Restricted Rotation about the C-N Bond in Thienopyridine Derivatives: NMR and DFT Study Kamlesh Lodha, Vaishali Shinde, Maneesha Shewale, Shridhar Gejji Current Organic Chemistry, 2025 N-acyl tetrahydrothienopyridine derivatives serve as important structural motifs in bioorganic chemistry. Restricted rotation of C-N bond in such molecules gives rise to two distinct chemical environments. Thienopyridine derivatives 4a-4i were synthesized and characterised by <sup>1</sup>H and <sup>13</sup>C NMR spectroscopy. The NMR spectra reveal a doubling of signals, which suggests the presence of two rotamers in the solution. Variable temperature (VT) <sup>1</sup>H-NMR studies supported this hypothesis. The NOESY analysis confirmed that Zrotamer is present in major form as compared to E-rotamer. The results were further corroborated through density functional theoretic calculations.
Synthesis and biological evaluation of 9-aryl-1,8-dioxo-octahydroxanthene derivatives as antileishmanial agents Kamlesh Lodha, Deepak Wavhal, Namdeo Bhujbal, Priyanka Mazire, Sneha Bhujbal, Ashlesha Korde, Kamini Bagul, Amit Roy, Rohan Meshram, Vaishali Shinde Results in Chemistry, 2023 In the current research, we designed and synthesized various derivatives of 9-aryl-1,8-dioxo-octahydroxanthene using flow chemistry technique and explored in vitro study for antileishmanial activity against the promastigote as well as amastigote form of Leishmania donovani strain. Among the tested analogs by various cell viability assays, six compounds exhibited antileishmanial activity with IC50 value ranging from 24.81 to 52.33 μM. Further, the functional dynamics study sheds light on the structural role of various functional groups presents in the xanthene derivatives for defining the actual antileishmanial activity. Molecular dynamics simulation data presented here attempts to provide a structural and mechanistic explanation of threonine synthase inhibition against Leishmania donovani by xanthene derivatives. Described structure–activity-relation advocates for further modification of the xanthene scaffolds for the accomplishment of challenging antileishmanial drugs.
Exploring New Tetrahydrothienopyridine Derivatives as Platelet Agglutination Inhibitors: Synthesis, Biological Evaluation and In Silico Study Kamlesh K. Lodha, Deepak S. Wavhal, Sujit B. Bhalekar, Rohan J. Meshram, Vaishali S. Shinde Chemistryselect, 2022 The P2Y12 receptor is the major target for antithrombic drugs which plays a key role in platelet activation. New derivatives of 4,5,6,7‐tetrahydrothieno[3,2‐c]pyridine (THP) were designed targeting P2Y12 receptor. An efficient route was developed for synthesis of THP derivatives and subsequently evaluated for their antiplatelet agglutination activity. Amongst the synthesized THP derivatives (4 a–4 g), the compounds 4 a and 4 g displayed significant activity (with 88.25 and 70.17 % inhibition) as compared to other analogs and comparable with that of the reference drugs, aspirin and prasugrel. Data extracted from computational chemistry techniques such as molecular docking, provided the structural rationale for the observed platelet agglutination inhibition by the newly synthesized tetrahydrothienopyridine analogs. We proposed the involvement of residues such as Cys‐194 in the formation of the covalent adduct with the active metabolite of tetrahydrothienopyridine derivatives. This study also put forward the possibility of the existence of an alternate pathway for metabolizing the tetrahydrothienopyridine compounds. The structural data presented in this study is expected to accelerate the research on developing a tetrahydrothienopyridine scaffold as an effective antithrombotic therapeutic modality.
MILD ACIDIC CHARCOAL CATALYZED SYNTHESIS OF 3,4-DIHYDROPYRIMIDIN-2(1H)-ONE/-THIONE DERIVATIVES Rajendra Patil, Jagdish Chavan, Shivnath Patel, Vaishali Shinde, Anil Beldar Chemistry Journal of Moldova, 2022 A green and efficient method for the multicomponent synthesis of 3,4-dihydropyrimidin-2(1H)-ones and -thiones using acetic acid supported on activated charcoal as a mild acid catalyst in ethanol under both conventional as well as microwave irradiation conditions has been developed. The catalyst system found more efficient under microwave irradiation conditions than conventional conditions with shorter reaction times and excellent yields.
Synthesis, characterization and cure behavior of phenol-crotonaldehyde-resorcinol resins M P Raghav Rao, Tukaram D Urmode, Vaishali S Shinde Materials Research Express, 2019 Phenol-crotonaldehyde-resorcinol (PCR) resins were synthesized by base-catalyzed condensation reaction of phenol, crotonaldehyde, and resorcinol. Three different bases utilized for condensation reaction were sodium hydroxide, hexamethylenetetramine (hexa) and liquid ammonia. The NaOH catalyzed resins were found to be thermoplastic in nature, while hexa- and liq. NH3 catalyzed resins showed thermoset behavior. Effect of varying mole ratio of phenol, crotonaldehyde and resorcinol was studied to investigate the curing and thermoset behavior of the synthesized resins. The average molecular weight of the resins was determined by gel permeation chromatography (GPC). All synthesized resins were characterized by various analytical techniques such as FT-IR, NMR, TGA, DSC and FE-SEM/EDX.
In situ formation of silver nanoparticles in thermosensitive glycogels and evaluation of its antibacterial activity Indian Journal of Chemistry Section A Inorganic Physical Theoretical and Analytical Chemistry, 2016
Thermoresponsive polystyrene-b-poly(N-isopropylacrylamide)copolymers by atom transfer radical polymerization Indian Journal of Chemistry Section A Inorganic Physical Theoretical and Analytical Chemistry, 2011
Recent advances in synthesis of carbohydrate-based surfactants: Comprehensive review and future perspective RR Kale, NK Jadhav, S Rajkhowa, BB Muntode, VA Dhere, ND Gaikwad, ... Carbohydrate Research 554, 109521 , 2025 2025 Citations: 2
Restricted Rotation about the CN Bond in Thienopyridine Derivatives: NMR and DFT Study K Lodha, V Shinde, M Shewale, S Gejji Current Organic Chemistry 29 (11), 900-912 , 2025 2025
Pd-catalysed regioselective cross dehydrogenative coupling of quinazolinones with aromatic carboxylic acids DS Waghmare, PM Lagad, UA Kshirsagar, VS Shinde Tetrahedron Letters 147, 155214 , 2024 2024 Citations: 1
Cultivation of Pleurotus florida (Mont.) Singer on Wheat Straw Supplemented with Biofertilizers RM Pawar, VS Shinde, BB Purane, DM Sawant, DV Pawar BIOINFOLET-A Quarterly Journal of Life Sciences 20 (2a), 185-188 , 2023 2023
Synthesis and biological evaluation of 9-aryl-1, 8-dioxo-octahydroxanthene derivatives as antileishmanial agents K Lodha, D Wavhal, N Bhujbal, P Mazire, S Bhujbal, A Korde, K Bagul, ... Results in Chemistry 5, 100943 , 2023 2023 Citations: 6
Exploring new tetrahydrothienopyridine derivatives as platelet agglutination inhibitors: Synthesis, biological evaluation and in silico study KK Lodha, DS Wavhal, SB Bhalekar, RJ Meshram, VS Shinde ChemistrySelect 7 (2), e202103428 , 2022 2022 Citations: 5
Polycystic ovarian syndrome with endometrial hyperplasia and uterine fibroids treated with homoeopathy: A case report V Shinde Indian Journal of Research in Homoeopathy 16 (3), 6 , 2022 2022 Citations: 5
MILD ACIDIC CHARCOAL CATALYZED SYNTHESIS OF 3,4-DIHYDROPYRIMIDIN-2(1H)-ONE/-THIONE DERIVATIVES AB Rajendra Patil, Jagdish Chavan, Shivnath Patel, Vaishali Shinde CHEMISTRY JOURNAL OF MOLDOVA 17 (2), 101-108 , 2022 2022 Citations: 7
Thermoresponsive Pluronic based microgels for controlled release of curcumin against breast cancer cell line AS Kulkarni, SR Tapase, KM Kodam, VS Shinde Colloids and Surfaces B: Biointerfaces 205, 111834 , 2021 2021 Citations: 19
Antibiotic resistance patterns of gram-negative isolates from water: a case study of Nasik PP Wagh, VS Shinde, GR Chaudhari, LL SAYYED, TU Khapre Educational Research (IJMCER) 3 (2), 41-48 , 2021 2021 Citations: 1
Synthesis of benzimidazole nucleosides and their anticancer activity VS Shinde, PP Lawande, VA Sontakke, A Khan Carbohydrate research 498, 108178 , 2020 2020 Citations: 24
Curcumin loaded nanofibrous mats for wound healing application AS Kulkarni, DD Gurav, AA Khan, VS Shinde Colloids and Surfaces B: Biointerfaces 189, 110885 , 2020 2020 Citations: 22
Homoeopathy in pandemic Spanish flu 1918 V Shinde Indian Journal of Research in Homoeopathy 14 (2), 152-159 , 2020 2020 Citations: 22
THE LOCAL DISTORTION IN MULTIFERROIC MN SUBSTITUTED BIFEO 3 NANOPARTICLES AND ITS EFFECT ON THE MAGNETIC AND FERROELECTRIC PROPERTIES UK Wadane, VK Barote, SS More, AR SHITRE, VS SHINDE, SB SHELKE GEDRAG & ORGANISATIE Учредители: UITGEVERIJ LEMMA BV 33 (2), 248-257 , 2020 2020
Synthesis, characterization and cure behavior of phenol-crotonaldehyde-resorcinol resins MPR Rao, TD Urmode, VS Shinde Materials Research Express 6 (11), 115329 , 2019 2019 Citations: 5
Biginelli reaction: Polymer supported catalytic approaches RV Patil, JU Chavan, DS Dalal, VS Shinde, AG Beldar ACS combinatorial science 21 (3), 105-148 , 2019 2019 Citations: 97
Homoeopathic medicine–Sepia for the management of menopausal symptoms: A multicentric, randomised, double-blind placebo-controlled clinical trial J Gupta, K Dimpi, C Lamba, P Gupta, V Shinde, B Wadhwa, A Soren, ... Indian Journal of Research in Homoeopathy 13 (4), 219-228 , 2019 2019 Citations: 11
Gnidia glauca ‐ and Plumbago zeylanica ‐Mediated Synthesis of Novel Copper Nanoparticles as Promising Antidiabetic Agents DA Jamdade, D Rajpali, KA Joshi, R Kitture, AS Kulkarni, VS Shinde, ... Advances in Pharmacological and Pharmaceutical Sciences 2019 (1), 9080279 , 2019 2019 Citations: 97
Platanus orientalis Leaf Mediated Rapid Synthesis of Catalytic Gold and Silver Nanoparticles SG Shriya Shende, Komal A Joshi, Anuja S Kulkarni, Chaitanya Charolkar ... Journal of Nanomedicine & Nanotechnology 9 (2), 1000494 , 2018 2018 Citations: 45
Gnidia glauca flower extract mediated synthesis of gold nanoparticles and evaluation of its chemocatalytic potential S Ghosh, S Patil, M Ahire, R Kitture, DD Gurav, AM Jabgunde, S Kale, ... Journal of Nanobiotechnology 10 (1), 17 , 2012 2012 Citations: 286
Diosgenin from Dioscorea bulbifera: novel hit for treatment of type II diabetes mellitus with inhibitory activity against α-amylase and α-glucosidase S Ghosh, P More, A Derle, AB Patil, P Markad, A Asok, N Kumbhar, ... PloS one 9 (9), e106039 , 2014 2014 Citations: 191
Phytochemical Analysis and Free Radical Scavenging Activity of Medicinal Plants Gnidia glauca and Dioscorea bulbifera S Ghosh, A Derle, M Ahire, P More, S Jagtap, SD Phadatare, AB Patil, ... PloS one 8 (12), e82529 , 2013 2013 Citations: 170
Biginelli reaction: Polymer supported catalytic approaches RV Patil, JU Chavan, DS Dalal, VS Shinde, AG Beldar ACS combinatorial science 21 (3), 105-148 , 2019 2019 Citations: 97
Gnidia glauca ‐ and Plumbago zeylanica ‐Mediated Synthesis of Novel Copper Nanoparticles as Promising Antidiabetic Agents DA Jamdade, D Rajpali, KA Joshi, R Kitture, AS Kulkarni, VS Shinde, ... Advances in Pharmacological and Pharmaceutical Sciences 2019 (1), 9080279 , 2019 2019 Citations: 97
Intramolecular 5- endo- Trig Aminomercuration of β-Hydroxy-γ-alkenylamines: Efficient Route to a Pyrrolidine Ring and Its Application for the Synthesis of (+ … NS Karanjule, SD Markad, VS Shinde, DD Dhavale The Journal of Organic Chemistry 71 (12), 4667-4670 , 2006 2006 Citations: 77
Efficient solvent system containing malonamides in room temperature ionic liquids: actinide extraction, fluorescence and radiolytic degradation studies AB Patil, P Pathak, VS Shinde, SV Godbole, PK Mohapatra Dalton Transactions 42 (5), 1519-1529 , 2013 2013 Citations: 76
Molecular Tailoring of Thermoreversible Copolymer Gels: Some New Mechanistic Insights SVRAM M. V. Badiger, A. K. Lele, V. S. Bhalerao (Mrs. V. S. Shinde) Journal of Chemical Physics 109 (3), 1175-1184 , 1998 1998 Citations: 71
5‐Mercuricytosine: An Organometallic Janus Nucleobase D Ukale, VS Shinde, T Lönnberg Chemistry–A European Journal 22 (23), 7917-7923 , 2016 2016 Citations: 67
Emissions and performance evaluation of DI CI-VCR engine fuelled with honne oil methyl ester/diesel blends SV Channapattana, C Kantharaj, VS Shinde, AA Pawar, PG Kamble Energy Procedia 74, 281-288 , 2015 2015 Citations: 56
pH-responsive targeted and controlled doxorubicin delivery using hyaluronic acid nanocarriers DD Gurav, AS Kulkarni, A Khan, VS Shinde Colloids and Surfaces B: Biointerfaces 143, 352-358 , 2016 2016 Citations: 55
Barleria prionitis Leaf Mediated Synthesis of Silver and Gold Nanocatalysts JBBAC Sougata Ghosh, Maliyackal Jini Chacko, Ashwini N. Harke, Sonal P ... Journal of Nanomedicine & Nanotechnology 7 (4), 1000394 , 2016 2016 Citations: 52
Gnidia glauca Leaf and Stem Extract Mediated Synthesis of Gold Nanocatalysts with Free Radical Scavenging Potential JBBAC Sougata Ghosh, Sumersing Patil , Niraja B. Chopade , Soching Luikham ... J Nanomed Nanotechnol 7 (02), 1-10 , 2016 2016 Citations: 50
Synthesis, DNA interaction and anticancer activity of 2-anthryl substituted benzimidazole derivatives VA Sontakke, AN Kate, S Ghosh, P More, R Gonnade, NM Kumbhar, ... New Journal of Chemistry 39 (6), 4882-4890 , 2015 2015 Citations: 49
Thermoreversible Hydrogel based on Radiation Induced Copolymerisation of Poly(N-isopropyl acrylamide and Poly(ethylene oxide) VSBVS Shinde), S Varghese, AK Lele, MV Badiger Polymer 39 (11), 2255-2260 , 1998 1998 Citations: 47
Dioscorea oppositifolia mediated synthesis of gold and silver nanoparticles with catalytic activity S Ghosh, SP Gurav, AN Harke, MJ Chacko, KA Joshi, A Dhepe, ... J Nanomed Nanotechnol 7 (5), 398 , 2016 2016 Citations: 46
Platanus orientalis Leaf Mediated Rapid Synthesis of Catalytic Gold and Silver Nanoparticles SG Shriya Shende, Komal A Joshi, Anuja S Kulkarni, Chaitanya Charolkar ... Journal of Nanomedicine & Nanotechnology 9 (2), 1000494 , 2018 2018 Citations: 45
Litchi chinensis peel: a novel source for synthesis of gold and silver nanocatalysts S Shende, KA Joshi, AS Kulkarni, VS Shinde, VS Parihar, R Kitture, ... Global Journal of Nanomedicine 3 (1), 555603 , 2017 2017 Citations: 44
Glycopolymer‐Grafted Polystyrene Nanospheres A Pfaff, VS Shinde, Y Lu, A Wittemann, M Ballauff, AHE Müller Macromolecular Bioscience 11 (2), 199-210 , 2011 2011 Citations: 43
A Simple, Efficient Synthesis of 2‐Aryl Benzimidazoles Using Silica Supported Periodic Acid Catalyst and Evaluation of Anticancer Activity VA Sontakke, S Ghosh, PP Lawande, BA Chopade, VS Shinde International Scholarly Research Notices 2013 (1), 453682 , 2013 2013 Citations: 38