Krishnamurthy Bhat

Scopus Publications

ANALYTICAL ASSESSMENT OF CHEMICAL STABILITY AND SHELF-LIFE OF GOKSHURA CHURNA: A SCIENTIFIC APPROACH
NIHARIKA GADDAM, RAVI GUNDAWAR, KRISHNAMURTHY BHAT, BASAVARAJ S. HADAPAD, MUDDUKRISHNA BS, MURALIDHAR BALLAL, VASANTHARAJU SG
International Journal of Applied Pharmaceutics, 2026
Objective: Gokshura Churna is a versatile Ayurvedic remedy with a rich history of therapeutic use in promoting urinary, reproductive and physical health, it holds a significant place in traditional medicine. However, to ensure its long-term efficacy and safety, especially in modern applications, it is essential to support its use with scientific validation, particularly in terms of quality, stability and shelf-life. Methods: The present study focuses on determining the shelf-life of Marketed Gokshura Churna formulation using reverse phase high performance liquid chromatography (RP-HPLC) method. Stability testing was conducted under both accelerated and long-term conditions, following international council for harmonisation of technical requirements for pharmaceuticals for human use (ICH) guidelines. Samples were analyzed at intervals of 0, 1, 3, 6, 9 and 12 mo. The chemical fingerprint of the formulation was established by using two analytical Markers Quercetin and Beta-sitosterol. In addition to chemical analysis, various quality control parameters were evaluated as per the Ayurvedic Pharmacopoeia of India (API), including organoleptic properties, Loss on drying, ash content, extractives values, pH and microbial load. Results: Quercetin and Beta-sitosterol were eluted at 5.7 and 7.8 min. The overall results of the validation parameters of the Markers were within the limits. Stress studies confirmed the absence of co-eluting peaks and degradants under various stress conditions. All the Physicochemical parameters of the formulation were within the acceptable limits. Total microbial load analysis of the formulation showed that the bacterial count was within acceptable limits, while there is a marginal increase in the fungal count was observed. Based on the stability analysis of Quercetin and Beta-sitosterol marker content, the shelf life of Gokshura churna was estimated to be 29.80 and 26.20 mo. Conclusion: This study provides a scientific foundation for future commercial stability testing and contributes to improved quality and safety of Gokshura churna.
Formulation Strategy of BCS-II Drugs by Coupling Mechanistic In-Vitro and Nonclinical In-Vivo Data with PBPK: Fundamentals of Absorption-Dissolution to Parameterization of Modelling and Simulation
Shriya V A, Usha Y. Nayak, Muddukrishna Badamane Sathyanarayana, Bhim Bahadur Chaudhari, Krishnamurthy Bhat
AAPS Pharmscitech, 2025
BCS class II candidates pose challenges in drug development due to their low solubility and permeability. Researchers have explored various techniques; co-amorphous and solid dispersion are major approaches to enhance in-vitro drug solubility and dissolution. However, in-vivo oral bioavailability remains challenging. Physiologically based pharmacokinetic (PBPK) modeling with a detailed understanding of drug absorption, distribution, metabolism, and excretion (ADME) using a mechanistic approach is emerging. This review summarizes the fundamentals of the PBPK, dissolution—absorption models, parameterization of oral absorption for BCS class II drugs, and provides information about newly emerging artificial intelligence/machine learning (AI/ML) linked PBPK approaches with their advantages, disadvantages, challenges and areas of further exploration. Additionally, the fully integrated workflow for formulation design for investigational new drugs (INDs) and virtual bioequivalence for generic molecules falling under BCS-II are discussed. Graphical Abstract
Erratum to “Raloxifene HCl – Naringin co-amorphous system: Preparation, characterization and pharmacokinetic studies” [Eur. J. Pharm. Biopharm. 209 (2025) 114667] (European Journal of Pharmaceutics and Biopharmaceutics (2025) 209, (S0939641125000438), (10.1016/j.ejpb.2025.114667))
Navya Sree Kola Srinivas, Dani Lakshman Yarlagadda, Brahmam Bheemishetty, Shaila Lewis, Swapnil Jayant Dengale, Krishnamurthy Bhat
European Journal of Pharmaceutics and Biopharmaceutics, 2025
Identification, synthesis, isolation, and characterization of formulation related degradation impurity of Cefadroxil Oral suspension
Sunil Ramrao Murkute, Surenehalli Gowdra Vasantharaju, Girij P. Singh, Krishnamurthy Bhat, Himanshu M. Godbole, Pritesh R. Upadhyay, Anurag Trivedi
Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences, 2025
Cefadroxil is an orally active, first-generation cephalosporin antibiotic utilized in the treatment of bronchitis, pharyngitis, tonsillitis, urinary tract infections, uncomplicated skin infections, bones, and joints (de Marco and Salgado, 2017 [1]). Cefadroxil for oral suspension is formulated as dry powder for oral suspension. After reconstitution during 14 days storage, we observed an unknown impurity at relative retention time (RRT) 1.29 in cefadroxil oral suspension. The observed level of an unknown impurity was greater than 0.1 % in high-performance liquid chromatography (HPLC) analysis. The present work is focused on the identification, synthesis, and characterization of the unknown impurity by employing several sophisticated analytical techniques. Such as High-resolution mass spectroscopy (HRMS), One dimensional (1D) and two dimensional (2D) nuclear magnetic resonance spectroscopy.
Raloxifene HCl – Naringin co-amorphous system: Preparation, characterization and pharmacokinetic studies
Navya Sree Kola Srinivas, Dani Lakshman Yarlagadda, Brahmam Bheemishetty, Shaila Lewis, Swapnil Jayant Dengale, Krishnamurthy Bhat
European Journal of Pharmaceutics and Biopharmaceutics, 2025
Approximately 90 % of NCEs in development and 40 % of recently approved drugs are poorly water-soluble. To improve solubility and stability, co-amorphous systems (CAMs) are used, involving the amorphization of an API with a co-former through interactions like hydrogen bonding. This study explores the co-amorphization of Raloxifene HCl (RLX) and Naringin (NRG). RLX, a BCS class II drug, has limited oral bioavailability of only 2 % due to its poor solubility (0.5 μg/mL) and extensive pre-systemic metabolism. Additionally, it interacts with CYP3A4 and P-glycoprotein (P-gp). NRG, a compound found in citrus fruits, inhibits both CYP3A4 and P-gp. Therefore, utilizing NRG to prepare RLX CAMs could result in a compound with improved solubility and enhanced bioavailability. CAMs were prepared using the solvent evaporation technique, followed by solid-state characterization at the molecular level. Solubility, drug release, and both ex vivo and in vitro studies were conducted. CAMs showed a 3.5-fold solubility increase and a 10-fold increase in ex-vivo permeation compared to RLX. In vivo studies showed an 8.1-fold improvement in Cmax and a 2.8-fold increase in AUC, indicating significantly enhanced bioavailability. These results suggest that co-amorphization could be a viable platform technology for improving API properties at the molecular level.
A Molecular Dynamic Simulation, Structural Analysis, and Ex Vivo Insights into the P-glycoprotein Mediated Interactions of Dietary Polyphenols with Cyclin-dependent Kinase Inhibitors: A Potential Strategy to Counteract Drug Efflux
Prajakta Harish Patil, Mrunal Pradeep Desai, Vullendula Sai Krishna Anand, Rajdeep Ray, G. Gautham Shenoy, Swapnil Jayant Dengale, Krishnamurthy Bhat, Jagadish Puralae Channabasavaiah
Current Medicinal Chemistry, 2025
Introduction: P-glycoprotein, an ATP-dependent efflux transporter, plays a crucial role in eliminating cellular toxins and affects the intracellular concentration and bioavailability of CDK 4/6 inhibitors. Moreover, dietary flavonoids are natural bio-enhancers that can effectively inhibit the efflux function of these transporters. Therefore, this study aimed to assess the impact of dietary polyphenols on the inhibition of P-glycoprotein and the subsequent efflux of CDK inhibitors palbociclib and ribociclib. Methods: A molecular docking approach was implemented to evaluate the binding interaction characteristics of CDK4/6 inhibitors in the presence of dietary polyphenols at the ATP binding site. Furthermore, the stability of the complexes was evaluated in two conformations of P-glycoprotein, followed by an ex vivo everted gut sac experiment. Results: The findings demonstrated that the binding of curcumin and quercetin with high affinity (-51.63 and -47.16 Kcal/mol) to ATP binding sites of P-glycoprotein-palbociclib and ribociclib inward conformation complexes resulted in good stability of complex and minimal fluctuation throughout the course of the simulation. It was evident from the everted gut sac ex vivo study that the presence of 100 μM of curcumin resulted in an increase of 1.77 and 4.20-fold in the intestinal transit of palbociclib and ribociclib, respectively. Conclusion: The study emphasizes the significance of curcumin and quercetin as inhibitors of P-glycoprotein, demonstrating their potential to decrease the efflux of palbociclib and ribociclib, consequently contributing to their bioavailability enhancement.
Physicochemical Interactions Between Concomitantly Administered Anti-Retroviral and Anti-Malarial Drug
Vullendula Sai Krishna Anand, Dani Lakshman Yarlagadda, Athira R. Nair, Krishnamurthy Bhat, Swapnil J. Dengale
Journal of Pharmaceutical Innovation, 2024
A deep dive into the development of complex generics: A comprehensive review
Amatha Sreedevi, Prashant B. Musmade, Krishnamurthy Bhat, Sreedhar Dharmagadda, Manthan D. Janodia, Bhavana B. Bhat, Virendra S. Ligade
Journal of Applied Pharmaceutical Science, 2024
In recent years, complex generics a special class has excel the scope of Generic Drug User Fee Act (GDUFA) in contrast to traditional small molecular drugs. The recent trends reveal a growing demand that has incentivized pharmaceutical companies to focus more on producing generic versions of complex drugs, such as biosimilars, drug-device combination products, nanotechnological products and controlled-release formulations, topical preparations containing complex drugs, long-acting injectables, and inhalation products. Despite the growth and benefits, the pharmaceutical companies engaged in the production of these products are facing many challenges mainly, advanced analytical techniques to demonstrate bioequivalence and safety, novel complex manufacturing processes to reduce losses, quality issues, regulatory approval, patent litigation, and market competition to bring low-cost products to market. The regulatory status of complex generics varies across different countries. Although the United States Food and Drug Administration (US FDA) has established clear pathways for complex generics by issuing case-by-case product-specific guidelines, other regulatory agencies mainly the European Medical Agency, Health Canada, and (Agencia Nacional de Vigilancia Sanitaria) Brazil are highlighting the challenges associated with the current product-specific guidelines. The regulatory aspect of complex generic is in the nascent stage for countries like India. Harmonization and convergence of regulatory standards are essential for streamlining global access to complex generics. The present review highlights the evolving frontier of complex generics, their classification, trends, regulatory status, and challenges to ensure patient access to safe, effective, and affordable alternative treatments.
Computational-Based Polyphenol Therapy for Nonsmall Cell Lung Cancer: Naringin Coamorphous Systems for Solubility and Bioavailability Enhancement
Dani Lakshman Yarlagadda, Subham Das, Sai Krishna Anand Vullendula, Suman Manandhar, Swapnil J. Dengale, K. Sreedhara Ranganath Pai, Krishnamurthy Bhat
Molecular Pharmaceutics, 2024
In this research, we utilized molecular simulations to create co-amorphous materials (CAMs) of ceritinib (CRT) with the objective of improving its solubility and bioavailability. We identified naringin (NRG) as a suitable co-former for CRT CAMs based on binding energy and intermolecular interactions through computational modeling. We used the solvent evaporation method to produce CAMs of CRT and NRG, expecting to enhance both solubility and bioavailability simultaneously. The solid-state characterization using techniques like differential scanning calorimeter, X-ray powder diffraction, and Fourier-transform infrared spectroscopy affirmed the formation of a single amorphous phase and the presence of intermolecular interactions between CRT and NRG in the CAMs. These materials remained physically stable for up to six months under dry conditions at 40 °C. Moreover, the CAMs demonstrated significant improvements in the solubility and dissolution of CRT (specifically in the ratio CRT:NRG 1:2). This, in turn, led to an increase in cytotoxicity, apoptotic cells, and G0/G1 phase inhibition in A549 cells compared to CRT alone. Furthermore, CRT permeability is also improved twofold, as estimated by the everted gut sac method. The enhanced solubility of CAMs also positively affected the pharmacokinetic parameters. When compared to the physical mixture, the CAMs of CRT:NRG 2:1 exhibited a 2.1-fold increase in CRT exposure (AUC0-t) and a 2.4-fold increase in plasma concentration (Cmax).
Shelf life determination of Khushmanda Rasayana towards scientific evidence for the chemical stability
Syeda Alisha Md. Isha Ali, Niharika Gaddam, Badamane Sathyanarayana Muddukrishna, Krishnamurthy Bhat, Sandeep Datarkar, Murlidhar Ballal, Surenehalli Gowdra Vasantharaju
Journal of Applied Pharmaceutical Science, 2024
Shelf life determination of herbal formulations based on a piece of scientific evidence for a mentioned period and storage conditions defined on the container label becomes paramount for quality. This work is aimed at evaluating the shelf life of Khushmanda Rasayana by reverse phase high performance liquid chromatography. International Council for Harmonisation storage conditions at specific time points were used to determine the marker content in the formulation. Stability studies were conducted at accelerated conditions and long-term conditions at time points (0, 1, 3, 6, 9, and 12 months). The two primary molecular markers used for developing Khushmanda Rasayana’s chemical fingerprint were Catechin and Piperine. Various quality control parameters such as appearance, thin layer chromatography, limit of detection, total ash, acid insoluble ash, alcohol soluble extractive, water soluble extractive, pH, and assay were observed by the Ayurvedic Pharmacopoeia of India. Analysis of the chemical markers over the prescribed period revealed a shelf life of 48.1 months considering the markers Catechin and Piperine. The shelf life estimated indicates the relative stability; this research expands the scope to conduct commercial stability studies in the future.
Physicochemical interaction of rifampicin and ritonavir-lopinavir solid dispersion: an in-vitro and ex-vivo investigation
Athira R. Nair, Sai Krishna Anand Vullendula, Dani Lakshman Yarlagadda, Brahmam Bheemisetty, Swapnil J. Dengale, Krishnamurthy Bhat
Drug Development and Industrial Pharmacy, 2024
SCIENTIFIC EVIDENCE FOR STABILITY EVALUATION AND SHELF-LIFE ESTIMATION OF VACHA CHURNA BY USING RP-HPLC
G. NIHARIKA, SYEDA ALISHA MD ISHA ALI, KRISHNAMURTHY BHAT, BASAVARAJ S. HADAPAD, B. S. MUDDUKRISHNA, GUNDAWAR RAVI, MURALIDHAR BALLAL, S. G. VASANTHARAJU
International Journal of Applied Pharmaceutics, 2024
A computational-based approach to fabricate Ceritinib co-amorphous system using a novel co-former Rutin for bioavailability enhancement
Dani Lakshman Yarlagadda, Vullendula Sai Krishna Anand, Athira R. Nair, Swapnil J. Dengale, Sudharsan Pandiyan, Chetan H. Mehta, Suman Manandhar, Usha Y. Nayak, Krishnamurthy Bhat
European Journal of Pharmaceutics and Biopharmaceutics, 2023
Solid State Characterization and Miscibility of Raltegravir in Soluplus Using Solid Dispersion Technology
Dani Lakshman Yarlagadda, Akshatha Manohar Nayak, Krishnamurthy Bhat
Indian Journal of Pharmaceutical Education and Research, 2023
DETERMINATION OF SHELF LIFE OF AN AYURVEDIC FORMULATION KAISHORA GUGGULU USING RP-HPLC ANALYSIS OF CHEMICAL MARKERS
Syeda Alisha Md Isha Ali, Niharika Gaddam, Krishnamurthy Bhat, B.S. Muddukrishna, Murlidhar Ballal, Sandeep G. Datarkar, S. G. Vasantharaju
Rasayan Journal of Chemistry, 2023
Occurrences of UV filters, endocrine disruptive chemicals, alkyl phenolic compounds, fragrances, and hormones in the wastewater and coastal waters of the Antarctica
Keshava Balakrishna, Yerabham Praveenkumarreddy, D'Souza Nishitha, Chikmagalur Mallappa Gopal, Jayakrishna Kanhangad Shenoy, Krishnamurthy Bhat, Neloy Khare, Kiran Dhangar, Manish Kumar
Environmental Research, 2023
Thiopurine therapy in inflammatory bowel disease in the pandemic era: Safe or unsafe?
Shailesh Perdalkar, Pooja Basthi Mohan, Balaji Musunuri, Siddheesh Rajpurohit, Shiran Shetty, Krishnamurthy Bhat, Cannanore Ganesh Pai
International Immunopharmacology, 2023
Exploring the Solubility and Bioavailability of Sodium Salt and Its Free Acid Solid Dispersions of Dolutegravir
Dani Lakshman Yarlagadda, Akshatha M. Nayak, Bheemisetty Brahmam, Krishnamurthy Bhat
Advances in Pharmacological and Pharmaceutical Sciences, 2023
Effervescence-induced amorphous solid dispersions with improved drug solubility and dissolution
Muralidhar Pisay, Dani Lakshman Yarlagadda, Sai Krishna Anand Vullendula, Krishnamurthy Bhat, Koteshwara Kunnatur Balasundara, Srinivas Mutalik
Pharmaceutical Development and Technology, 2023
Molecular Insights into the Mechanism of Modulatory Effects of Proton Pump Inhib-itors on P-glycoprotein Mediated Drug Transport of Palbociclib and Ribociclib
Mrunal Pradeep Desai, Prajakta Harish Patil, Sai Krishna Anand Vullendula, Sumit Birangal, G. Gautham Shenoy, Mahadev Rao, Swapnil Jayant Dengale, Krishnamurthy Bhat, Jagadish Puralae Channabasavaiah
Current Drug Metabolism, 2023
Polymeric solid dispersion Vs co-amorphous technology: A critical comparison
Sai Krishna Anand Vullendula, Athira R. Nair, Dani Lakshman Yarlagadda, K.S. Navya Sree, Krishnamurthy Bhat, Swapnil J. Dengale
Journal of Drug Delivery Science and Technology, 2022
Full Factorial Design for Development and Validation of a Stability-Indicating RP-HPLC Method for the Estimation of Timolol Maleate in Surfactant-Based Elastic Nano-Vesicular Systems
Santoshi Naik, Prashansha Mullick, Sadhana P Mutalik, Aswathi R Hegde, Shaila Angela Lewis, Krishnamurthy Bhat, Bola Sadashiva Satish Rao, Srinivas Mutalik
Journal of Chromatographic Science, 2022
Corrigendum: “Bioanalytical method development and validation of highly selective and sensitive LC-MS/MS method for determination of teriparatide (parathyroid hormone fragment 1–34) in human serum through direct detection of intact teriparatide molecule” (Journal of Chromatography B (2021) 1187, (123046), (S1570023221005274), (10.1016/j.jchromb.2021.123046))
Manoj Bob Kusuma, Ravisekhar Kashibhatta, Anil Gavande, Ravi Kiran, Sandeep Jagtap, Praveen Vithala, Sudheer Moorkoth, Krishnamurthy Bhat
Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences, 2022
Corrigendum: to “A selective and sensitive UPLC–ESI-MS/MS method for quantification of Pegylated Interferon Alfa-2b in human serum using signature peptide-based quantitation” (Journal of Chromatography B (2021) 1180, (122883), (S1570023221003640), (10.1016/j.jchromb.2021.122883))
Manoj Bob Kusuma, Ravisekhar Kashibhatta, Sandeep S. Jagtap, Vijay Nadawade, Suresh Adsul, Sudheer Moorkoth, Krishnamurthy Bhat, Rustom Mody, Praveen Vithala
Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences, 2022
Identification of Novel Impurity of Ziprasidone
Sunil R. Murkute, Girij P. Singh, S.G. Vasantharaju, Krishnamurthy Bhat, Himanshu M. Godbole, Pritesh R. Upadhyay, Anurag Trivedi
Journal of Pharmaceutical and Biomedical Analysis, 2022
Raloxifene HCl–quercetin co-amorphous system: preparation, characterization, and investigation of its behavior in phosphate buffer
Navya Sree K. S., Swapnil J. Dengale, Srinivas Mutalik, Krishnamurthy Bhat
Drug Development and Industrial Pharmacy, 2022
Liquid chromatographic methods in the determination of inosine monophosphate dehydrogenase enzyme activity: a review
Shailesh Perdalkar, Dani Lakshman Yarlagadda, Cannanore Ganesh Pai, Shiran Shetty, Krishnamurthy Bhat
Bioanalysis, 2022
Bioanalytical method development and validation of highly selective and sensitive LC-MS/MS method for determination of teriparatide (parathyroid hormone fragment 1–34) in human serum through direct detection of intact teriparatide molecule
Manoj Bob Kusuma, Ravisekhar Kashibhatta, Anil Gavande, Ravi Kiran, Sandeep Jagtap, Praveen Vithala, Sudheer Moorkoth, Krishnamurthy Bhat
Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences, 2021
Dronedarone HCl-Quercetin Co-Amorphous System: Characterization and RP-HPLC Method Development for Simultaneous Estimation
K S Navya Sree, Swapnil J Dengale, Srinivas Mutalik, Krishnamurthy Bhat
Journal of AOAC International, 2021
A selective and sensitive UPLC–ESI-MS/MS method for quantification of Pegylated Interferon Alfa-2b in human serum using signature peptide-based quantitation
Manoj Bob Kusuma, Ravisekhar Kashibhatta, Sandeep S. Jagtap, Vijay Nadawade, Suresh Adsul, Sudheer Moorkoth, Krishnamurthy Bhat, Rustom Mody, Praveen Vithala
Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences, 2021
Seasonal occurrence and risk assessment of pharmaceutical and personal care products in Bengaluru rivers and lakes, India
Chikmagalur Mallappa Gopal, Krishnamurthy Bhat, Babu Rajendran Ramaswamy, Virendra Kumar, Rakesh Kumar Singhal, Hirakendu Basu, Harikripa Narayana Udayashankar, Surenehalli Gowdra Vasantharaju, Yerabham Praveenkumarreddy, Shailesh, Yovan Lino, Keshava Balakrishna
Journal of Environmental Chemical Engineering, 2021
Considerations for the selection of co-formers in the preparation of co-amorphous formulations
Dani Lakshman Yarlagadda, Vullendula Sai Krishna Anand, Athira R. Nair, K.S. Navya Sree, Swapnil J. Dengale, Krishnamurthy Bhat
International Journal of Pharmaceutics, 2021
Assessment of non-steroidal anti-inflammatory drugs from selected wastewater treatment plants of Southwestern India
Yerabham Praveenkumarreddy, Krishnamoorthi Vimalkumar, Babu Rajendran Ramaswamy, Virendra Kumar, Rakesh Kumar Singhal, Hirakendu Basu, Chikmagalur Mallappa Gopal, Kalwaje Eshwara Vandana, Krishnamurthy Bhat, Harikripa Narayana Udayashankar, Keshava Balakrishna
Emerging Contaminants, 2021
Overview of Extensively Employed Polymeric Carriers in Solid Dispersion Technology
Athira R. Nair, Yarlagadda Dani Lakshman, Vullendula Sai Krishna Anand, K. S. Navya Sree, Krishnamurthy Bhat, Swapnil J. Dengale
AAPS Pharmscitech, 2020
Complex Generic Products: Insight of Current Regulatory Frameworks in US, EU and Canada and the Need of Harmonisation
Sandeesha Lunawat, Krishnamurthy Bhat
Therapeutic Innovation and Regulatory Science, 2020
Influence of Preparation Methods on Physicochemical and Pharmacokinetic Properties of Co-amorphous Formulations: The Case of Co-amorphous Atorvastatin: Naringin
Athira Nair, Raghava Varma, Karthik Gourishetti, Krishnamurthy Bhat, Swapnil Dengale
Journal of Pharmaceutical Innovation, 2020
Evaluation of selected pharmaceuticals and personal care products in water matrix using ion trap mass spectrometry: A simple weighted calibration curve approach
Chikmagalur Mallappa Gopal, Krishnamurthy Bhat, Yerabham Praveenkumarreddy, Shailesh, Virendra Kumar, Hirakendu Basu, Derrick Ian Joshua, Rakesh Kumar Singhal, Keshava Balakrishna
Journal of Pharmaceutical and Biomedical Analysis, 2020
Lower melting pharmaceutical cocrystals of metaxalone with carboxamide functionalities
SunilKumar V. Gohel, Palash Sanphui, Girij Pal Singh, Krishnamurthy Bhat, Muthuramalingam Prakash
Journal of Molecular Structure, 2019
Quantification of Sofosbuvir in Human Plasma: RP-HPLC Method Development and Validation
Rahul U. Rathod, K. S. Navyasree, Krishnamurthy Bhat
Pharmaceutical Chemistry Journal, 2018
Analytical Method Development and Validation for HPLC-ECD Determination of Moxifloxacin in Marketed Formulations
G. Phani Sekhar Reddy, K. S. Navyasree, P. C. Jagadish, Krishnamurthy Bhat
Pharmaceutical Chemistry Journal, 2018
A pilot randomized controlled trial to compare the effectiveness of two 14-day primaquine regimens for the radical cure of vivax malaria in South India CTRI/2017/03/007999 CTRI
Kavitha Saravu, Chaitanya Tellapragada, Shrivathsa Kulavalli, Wilbin Xavier, Shashikiran Umakanth, Gouthami Brahmarouphu, Navyasree Kola Srinivas, Jagadish Puralae Channabasavaiah, Anzil Bava, Abdul Vahab Saadi, Vasudev Guddattu, Kapaettu Satyamoorthy, Krishnamurthy Bhat
Malaria Journal, 2018
Simultaneous estimation of telmisartan, hydrochlorothiazide and amlodipine besylate in tablet preparation by chemometric asisted spectrophotometric analysis
Indian Drugs, 2018
President’s emergency plan for AIDS relief
Siddharth Jadeja, Girish Pai, Krishnamurthy Bhat, Muddukrishna Badamane Sathyanarayana
Systematic Reviews in Pharmacy, 2018
Low frequency ultrasound and PAMAM dendrimer facilitated transdermal delivery of ketoprofen
Jyothsna Manikkath, Aparna Manikkath, Gopal Venkatesh Shavi, Krishnamurthy Bhat, Srinivas Mutalik
Journal of Drug Delivery Science and Technology, 2017
Switching drugs from rx to otc status-a regulatory perspective
Journal of Young Pharmacists, 2017
Simultaneous estimation of emitricitabine, efavirenz, tenofovir disproxil fumarate by chemometry and reverse phase-high performance liquid chromatography
Indian Drugs, 2016
Acyclovir entrapped N-trimethyl chitosan nanoparticles for oral bioavailability enhancement
Ushasree Medikonduri, Zenab Attari, Krishnamurthy Bhat, Shaila Lewis
Current Nanoscience, 2016
Bioavailability enhancement of rizatriptan benzoate by oral disintegrating strip: In vitro and in vivo evaluation
S. T. Bhagawati, Ankita D. Chonkar, Swapnil J. Dengale, Sreenivasa M. Reddy, Krishnamurthy Bhat
Current Drug Delivery, 2016
Preparation, solid state characterisation of Paclitaxel and Naringen Cocrystals with improved solubility
International Journal of Applied Pharmaceutics, 2016
Fabrication, solid state characterization and bioavailability assessment of stable binary amorphous phases of Ritonavir with Quercetin
Swapnil J. Dengale, Syed Sajjad Hussen, B.S.M. Krishna, Prashant B. Musmade, G. Gautham Shenoy, Krishnamurthy Bhat
European Journal of Pharmaceutics and Biopharmaceutics, 2015
Preparation and characterization of co-amorphous Ritonavir-Indomethacin systems by solvent evaporation technique: Improved dissolution behavior and physical stability without evidence of intermolecular interactions
Swapnil J. Dengale, Om Prakash Ranjan, Syed Sajjad Hussen, B.S.M. Krishna, Prashant B. Musmade, G. Gautham Shenoy, Krishnamurthy Bhat
European Journal of Pharmaceutical Sciences, 2014
Development and validation of stability indicating HPLC method for Clotrimazole lozenges formulation
International Journal of Pharmacy and Pharmaceutical Sciences, 2014
Preparation and solid state characterization of paclitaxel cocrystals
Research Journal of Pharmacy and Technology, 2014
Determination of lamotrigine and feibamate in pediatric plasma samples by reverse phase high-performance liquid chromatography
Indian Journal of Pharmaceutical Education and Research, 2013
An unusual cause of cardiac arrest in a hospitalized patient
Ranjan Shetty K., Anil Tumkur, Krishnamurthy Bhat, Biby Chacko
Journal of Pharmacology and Pharmacotherapeutics, 2013
Drug product registration and marketing authorization procedures in EU-A perspective
Ashish Kekare
Marmara Pharmaceutical Journal, 2013
Informed consent: Issues and challenges
PrashantB Musmade, LokeshP Nijhawan, ManthanD Janodia, BS Muddukrishna, KM Bhat, KL Bairy, N Udupa
Journal of Advanced Pharmaceutical Technology and Research, 2013
Estimation of stavudine, lamivudine and nevirapine by chemometric UV spectroscopic method
Indian Journal of Pharmaceutical Education and Research, 2012
Simultaneous estimation of ascorbic acid and calcium pantothenate in: Multivitamin and multimineral tablets by reverse-phase HPLC
Der Pharma Chemica, 2011
High performance liquid chromatographic determination of carboplatin in injections
Asian Journal of Chemistry, 2011
Enhanced oral absorption of saquinavir with Methyl-Beta-Cyclodextrin-Preparation and in vitro and in vivo evaluation
Shriram M. Pathak, Prashant Musmade, Swapnil Dengle, Arumugam Karthik, Krishnamurthy Bhat, Nayanabhirama Udupa
European Journal of Pharmaceutical Sciences, 2010
Analytical method development and validation for dipyridamole
Journal of Pharmaceutical Research and Health Care, 2010
Comparison of US and Japanese regulations for invitro dissolution and invivo bioequivalence studies
Latif D. Jamadar Krishnamurthy Bhat, Yogesh Shirode Prashant B. Musmade
Journal of Bioanalysis and Biomedicine, 2010
High performance liquid chromatographic method for determination of clobetasol in rat plasma and its application to skin penetration
Prashant B Musmade, Praful B Deshpande, Shriram M Pathak, Adiga MNS Krishnamurthy M. Bhat
Journal of Bioanalysis and Biomedicine, 2010
Validated HPLC method for quantitative determination of talinolol in rat plasma and application to a preclinical pharmacokinetic study
Shriram M Pathak, Prashant B Musmade, Krishnamurthy M Bhat, Nayanabhirama Udupa
Bioanalysis, 2010
Analytical method development and validation for aspirin
International Journal of Chemtech Research, 2010
Quantification of quetiapine in human plasma by reverse phase high performance liquid chromatography
Dev Prakash, Krishnamurthy Bhat, Raghavendra Shetty, Parveen Chaudhary, Sri Pathak, Ghosh Amitabha
Arzneimittel Forschung Drug Research, 2010
A sensitive and selective HPLC method for estimation of lamotrigine in human plasma and saliva: Application to plasma-saliva correlation in epileptic patients
Surulivel Mallayasamy, Karthik Arumugam, Tarun Jain, Thiyagu Rajakannan, Krishnamurthy Bhat, Padma Gurumadhavrao, Ramakrishna Devarakonda
Arzneimittel Forschung Drug Research, 2010
Gender differences in the pharmacokinetics of rivastigmine in rats
Karthik Arumugam, Mallikarjuna Chamallamudi, Surulivel Mallayasamy, Subramanian Ganesan, Gopal Shavi, Ranjithkumar Averineni, Ravindranath Reddy, Krishnamurthy Bhat, Nayanabhirama Udupa
Arzneimittel Forschung Drug Research, 2009
Imatinib quantification in rat plasma by high performance liquid chromatography with ultra violet detection - An application to preclinical pharmacokinetic study
Pharmacologyonline, 2008
Simultaneous determination of pioglitazone and glimepiride in bulk drug and pharmaceutical dosage form by RP-HPLC method
Pakistan Journal of Pharmaceutical Sciences, 2008
LC method for the estimation of Cefprozil in human plasma and its pharmacokinetics
Indian Drugs, 2004
Development of HPLC assay method for the estimation of olanzapine in human plasma and its application to pharmacokinetics
Indian Drugs, 2003
Development of a new spectrophotometric method for the analysis of atropine sulphate
Indian Journal of Pharmaceutical Sciences, 2002
LC determination and pharmacokinetics of meloxicam
Bhavesh Dasandi, Shivaprakash, H. Saroj, K.M. Bhat
Journal of Pharmaceutical and Biomedical Analysis, 2002
A Sensitive High Performance Liquid Chromatography Method for Determination of Bioequivalence of Atenolol Formulations
Indian Journal of Pharmaceutical Sciences, 2000

Krishnamurthy Bhat

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