JOSE AUGUSTO SGARBI

Scopus Publications

Natural history of thyroid function in ageing: an individual participant data analysis of 137 488 participants from 31 prospective cohort studies
Yanning Xu, Ola Hysaj, Xiaoyi Qi, Martin Feller, Alessandro Pingitore, Suzanne J Brown, Till Ittermann, Massimo Iacoviello, Stella Trompet, Ji Won Han, Börge Schmidt, José A Sgarbi, Sergio Valdés, Axel Muendlein, Johannes Riis, Stig Andersen, Heinz Drexel, Alexander Teumer, Marcus Dörr, Mark P J Vanderpump, Nick Wareham, Bert Vaes, W Edward Visser, J Wouter Jukema, Misa Imaizumi, Robin P F Dullaart, Marco Medici, Howard A Fink, Graziano Ceresini, Luigi Ferrucci, M Arfan Ikram, Graeme J Hankey, Giorgio Iervasi, Richard Eastell, Douglas C Bauer, Graham R Williams, Kristien Boelaert, Bruce M Psaty, Dagmar Führer-Sakel, Stephan J L Bakker, Lambertus A L M Kiemeney, Niels P Riksen, Ki Woong Kim, Fereidoun Azizi, Henry Völzke, Bu B Yeap, Salman Razvi, Jacobijn Gussekloo, John P Walsh, Isabela M Bensenor, Jennifer Mammen, Nicolas Rodondi, Anne R Cappola, Robin P Peeters, Layal Chaker, Yanning Xu, Ola Hysaj, Xiaoyi Qi, Martin Feller, Alessandro Pingitore, Suzanne J Brown, Till Ittermann, Massimo Iacoviello, Stella Trompet, Ji Won Han, Börge Schmidt, José A Sgarbi, Sergio Valdés, Axel Muendlein, Johannes Riis, Stig Andersen, Heinz Drexel, Alexander Teumer, Marcus Dörr, Mark P J Vanderpump, Nick Wareham, Bert Vaes, W. Edward Visser, J. Wouter Jukema, Misa Imaizumi, Robin P F Dullaart, Marco Medici, Howard A Fink, Graziano Ceresini, Luigi Ferrucci, M. Arfan Ikram, Graeme J Hankey, Giorgio Iervasi, Richard Eastell, Douglas C Bauer, Graham R Williams, Kristien Boelaert, Bruce M Psaty, Dagmar Führer-Sakel, Stephan J L Bakker, Lambertus A L M Kiemeney, Niels P Riksen, Ki Woong Kim, Fereidoun Azizi, Henry Völzke, Bu B Yeap, Salman Razvi, Jacobijn Gussekloo, John P Walsh, Isabela M Bensenor, Jennifer Mammen, Nicolas Rodondi, Anne R Cappola, Robin P Peeters, Layal Chaker
Lancet Diabetes Endocrinology, 2026
Thyroid antibody status, thyroid function, and the risk of coronary heart disease and stroke: An individual participant data analysis from 14 cohorts
Ola Hysaj, Orestis Efthimiou, Tinh-Hai Collet, Anne R Cappola, Heba Alwan, Jacobijn Gussekloo, Layal Chaker, Maryam Kavousi, Fereidoun Azizi, Anna Köttgen, Elizabeth Selvin, Stella Trompet, John P Walsh, Suzanne J Brown, Massimo Iacoviello, Robin P F Dullaart, Stephan J L Bakker, José A Sgarbi, Till Ittermann, Henry Völzke, Isabela M Benseñor, Sergio Valdés, Cristina Maldonado-Araque, Bruce M Psaty, Frank J Wolters, Bjørn O Åsvold, Cinzia Del Giovane, Nicolas Rodondi
European Journal of Endocrinology, 2025
Objective The association of thyroid peroxidase antibodies (TPOAb) status with cardiovascular disease (CVD) risk, independent of thyroid function, remains unclear. We aimed to determine whether positive TPOAb is associated with increased CVD risk, overall and among individuals with subclinical hypothyroidism. Methods We conducted a 2-stage individual participant data analysis including cohort studies identified through the Thyroid Studies Collaboration and systematic database searches (MEDLINE, EMBASE, Cochrane Library) through November 2024. Primary outcomes were coronary heart disease (CHD) events, CHD mortality, stroke events, and stroke mortality. We used Cox proportional hazards models, adjusted for age, sex, and thyroid-stimulating hormone (TSH) within each cohort, followed by a random-effects meta-analysis to assess cardiovascular outcomes by TPOAb status, overall and in the subclinical hypothyroidism subgroup. Results Among 100 250 adults from 14 cohort studies (median age 55 years, 56.7% women), 11.9% were TPOAb-positive, and 5.4% had subclinical hypothyroidism. In the overall population, we found no evidence of increased CVD risk in TPOAb-positive compared to TPOAb-negative individuals: Hazard ratio (HR) 1.00 (95% CI 0.90-1.11) for CHD events; HR 0.95 (95% CI 0.78-1.16) for CHD mortality; HR 0.98 (95% CI 0.87-1.11) for stroke events; and HR 1.06 (95% CI 0.81-1.40) for stroke mortality. In subclinical hypothyroidism, positive TPOAb was similarly not associated with increased risk for any of the CVD outcomes. Conclusions Positive TPOAb status was not associated with increased risk of CHD or stroke. These findings do not support the use of TPOAb testing for cardiovascular risk assessment in the overall population or among individuals with subclinical hypothyroidism.
The Metabolic Vulnerability Index (MVX) in Subclinical Thyroid Disorders and Euthyroidism: A Cross-Sectional Exploratory Analysis from the ELSA-Brasil Study
Carolina Castro Porto Silva Janovsky, Vandrize Meneghini, William Tebar, Joao Roberto Maciel Martins, José Augusto Sgarbi, Patrícia de Fatima dos Santos Teixeira, Itamar de Souza Santos, Steven R. Jones, Michael J. Blaha, Peter P. Toth, Marcio S. Bittencourt, Raul D. Santos, Paulo A. Lotufo, Layal Chaker, Isabela M. Bensenor
Metabolites, 2025
Background: Recently, a new biomarker index that reflects inflammation and protein energy malnutrition has emerged as a predictor of mortality in cardiovascular diseases. The metabolic vulnerability index (MVX) derives from blood-based inflammation (IVX) and malnutrition (MMX) markers measured by nuclear magnetic resonance (NMR) spectroscopy. We aimed to explore the association of subclinical hypothyroidism and thyroid-related parameters with IVX, MMX, and MVX scores. Methods: This cross-sectional study used the baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Individuals with normal thyroid function and subclinical hypothyroidism were included. Thyroid-related parameters—thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), the FT3–FT4 ratio, and antithyroperoxidase antibodies (TPOAb)—were the explanatory variables. The primary outcomes, MVX, MMX, and IVX scores, were analyzed as continuous variables. Linear regression analyses were performed for both univariate and multivariable models, with sensitivity and subgroup analyses applied to assess robustness. Findings: There were 3979 participants (51.4% female) with a mean age of 51.26 (SD: 9.02) years. After full adjustment for potential confounder variables, FT3 levels [B: −1.37 (−2.43;−0.31) p = 0.011] and the FT3–FT4 ratio [B: −0.90 (−1.79;−0.01) p = 0.047] were inversely associated with MVX scores. FT3 levels were also inversely associated with IVX [B: −1.32 (−2.39;−0.24) p = 0.017]. These results were consistent in euthyroid individuals and those with cardiometabolic diseases. In the sex-stratified analysis, FT3 levels were inversely associated with MVX, MMX, and IVX scores for men. Conclusion: Lower FT3 levels and the FT3–FT4 ratio were associated with a higher metabolic vulnerability in our cohort. Our study sheds light on the importance of metabolic surveillance in these patients, especially for men with cardiometabolic diseases.
Associations Between Subclinical Thyroid Dysfunction and Cardiovascular Risk Factors According to Age and Sex
Oliver Baretella, Manuel R Blum, Nazanin Abolhassani, Heba Alwan, Lea Wildisen, Cinzia Del Giovane, Kali Tal, Elisavet Moutzouri, Bjørn O Åsvold, Anne R Cappola, Jacobijn Gussekloo, Massimo Iacoviello, Giorgio Iervasi, Misa Imaizumi, Stefan Weiler, Salman Razvi, José A Sgarbi, Henry Völzke, Suzanne J Brown, John P Walsh, Bert Vaes, Bu B Yeap, Robin P F Dullaart, Stephan J L Bakker, Maryam Kavousi, Graziano Ceresini, Luigi Ferrucci, Drahomir Aujesky, Robin P Peeters, Douglas C Bauer, Martin Feller, Nicolas Rodondi
Journal of Clinical Endocrinology and Metabolism, 2025
Context Subclinical thyroid dysfunction (ScTD), comprising subclinical hypothyroidism (SHypo) and subclinical hyperthyroidism (SHyper), has been associated with increased risk for cardiovascular events. Objective To assess associations between ScTD and cardiovascular risk factors (cvRFs) according to age and sex. Methods This analysis of pooled participant data from large prospective cohort studies from the Thyroid Studies Collaboration assessed cvRFs (blood pressure [BP], lipid levels, high-sensitivity C-reactive protein [hs-CRP]) among participants aged 18 to 103 years with SHypo (thyroid-stimulating hormone [TSH] &gt; 4.50 mU/L, normal fT4) and SHyper (TSH &lt; 0.45 mU/L, normal fT4) vs euthyroid (TSH 0.45-4.50 mU/L). Results Of 69 006 participants (mean age 62 years, 55% women, 25% current smokers) from 16 international cohorts, 3748 (5.4%) had SHypo and 3428 (5.0%) had SHyper. In both women and men, systolic and diastolic BP were similar regardless of thyroid status. Exceptions were lower diastolic BP in women with SHyper compared to euthyroid participants (adjusted mean difference [aMD] −1.3 mmHg, 95% CI −2.0 to −0.5), and lower systolic BP in men with SHyper compared to euthyroid participants (aMD −3.1 mmHg, 95% CI −4.8 to −1.4). In both women and men, lipid levels (total, HDL, LDL-cholesterol, triglycerides) and hs-CRP were similar regardless of thyroid status. The only exception were women with SHyper who had lower LDL-cholesterol vs euthyroid (aMD −0.17 mmol/L, 95% CI −0.29 to −0.05). Conclusion Participants with ScTD and euthyroid participants have similar cvRFs and differences are arguably too small to explain the increased cardiovascular risk in ScTD observed in previous studies.
Thyroid peroxidase antibodies were associated with prevalent carotid intima-media thickness in middle-age and older adults: the ELSA-Brasil cohort
Vandrize Meneghini, William R. Tebar, Itamar S. Santos, Carolina C.P.S. Janovsky, Ana C. Varella, Paulo A. Lotufo, José A. Sgarbi, Patrícia F.S. Teixeira, Isabela M. Benseñor
Journal of Endocrinological Investigation, 2025
Branched-Chain Amino Acids, Alanine, and Thyroid Function: A Cross-Sectional, Nuclear Magnetic Resonance (NMR)-Based Approach from ELSA-Brasil
Carolina Castro Porto Silva Janovsky, Vandrize Meneghini, William Tebar, Joao Roberto Maciel Martins, José Augusto Sgarbi, Patrícia de Fatima dos Santos Teixeira, Steven R. Jones, Michael J. Blaha, Peter P. Toth, Paulo A. Lotufo, Marcio S. Bittencourt, Raul D. Santos, Itamar S. Santos, Layal Chaker, Isabela M. Bensenor
Metabolites, 2024
The association of thyroid function with essential and non-essential amino acids is understudied, despite their common metabolic roles. Thus, our aim was to evaluate the association of thyroid function with the levels of branched-chain amino acids (BCAAs—leucine, isoleucine, and valine) and of alanine in the general population. We utilized data from the São Paulo research center of ELSA-Brasil, a longitudinal population-based cohort study. Thyroid parameters included thyroid stimulating hormone (TSH), free T4 and free T3 levels, and the FT4:FT3 ratio. BCAAs and alanine were analyzed on a fully automated NMR platform. The current analysis included euthyroid participants and participants with subclinical hyperthyroidism and hypothyroidism. We used Pearson’s coefficient to quantify the correlation between thyroid-related parameters and amino acids. Linear regression models were performed to analyze whether thyroid parameters were associated with BCAAs and alanine levels. We included 4098 participants (51.3 ± 9.0 years old, 51.5% women) in this study. In the most adjusted model, higher levels of TSH were associated with higher levels of alanine, FT4 levels were inversely associated with isoleucine levels, FT3 levels were statistically significant and positively associated with valine and leucine, and the T3:T4 ratio was positively associated with all amino acids. We observed that subclinical hypothyroidism was positively associated with isoleucine and alanine levels in all models, even after full adjustment. Our findings highlight the association of subclinical hypothyroidism and thyroid-related parameters (including TSH, free T4, free T3, and FT4:FT3 ratio) with BCAAs and alanine. Further studies are needed to explore the mechanisms underlying this association. These insights contribute to our understanding of the influence of thyroid-related parameters on BCAA and alanine metabolism.
Potential Determinants of Thyroid Peroxidase Antibodies and Mortality Risk: Results From the ELSA-Brasil Study
Vandrize Meneghini, William Rodrigues Tebar, Itamar Souza Santos, Carolina Castro Porto Silva Janovsky, Bianca de Almeida-Pititto, Marina Gabriela Birck, Paulo Andrade Lotufo, Alessandra Carvalho Goulart, José Augusto Sgarbi, Patrícia de Fátima dos Santos Teixeira, Gisela Tunes da Silva, Isabela Martins Benseñor
Journal of Clinical Endocrinology and Metabolism, 2024
Context The presence of thyroid peroxidase antibodies (TPOAbs) may be considered as an indicator of adverse health outcomes. Objective We aimed to investigate the potential determinants of TPOAb levels and to analyze the association between TPOAb titers and the risk of all- and specific-cause mortality. Methods Baseline and longitudinal data of 13 187 participants from the ELSA-Brasil Study were analyzed. We investigated the association of TPOAb, detectability, positivity, and persistent positivity with sociodemographic and lifestyle factors using logistic regressions. Cox proportional hazards and Fine-Gray subdistribution hazard regression analyses were used to verify the association of TPOAbs with mortality. Results The determinants of TPOAb detectability and positivity were younger age, higher body mass index, female sex, and former and current smoking status. Black, mixed, and other self-reported races, intermediate and higher education, and heavy drinking were determinants of detectable and positive TPOAb levels. Female sex, White race, and former smoking were determinants of persistent TPOAb positivity at 2 visits, although only the female sex maintained its association at 3 visits. Moreover, after multivariate adjustment, there were associations between higher levels of TPOAbs and higher risk of cancer-related mortality among men, and TPOAb detectability and mortality by other causes among women. Conclusion Sociodemographic and lifestyle-related factors were determinants of multiple TPOAb categories. TPOAb levels were associated with mortality risk; however, the low mortality rate in this sample might have compromised this finding. We suggest further studies to explore the clinical importance of detectable TPOAb levels, not only its positivity, as a potential marker of inflammation.
Associations of TSH, free T3, free T4, and conversion ratio with incident hypertension: results from the prospective Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
Marina Gabriela Birck, Carolina C. P. S. Janovsky, Alessandra Carvalho Goulart, Vandrize Meneghini, Bianca de Almeida Pititto, José Augusto Sgarbi, Patrícia de Fátima dos Santos Teixeira, Isabela M. Bensenor
Archives of Endocrinology and Metabolism, 2024
Objective To evaluate the association of TSH, free T3 (FT3), free T4 (FT4), and conversion (FT3:FT4) ratio values with incident hypertension. Materials and methods The study included data from participants of the ELSA-Brasil study without baseline hypertension. Serum TSH, FT4 and FT3 levels, and FT3:FT4 ratio values were assessed at baseline, and incident hypertension (defined by blood pressure levels ≥ 140/90 mmHg) was estimated over a median of 8.2 years of follow-up. The risk of incident hypertension was evaluated considering a 1-unit increase in TSH, FT4, FT3, and conversion ratio values and after dividing these variables into quintiles for further analysis using Poisson regression with robust variance. The results are presented as relative risks (RR) and 95% confidence intervals (CIs) before and after adjustment for multiple variables. Results The primary analysis incorporated data from 5,915 euthyroid individuals, and the secondary analysis combined data from all euthyroid individuals, 587 individuals with subclinical hypothyroidism, and 31 individuals with subclinical hyperthyroidism. The rate of incident hypertension was 28% (95% CI: 27%-29.3%). The FT4 levels in the first quintile (0.18-1.06 ng/dL) were significantly associated with incident hypertension (RR: 1.03, 95% CI: 1.01-1.06) at follow-up. The association between FT4 levels in the first quintile and incident hypertension was also observed in the analysis of combined data from euthyroid individuals and participants with subclinical thyroid dysfunction (RR: 1.04, 95% CI: 1.01-1.07). The associations were predominantly observed with systolic blood pressure levels in euthyroid individuals. However, in the combined analysis incorporating euthyroid participants and individuals with subclinical thyroid dysfunction, the associations were more pronounced with diastolic blood pressure levels. Conclusion Low FT4 levels may be a mild risk factor for incident hypertension in euthyroid individuals and persons with subclinical thyroid dysfunction.
The optimal healthy ranges of thyroid function defined by the risk of cardiovascular disease and mortality: systematic review and individual participant data meta-analysis
Yanning Xu, Arash Derakhshan, Ola Hysaj, Lea Wildisen, Till Ittermann, Alessandro Pingitore, Nazanin Abolhassani, Marco Medici, Lambertus A L M Kiemeney, Niels P Riksen, Robin P F Dullaart, Stella Trompet, Marcus Dörr, Suzanne J Brown, Börge Schmidt, Dagmar Führer-Sakel, Mark P J Vanderpump, Axel Muendlein, Heinz Drexel, Howard A Fink, M Kamran Ikram, Maryam Kavousi, Connie M Rhee, Isabela M Bensenor, Fereidoun Azizi, Graeme J Hankey, Massimo Iacoviello, Misa Imaizumi, Graziano Ceresini, Luigi Ferrucci, José A Sgarbi, Douglas C Bauer, Nick Wareham, Kristien Boelaert, Stephan J L Bakker, J Wouter Jukema, Bert Vaes, Giorgio Iervasi, Bu B Yeap, Rudi G J Westendorp, Tim I M Korevaar, Henry Völzke, Salman Razvi, Jacobijn Gussekloo, John P Walsh, Anne R Cappola, Nicolas Rodondi, Robin P Peeters, Layal Chaker
Lancet Diabetes and Endocrinology, 2023
The Relationship between Type 1 Diabetes Mellitus, TNF-α, and IL-10 Gene Expression
Jesselina Francisco dos Santos Haber, Sandra Maria Barbalho, Jose Augusto Sgarbi, Rafael Santos de Argollo Haber, Roger William de Labio, Lucas Fornari Laurindo, Eduardo Federighi Baisi Chagas, Spencer Luiz Marques Payão
Biomedicines, 2023
Type 1 diabetes mellitus (T1DM) is one of the major chronic diseases in children worldwide. This study aimed to investigate interleukin-10 (IL-10) gene expression and tumor necrosis factor-alpha (TNF-α) in T1DM. A total of 107 patients were included, 15 were T1DM in ketoacidosis, 30 patients had T1DM and HbA1c ≥ 8%; 32 patients had T1DM and presented HbA1c < 8%; and 30 were controls. The expression of peripheral blood mononuclear cells was performed using the reverse transcriptase–polymerase chain reaction in real time. The cytokines gene expression was higher in patients with T1DM. The IL-10 gene expression increased substantially in patients with ketoacidosis, and there was a positive correlation with HbA1c. A negative correlation was found for IL-10 expression and the age of patients with diabetes, and the time of diagnosis of the disease. There was a positive correlation between TNF-α expression with age. The expression of IL-10 and TNF-α genes showed a significant increase in DM1 patients. Once current T1DM treatment is based on exogenous insulin, there is a need for other therapies, and inflammatory biomarkers could bring new possibilities to the therapeutic approach of the patients.
Editorial: The thyroid and Covid-19, volume II
Gabriela Brenta, Marco António Campinho, Celia Regina Nogueira, Jose Sgarbi
Frontiers in Endocrinology, 2023
Editorial: New insights in thyroid and Covid-19
Jose Augusto Sgarbi, Celia Regina Nogueira, Gabriela Brenta, Marco Antonio Campinho
Frontiers in Endocrinology, 2022
Thyroid-Stimulating Hormone and Thyroid Hormones and Incidence of Diabetes: Prospective Results of the Brazilian Longitudinal Study of Adult Health (ELSA-BRASIL)
Marina Gabriela Birck, Bianca de Almeida-Pititto, Carolina C.P.S. Janovsky, Alessandra Carvalho Goulart, Itamar S. Santos, Patrícia de Fátima dos Santos Teixeira, Jose A. Sgarbi, Sandhi M. Barreto, Bruce B. Duncan, Maria Inês Schmidt, Paulo A. Lotufo, Isabela M. Bensenor
Thyroid, 2022
Incorporating Baseline Outcome Data in Individual Participant Data Meta-Analysis of Non-randomized Studies
Lamprini Syrogiannouli, Lea Wildisen, Christiaan Meuwese, Douglas C. Bauer, Anne R. Cappola, Jacobijn Gussekloo, Wendy P. J. den Elzen, Stella Trompet, Rudi G. J. Westendorp, J. Wouter Jukema, Luigi Ferrucci, Graziano Ceresini, Bjørn O. Åsvold, Layal Chaker, Robin P. Peeters, Misa Imaizumi, Waka Ohishi, Bert Vaes, Henry Völzke, Josè A. Sgarbi, John P. Walsh, Robin P. F. Dullaart, Stephan J. L. Bakker, Massimo Iacoviello, Nicolas Rodondi, Cinzia Del Giovane
Frontiers in Psychiatry, 2022
Level of physical activity and gene expression of IL-10 and TNF-α in children and adolescents with Type 1 diabetes
Jesselina Francisco dos Santos Haber, Eduardo Federighi Baisi Chagas, Sandra Maria Barbalho, Jose Augusto Sgarbi, Rafael Santos De Argollo Haber, Roger William de Labio, Spencer Luiz Marques Payão
Journal of Diabetes and Its Complications, 2022
Approach to adult patients with primary hypothyroidism in some special situations: a position statement from the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism (SBEM)
Gláucia Maria Ferreira da Silva Mazeto, José Augusto Sgarbi, Helton Estrela Ramos, Danilo Glauco Pereira Villagelin, Célia Regina Nogueira, Mario Vaisman, Hans Graf, Gisah Amaral de Carvalho
Archives of Endocrinology and Metabolism, 2022
Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: Design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasil
Isabela M. Bensenor, Alessandra C. Goulart, Alexandre C. Pereira, André R. Brunoni, Airlane Alencar, Raul D. Santos, Márcio S. Bittencourt, Rosa W. Telles, Luciana Andrade Carneiro Machado, Sandhi Maria Barreto, Bianca de Almeida-Pititto, Carolina Porto Silva Janovsky, José Augusto Sgarbi, William R. Tebar, Vandrize Meneghini, Fernando Barbosa Junior, Ana Cristina de Medeiros Ribeiro, Sandra Gofinet Pasoto, Rosa Maria R. Pereira, Eloísa Bonfá, Aytan M. Sipahi, Itamar de S. Santos, Paulo A. Lotufo
Clinics, 2022
Urinary iodine and sodium concentration and thyroid status in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
Isabela M. Benseñor, Fernando Barbosa Junior, Carolina Castro Porto Silva Janovsky, Dirce Marchioni, Maria de Fátima Haueisen Sander Diniz, Itamar de Souza Santos, Bianca de Almeida-Pititto, José Augusto Sgarbi, Maria del Carmen B. Molina, José Geraldo Mill, Paulo A. Lotufo
Journal of Trace Elements in Medicine and Biology, 2021
A practical contemporary approach to decision-making on subclinical hypothyroidism
José Augusto Sgarbi, Laura Sterian Ward
Archives of Endocrinology and Metabolism, 2021
Management of thyroid disorders during the COVID-19 outbreak: a position statement from the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism (SBEM)
João Roberto M. Martins, Danilo G. P. Villagelin, Gisah A. Carvalho, Fernanda Vaisman, Patrícia F. S. Teixeira, Rafael S. Scheffel, José A. Sgarbi
Archives of Endocrinology and Metabolism, 2021
Incidence of TPOAb over a 4-year follow-up period: results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
Isabela M. Benseñor, Carolina Castro Porto Silva Janovsky, Alessandra C. Goulart, Itamar de Souza Santos, Maria de Fátima Haueisen Sander Diniz, Bianca de Almeida-Pititto, José Augusto Sgarbi, Paulo A. Lotufo
Archives of Endocrinology and Metabolism, 2021
Incidence of thyroid diseases: Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
Isabela M. Benseñor, José Augusto Sgarbi, Carolina Castro Porto Silva Janovsky, Bianca Almeida Pittito, Maria de Fátima Haueisen Sander Diniz, Maria da Conceição Chagas de Almeida, Sheila Maria Alvim, Sandhi M. Barreto, Luana Giatti, Bruce B. Duncan, Maria Inês Schmidt, Maria de Jesus M. Fonseca, Rosane H. Griep, Maria del Carmen B. Molina, José Geraldo Mill, Itamar de Souza Santos, Alessandra C. Goulart, Paulo A. Lotufo
Archives of Endocrinology and Metabolism, 2021
Thyroid and the Heart: A Historical Perspective
José Augusto Sgarbi
Thyroid and Heart A Comprehensive Translational Essay Second Edition, 2020
Efficacy and safety of a biosimilar recombinant human growth hormone (r-hGH Cristalia) compared with reference r-hGH in children with growth hormone deficiency (CERES study): A randomized, multicentric, investigator-blind, phase 3 trial
M.A. Czepielewski, Q. Garret, S.A.C. Vencio, N. Rassi, J.S. Felicio, M.S. Faria, C.C.P. Senn, M.D. Bronstein, M.J.A.G. Cerqueira, A.C.L. Neves, J.A. Sgarbi, A.M. Spinola-Castro, M.P.R. Cunha, F. Bandeira, O. Toffoletto, J. Afiune, R. Baradelli, D.G. Rodrigues, M. Scharf
Growth Hormone and IGF Research, 2019
Low thyroid function is not associated with an accelerated deterioration in renal function
Christiaan L Meuwese, Merel van Diepen, Anne R Cappola, Mark J Sarnak, Michael G Shlipak, Douglas C Bauer, Linda P Fried, Massimo Iacoviello, Bert Vaes, Jean Degryse, Kay-Tee Khaw, Robert N Luben, Bjørn O Åsvold, Trine Bjøro, Lars J Vatten, Anton J M de Craen, Stella Trompet, Giorgio Iervasi, Sabrina Molinaro, Graziano Ceresini, Luigi Ferrucci, Robin P F Dullaart, Stephan J L Bakker, J Wouter Jukema, Patricia M Kearney, David J Stott, Robin P Peeters, Oscar H Franco, Henry Völzke, John P Walsh, Alexandra Bremner, José A Sgarbi, Rui M B Maciel, Misa Imaizumi, Waka Ohishi, Friedo W Dekker, Nicolas Rodondi, Jacobijn Gussekloo, Wendy P J den Elzen, and
Nephrology Dialysis Transplantation, 2019
Subclinical Hyperthyroidism
Gabriela Brenta, José Sgarbi
Thyroid and Its Diseases A Comprehensive Guide for the Clinician, 2019
Region-specific reference intervals for TSH in pregnancy: Time for changes in Brazil
José Augusto Sgarbi
Archives of Endocrinology and Metabolism, 2018
Thyroid function within the reference range and the risk of stroke: An individual participant data analysis
Layal Chaker, Christine Baumgartner, Wendy P. J. den Elzen, Tinh-Hai Collet, M. Arfan Ikram, Manuel R. Blum, Abbas Dehghan, Christiane Drechsler, Robert N. Luben, Marileen L. P. Portegies, Giorgio Iervasi, Marco Medici, David J. Stott, Robin P. Dullaart, Ian Ford, Alexandra Bremner, Anne B. Newman, Christoph Wanner, José A. Sgarbi, Marcus Dörr, W. T. Longstreth, Bruce M. Psaty, Luigi Ferrucci, Rui M. B. Maciel, Rudi G. Westendorp, J. Wouter Jukema, Graziano Ceresini, Misa Imaizumi, Albert Hofman, Stephan J. L. Bakker, Jayne A. Franklyn, Kay-Tee Khaw, Douglas C. Bauer, John P. Walsh, Salman Razvi, Jacobijn Gussekloo, Henry Völzke, Oscar H. Franco, Anne R. Cappola, Nicolas Rodondi, Robin P. Peeters, and
Journal of Clinical Endocrinology and Metabolism, 2016
Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes
Jennifer B. Green, M. Angelyn Bethel, Paul W. Armstrong, John B. Buse, Samuel S. Engel, Jyotsna Garg, Robert Josse, Keith D. Kaufman, Joerg Koglin, Scott Korn, John M. Lachin, Darren K. McGuire, Michael J. Pencina, Eberhard Standl, Peter P. Stein, Shailaja Suryawanshi, Frans Van de Werf, Eric D. Peterson, Rury R. Holman
New England Journal of Medicine, 2015
Thyroid function within the normal range and risk of coronary heart disease an individual participant data analysis of 14 cohorts
Bjørn O. Åsvold, Lars J. Vatten, Trine Bjøro, Douglas C. Bauer, Alexandra Bremner, Anne R. Cappola, Graziano Ceresini, Wendy P. J. den Elzen, Luigi Ferrucci, Oscar H. Franco, Jayne A. Franklyn, Jacobijn Gussekloo, Giorgio Iervasi, Misa Imaizumi, Patricia M. Kearney, Kay-Tee Khaw, Rui M. B. Maciel, Anne. B. Newman, Robin P. Peeters, Bruce M. Psaty, Salman Razvi, José A. Sgarbi, David J. Stott, Stella Trompet, Mark P. J. Vanderpump, Henry Völzke, John P. Walsh, Rudi G. J. Westendorp, Nicolas Rodondi
JAMA Internal Medicine, 2015
Subclinical hypothyroidism and the risk of stroke events and fatal stroke: An individual participant data analysis
Layal Chaker, Christine Baumgartner, Wendy P. J. den Elzen, M. Arfan Ikram, Manuel R. Blum, Tinh-Hai Collet, Stephan J. L. Bakker, Abbas Dehghan, Christiane Drechsler, Robert N. Luben, Albert Hofman, Marileen L. P. Portegies, Marco Medici, Giorgio Iervasi, David J. Stott, Ian Ford, Alexandra Bremner, Christoph Wanner, Luigi Ferrucci, Anne B. Newman, Robin P. Dullaart, José A. Sgarbi, Graziano Ceresini, Rui M. B. Maciel, Rudi G. Westendorp, J. Wouter Jukema, Misa Imaizumi, Jayne A. Franklyn, Douglas C. Bauer, John P. Walsh, Salman Razvi, Kay-Tee Khaw, Anne R. Cappola, Henry Völzke, Oscar H. Franco, Jacobijn Gussekloo, Nicolas Rodondi, Robin P. Peeters
Journal of Clinical Endocrinology and Metabolism, 2015
Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial of lixisenatide versus placebo
Rhonda Bentley-Lewis, David Aguilar, Matthew C. Riddle, Brian Claggett, Rafael Diaz, Kenneth Dickstein, Hertzel C. Gerstein, Peter Johnston, Lars V. Køber, Francesca Lawson, Eldrin F. Lewis, Aldo P. Maggioni, John J.V. McMurray, Lin Ping, Jeffrey L. Probstfield, Scott D. Solomon, Jean-Claude Tardif, Yujun Wu, Marc A. Pfeffer
American Heart Journal, 2015
Autoimmune thyroid disease: What secrets we still need to unravel?
José Augusto Sgarbi
Archives of Endocrinology and Metabolism, 2015
Thyroid antibody status, subclinical hypothyroidism, and the risk of coronary heart disease: An individual participant data analysis
Tinh-Hai Collet, Douglas C. Bauer, Anne R. Cappola, Bjørn O. Åsvold, Stefan Weiler, Eric Vittinghoff, Jacobijn Gussekloo, Alexandra Bremner, Wendy P. J. den Elzen, Rui M. B. Maciel, Mark P. J. Vanderpump, Jacques Cornuz, Marcus Dörr, Henri Wallaschofski, Anne B. Newman, José A. Sgarbi, Salman Razvi, Henry Völzke, John P. Walsh, Drahomir Aujesky, Nicolas Rodondi
Journal of Clinical Endocrinology and Metabolism, 2014
Clinical practice guidelines for the management of hypothyroidism
Gabriela Brenta, Mario Vaisman, José Augusto Sgarbi, Liliana Maria Bergoglio, Nathalia Carvalho de Andrada, Pedro Pineda Bravo, Ana Maria Orlandi, Hans Graf
Arquivos Brasileiros De Endocrinologia E Metabologia, 2013
The Brazilian consensus for the clinical approach and treatment of subclinical hypothyroidism in adults: Recommendations of the thyroid department of the Brazilian Society of Endocrinology and Metabolism
Jose A. Sgarbi, Patrícia F. S. Teixeira, Lea M. Z. Maciel, Glaucia M. F. S. Mazeto, Mario Vaisman, Renan M. Montenegro Junior, Laura S. Ward
Arquivos Brasileiros De Endocrinologia E Metabologia, 2013
Subclinical hyperthyroidism and the risk of coronary heart disease and mortality
Tinh-Hai Collet, Jacobijn Gussekloo, Douglas C. Bauer, Wendy P. J. den Elzen, Anne R. Cappola, Philippe Balmer, Giorgio Iervasi, Bjørn O. Åsvold, José A. Sgarbi, Henry Völzke, Bariş Gencer, Rui M. B. Maciel, Sabrina Molinaro, Alexandra Bremner, Robert N. Luben, Patrick Maisonneuve, Jacques Cornuz, Anne B. Newman, Kay-Tee Khaw, Rudi G. J. Westendorp, Jayne A. Franklyn, Eric Vittinghoff, John P. Walsh, Nicolas Rodondi, for the Thyroid Studies Collaboration
Archives of Internal Medicine, 2012
Parity is not related to autoimmune thyroid disease in a population-based study of Japanese-Brazilians
José A. Sgarbi, Teresa S. Kasamatsu, Luiza K. Matsumura, Rui M.B. Maciel
Thyroid, 2010
Subclinical thyroid dysfunctions are independent risk factors for mortality in a 7.5-year follow-up: The Japanese-Brazilian thyroid study
José A Sgarbi, Luiza K Matsumura, Teresa S Kasamatsu, Sandra R Ferreira, Rui M B Maciel
European Journal of Endocrinology, 2010
Subclinical hypothyroidism and the risk of coronary heart disease and mortality
Nicolas Rodondi, Wendy P. J. den Elzen, Douglas C. Bauer, Anne R. Cappola, Salman Razvi, John P. Walsh, Bjørn O. Åsvold, Giorgio Iervasi, Misa Imaizumi, Tinh-Hai Collet, Alexandra Bremner, Patrick Maisonneuve, José A. Sgarbi, Kay-Tee Khaw, Mark P. J. Vanderpump, Anne B. Newman, Jacques Cornuz, Jayne A. Franklyn, Rudi G. J. Westendorp, Eric Vittinghoff, Jacobijn Gussekloo, for the Thyroid Studies Collaboration
JAMA, 2010
Pathogenesis of autoimmune thyroid diseases
José Augusto Sgarbi, Rui M. B. Maciel
Arquivos Brasileiros De Endocrinologia E Metabologia, 2009
Saxagliptin given in combination with metformin as initial therapy improves glycaemic control in patients with type 2 diabetes compared with either monotherapy: A randomized controlled trial
M. Jadzinsky, A. Pfützner, E. Paz‐Pacheco, Z. Xu, E. Allen, R. Chen, and
Diabetes Obesity and Metabolism, 2009
Subclinical thyroid disease: subclinical hypothyroidism and hyperthyroidism
João Hamilton Romaldini, José Augusto Sgarbi, Chady Satt Farah
Arquivos Brasileiros De Endocrinologia E Metabologia, 2004
The effects of early antithyroid therapy for endogenous subclinical hyperthyroidism in clinical and heart abnormalities
José A. Sgarbi, Fábio G. Villaça, Benito Garbeline, HeloÍsa E. Villar, João H. Romaldini
Journal of Clinical Endocrinology and Metabolism, 2003
The evolution of Graves’ ophthalmopathy during treatment with antithyroid drug alone and combined with triiodothyronine
N. Bromberg, J. H. Romaldini, R. S. Werner, J. A. Sgarbi, M. C. Werner
Journal of Endocrinological Investigation, 1992
The Evolution of the Ophthalmopathy during Antithyroid Drug Therapy and its Relationship with Serum Thyroglobulin and Antithyroglobulin Antibody in Patients with Basedow's Disease
N. Bromberg, R. S. Werner, J. A. Sgarbi, M. C. Werner, J. H. Romaldini
Experimental and Clinical Endocrinology and Diabetes, 1991

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