworks and equitable implementation strategies to ensure that advances in genetic technology translate into meaningful and responsible improvements in maternal–fetal care.
Nurse-Led Strategies to Enhance Medication Adherence in Older Patients after Hospital Discharge Upendra Sharma Udayashankar Sulibele, Jitendra Singh, Ravindra Salud Ciencia Y Tecnologia, 2023 A los adultos mayores hospitalizados que reciben el alta se les suelen administrar diversos fármacos. Sin embargo, muchos sólo toman aproximadamente la mitad de sus medicamentos y muchos interrumpen el tratamiento. Las estrategias de enfermería podrían mejorar la adherencia a la medicación en este grupo. El objetivo de esta investigación es evaluar la eficacia de las estrategias de cuidados de transición dirigidas por enfermeras tras el alta hospitalaria de pacientes de edad avanzada frente a los cuidados habituales para mejorar los procesos cognitivos, el rendimiento físico, los signos de depresión y estrés, las percepciones de apoyo social, la satisfacción del paciente y los costes asociados al uso de servicios médicos entre pacientes de edad avanzada con múltiples enfermedades crónicas y signos de depresión. Se utilizaron tres centros de Ontario (Canadá) para una investigación controlada aleatoria pragmática en varios centros. Las personas fueron asignadas aleatoriamente a un grupo de intervención o a un grupo de control (atención normal). 127 personas mayores de 65 años fueron dadas de alta del hospital con varias enfermedades crónicas y signos de depresión. A lo largo de seis meses, una enfermera diplomada proporcionó atención individualizada mediante seguimiento por teléfono móvil, visitas a domicilio y ayuda para la navegación por dispositivos como parte de una intervención basada en pruebas y centrada en el paciente. El principal resultado fue un cambio en el rendimiento cognitivo entre el primer y el sexto mes. Las alteraciones en el rendimiento físico, los síntomas de depresión, el estrés y el apoyo social percibido, la satisfacción del paciente y el coste del uso de la atención sanitaria fueron resultados secundarios medidos desde el inicio hasta los seis meses. Se utilizó el modelo ANCOVA para el análisis por intención de tratar.
RECENT SCHOLAR PUBLICATIONS
EFFECTIVENESS OF PULMONARY INTERVENTIONS ON HEALTH-RELATED QUALITY OF LIFE AND CLINICAL OUTCOMES IN COPD PATIENTS: AN INTEGRATIVE REVIEW M 1Prof. Jitendra Singh Research Scholar, Teerthanker Mahaveer University ... JOURNAL OF APPLIED BIOANALYSIS 11 (Special Issue 2-(2025)), 1399-1404 , 2025 2025.0
Bridging the gap: Ensuring equitable access to healthcare services for cardiovascular diseases prevention RK Garg, J Singh, Y Kumar, R Niwas Journal of the Practice of Cardiovascular Sciences 11 (02), 131-138 , 2025 2025.0 Citations: 3
Concept Analysis: Effectiveness of Pulmonary Interventions Package on Health-Related Quality of Life and Clinical Outcomes among COPD Patients in Selected Hospitals PDSPS Jitendra Singh1* Journal of Neonatal Surgery 14 (32s(2025)), 1433-1436 , 2025 2025.0
The impact of organised educational campaigns on understanding of needle sticks injuries and related post-exposure HIV/AIDS prophylaxis RK Garg, Y Kumar, R Niwas, J Singh Journal: Journal of Family Medicine and Primary Care 14 (1), 395-400 , 2025 2025.0 Citations: 2
Non‑invasive prenatal testing (NIPT): A paradigm shift in prenatal care RK Garg, R Niwas, J Singh International Journal of Preventive Medicine 16 , 2025 2025.0 Citations: 1
TEMPERATURE SCANNER DSP Subashini, PJ Singh IN Patent 440060-001 , 2024 2024.0
A PERSONALIZED HEALTH CARE MONITORING FOR DIABETIC PATIENT BY GIS BM Mudhol, J Singh IN Patent App. 202411029661 A , 2024 2024.0
Biomedical waste management and its awareness among registered nurses working in different hospitals, Uttar Pradesh PJ Singh, MM Kumar, PDM Jasline Journal: International Journal of Scientific Research 13 (08) , 2024 2024.0
Effectiveness of Interactional ECG program on knowledge regarding interpretation of Normal and Abnormal ECG among nursing students J Singh, M Dasyal International Journal of Creative Research Thoughts (IJCRT) 12 (11), 845-848 , 2024 2024.0
Virtual autism among children: A leading hazard of gadget exposure and preventive measures RK Garg, P Garg, P Sharma, Y Kumar, R Niwas, J Singh, S Singh Journal of Education and Health Promotion 13 (1), 76 , 2024 2024.0 Citations: 10
Beyond Medications: Non-Pharmacological Approaches in Cancer Care RK Garg, P Garg, B Sharma, Y Kumar, R Niwas, J Singh International Research Journal of Multidisciplinary Scope 5 (1), 417-420 , 2024 2024.0 Citations: 2
Evaluate the Effectiveness of Demonstration in Terms of Knowledge and Practice Regarding Basic Life Support among Policemen in Selected Police Station of Moradabad Uttar Pradesh J Singh South Asian Research Journal of Nursing and Healthcare (SARJNHC) 5 (3), 40-47 , 2023 2023.0
A study to assess the effectiveness of an awareness programme on knowledge and attitude regarding multi drug resistant-tuberculosis (MDR-TB) among tuberculosis patients … MN Fatima, MJ Singh European Chemical Bulletin (Eur. Chem. Bull.) 12 (10), 2716-2725 , 2023 2023.0
A study to assess the effectiveness of an educational programme on knowledge and attitude regarding cardiac rehabilitation among patients with coronary artery disease in … J Singh International Journal of Multidisciplinary Educational Research (IJMER) 11 … , 2022 2022.0
Does Quality Nursing Care Affects the Patient Satisfaction S Kumar, M Jasline, Himanshi, J Singh International Journal of Research in Medical Surgical Nursing 4 (1), 1-9 , 2022 2022.0
A Study to Evaluate the Effectiveness of Structured Teaching Programme on Knowledge Regarding Breathing Exercises among Asthmatic Clients in Selected Hospital of Moradabad R John, M Jasline, J Singh INTERNATIONAL JOURNAL 10 (10), 47-51 , 2021 2021.0
Screening of colocasia genotypes for natural occurrence and reactions against leaf blight GP Nag, HC Nanda, J Singh, A Kerketta, V Ramteke, B Kumar IJCS 8 (3), 2830-2832 , 2020 2020.0
Study of the relationship between dependent and independent yield and its traits in colocasia (Colocasia esculenta var. antiquoroum (L.) Schott) GP Nag, HC Nanda, J Singh, RR Saxena Journal of Pharmacognosy and Phytochemistry 9 (3), 2202-2205 , 2020 2020.0
THE INDIAN JOURNAL OF COMMERCE A Lawrence, G Simon, A Saxena, M Dhingra, N Goyal, J Singh, A Wagh, ...
Effectiveness of an awareness Programme on knowledge regarding early recognition of stroke among General Public: Moradabad V Singh¹, JSM Jasline
MOST CITED SCHOLAR PUBLICATIONS
Virtual autism among children: A leading hazard of gadget exposure and preventive measures RK Garg, P Garg, P Sharma, Y Kumar, R Niwas, J Singh, S Singh Journal of Education and Health Promotion 13 (1), 76 , 2024 2024.0 Citations: 10
Bridging the gap: Ensuring equitable access to healthcare services for cardiovascular diseases prevention RK Garg, J Singh, Y Kumar, R Niwas Journal of the Practice of Cardiovascular Sciences 11 (02), 131-138 , 2025 2025.0 Citations: 3
The impact of organised educational campaigns on understanding of needle sticks injuries and related post-exposure HIV/AIDS prophylaxis RK Garg, Y Kumar, R Niwas, J Singh Journal: Journal of Family Medicine and Primary Care 14 (1), 395-400 , 2025 2025.0 Citations: 2
Beyond Medications: Non-Pharmacological Approaches in Cancer Care RK Garg, P Garg, B Sharma, Y Kumar, R Niwas, J Singh International Research Journal of Multidisciplinary Scope 5 (1), 417-420 , 2024 2024.0 Citations: 2
Non‑invasive prenatal testing (NIPT): A paradigm shift in prenatal care RK Garg, R Niwas, J Singh International Journal of Preventive Medicine 16 , 2025 2025.0 Citations: 1
EFFECTIVENESS OF PULMONARY INTERVENTIONS ON HEALTH-RELATED QUALITY OF LIFE AND CLINICAL OUTCOMES IN COPD PATIENTS: AN INTEGRATIVE REVIEW M 1Prof. Jitendra Singh Research Scholar, Teerthanker Mahaveer University ... JOURNAL OF APPLIED BIOANALYSIS 11 (Special Issue 2-(2025)), 1399-1404 , 2025 2025.0
Concept Analysis: Effectiveness of Pulmonary Interventions Package on Health-Related Quality of Life and Clinical Outcomes among COPD Patients in Selected Hospitals PDSPS Jitendra Singh1* Journal of Neonatal Surgery 14 (32s(2025)), 1433-1436 , 2025 2025.0
TEMPERATURE SCANNER DSP Subashini, PJ Singh IN Patent 440060-001 , 2024 2024.0
A PERSONALIZED HEALTH CARE MONITORING FOR DIABETIC PATIENT BY GIS BM Mudhol, J Singh IN Patent App. 202411029661 A , 2024 2024.0
Biomedical waste management and its awareness among registered nurses working in different hospitals, Uttar Pradesh PJ Singh, MM Kumar, PDM Jasline Journal: International Journal of Scientific Research 13 (08) , 2024 2024.0
Effectiveness of Interactional ECG program on knowledge regarding interpretation of Normal and Abnormal ECG among nursing students J Singh, M Dasyal International Journal of Creative Research Thoughts (IJCRT) 12 (11), 845-848 , 2024 2024.0
Evaluate the Effectiveness of Demonstration in Terms of Knowledge and Practice Regarding Basic Life Support among Policemen in Selected Police Station of Moradabad Uttar Pradesh J Singh South Asian Research Journal of Nursing and Healthcare (SARJNHC) 5 (3), 40-47 , 2023 2023.0
A study to assess the effectiveness of an awareness programme on knowledge and attitude regarding multi drug resistant-tuberculosis (MDR-TB) among tuberculosis patients … MN Fatima, MJ Singh European Chemical Bulletin (Eur. Chem. Bull.) 12 (10), 2716-2725 , 2023 2023.0
A study to assess the effectiveness of an educational programme on knowledge and attitude regarding cardiac rehabilitation among patients with coronary artery disease in … J Singh International Journal of Multidisciplinary Educational Research (IJMER) 11 … , 2022 2022.0
Does Quality Nursing Care Affects the Patient Satisfaction S Kumar, M Jasline, Himanshi, J Singh International Journal of Research in Medical Surgical Nursing 4 (1), 1-9 , 2022 2022.0
A Study to Evaluate the Effectiveness of Structured Teaching Programme on Knowledge Regarding Breathing Exercises among Asthmatic Clients in Selected Hospital of Moradabad R John, M Jasline, J Singh INTERNATIONAL JOURNAL 10 (10), 47-51 , 2021 2021.0
Screening of colocasia genotypes for natural occurrence and reactions against leaf blight GP Nag, HC Nanda, J Singh, A Kerketta, V Ramteke, B Kumar IJCS 8 (3), 2830-2832 , 2020 2020.0
Study of the relationship between dependent and independent yield and its traits in colocasia (Colocasia esculenta var. antiquoroum (L.) Schott) GP Nag, HC Nanda, J Singh, RR Saxena Journal of Pharmacognosy and Phytochemistry 9 (3), 2202-2205 , 2020 2020.0
THE INDIAN JOURNAL OF COMMERCE A Lawrence, G Simon, A Saxena, M Dhingra, N Goyal, J Singh, A Wagh, ...
Effectiveness of an awareness Programme on knowledge regarding early recognition of stroke among General Public: Moradabad V Singh¹, JSM Jasline
