Vaishali Shinde
@unipune.ac.in
Professor and Deprtment of Chemistry
Savitribai Phule Pune University
RESEARCH, TEACHING, or OTHER INTERESTS
Organic Chemistry, Polymers and Plastics, Materials Chemistry, General Chemistry
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Kamlesh Lodha, Deepak Wavhal, Namdeo Bhujbal, Priyanka Mazire, Sneha Bhujbal, Ashlesha Korde, Kamini Bagul, Amit Roy, Rohan Meshram, and Vaishali Shinde
Elsevier BV
Kamlesh K. Lodha, Deepak S. Wavhal, Sujit B. Bhalekar, Rohan J. Meshram, and Vaishali S. Shinde
Wiley
AbstractThe P2Y12 receptor is the major target for antithrombic drugs which plays a key role in platelet activation. New derivatives of 4,5,6,7‐tetrahydrothieno[3,2‐c]pyridine (THP) were designed targeting P2Y12 receptor. An efficient route was developed for synthesis of THP derivatives and subsequently evaluated for their antiplatelet agglutination activity. Amongst the synthesized THP derivatives (4 a–4 g), the compounds 4 a and 4 g displayed significant activity (with 88.25 and 70.17 % inhibition) as compared to other analogs and comparable with that of the reference drugs, aspirin and prasugrel. Data extracted from computational chemistry techniques such as molecular docking, provided the structural rationale for the observed platelet agglutination inhibition by the newly synthesized tetrahydrothienopyridine analogs. We proposed the involvement of residues such as Cys‐194 in the formation of the covalent adduct with the active metabolite of tetrahydrothienopyridine derivatives. This study also put forward the possibility of the existence of an alternate pathway for metabolizing the tetrahydrothienopyridine compounds. The structural data presented in this study is expected to accelerate the research on developing a tetrahydrothienopyridine scaffold as an effective antithrombotic therapeutic modality.
Rajendra Patil, Jagdish Chavan, Shivnath Patel, Vaishali Shinde, and Anil Beldar
Institute of Chemistry
A green and efficient method for the multicomponent synthesis of 3,4-dihydropyrimidin-2(1H)-ones and -thiones using acetic acid supported on activated charcoal as a mild acid catalyst in ethanol under both conventional as well as microwave irradiation conditions has been developed. The catalyst system found more efficient under microwave irradiation conditions than conventional conditions with shorter reaction times and excellent yields.
Anuja S. Kulkarni, Savita R. Tapase, Kisan M. Kodam, and Vaishali S. Shinde
Elsevier BV
Vaishali S. Shinde, Pravin P. Lawande, Vyankat A. Sontakke, and Ayesha Khan
Elsevier BV
Anuja S. Kulkarni, Deepanjali D. Gurav, Ayesha A. Khan, and Vaishali S. Shinde
Elsevier BV
M P Raghav Rao, Tukaram D Urmode, and Vaishali S Shinde
IOP Publishing
Phenol-crotonaldehyde-resorcinol (PCR) resins were synthesized by base-catalyzed condensation reaction of phenol, crotonaldehyde, and resorcinol. Three different bases utilized for condensation reaction were sodium hydroxide, hexamethylenetetramine (hexa) and liquid ammonia. The NaOH catalyzed resins were found to be thermoplastic in nature, while hexa- and liq. NH3 catalyzed resins showed thermoset behavior. Effect of varying mole ratio of phenol, crotonaldehyde and resorcinol was studied to investigate the curing and thermoset behavior of the synthesized resins. The average molecular weight of the resins was determined by gel permeation chromatography (GPC). All synthesized resins were characterized by various analytical techniques such as FT-IR, NMR, TGA, DSC and FE-SEM/EDX.
Rajendra V. Patil, Jagdish U. Chavan, Dipak S. Dalal, Vaishali S. Shinde, and Anil G. Beldar
American Chemical Society (ACS)
The Biginelli product, dihydropyrimidinone (DHPM) core, and its derivatives are of immense biological importance. There are several methods reported as modifications to the original Biginelli reaction. Among them, many involve the use of different catalysts. Also, among the advancements that have been made to the Biginelli reaction, improvements in product yields, less hazardous reaction conditions, and simplified isolation of products from the reaction predominate. Recently, solid-phase synthetic protocols have attracted the research community for improved yields, simplified product purification, recyclability of the solid support, which forms a special economic approach for Biginelli reaction. The present Review highlights the role of polymer-supported catalysts in Biginelli reaction, which may involve organic, inorganic, or hybrid polymers as support for catalysts. A few of the schemes involve magnetically recoverable catalysts where work up provides green approach relative to traditional methods. Some research groups used polymer-catalyst nanocomposites and polymer-supported ionic liquids as catalyst. Solvent-free, an ultrasound or microwave-assisted Biginelli reactions with polymer-supported catalysts are also reported.
Dhiraj A. Jamdade, Dishantsingh Rajpali, Komal A. Joshi, Rohini Kitture, Anuja S. Kulkarni, Vaishali S. Shinde, Jayesh Bellare, Kaushik R. Babiya, and Sougata Ghosh
Hindawi Limited
Rapid, eco-friendly, and cost-effective one-pot synthesis of copper nanoparticles is reported here using medicinal plants like Gnidia glauca and Plumbago zeylanica. Aqueous extracts of flower, leaf, and stem of G. glauca and leaves of P. zeylanica were prepared which could effectively reduce Cu2+ ions to CuNPs within 5 h at 100°C which were further characterized using UV-visible spectroscopy, field emission scanning electron microscopy, high-resolution transmission electron microscopy, energy dispersive spectroscopy, dynamic light scattering, X-ray diffraction, and Fourier-transform infrared spectroscopy. Further, the CuNPs were checked for antidiabetic activity using porcine pancreatic α-amylase and α-glucosidase inhibition followed by evaluation of mechanism using circular dichroism spectroscopy. CuNPs were found to be predominantly spherical in nature with a diameter ranging from 1 to 5 nm. The phenolics and flavonoids in the extracts might play a critical role in the synthesis and stabilization process. Significant change in the peak at ∼1095 cm−1 corresponding to C-O-C bond in ether was observed. CuNPs could inhibit porcine pancreatic α-amylase up to 30% to 50%, while they exhibited a more significant inhibition of α-glucosidase from 70% to 88%. The mechanism of enzyme inhibition was attributed due to the conformational change owing to drastic alteration of secondary structure by CuNPs. This is the first study of its kind that provides a strong scientific rationale that phytogenic CuNPs synthesized using G. glauca and P. zeylanica can be considered to develop candidate antidiabetic nanomedicine.
Pravin P. Lawande, Vyankat A. Sontakke, Navanath M. Kumbhar, Tanay R. Bhagwat, Sougata Ghosh, and Vaishali S. Shinde
Elsevier BV
Tukaram D. Urmode, Monali A. Dawange, Vaishali S. Shinde, and Radhika S. Kusurkar
Elsevier BV
Anant B. Kanagare, K. K. Singh, M. Kumar, M. Yadav, R. Ruhela, A. K. Singh, A. Kumar, and V. S. Shinde
American Chemical Society (ACS)
DTDGA-extractant-impregnated XAD-16 polymeric beads (DTGA–XAD-16) were synthesized and evaluated for the separation of gold from electronic waste solutions. Batch sorption studies were carried out to understand the effects of various physical parameters on the recovery of gold from aqueous media. These synthesized beads were characterized by various techniques, namely, FTIR spectroscopy, optical microscopy, SEM, and TGA, to gain insight into the composition and morphology of the beads. Kinetics measurements showed that an equilibration time of about 180 min was sufficient to remove the saturation amount of gold from the solution. Further, various kinetic modeling analyses of the extraction results were carried out using pseudo-first-order, pseudo-second-order, and intraparticle-diffusion equations, and the corresponding rate constants were determined. The maximum experimental sorption capacity of the beads was found to be ∼35 mg g–1. The equilibrium sorption data were fitted to different isotherm models a...
Anant B. Kanagare, K.K. Singh, K.K. Bairwa, R. Ruhela, V.S. Shinde, M. Kumar, and A.K. Singh
Elsevier BV
Deepanjali D. Gurav, Anuja S. Kulkarni, Ayesha Khan, and Vaishali S. Shinde
Elsevier BV
Dattatraya Ukale, Vaishali S. Shinde, and Tuomas Lönnberg
Wiley
AbstractThe base‐pairing properties of 5‐mercuricytosine have been explored at the monomer level by NMR titrations and at the oligonucleotide level by melting temperature measurements. The NMR studies revealed a relatively high affinity for guanine, hypoxanthine, and uridine, that is, bases that are deprotonated upon coordination of HgII. Within an oligonucleotide duplex, 5‐mercuricytosine formed HgII‐mediated base pairs with thymine and guanine. In the former case, the duplex formed was as stable as the respective duplex comprising solely Watson–Crick base pairs. Based on detailed thermodynamic analysis of the melting curves, the stabilization by the HgII‐mediated base pairs may be attributed to a comparatively low entropic penalty of hybridization.
Shashikant B. Bhorkade, Kishor B. Gavhane, and Vaishali S. Shinde
Elsevier BV
Vyankat A. Sontakke, Pravin P. Lawande, Anup N. Kate, Ayesha Khan, Rakesh Joshi, Anupa A. Kumbhar, and Vaishali S. Shinde
Royal Society of Chemistry (RSC)
Bicyclic benzimidazole nucleosides were synthesized from d-glucose as a starting material. DNA binding, antiproliferative activity and cell cycle analysis were performed.
Ajay B. Patil, P. N. Pathak, V. S. Shinde, M. Yu. Alyapyshev, V. A. Babain, and P. K. Mohapatra
Springer Science and Business Media LLC
Archana B. Dhumure, Ajay B. Patil, Anuja S. Kulkarni, Irina Voevodina, Mariastella Scandola, and Vaishali S. Shinde
Royal Society of Chemistry (RSC)
A series of glycopolymers containing d-galactosyl 1,2,3-triazole groups were synthesized which exhibited thermosensitivity properties.
Pravin P. Lawande, Vyankat A. Sontakke, Roopa J. Nair, Ayesha Khan, Sushma G. Sabharwal, and Vaishali S. Shinde
Elsevier BV
Vyankat A. Sontakke, Anup N. Kate, Sougata Ghosh, Piyush More, Rajesh Gonnade, Navanath M. Kumbhar, Anupa A. Kumbhar, Balu A. Chopade, and Vaishali S. Shinde
Royal Society of Chemistry (RSC)
2-Anthryl substituted benzimidazole derivatives were synthesized and anticancer activity, cellular uptake, DNA interaction and molecular docking studies have been accomplished.
Ajay B. Patil, Vaishali S. Shinde, Priyanath Pathak, and Prasanta K. Mohapatra
Elsevier BV
Ajay B. Patil, Sougata Ghosh, Suvarna D. Phadatare, Priyanath Pathak, Geeta K. Sharma, Balu A. Chopade, and Vaishali S. Shinde
Royal Society of Chemistry (RSC)
The radical scavenging ability of malonamides has been explored by use of the pulse radiolysis technique.
Vyankat A. Sontakke, Vaishali S. Shinde, Harri Lönnberg, and Mikko Ora
Wiley
AbstractAppropriately protected structurally modified nucleoside 3′,5′‐cyclic monophosphates are known to show antiviral activity. For this reason, a straightforward synthesis of nucleoside 3′,5′‐cyclic phosphates protected with three different enzymatically removable groups, viz. 3‐acetyloxy‐2,2‐bis(ethoxycarbonyl)propyl (in 1 and 4), 4‐acetylthio‐2,2‐dimethyl‐3‐oxobutyl (in 2), and 4‐(tert‐butyldisulfanyl)‐2,2‐dimethyl‐3‐oxobutyl (in 3) groups, is described. Removal of these protecting groups at pH 7.5 and 37 °C was monitored by reverse‐phase HPLC.