Sameh Ahmad Muhammad Abdel-Ghany Aly

EDUCATION

• Assistant Professor(Lecturer) (from 23/1/2018 till now).
• Assistant lecturer of clinical pharmacology (29/9/2008 to 22/1/2018).
• Demonstrator of clinical pharmacology (23/6/2000 to 28/9/2008).

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmacology (medical)

RECENT SCHOLAR PUBLICATIONS

A novel combination therapy targets sonic hedgehog signaling by the dual inhibition of HMG-CoA reductase and HSP90 in rats with non-alcoholic steatohepatitis
OA Mohammed, ME Youssef, AS Doghish, RS Hamad, MA Abdel-Reheim, ...
European Journal of Pharmaceutical Sciences 198, 106792 2024



Hedgehog signaling mastery: R51211's promise in augmenting the therapeutic efficacy of sorafenib
AM Hasan, S Cavalu, S Saber, AS Doghish, RS Hamad, ...
Life Sciences, 122791 2024



Tracking the therapeutic efficacy of a ketone mono ester and β-hydroxybutyrate for ulcerative colitis in rats: New perspectives
OA Mohammed, S Saber, MA Abdel-Reheim, MMS Alamri, J Alfaifi, ...
Toxicology and Applied Pharmacology 486, 116943 2024



Linagliptin, a DPP‐4 inhibitor, activates AMPK/FOXO3a and suppresses NFκB to mitigate the debilitating effects of diethylnitrosamine exposure in rat liver: Novel mechanistic
R Abdelhady, OA Mohammed, AS Doghish, RS Hamad, ...
The FASEB Journal 38 (4), e23480 2024



Alvespimycin exhibits potential anti-TGF-β signaling in the setting of a proteasome activator in rats with bleomycin-induced pulmonary fibrosis: a promising novel approach
OA Mohammed, MA Abdel-Reheim, LA Saleh, MMS Alamri, J Alfaifi, ...
Pharmaceuticals 16 (8), 1123 2023



STA9090 as a potential therapeutic agent for liver fibrosis by modulating the HSP90/TβRII/proteasome interplay: novel insights from in vitro and in vivo investigations
OA Mohammed, MA Abdel-Reheim, MMS Alamri, J Alfaifi, MIE Adam, ...
Pharmaceuticals 16 (8), 1080 2023



(R, R)-BD-AcAc2 mitigates chronic colitis in rats: A promising multi-pronged approach modulating inflammasome activity, autophagy, and pyroptosis
S Saber, MMS Alamri, J Alfaifi, LA Saleh, S Abdel-Ghany, AM Aboregela, ...
Pharmaceuticals 16 (7), 953 2023



Potential effect of ferulic acid on NF-κB in a rat model of doxorubicin toxicity
SSELK Sameh Abdel Ghany, Hala Abdel Malek, Sahar EL Dakroory, Amira Kamal El ...
Medical Science 24 (106), 4321-4331 2020



Hepatic ischemia-reperfusion injury: pathogenesis and pharmacological treatment
SA Abdel-Ghany, HA Elashry, MM Ameen, KM Abdel-Rahman, ...
Advances in Medicine and Medical Research 1 (1), 02-18 2018



Potential effect of captopril , valsartan on nuclear factor kappa B and lipid peroxidation in hepatic ischemia-reperfusion injury in rats.
KMAERARAFY Sameh Ahmad Muhammad Abdel-ghany , Hala Abdel-Malek Elashry ...
Mansoura Medical Journal 44 (1) 2015

MOST CITED SCHOLAR PUBLICATIONS

Alvespimycin exhibits potential anti-TGF-β signaling in the setting of a proteasome activator in rats with bleomycin-induced pulmonary fibrosis: a promising novel approach
OA Mohammed, MA Abdel-Reheim, LA Saleh, MMS Alamri, J Alfaifi, ...
Pharmaceuticals 16 (8), 1123 2023
Citations: 24



STA9090 as a potential therapeutic agent for liver fibrosis by modulating the HSP90/TβRII/proteasome interplay: novel insights from in vitro and in vivo investigations
OA Mohammed, MA Abdel-Reheim, MMS Alamri, J Alfaifi, MIE Adam, ...
Pharmaceuticals 16 (8), 1080 2023
Citations: 8



(R, R)-BD-AcAc2 mitigates chronic colitis in rats: A promising multi-pronged approach modulating inflammasome activity, autophagy, and pyroptosis
S Saber, MMS Alamri, J Alfaifi, LA Saleh, S Abdel-Ghany, AM Aboregela, ...
Pharmaceuticals 16 (7), 953 2023
Citations: 3



Linagliptin, a DPP‐4 inhibitor, activates AMPK/FOXO3a and suppresses NFκB to mitigate the debilitating effects of diethylnitrosamine exposure in rat liver: Novel mechanistic
R Abdelhady, OA Mohammed, AS Doghish, RS Hamad, ...
The FASEB Journal 38 (4), e23480 2024
Citations: 2



Hepatic ischemia-reperfusion injury: pathogenesis and pharmacological treatment
SA Abdel-Ghany, HA Elashry, MM Ameen, KM Abdel-Rahman, ...
Advances in Medicine and Medical Research 1 (1), 02-18 2018
Citations: 2

Publications

Abdelhady, R., Mohammed, O.A., Doghish, A.S., Hamad, R.S., Mustafa Ahmed Abdel‐Reheim, Alamri, M.S., Muffarah Hamid Alharthi, Jaber Alfaifi, Adam, Abdullah Hassan Alhalafi, Mohammed, N.A., Adamu Imam Isa, Sameh Abdel‐Ghany, Attia, M.A., Elmorsy, E.A., Tohada M. AL‐Noshokaty, Yousra Nomier, El‐Dakroury, W.A. and Saber, S. (2024). Linagliptin, a DPP‐4 inhibitor, activates AMPK/FOXO3a and suppresses NFκB to mitigate the debilitating effects of diethylnitrosamine exposure in rat liver: Novel mechanistic insights. The FASEB Journal, 38(4). doi:.
Mohammed, O.A., Abdel-Reheim, M.A., Saleh, L.A., Alamri, M.M.S., Alfaifi, J., Adam, M.I., Farrag, A.A., AlQahtani, A.A.J., BinAfif, W.F., Hashish, A.A. and Abdel-Ghany, S., 2023. Alvespimycin exhibits potential anti-TGF-β signaling in the setting of a proteasome activator in rats with bleomycin-induced pulmonary fibrosis: a promising novel approach. Pharmaceuticals, 16(8), p.1123.
Mohammed, O.A., Abdel-Reheim, M.A., Alamri, M.M.S., Alfaifi, J., Adam, M.I., Saleh, L.A., Farrag, A.A., Yahia, A.I.O., Abdel-Ghany, S., AlQahtani, A.A.J. and Bahashwan, E., 2023. STA9090 as a potential therapeutic agent for liver fibrosis by modulating the HSP90/TβRII/proteasome interplay: novel insights from in vitro and in vivo investigations. Pharmaceuticals, 16(8), p.1080. Saber, S., Alamri, M.M.S., Alfaifi, J., Saleh, L.A., Abdel-Ghany, S., Aboregela, A.M., Farrag, A.A., Almaeen, A.H., Adam, M.I., AlQahtani, A.A.J. and E